Justus Adamson
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View article: SURG-34. Real-world predictors of resection prior to stereotactic radiosurgery for brain metastases: a multi-center study
SURG-34. Real-world predictors of resection prior to stereotactic radiosurgery for brain metastases: a multi-center study Open
Stereotactic radiosurgery (SRS) is standard of care for brain metastases, yet the selection criteria for performing upfront craniotomy are inconsistently defined. Among 1172 patients from two institutions, we identified clinical and radiot…
View article: Benchmarking of a new integrated 3D dosimetry system against Monte Carlo calculations and an established optical CT scanner
Benchmarking of a new integrated 3D dosimetry system against Monte Carlo calculations and an established optical CT scanner Open
Background Advanced radiation therapy techniques, including intensity‐modulated radiation therapy (IMRT), stereotactic radiosurgery (SRS), adaptive therapy, and proton therapy, offer high precision in delivering radiation doses to tumors w…
View article: Uncertainty quantification in multi-parametric MRI-based meningioma radiotherapy target segmentation
Uncertainty quantification in multi-parametric MRI-based meningioma radiotherapy target segmentation Open
Purpose This work investigates the use of a spherical projection-based U-Net (SPU-Net) segmentation model to improve meningioma segmentation performance and allow for uncertainty quantification. Methods A total of 76 supratentorial meningi…
View article: Clinical applicability of Linac-integrated CBCT based NIPAM 3D dosimetry: a dual-institutional investigation
Clinical applicability of Linac-integrated CBCT based NIPAM 3D dosimetry: a dual-institutional investigation Open
Objective. To develop and benchmark a novel 3D dose verification technique consisting of polymer gel dosimetry (PGD) with cone-beam-CT (CBCT) readout through a two-institution study. The technique has potential for wide and robust applicab…
View article: Independent Monte Carlo dose calculation identifies single isocenter multi‐target radiosurgery targets most likely to fail pre‐treatment measurement
Independent Monte Carlo dose calculation identifies single isocenter multi‐target radiosurgery targets most likely to fail pre‐treatment measurement Open
Purpose For individual targets of single isocenter multi‐target (SIMT) Stereotactic radiosurgery (SRS), we assess dose difference between the treatment planning system (TPS) and independent Monte Carlo (MC), and demonstrate persistence int…
View article: A radiomics-incorporated deep ensemble learning model for multi-parametric MRI-based glioma segmentation
A radiomics-incorporated deep ensemble learning model for multi-parametric MRI-based glioma segmentation Open
Objective. To develop a deep ensemble learning (DEL) model with radiomics spatial encoding execution for improved glioma segmentation accuracy using multi-parametric magnetic resonance imaging (mp-MRI). Approach. This model was developed u…
View article: A structured FMEA approach to optimizing combinations of plan‐specific quality assurance techniques for IMRT and VMAT QA
A structured FMEA approach to optimizing combinations of plan‐specific quality assurance techniques for IMRT and VMAT QA Open
Background Many commercial tools are available for plan‐specific quality assurance (QA) of radiotherapy plans, with their functionality assessed in isolation. However, multiple QA tools are required to review the full range of potential er…
View article: A Radiomics-Incorporated Deep Ensemble Learning Model for Multi-Parametric MRI-based Glioma Segmentation
A Radiomics-Incorporated Deep Ensemble Learning Model for Multi-Parametric MRI-based Glioma Segmentation Open
We developed a deep ensemble learning model with a radiomics spatial encoding execution for improved glioma segmentation accuracy using multi-parametric MRI (mp-MRI). This model was developed using 369 glioma patients with a 4-modality mp-…
View article: Erratum to “E.C. Lerner, E.S. Srinivasan, G. Broadwater, et al. Factors Associated With New-Onset Seizures Following Stereotactic Radiosurgery for Newly Diagnosed Brain Metastases. Adv Radiat Oncol. 2022;7:101054.”
Erratum to “E.C. Lerner, E.S. Srinivasan, G. Broadwater, et al. Factors Associated With New-Onset Seizures Following Stereotactic Radiosurgery for Newly Diagnosed Brain Metastases. Adv Radiat Oncol. 2022;7:101054.” Open
[This corrects the article DOI: 10.1016/j.adro.2022.101054.].
View article: Uncertainties in the dosimetric heterogeneity correction and its potential effect on local control in lung SBRT
Uncertainties in the dosimetric heterogeneity correction and its potential effect on local control in lung SBRT Open
Objective . Dose calculation in lung stereotactic body radiation therapy (SBRT) is challenging due to the low density of the lungs and small volumes. Here we assess uncertainties associated with tissue heterogeneities using different dose …
View article: Outcomes in Patients with Intact and Resected Brain Metastasis Treated with 5-Fraction Stereotactic Radiosurgery
Outcomes in Patients with Intact and Resected Brain Metastasis Treated with 5-Fraction Stereotactic Radiosurgery Open
HF-SRS demonstrated favorable rates of LC and radionecrosis in postoperative and intact settings. Corresponding LMD and RN rates were comparable to those of other studies.
