Explanipedia

A combinatorial oligonucleotide therapy to improve dystrophin restoration and dystrophin-deficient muscle health Open

Young Jae Moon, Ravi Hindupur, Iteoluwakishi H. Gamu, Nikki M. McCormack, Fatima Shaikh , et al. · 2025

Failure to resolve inflammation contributes to juvenile onset cardiac damage in a mouse model of Duchenne muscular dystrophy Open

James S. Novak, Amy Lischin, Prech Uapinyoying, Ravi Hindupur, Young Jae Moon , et al. · 2025

Absence of dystrophin protein causes cardiac dysfunction in patients with Duchenne muscular dystrophy (DMD). Unlike boys with DMD, the common mouse model of DMD (B10- mdx ) does not manifest cardiac deficits until late adulthood. This has …

Impaired airway epithelial miR-155/BACH1/NRF2 axis and hypoxia gene expression during RSV infection in children with down syndrome Open

A. Welham, Elizabeth Chorvinsky, Surajit Bhattacharya, K. Salka, Betelehem Solomon Bera , et al. · 2025

Background Children with Down Syndrome (DS) are at high risk for severe respiratory syncytial virus (RSV) infections. DS is associated with impaired cellular responses to oxidative stress and hypoxia; however, these abnormalities have not …

Exploring the therapeutic potential of fibroadipogenic progenitors in muscle disease Open

Marshall W. Hogarth, Medha P Kurukunda, Karim Ismat, Prech Uapinyoying, Jyoti K. Jaiswal · 2025

Skeletal muscle relies on its inherent self-repair ability to withstand continuous mechanical damage. Myofiber-intrinsic processes facilitate the repair of damage to sarcolemma and sarcomeres, but it is the coordinated interaction between …

Dysregulated airway epithelial antiviral immunity in Down Syndrome impairs type III IFN response and amplifies airway inflammation during RSV infection Open

Elizabeth Chorvinsky, Surajit Bhattacharya, Betelehem Solomon Bera, A. Welham, Karim Ismat , et al. · 2024

Trisomy 21 (TS21), also known as Down syndrome (DS), increases pediatric mortality risk from respiratory syncytial virus (RSV) by nine-fold, yet its underlying immunological basis remains unclear. Here, we investigated RSV-induced immunolo…

Failure to resolve inflammation contributes to juvenile onset cardiac damage in a mouse model of Duchenne Muscular Dystrophy Open

James S. Novak, Amy Lischin, Prech Uapinyoying, Ravi Hindupur, Young Jae Moon , et al. · 2024

Absence of dystrophin protein causes cardiac dysfunction in patients with Duchenne muscular dystrophy (DMD). Unlike boys with DMD, the common mouse model of DMD (B10- mdx ) does not manifest cardiac deficits until late adulthood. This has …

Annexins—a family of proteins with distinctive tastes for cell signaling and membrane dynamics Open

Volker Gerke, Felicity N. E. Gavins, Michael J. Geisow, Thomas Grewal, Jyoti K. Jaiswal , et al. · 2024

Algal biofertilizers as plant growth stimulants for sustainable agriculture Open

Jainendra Pathak, Jyoti K. Jaiswal, Ramesh K. Shukla, Deepak Singh, Rajeshwar P. Sinha · 2024

Population of the Earth has been projected to reach ~9.7 billion by 2050 and Asia and Africa would be the major contributors to this enhanced population. This increased population is directly related with higher demand of food security in …

Efficacy of Nasal Continuous Positive Airway Pressure Delivered by Nasal mask Versus Nasal Prongs in Neonates Open

Suhas Kulkarni, Jyoti K. Jaiswal · 2023

Introduction: Nasal continuous positive airway pressure (CPAP) is the standard therapy for neonatal respiratory distress. It is delivered using nasal mask (NM) or nasal prong (NP), both of which can result in nasal trauma. The type of nasa…

Early Endosomes Undergo Calcium‐Triggered Exocytosis and Enable Repair of Diffuse and Focal Plasma Membrane Injury (Adv. Sci. 33/2023) Open

