Jyothi Kumaran
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View article: Cell-targeted PD-1 agonists that mimic PD-L1 are potent T cell inhibitors
Cell-targeted PD-1 agonists that mimic PD-L1 are potent T cell inhibitors Open
The PD-1/PD-L1 pathway is a key immune checkpoint that regulates T cell activation. There is strong rationale to develop PD-1 agonists as therapeutics against autoimmunity, but progress in this area has been limited. Here, we generated T c…