View article: Factors Associated With New-Onset Seizures Following Stereotactic Radiosurgery for Newly Diagnosed Brain Metastases
Factors Associated With New-Onset Seizures Following Stereotactic Radiosurgery for Newly Diagnosed Brain Metastases Open
Our data suggest that larger total treatment volume and the presence of focal neurologic deficits at presentation are associated with new-onset seizures within 3 months of SRS. High-risk patients undergoing SRS may benefit from counseling …
View article: TARDIS: An updated artificial intelligence model to predict linear accelerator machine parameters at treatment delivery
TARDIS: An updated artificial intelligence model to predict linear accelerator machine parameters at treatment delivery Open
We present an open-source artificial intelligence (AI) model that predicts machine parameters at treatment delivery using trajectory files from prior patients. Predictive models for IMRT and VMAT utilized a boosted and bagged tree, respect…
View article: Virtual patient‐specific QA with DVH‐based metrics
Virtual patient‐specific QA with DVH‐based metrics Open
We demonstrate a virtual pretreatment patient‐specific QA (PSQA) procedure that is capable of quantifying dosimetric effect on patient anatomy for both intensity modulated radiotherapy (IMRT) and volumetric modulated arc therapy (VMAT). A …
View article: Development of a practical clinical application of NIPAM kV-CBCT dosimetry
Development of a practical clinical application of NIPAM kV-CBCT dosimetry Open
We report our progress towards developing a clinical application of NIPAM kV-CBCT dosimetry. The goal is to develop a practical kV-MV isocenter verification test for which the measurement and analysis can be carried out quickly (within an …
View article: RADT-02. FACTORS ASSOCIATED WITH NEW-ONSET SEIZURES AFTER STEREOTACTIC RADIOSURGERY FOR NEWLY DIAGNOSED BRAIN METASTASES
RADT-02. FACTORS ASSOCIATED WITH NEW-ONSET SEIZURES AFTER STEREOTACTIC RADIOSURGERY FOR NEWLY DIAGNOSED BRAIN METASTASES Open
INTRODUCTION Stereotactic radiosurgery (SRS) is a highly effective therapy for newly diagnosed brain metastases. Risk factors for new-onset seizures after SRS have not been well established. In this study, we aimed to characterize the vari…
View article: Outcomes in Patients With 4 to 10 Brain Metastases Treated With Dose-Adapted Single-Isocenter Multitarget Stereotactic Radiosurgery: A Prospective Study
Outcomes in Patients With 4 to 10 Brain Metastases Treated With Dose-Adapted Single-Isocenter Multitarget Stereotactic Radiosurgery: A Prospective Study Open
These results suggest that volume-adapted dosing single-isocenter multitarget stereotactic radiosurgery is an effective and safe treatment for patients with 4 to 10 brain metastases.
View article: Single isocenter SRS using CAVMAT offers improved robustness to commissioning and treatment delivery uncertainty compared to VMAT
Single isocenter SRS using CAVMAT offers improved robustness to commissioning and treatment delivery uncertainty compared to VMAT Open
Purpose In this study, we evaluate and compare single isocenter multiple target VMAT (SIMT) and Conformal Arc Informed VMAT (CAVMAT) radiosurgery's sensitivity to uncertainties in dosimetric leaf gap (DLG) and treatment delivery. CAVMAT is…
View article: Current multidisciplinary management of brain metastases
Current multidisciplinary management of brain metastases Open
Brain metastasis (BM), the most common adult brain tumor, develops in 20% to 40% of patients with late‐stage cancer and traditionally are associated with a poor prognosis. The management of patients with BM has become increasingly complex …
View article: Application of TG-218 action limits to SRS and SBRT pre-treatment patient specific QA.
Application of TG-218 action limits to SRS and SBRT pre-treatment patient specific QA. Open
AAPM TG-218 provides recommendations for standard IMRT pre-treatment QA without giving specifics for stereotactic radiosurgery (SRS) and stereotactic body radiotherapy (SBRT). In light of this, our purpose is to report our experience with …
View article: Evaluation of UVA emission from x-ray megavoltage-irradiated tissues and phantoms
Evaluation of UVA emission from x-ray megavoltage-irradiated tissues and phantoms Open
RECA (Radiotherapy enhanced with Cherenkov photo-activation) is a proposed treatment where the anti-cancer drug psoralen is photo-activated in situ by UVA (Ultraviolet A, 320-400 nm) Cherenkov light (CL) produced directly by the treatment …
View article: RADI-06. SINGLE- VERSUS MULTI-FRACTION STEREOTACTIC RADIOSURGERY FOR BRAINSTEM METASTASES
RADI-06. SINGLE- VERSUS MULTI-FRACTION STEREOTACTIC RADIOSURGERY FOR BRAINSTEM METASTASES Open
BACKGROUND: For intracranial metastases with planning target volume (PTV) overlap of the brainstem (BSmet), the radiosurgical dose-fractionation that optimizes the therapeutic window is unknown. MATERIALS/METHODS: A retrospective review of…
View article: Feasibility of radiosurgery dosimetry using NIPAM 3D dosimeters and x-ray CT
Feasibility of radiosurgery dosimetry using NIPAM 3D dosimeters and x-ray CT Open
We investigated the feasibility of using N-isopropylacrylamide (NIPAM) dosimeters with x-ray CT to verify radiosurgery dose. Dosimeters were prepared at one facility and shipped to a second facility for irradiation. A simulation CT was acq…
View article: Predicting intracranial progression following stereotactic radiosurgery for brain metastases: Implications for post SRS imaging.
Predicting intracranial progression following stereotactic radiosurgery for brain metastases: Implications for post SRS imaging. Open
We present a nomogram estimating time to BM progression following SRS to potentially personalize surveillance imaging.
View article: The effect of MLC leaf width in single-isocenter multi-target radiosurgery with volumetric modulated arc therapy.
The effect of MLC leaf width in single-isocenter multi-target radiosurgery with volumetric modulated arc therapy. Open
SIMT radiosurgery delivered via VMAT using 5 mm wide MLCs can achieve similar CI compared to that using 2.5 mm leaf width MLCs but with moderately increased isodose spill, which can be only partially mitigated by increasing the number of V…