Juxiang Chen
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View article: Activation of hypothalamic-pontine-spinal pathway promotes locomotor initiation and functional recovery after spinal cord injury in mice
Activation of hypothalamic-pontine-spinal pathway promotes locomotor initiation and functional recovery after spinal cord injury in mice Open
The hypothalamus is critical for regulating behaviors essential for survival and locomotion, but how it integrates internal needs and transmits locomotion commands to the spinal cord (SC) remains unclear. We found that glutamatergic neuron…
View article: Targeting PGE2 mediated senescent neuron improves tumor therapy
Targeting PGE2 mediated senescent neuron improves tumor therapy Open
Background Recent studies have highlighted bidirectional signaling between tumors and neurons; however, the interactions between tumors and neurons in response to radio-/chemotherapy remain obscure, which hampers the tumor treatment. Metho…
View article: Brain-targeting drug delivery systems: The state of the art in treatment of glioblastoma
Brain-targeting drug delivery systems: The state of the art in treatment of glioblastoma Open
Glioblastoma (GBM) is the most prevalent primary malignant brain tumor, characterized by a high mortality rate and a poor prognosis. The blood-brain barrier (BBB) and the blood-tumor barrier (BTB) present significant obstacles to the effic…
View article: Activation of hypothalamic-pontine-spinal pathway promotes locomotor initiation and functional recovery after spinal cord injury in mice
Activation of hypothalamic-pontine-spinal pathway promotes locomotor initiation and functional recovery after spinal cord injury in mice Open
SUMMARY The hypothalamus is critical for regulating behaviors essential for survival and locomotion, but how it integrates internal needs and transmits locomotion commands to the spinal cord (SC) remains unclear. We found that glutamatergi…
View article: The Brain–Gut–Bone Axis in Neurodegenerative Diseases: Insights, Challenges, and Future Prospects
The Brain–Gut–Bone Axis in Neurodegenerative Diseases: Insights, Challenges, and Future Prospects Open
Neurodegenerative diseases are global health challenges characterized by the progressive degeneration of nerve cells, leading to cognitive and motor impairments. The brain–gut–bone axis, a complex network that modulates multiple physiologi…
View article: AGBL4 promotes malignant progression of glioblastoma via modulation of MMP-1 and inflammatory pathways
AGBL4 promotes malignant progression of glioblastoma via modulation of MMP-1 and inflammatory pathways Open
Introduction Glioblastoma multiforme (GBM), the most common primary malignant brain tumor, is notorious for its aggressive growth and dismal prognosis. This study aimed to elucidate the molecular underpinnings of GBM, particularly focusing…
View article: Dysregulated inter-mitochondrial crosstalk in glioblastoma cells revealed by in situ cryo-electron tomography
Dysregulated inter-mitochondrial crosstalk in glioblastoma cells revealed by in situ cryo-electron tomography Open
Glioblastomas (GBMs) are the most lethal primary brain tumors with limited survival, even under aggressive treatments. The current therapeutics for GBMs are flawed due to the failure to accurately discriminate between normal proliferating …
View article: UBDP1 pseudogene and UBD network competitively bind miR‑6072 to promote glioma progression
UBDP1 pseudogene and UBD network competitively bind miR‑6072 to promote glioma progression Open
Increasing evidence suggests that pseudogenes play crucial roles in various cancers, yet their functions and regulatory mechanisms in glioma pathogenesis remain enigmatic. In the present study, a novel pseudogene was identified, UBDP1, whi…
View article: Step-by-step dissection of the pterygopalatine fossa, infratemporal fossa, and parapharyngeal space via the middle cranial fossa approach with preservation of the temporomandibular joint
