Justyn DuSold
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View article: Metabolic dialogues: regulators of chimeric antigen receptor T cell function in the tumor microenvironment
Metabolic dialogues: regulators of chimeric antigen receptor T cell function in the tumor microenvironment Open
Tumor‐infiltrating lymphocytes (TILs) and chimeric antigen receptor (CAR) T cells have demonstrated remarkable success in the treatment of relapsed/refractory melanoma and hematological malignancies, respectively. These treatments have mar…
View article: Harnessing arginine metabolism overcomes hyperthermia-induced metabolic dysfunction of CAR T-cells
Harnessing arginine metabolism overcomes hyperthermia-induced metabolic dysfunction of CAR T-cells Open
Chimeric antigen receptor (CAR) T-cells have shown remarkable success in the treatment of hematological malignancies, but many patients still relapse. One common adverse on-target effect of CAR T-cells is cytokine release syndrome. Importa…
View article: TCR/Chimeric Antigen Receptor (CAR) Cross-Antagonism to Fine-Tune CAR-T cell Immunotherapy
TCR/Chimeric Antigen Receptor (CAR) Cross-Antagonism to Fine-Tune CAR-T cell Immunotherapy Open
Chimeric antigen receptor (CAR) T cells, are created by extracting T cells from a cancer patient, engineering them to express a CAR targeting a tumor specific molecule, then reintroducing them back into the patient. A patient’s T cells con…
View article: 350 Harnessing arginine metabolism to overcome hyperthermia-induced metabolic dysfunction of CAR T-cells
350 Harnessing arginine metabolism to overcome hyperthermia-induced metabolic dysfunction of CAR T-cells Open
Background Chimeric antigen receptor (CAR) T-cells have shown remarkable success in the treatment of hematological malignancies, but many patients still relapse. One common adverse on-target effect of CAR T-cells is cytokine release syndro…