Daniel C. Bittel, Jyoti K. Jaiswal · 2023

Early Endosomes The graphic scenery depicts a cell, observed en‐face (from the side) being subjected to an onslaught of plasma‐membrane damaging agents. These agents include extracellular barrel‐shaped bacteria‐secreted pore‐forming toxins…

Early Endosomes Undergo Calcium‐Triggered Exocytosis and Enable Repair of Diffuse and Focal Plasma Membrane Injury Open

Daniel C. Bittel, Jyoti K. Jaiswal · 2023

Cells are routinely exposed to agents that cause plasma membrane (PM) injury. While pore‐forming toxins (PFTs), and chemicals cause nanoscale holes dispersed throughout the PM, mechanical trauma causes focal lesions in the PM. To examine i…

Single-cell transcriptomic analysis of the identity and function of fibro/adipogenic progenitors in healthy and dystrophic muscle Open

Prech Uapinyoying, Marshall W. Hogarth, Surajit Battacharya, Davi A. G. Mázala, Karuna Panchapakesan , et al. · 2023

Fibro/adipogenic progenitors (FAPs) are skeletal muscle stromal cells that support regeneration of injured myofibers and their maintenance in healthy muscles. FAPs are related to mesenchymal stem cells (MSCs/MeSCs) found in other adult tis…

Single-cell and spatial transcriptomics identify a macrophage population associated with skeletal muscle fibrosis Open

Gérald Coulis, Diego Jaime, Christian F. Guerrero‐Juarez, Jenna M. Kastenschmidt, Philip K. Farahat , et al. · 2023

Macrophages are essential for skeletal muscle homeostasis, but how their dysregulation contributes to the development of fibrosis in muscle disease remains unclear. Here, we used single-cell transcriptomics to determine the molecular attri…

Altered muscle niche contributes to myogenic deficit in the D2-mdx model of severe DMD Open

Davi A. G. Mázala, Ravi Hindupur, Young Jae Moon, Fatima Shaikh, Iteoluwakishi H. Gamu , et al. · 2023

Single-cell and spatial transcriptomics identify a macrophage population associated with skeletal muscle fibrosis Open

Gérald Coulis, Diego Jaime, Christian F. Guerrero‐Juarez, Jenna M. Kastenschmidt, Philip K. Farahat , et al. · 2023

The monocytic/macrophage system is essential for skeletal muscle homeostasis, but its dysregulation contributes to the pathogenesis of muscle degenerative disorders. Despite our increasing knowledge of the role of macrophages in degenerati…

Altered muscle niche contributes to myogenic deficit in the D2-<i>mdx</i>model of severe DMD Open

Davi A. G. Mázala, Ravi Hindupur, Young Jae Moon, Fatima Shaikh, Iteoluwakishi H. Gamu , et al. · 2023

Lack of dystrophin is the genetic basis for the Duchenne muscular dystrophy (DMD). However, disease severity varies between patients, based on specific genetic modifiers. D2- mdx is a model for severe DMD that exhibits exacerbated muscle d…

Monitoring Plasma Membrane Injury-Triggered Endocytosis at Single-Cell and Single-Vesicle Resolution Open

Daniel C. Bittel, Jyoti K. Jaiswal · 2022

The hidden uterus in Swyer syndrome with gonadoblastoma: a diagnostic dilemma Open

Yashaswi Pandey, Jyoti K. Jaiswal, Smriti Naik, Pratibha Lambodari · 2022

Disorders of sex development (DSD) comprise a rare group of disorders in which genotype and phenotype are discordant. In 46 XY DSD, also known as Swyer syndrome, patients present a complete female phenotype and the 46 XY karyotype is usual…

Editorial: The subcellular architecture of mitochondria in driving cellular processes Open

Brian Cunniff, Jyoti K. Jaiswal · 2022

EDITORIAL article Front. Cell Dev. Biol., 26 August 2022Sec. Signaling https://doi.org/10.3389/fcell.2022.1003779

CARCINOMA COLON SIGNET-RING CELL TYPE: A RARE CASE REPORT Open

Shivangi Shukla, Jyoti K. Jaiswal, Saba Naziya, Garima Shukla, Priyanka Verma , et al. · 2022

Carcinoma colon ranks third among the commonest cancer in the world, while seen less common in the Asian countries however lately an increasing trend has been observed. Majorly the elderly population is at an increased risk of colon cancer…