Step-by-step dissection of the pterygopalatine fossa, infratemporal fossa, and parapharyngeal space via the middle cranial fossa approach with preservation of the temporomandibular joint Open
The MCF is a promising corridor for accessing these complex exocranial skull base areas. Although live surgery may be quite different from cadaver dissection, every surgeon must master the relevant anatomy before entering the operation the…
View article: Exploring cerebral structural and functional abnormalities in a mouse model of post-traumatic headache induced by mild traumatic brain injury
Exploring cerebral structural and functional abnormalities in a mouse model of post-traumatic headache induced by mild traumatic brain injury Open
Mild traumatic brain injury (mTBI)-induced post-traumatic headache (PTH) is a pressing public health concern and leading cause of disability worldwide. Although PTH is often accompanied by neurological disorders, the exact underlying mecha…
View article: FOXO1-miR-506 axis promotes chemosensitivity to temozolomide and suppresses invasiveness in glioblastoma through a feedback loop of FOXO1/miR-506/ETS1/FOXO1
FOXO1-miR-506 axis promotes chemosensitivity to temozolomide and suppresses invasiveness in glioblastoma through a feedback loop of FOXO1/miR-506/ETS1/FOXO1 Open
To explore the role of forkhead box protein O1 (FOXO1) in the progression of glioblastoma multiforme (GBM) and related drug resistance, we deciphered the roles of FOXO1 and miR-506 in proliferation, apoptosis, migration, invasion, autophag…
View article: Supplementary Figure 3 from Targetable Signaling Pathway Mutations Are Associated with Malignant Phenotype in <i>IDH</i>-Mutant Gliomas
Supplementary Figure 3 from Targetable Signaling Pathway Mutations Are Associated with Malignant Phenotype in <i>IDH</i>-Mutant Gliomas Open
PDF file - 347KB, Supplementary Figure S3. Proliferation index of IDH1-mutant glioma orthotopic xenografts (MIB-1).
View article: Supplementary Figure 4 from Targetable Signaling Pathway Mutations Are Associated with Malignant Phenotype in <i>IDH</i>-Mutant Gliomas
Supplementary Figure 4 from Targetable Signaling Pathway Mutations Are Associated with Malignant Phenotype in <i>IDH</i>-Mutant Gliomas Open
PDF file - 323KB, Supplementary Figure S4. Sequencing of the IDH1 R132 locus in IDH1-mutant glioma xenografts.
View article: Supplementary Table 2 from Targetable Signaling Pathway Mutations Are Associated with Malignant Phenotype in <i>IDH</i>-Mutant Gliomas
Supplementary Table 2 from Targetable Signaling Pathway Mutations Are Associated with Malignant Phenotype in <i>IDH</i>-Mutant Gliomas Open
XLS file - 24KB, Supplementary Table S2. Primers used for sequencing.
View article: Supplementary Table 2 from Targetable Signaling Pathway Mutations Are Associated with Malignant Phenotype in <i>IDH</i>-Mutant Gliomas
Supplementary Table 2 from Targetable Signaling Pathway Mutations Are Associated with Malignant Phenotype in <i>IDH</i>-Mutant Gliomas Open
XLS file - 24KB, Supplementary Table S2. Primers used for sequencing.
View article: Supplementary Figure 6 from Targetable Signaling Pathway Mutations Are Associated with Malignant Phenotype in <i>IDH</i>-Mutant Gliomas
Supplementary Figure 6 from Targetable Signaling Pathway Mutations Are Associated with Malignant Phenotype in <i>IDH</i>-Mutant Gliomas Open
PDF file - 102KB, Supplementary Figure S6. Sphere formation assay of MGG152 expressing N-MYC shRNA.
View article: Supplementary Figure 5 from Targetable Signaling Pathway Mutations Are Associated with Malignant Phenotype in <i>IDH</i>-Mutant Gliomas
Supplementary Figure 5 from Targetable Signaling Pathway Mutations Are Associated with Malignant Phenotype in <i>IDH</i>-Mutant Gliomas Open
PDF file - 266KB, Supplementary Figure S5. Maintenance of genotype upon serial xenotransplantation.
