Ruairí J.V. Roberts
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View article: Sexual dimorphism in the complete connectome of the <i>Drosophila</i> male central nervous system
Sexual dimorphism in the complete connectome of the <i>Drosophila</i> male central nervous system Open
Sex differences in behaviour exist across all animals, typically under strong genetic regulation. In Drosophila , fruitless / doublesex transcription factors can identify dimorphic neurons but their organisation into functional circuits re…
View article: Distributed control circuits across a brain-and-cord connectome
Distributed control circuits across a brain-and-cord connectome Open
Just as genomes revolutionized molecular genetics, connectomes (maps of neurons and synapses) are transforming neuroscience. To date, the only species with complete connectomes are worms 1-3 and sea squirts 4 (10 3 -10 4 synapses). By cont…
View article: Cross-species comparative connectomics reveals the evolution of an olfactory circuit
Cross-species comparative connectomics reveals the evolution of an olfactory circuit Open
Animal behavioural diversity ultimately stems from variation in neural circuitry, yet how central neural circuits evolve remains poorly understood. Studies of neural circuit evolution often focus on a few elements within a network. However…
View article: OptoPi: An open source flexible platform for the analysis of small animal behaviour
OptoPi: An open source flexible platform for the analysis of small animal behaviour Open
Behaviour is the ultimate output of neural circuit computations, and therefore its analysis is a cornerstone of neuroscience research. However, every animal and experimental paradigm requires different illumination conditions to capture an…
View article: OptoPi: An open source flexible platform for the analysis of small animal behaviour
OptoPi: An open source flexible platform for the analysis of small animal behaviour Open
Behaviour is the ultimate output of neural circuit computations, and therefore its analysis is a cornerstone of neuroscience research. However, every animal and experimental paradigm requires different illumination conditions to capture an…
View article: Parallel evolution of a splicing program controlling neuronal excitability in flies and mammals
Parallel evolution of a splicing program controlling neuronal excitability in flies and mammals Open
Alternative splicing increases neuronal transcriptomic complexity throughout animal phylogeny. To delve into the mechanisms controlling the assembly and evolution of this regulatory layer, we characterized the neuronal microexon program in…
View article: Supplemental Data and Code for "A physical theory of movement in small animals"
Supplemental Data and Code for "A physical theory of movement in small animals" Open
Supplemental Data and Code for "A physical theory of movement in small animals" This manuscript is currently a preprint, available on biorxiv: https://doi.org/10.1101/2020.08.25.266163
View article: Parallel evolution of a splicing program controlling neuronal excitability in flies and mammals
Parallel evolution of a splicing program controlling neuronal excitability in flies and mammals Open
Summary Neurons draw on alternative splicing for their increased transcriptomic complexity throughout animal phylogeny. To delve into the mechanisms controlling the assembly and evolution of this regulatory layer, we characterized the neur…
View article: A physical theory of movement in small animals
A physical theory of movement in small animals Open
All animal behaviour must ultimately be governed by physical laws. As a basis for understanding the physics of behaviour in a simple system, we here develop an effective theory for the motion of the larval form of the fruitfly Drosophila m…
View article: Complete Connectomic Reconstruction of Olfactory Projection Neurons in the Fly Brain
Complete Connectomic Reconstruction of Olfactory Projection Neurons in the Fly Brain Open
Nervous systems contain sensory neurons, local neurons, projection neurons, and motor neurons. To understand how these building blocks form whole circuits, we must distil these broad classes into neuronal cell types and describe their netw…
View article: Connectomics analysis reveals first, second, and third order thermosensory and hygrosensory neurons in the adult<i>Drosophila</i>brain
Connectomics analysis reveals first, second, and third order thermosensory and hygrosensory neurons in the adult<i>Drosophila</i>brain Open
SUMMARY Animals exhibit innate and learned preferences for temperature and humidity – conditions critical for their survival and reproduction. Here, we leveraged a whole adult brain electron microscopy volume to study the circuitry associa…
View article: Complete connectomic reconstruction of olfactory projection neurons in the fly brain
Complete connectomic reconstruction of olfactory projection neurons in the fly brain Open
Nervous systems contain sensory neurons, local neurons, projection neurons and motor neurons. To understand how these building blocks form whole circuits, we must distil these broad classes into neuronal cell types and describe their netwo…
View article: Neurogenetic dissection of the Drosophila lateral horn reveals major outputs, diverse behavioural functions, and interactions with the mushroom body
Neurogenetic dissection of the Drosophila lateral horn reveals major outputs, diverse behavioural functions, and interactions with the mushroom body Open
Animals exhibit innate behaviours to a variety of sensory stimuli including olfactory cues. In Drosophila, one higher olfactory centre, the lateral horn (LH), is implicated in innate behaviour. However, our structural and functional unders…
View article: Author response: Neurogenetic dissection of the Drosophila lateral horn reveals major outputs, diverse behavioural functions, and interactions with the mushroom body
Author response: Neurogenetic dissection of the Drosophila lateral horn reveals major outputs, diverse behavioural functions, and interactions with the mushroom body Open
Article Figures and data Abstract Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Animals exhibit innate behaviours to a var…
View article: Neurogenetic dissection of the <i>Drosophila</i> innate olfactory processing center
Neurogenetic dissection of the <i>Drosophila</i> innate olfactory processing center Open
Animals exhibit innate behaviours in response to a variety of sensory stimuli such as olfactory cues. In Drosophila , a higher olfactory centre called the lateral horn (LH) is implicated in innate behaviour. However, our knowledge of the s…
View article: Neural circuit basis of aversive odour processing in <i>Drosophila</i> from sensory input to descending output
Neural circuit basis of aversive odour processing in <i>Drosophila</i> from sensory input to descending output Open
Evolution has shaped nervous systems to produce stereotyped behavioural responses to ethologically relevant stimuli. For example when laying eggs, female Drosophila avoid geosmin, an odorant produced by toxic moulds. Here we identify secon…
View article: Communication from learned to innate olfactory processing centers is required for memory retrieval in<i>Drosophila</i>
Communication from learned to innate olfactory processing centers is required for memory retrieval in<i>Drosophila</i> Open
Animals can show either learned or innate behavioral responses to a given stimulus. How these circuits interact to produce an appropriate behavioral response is unknown. In the Drosophila olfactory system, the lateral horn (LH) and the mus…