HIGH GRADE GLIOMA IN A 2 1/2 YEAR OLD: A CASE REPORT Open

Reeta Chaudhary, Nishi Tandon, Andleeb Zehra, Jyoti K. Jaiswal, Nirupma Lal , et al. · 2022

Gliomas are the tumor of glial cells found in Central nervous System. High Grade Gliomas are rare in pediatric age group. Definitive diagnosis is made by histopathological examination. A 2 ½ year old male admitted with the complaint of abn…

PARATHYROID ADENOMA: A RARE TUMOUR CASE REPORT Open

Garima Shukla, Priyanka Verma, Jyoti K. Jaiswal, Shivangi Shukla, Saba Nazia , et al. · 2022

Parathyroid adenoma is a rare tumour and are generally small size (< 2 cm) and 3.5 gm weight, along with few reports weights up to 110 gm. Parathyroid adenoma are usually found with primary hyperparathyroidism syndrome which is common, se…

LYMPHOEPITHELIOMA LIKE CARCINOMA OF URINARY BLADDER: A RARE CASE REPORT Open

Jyoti K. Jaiswal, Shivangi Shukla, Garima Shukla, Huma Parveen, Reeta Chaudhary , et al. · 2022

Urinary bladder neoplasm is the 10th most common cancer in the world, predominantly affecting males. Nowadays incidence of urinary bladder carcinoma in female has increased. It is a uncommon type carcinoma of urinary bladder. It resembles …

Secreted acid sphingomyelinase as a potential gene therapy for limb girdle muscular dystrophy 2B Open

Daniel C. Bittel, Sen Chandra Sreetama, Goutam Chandra, Robin J. Ziegler, Kanneboyina Nagaraju , et al. · 2022

Efficient sarcolemmal repair is required for muscle cell survival, with deficits in this process leading to muscle degeneration. Lack of the sarcolemmal protein dysferlin impairs sarcolemmal repair by reducing secretion of the enzyme acid …

Assessing Protein Interactions for Clustering of Mitochondrial Urea Cycle Enzymes Open

Ljubica Caldovic, Shivaprasad Bhuvanendran, Jyoti K. Jaiswal · 2022

Single Cell Transcriptomic Analysis of the Identity and Function of Fibro/Adipogenic Progenitors in Healthy and Dystrophic Muscle Open

Prech Uapinyoying, Marshall W. Hogarth, Surajit Battacharya, Davi A. G. Mázala, Karuna Panchapakesan , et al. · 2022

Pathogenic role and therapeutic potential of fibro-adipogenic progenitors in muscle disease Open

Marshall W. Hogarth, Prech Uapinyoying, Davi A. G. Mázala, Jyoti K. Jaiswal · 2021

Anoctamin 5 Knockout Mouse Model Recapitulates LGMD2L Muscle Pathology and Offers Insight Into in vivo Functional Deficits Open

Girija Thiruvengadam, Sen Chandra Sreetama, Karine Charton, Marshall W. Hogarth, James S. Novak , et al. · 2021

Mutations in the Anoctamin 5 (Ano5) gene that result in the lack of expression or function of ANO5 protein, cause Limb Girdle Muscular Dystrophy (LGMD) 2L/R12, and Miyoshi Muscular Dystrophy (MMD3). However, the dystrophic phenotype observ…

Isolation of human fibroadipogenic progenitors and satellite cells from frozen muscle biopsies Open

Xavier Suárez‐Calvet, Esther Fernández‐Simón, Patricia Piñol‐Jurado, Jorge Alonso‐Pérez, Ana Carrasco‐Rozas , et al. · 2021

Skeletal muscle contains multiple cell types that work together to maintain tissue homeostasis. Among these, satellite cells (SC) and fibroadipogenic progenitors cells (FAPs) are the two main stem cell pools. Studies of these cells using a…

Recent Developments in Annexin Biology Open

Jyoti K. Jaiswal, Volker Gerke, Ursula Rescher, Lina H. K. Lim · 2021

Discovered over 40 years ago, the annexin proteins were found to be a structurally conserved subgroup of Ca2+-binding proteins. While the initial research on annexins focused on their signature feature of Ca2+-dependent binding to membrane…

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