Juston C. Weems
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View article: #4743 OMNIGRAF (COMBINED GENE EXPRESSION AND DD-CF DNA) USE IN MONITORING RENAL ALLOGRAFT REJECTION IN MULTIORGAN TRANSPLANT RECIPIENTS
#4743 OMNIGRAF (COMBINED GENE EXPRESSION AND DD-CF DNA) USE IN MONITORING RENAL ALLOGRAFT REJECTION IN MULTIORGAN TRANSPLANT RECIPIENTS Open
Background and Aims To date there is no clinically available non-invasive biomarker to monitor for renal allograft rejection in multiorgan transplant recipients. TruGraf (Gene expression profile) and TRAC (dd-cf DNA), as part of the biomar…
View article: Clinical Utility of the OmniGraf Biomarker Panel in the Care of Kidney Transplant Recipients (CLARITY): Protocol for a Prospective, Multisite Observational Study
Clinical Utility of the OmniGraf Biomarker Panel in the Care of Kidney Transplant Recipients (CLARITY): Protocol for a Prospective, Multisite Observational Study Open
Background Death with a functioning allograft has become the leading category of graft loss in kidney transplant recipients at all time points. Previous analyses have demonstrated that causes of death in kidney transplant recipients are pr…
View article: TruGraf® Long-term Clinical Outcomes Clinical: TRULO Trial Study Protocol (Preprint)
TruGraf® Long-term Clinical Outcomes Clinical: TRULO Trial Study Protocol (Preprint) Open
BACKGROUND Kidney transplant provides survival benefits to many patients in end stage renal failure. Advancements in medicine and technology have provided significant improvements in short term outcomes; however, long term outcomes are st…
View article: CLinical utility of the omnigrAf® biomarkeR panel In The care of kidneY transplant recipients: CLARITY Trial Study Protocol (Preprint)
CLinical utility of the omnigrAf® biomarkeR panel In The care of kidneY transplant recipients: CLARITY Trial Study Protocol (Preprint) Open
BACKGROUND Death with a functioning allograft has become the leading category of graft loss in kidney transplant recipients at all time points. Previous analyses have demonstrated that causes of death in kidney transplant recipients are p…
View article: UBAP2/UBAP2L regulate UV-induced ubiquitylation of RNA polymerase II and are the human orthologues of yeast Def1
UBAP2/UBAP2L regulate UV-induced ubiquitylation of RNA polymerase II and are the human orthologues of yeast Def1 Open
During transcription, RNA polymerase II (RNAPII) faces numerous obstacles, including DNA damage, which can lead to stalling or arrest. One mechanism to contend with this situation is ubiquitylation and degradation of the largest RNAPII sub…
View article: Combining Blood Gene Expression and Cellfree DNA to Diagnose Subclinical Rejection in Kidney Transplant Recipients
Combining Blood Gene Expression and Cellfree DNA to Diagnose Subclinical Rejection in Kidney Transplant Recipients Open
Background and objectives Subclinical acute rejection is associated with poor outcomes in kidney transplant recipients. As an alternative to surveillance biopsies, noninvasive screening has been established with a blood gene expression pro…
View article: A role for the Cockayne Syndrome B (CSB)-Elongin ubiquitin ligase complex in signal-dependent RNA polymerase II transcription
A role for the Cockayne Syndrome B (CSB)-Elongin ubiquitin ligase complex in signal-dependent RNA polymerase II transcription Open
The Elongin complex was originally identified as an RNA polymerase II (RNAPII) elongation factor and subsequently as the substrate recognition component of a Cullin-RING E3 ubiquitin ligase. More recent evidence indicates that the Elongin …
View article: Regulation of the RNAPII Pool Is Integral to the DNA Damage Response
Regulation of the RNAPII Pool Is Integral to the DNA Damage Response Open
View article: Cockayne syndrome B protein regulates recruitment of the Elongin A ubiquitin ligase to sites of DNA damage
Cockayne syndrome B protein regulates recruitment of the Elongin A ubiquitin ligase to sites of DNA damage Open
View article: Multiomic Analysis of the UV-Induced DNA Damage Response
Multiomic Analysis of the UV-Induced DNA Damage Response Open
View article: Assembly of the Elongin A Ubiquitin Ligase Is Regulated by Genotoxic and Other Stresses
Assembly of the Elongin A Ubiquitin Ligase Is Regulated by Genotoxic and Other Stresses Open