Justine Webster
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View article: SUN-488 Activin Type II Receptor Blockade Impacts on Muscle Wasting in Glucocorticoid-Treated Exacerbations of COPD
SUN-488 Activin Type II Receptor Blockade Impacts on Muscle Wasting in Glucocorticoid-Treated Exacerbations of COPD Open
Disclosure: S.J. van Krimpen: None. J.M. Webster: None. P. Qiu: None. P. Henrot: None. B. Rezaeifar: None. S.O. Simons: None. A.M. Schols: None. R.C. Langen: None. H.R. Gosker: None. Chronic obstructive pulmonary disease (COPD) is the most…
View article: SUN-487 The Effects of Nandrolone on Muscle Wasting in a Mouse Model of Glucocorticoid-Treated Exacerbations of COPD
SUN-487 The Effects of Nandrolone on Muscle Wasting in a Mouse Model of Glucocorticoid-Treated Exacerbations of COPD Open
Disclosure: S.J. van Krimpen: None. J.M. Webster: None. P. Qiu: None. P. Henrot: None. B. Rezaeifar: None. S.O. Simons: None. A.M. Schols: None. H.R. Gosker: None. R.C. Langen: None. Chronic obstructive pulmonary disease (COPD) is the most…
View article: A trafficking regulatory subnetwork governs α <sub>V</sub> β <sub>6</sub> integrin-HER2 cross-talk to control breast cancer invasion and drug resistance
A trafficking regulatory subnetwork governs α <sub>V</sub> β <sub>6</sub> integrin-HER2 cross-talk to control breast cancer invasion and drug resistance Open
HER2 and α V β 6 integrin are independent predictors of breast cancer survival and metastasis. We identify an α V β 6 /HER2 cross-talk mechanism driving invasion, which is dysregulated in drug-resistant HER2+ breast cancer cells. Proteomic…
View article: Towards a fully automatic workflow for investigating the dynamics of lung cancer cachexia during radiotherapy using cone beam computed tomography
Towards a fully automatic workflow for investigating the dynamics of lung cancer cachexia during radiotherapy using cone beam computed tomography Open
Objective. Cachexia is a devastating condition, characterized by involuntary loss of muscle mass with or without loss of adipose tissue mass. It affects more than half of patients with lung cancer, diminishing treatment effects and increas…
View article: A trafficking regulatory subnetwork governs αVβ6 Integrin-HER2 crosstalk to control breast cancer invasion and drug resistance
A trafficking regulatory subnetwork governs αVβ6 Integrin-HER2 crosstalk to control breast cancer invasion and drug resistance Open
HER2 and αVβ6 integrin are independent predictors of breast cancer survival and metastasis. We investigated αVβ6 signalling and identified an αVβ6/HER2 crosstalk mechanism, which drives invasion and is dysregulated in drug resistant HER2+ …
View article: A trafficking regulatory subnetwork governs αVβ6 Integrin-HER2 crosstalk to control breast cancer invasion and drug resistance
A trafficking regulatory subnetwork governs αVβ6 Integrin-HER2 crosstalk to control breast cancer invasion and drug resistance Open
HER2 and α V β 6 integrin are independent predictors of breast cancer survival and metastasis. We investigated α V β 6 signalling and identified an α V β 6 /HER2 crosstalk mechanism, which drives invasion and is dysregulated in drug resist…
View article: 11β-HSD1 determines the extent of muscle atrophy in a model of acute exacerbation of COPD
11β-HSD1 determines the extent of muscle atrophy in a model of acute exacerbation of COPD Open
Muscle atrophy is an extrapulmonary complication of acute exacerbations (AE) in chronic obstructive pulmonary disease (COPD). The endogenous production and therapeutic application of glucocorticoids (GCs) have been implicated as drivers of…
View article: The role of pre-receptor glucocorticoid metabolism in chronic inflammatory disease-associated muscle atrophy
The role of pre-receptor glucocorticoid metabolism in chronic inflammatory disease-associated muscle atrophy Open
Chronic inflammatory diseases (CIDs) such as rheumatoid arthritis (RA) and chronic obstructive pulmonary disease (COPD) are associated with prolonged periods of local and systemic inflammation.As a result, patients with CIDs often encounte…
View article: Adaptive exhaustion during prolonged intermittent hypoxia causes dysregulated skeletal muscle protein homeostasis
Adaptive exhaustion during prolonged intermittent hypoxia causes dysregulated skeletal muscle protein homeostasis Open
Nocturnal hypoxaemia, which is common in chronic obstructive pulmonary disease (COPD) patients, is associated with skeletal muscle loss or sarcopenia, which contributes to adverse clinical outcomes. In COPD, we have defined this as prolong…
View article: Global Deletion of 11β-HSD1 Prevents Muscle Wasting Associated with Glucocorticoid Therapy in Polyarthritis
Global Deletion of 11β-HSD1 Prevents Muscle Wasting Associated with Glucocorticoid Therapy in Polyarthritis Open
Glucocorticoids provide indispensable anti-inflammatory therapies. However, metabolic adverse effects including muscle wasting restrict their use. The enzyme 11beta-hydroxysteroid dehydrogenase type 1 (11β-HSD1) modulates peripheral glucoc…
View article: Inflammation and Skeletal Muscle Wasting During Cachexia
Inflammation and Skeletal Muscle Wasting During Cachexia Open
Cachexia is the involuntary loss of muscle and adipose tissue that strongly affects mortality and treatment efficacy in patients with cancer or chronic inflammatory disease. Currently, no specific treatments or interventions are available …
View article: Exploring the Interface between Inflammatory and Therapeutic Glucocorticoid Induced Bone and Muscle Loss
Exploring the Interface between Inflammatory and Therapeutic Glucocorticoid Induced Bone and Muscle Loss Open
Due to their potent immunomodulatory anti-inflammatory properties, synthetic glucocorticoids (GCs) are widely utilized in the treatment of chronic inflammatory disease. In this review, we examine our current understanding of how chronic in…
View article: SAT-003 Therapeutic Glucocorticoids Prevent Local and Systemic Bone Loss but Exacerbate Muscle Wasting When Administered in Chronic Inflammation
SAT-003 Therapeutic Glucocorticoids Prevent Local and Systemic Bone Loss but Exacerbate Muscle Wasting When Administered in Chronic Inflammation Open
Glucocorticoids (GCs) are used in the treatment of chronic inflammatory diseases due to their potent anti-inflammatory actions. Their use is limited due to major systemic side effects including osteoporosis and muscle wasting. This is furt…
View article: OR09-3 11β-HSD1 Mediates a Partial Suppression of Muscle Atrophy in Chronic Inflammatory Disease in Response to Therapeutic Glucocorticoids
OR09-3 11β-HSD1 Mediates a Partial Suppression of Muscle Atrophy in Chronic Inflammatory Disease in Response to Therapeutic Glucocorticoids Open
Objective: Therapeutic glucocorticoids (GCs) are routinely used in the treatment of chronic inflammatory disease due to their potent anti-inflammatory effects. Despite their efficacy, chronic exposure to GCs elicits undesirable side effect…