Christopher Brown
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View article: Evaluation of Copathology and Clinical Trajectories in Individuals With Tau-Clinical Mismatch
Evaluation of Copathology and Clinical Trajectories in Individuals With Tau-Clinical Mismatch Open
Importance Even within individuals who are amyloid positive, clinical symptoms can be impacted by Alzheimer pathology, other pathologic proteins, and cognitive reserve or resilience. Understanding how each of these factors contributes to a…
View article: Monitoring Cognition in Patients Undergoing Anti‐Amyloid Therapies with A Remote App‐Based Digital Cognitive Assessment Tool
Monitoring Cognition in Patients Undergoing Anti‐Amyloid Therapies with A Remote App‐Based Digital Cognitive Assessment Tool Open
Background Mobile, valid and engaging cognitive assessments are essential for detecting and tracking change in cognition. With the approval of anti‐amyloid therapies (AATs), there is a need to monitor for both benefits and risks of these t…
View article: EEG Correlates of the Influence of Somatosensory Input, Expectations and Trait‐Like Bias on Pain Perception
EEG Correlates of the Influence of Somatosensory Input, Expectations and Trait‐Like Bias on Pain Perception Open
Background The weighting of somatosensory input and pain expectation during pain perception is promising for pain phenotyping, with good test–retest reliability. Yet, their concurrent validity with neural and psychological variables requir…
View article: Biological age acceleration in Alzheimer’s disease modulates relative cortical to medial temporal lobe neurodegeneration
Biological age acceleration in Alzheimer’s disease modulates relative cortical to medial temporal lobe neurodegeneration Open
Alzheimer's disease (AD) is highly associated with aging, typically presenting with amnestic, multi-domain cognitive impairment and greater medial temporal lobe (MTL) atrophy relative to cortex. However, approximately 15 % of AD cases pres…
View article: A novel human-centred approach using Axiomatic Design and Kansei engineering for designing physically and cognitively safe human-robot collaborative workstations
A novel human-centred approach using Axiomatic Design and Kansei engineering for designing physically and cognitively safe human-robot collaborative workstations Open
Human-centred design of collaborative human-robot (HRC) workspaces is central to Industry 5.0. While proximity with collaborative robots offers productivity and flexibility gains, it also raises concerns for both physical safety and cognit…
View article: Safeguarding climate-resilient mangroves requires a small increase in the global protected area
Safeguarding climate-resilient mangroves requires a small increase in the global protected area Open
Climate change and anthropogenic activities threaten biodiversity and ecosystem services. Climate-smart conservation plans address these challenges by focusing protection in climate-resilient areas. However, integrating climate change in t…
View article: Tau Burden is Best Captured by Magnitude and Extent: Tau-MaX as a Measure of Global Tau
Tau Burden is Best Captured by Magnitude and Extent: Tau-MaX as a Measure of Global Tau Open
Tau exhibits change in both spatial extent and density of pathology along the Alzheimer’s disease (AD) spectrum with each aspect contributing to the overall burden of pathological tau. Nevertheless, studies using Tau PET have measured eith…
View article: “We Could Hold Our Own Here at Home”: Longitudinal Experience of COVID‐19 Lockdowns in Parents With Children Affected With Interstitial Lung Disease
“We Could Hold Our Own Here at Home”: Longitudinal Experience of COVID‐19 Lockdowns in Parents With Children Affected With Interstitial Lung Disease Open
The global health emergency of COVID‐19 in early 2020 placed much of the population under quarantine. Interstitial Lung Disease in childhood (chILD) was recommended to be a pediatric clinically extremely vulnerable (CEV) group in April 202…
View article: Support for transmission of tau pathology in humans using individualized epicenters and structural connectomes
Support for transmission of tau pathology in humans using individualized epicenters and structural connectomes Open
Background Population‐based functional connectomes help explain heterogeneity in tau spread in Alzheimer’s disease by demonstrating spread among connected neurons from canonical epicenters. However, if the hypothesis of cell‐to‐cell transm…
View article: Support for transmission of tau pathology in humans using individualized epicenters and structural connectomes
Support for transmission of tau pathology in humans using individualized epicenters and structural connectomes Open
Background Population‐based functional connectomes help explain heterogeneity in tau spread in Alzheimer’s disease by demonstrating spread among connected neurons from canonical epicenters. However, if the hypothesis of cell‐to‐cell transm…
View article: Morphometry of medial temporal lobe subregions using high‐resolution T2‐weighted MRI in ADNI3: Why, how, and what's next?
