Justus Wilke
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View article: Erythropoietin alleviates intellectual disability and autism-like behavior of mice caused by <i>Zbtb20</i> haploinsufficiency, a construct-valid model of Primrose syndrome
Erythropoietin alleviates intellectual disability and autism-like behavior of mice caused by <i>Zbtb20</i> haploinsufficiency, a construct-valid model of Primrose syndrome Open
Among the known genetic causes of syndromic autism spectrum disorders (ASD) are transcription factor deficiencies. In this regard, haploinsufficiency of the ‘zinc finger and broad complex, tramtrack, bric and brac domain-containing protein…
View article: Acute neuronal cell death and neuroinflammation per se do not trigger secondary autoimmune encephalitis in mice
Acute neuronal cell death and neuroinflammation per se do not trigger secondary autoimmune encephalitis in mice Open
Patients with virus encephalitis, such as herpes simplex encephalitis and Japanese encephalitis frequently relapse with autoimmune encephalitides associated with neural autoantibodies. It has been hypothesized that the infection-induced da…
View article: Acute neuronal cell death and neuroinflammation per se do not trigger secondary autoimmune encephalitis
Acute neuronal cell death and neuroinflammation per se do not trigger secondary autoimmune encephalitis Open
Patients with virus encephalitis, such as herpes simplex encephalitis and Japanese encephalitis frequently relapse with autoimmune encephalitides associated with neural autoantibodies. It has been hypothesized that the infection-induced da…
View article: A comprehensive and standardized pipeline for automated profiling of higher cognition in mice
A comprehensive and standardized pipeline for automated profiling of higher cognition in mice Open
In rodent behavior research, observer-independent methods, such as the IntelliCage, enhance data collection in a social, and thus stress-reduced, environment. The IntelliCage system allows experimenters to create cognitive challenges for m…
View article: Balance Performance After Mild Traumatic Brain Injury in Children and Adolescents: Instrumented BESS in the Acute Situation and Over Time
Balance Performance After Mild Traumatic Brain Injury in Children and Adolescents: Instrumented BESS in the Acute Situation and Over Time Open
Background: Mild traumatic brain injury (mTBI) in the pediatric population is a significant public health concern, often associated with persistent post-concussion symptoms, including postural instability. Current tools for assessing postu…
View article: Tolerability and first hints for potential efficacy of motor‐cognitive training under inspiratory hypoxia in health and neuropsychiatric disorders: A translational viewpoint
Tolerability and first hints for potential efficacy of motor‐cognitive training under inspiratory hypoxia in health and neuropsychiatric disorders: A translational viewpoint Open
Hypoxia is more and more perceived as pivotal physiological driving force, allowing cells in the brain and elsewhere to acclimate to lowered oxygen (O 2 ), and abridged metabolism. The mediating transcription program is induced by inspirat…
View article: IntelliR: A comprehensive and standardized pipeline for automated profiling of higher cognition in mice
IntelliR: A comprehensive and standardized pipeline for automated profiling of higher cognition in mice Open
In the rapidly evolving field of rodent behavior research, observer-independent methods facilitate data collection within a social, stress-reduced, and thus more natural environment. A prevalent system in this research area is the IntelliC…
View article: Factors predisposing to humoral autoimmunity against brain-antigens in health and disease: Analysis of 49 autoantibodies in over 7000 subjects
Factors predisposing to humoral autoimmunity against brain-antigens in health and disease: Analysis of 49 autoantibodies in over 7000 subjects Open
Humoral autoimmunity against brain-antigens, frequent across health and disease, is predicted by age, gender, genetic predisposition, and brain injury. Seroprevalence, immunoglobulin class, or titers do not predict disease.
View article: Introducing the brain erythropoietin circle to explain adaptive brain hardware upgrade and improved performance
Introducing the brain erythropoietin circle to explain adaptive brain hardware upgrade and improved performance Open
Preface Executive functions, learning, attention, and processing speed are imperative facets of cognitive performance, affected in neuropsychiatric disorders. In clinical studies on different patient groups, recombinant human (rh) erythrop…
View article: Adjusting the neuron to astrocyte ratio with cytostatics in hippocampal cell cultures from postnatal rats: A comparison of cytarabino furanoside (AraC) and 5-fluoro-2’-deoxyuridine (FUdR)
Adjusting the neuron to astrocyte ratio with cytostatics in hippocampal cell cultures from postnatal rats: A comparison of cytarabino furanoside (AraC) and 5-fluoro-2’-deoxyuridine (FUdR) Open
Cell culture studies offer the unique possibility to investigate the influence of pharmacological treatments with quantified dosages applied for defined time durations on survival, morphological maturation, protein expression and function …
View article: Modeling anti-NMDAR encephalitis
Modeling anti-NMDAR encephalitis Open
The anti-NMDAR encephalitis (NMDARE) is an autoimmune condition with so far unclear etiology and pathogenesis. It manifests with a heterogeneous clinical disease course and is diagnosed based on the presence of NMDAR1-autoantibodies (NMDAR…