View article: Supplementary Figure 2 from Targetable Signaling Pathway Mutations Are Associated with Malignant Phenotype in <i>IDH</i>-Mutant Gliomas
Supplementary Figure 2 from Targetable Signaling Pathway Mutations Are Associated with Malignant Phenotype in <i>IDH</i>-Mutant Gliomas Open
PDF file - 404KB, Supplementary Figure S2. IDH1-mutant glioma orthotopic xenografts recapitulate histopathological features of the respective patient tumors.
View article: Supplementary Figure 5 from Targetable Signaling Pathway Mutations Are Associated with Malignant Phenotype in <i>IDH</i>-Mutant Gliomas
Supplementary Figure 5 from Targetable Signaling Pathway Mutations Are Associated with Malignant Phenotype in <i>IDH</i>-Mutant Gliomas Open
PDF file - 266KB, Supplementary Figure S5. Maintenance of genotype upon serial xenotransplantation.
View article: Data from Targetable Signaling Pathway Mutations Are Associated with Malignant Phenotype in <i>IDH</i>-Mutant Gliomas
Data from Targetable Signaling Pathway Mutations Are Associated with Malignant Phenotype in <i>IDH</i>-Mutant Gliomas Open
Purpose: Isocitrate dehydrogenase (IDH) gene mutations occur in low-grade and high-grade gliomas. We sought to identify the genetic basis of malignant phenotype heterogeneity in IDH-mutant gliomas.Methods: We prospectively implanted tumor …
View article: Supplementary Table 1 from Targetable Signaling Pathway Mutations Are Associated with Malignant Phenotype in <i>IDH</i>-Mutant Gliomas
Supplementary Table 1 from Targetable Signaling Pathway Mutations Are Associated with Malignant Phenotype in <i>IDH</i>-Mutant Gliomas Open
PDF file - 85KB, Supplementary Table S1. 2-hydroxyglutarate (2HG) measurements of mouse glioma orthotopic xenografts.
View article: Supplementary Figure 7 from Targetable Signaling Pathway Mutations Are Associated with Malignant Phenotype in <i>IDH</i>-Mutant Gliomas
Supplementary Figure 7 from Targetable Signaling Pathway Mutations Are Associated with Malignant Phenotype in <i>IDH</i>-Mutant Gliomas Open
PDF file - 294KB, Supplementary Figure S7. PDGFRA and MET amplification sensitize IDH1-mutant glioma TICs to targeted inhibitors.
View article: Supplementary Figure 2 from Targetable Signaling Pathway Mutations Are Associated with Malignant Phenotype in <i>IDH</i>-Mutant Gliomas
Supplementary Figure 2 from Targetable Signaling Pathway Mutations Are Associated with Malignant Phenotype in <i>IDH</i>-Mutant Gliomas Open
PDF file - 404KB, Supplementary Figure S2. IDH1-mutant glioma orthotopic xenografts recapitulate histopathological features of the respective patient tumors.
View article: Supplementary Figure 4 from Targetable Signaling Pathway Mutations Are Associated with Malignant Phenotype in <i>IDH</i>-Mutant Gliomas
Supplementary Figure 4 from Targetable Signaling Pathway Mutations Are Associated with Malignant Phenotype in <i>IDH</i>-Mutant Gliomas Open
PDF file - 323KB, Supplementary Figure S4. Sequencing of the IDH1 R132 locus in IDH1-mutant glioma xenografts.
View article: Data from Targetable Signaling Pathway Mutations Are Associated with Malignant Phenotype in <i>IDH</i>-Mutant Gliomas
Data from Targetable Signaling Pathway Mutations Are Associated with Malignant Phenotype in <i>IDH</i>-Mutant Gliomas Open
Purpose: Isocitrate dehydrogenase (IDH) gene mutations occur in low-grade and high-grade gliomas. We sought to identify the genetic basis of malignant phenotype heterogeneity in IDH-mutant gliomas.Methods: We prospectively implanted tumor …