Morphometry of medial temporal lobe subregions using high‐resolution T2‐weighted MRI in ADNI3: Why, how, and what's next? Open
This paper for the 20th anniversary of the Alzheimer's Disease Neuroimaging Initiative (ADNI) provides an overview of magnetic resonance imaging (MRI) of medial temporal lobe (MTL) subregions in ADNI using a dedicated high‐resolution T2‐we…
View article: “We could hold our own here at home”: Longitudinal experience of COVID-19 lockdowns in parents with children affected with Interstitial Lung Disease.
“We could hold our own here at home”: Longitudinal experience of COVID-19 lockdowns in parents with children affected with Interstitial Lung Disease. Open
The global health emergency of COVID-19 in early 2020 placed much of the population under quarantine. Interstitial Lung Disease in childhood (chILD) was recommended to be a paediatric clinically extremely vulnerable (CEV) group in April 20…
View article: Childhood Interstitial Lung Disease clinical research: A child-parent dyad survey on research preferences and acceptability
Childhood Interstitial Lung Disease clinical research: A child-parent dyad survey on research preferences and acceptability Open
Despite patient and public involvement (PPI) in paediatric rare disease research being a challenge, PPI is strongly advocated for clinical research. PPI provides the opportunity for young people to support research for the future of their …
View article: Magnified interaural level differences enhance binaural unmasking in bilateral cochlear implant users
Magnified interaural level differences enhance binaural unmasking in bilateral cochlear implant users Open
Bilateral cochlear implant (BiCI) usage makes binaural benefits a possibility for implant users. Yet for BiCI users, limited access to interaural time difference (ITD) cues and reduced saliency of interaural level difference (ILD) cues res…
View article: Automatic segmentation of medial temporal lobe subregions in multi-scanner, multi-modality magnetic resonance imaging of variable quality
Automatic segmentation of medial temporal lobe subregions in multi-scanner, multi-modality magnetic resonance imaging of variable quality Open
Objectives Volumetry of subregions in the medial temporal lobe (MTL) computed from automatic segmentation in MRI can track neurodegeneration in Alzheimer’s disease. However, poor quality MR images can lead to unreliable segmentation of MTL…
View article: A systematic review of quantitative EEG findings in Fibromyalgia, Chronic Fatigue Syndrome and Long COVID
A systematic review of quantitative EEG findings in Fibromyalgia, Chronic Fatigue Syndrome and Long COVID Open
Fibromyalgia Syndrome (FMS), Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Long COVID (LC) are similar multisymptom clinical syndromes but with difference in dominant symptoms in each individual. There is existing and eme…
View article: Characteristics and outcomes of hospitalised adults with COVID-19 in a Global Health Research Network: A cohort study
Characteristics and outcomes of hospitalised adults with COVID-19 in a Global Health Research Network: A cohort study Open
Objective To examine age, gender, and temporal differences in baseline characteristics and clinical outcomes of adult patients hospitalised with COVID-19. Design A cohort study using deidentified electronic medical records from a Global Re…
View article: Scale-dependent wetting behavior of bioinspired lubricants on electrical discharge machined Ti6Al4V surfaces
Scale-dependent wetting behavior of bioinspired lubricants on electrical discharge machined Ti6Al4V surfaces Open
The relationships between the geometric features of material surfaces and topographically related phenomena, such as wetting, change with the scale of observation. In these studies, multiscale analyzes allow characterizing the relationship…
View article: Medial temporal lobe gray matter microstructure alterations provide improved sensitivity to detect neurodegeneration associated with Alzheimer’s disease biomarkers
Medial temporal lobe gray matter microstructure alterations provide improved sensitivity to detect neurodegeneration associated with Alzheimer’s disease biomarkers Open
Background Despite the strengths conventional structural imaging measures to detect atrophy, cross‐sectional relationships between neurodegeneration and Alzheimer’s disease (AD) biomarkers in early stages is limited. Neurite orientation di…
View article: Medial temporal lobe gray matter microstructure alterations provide improved sensitivity to detect neurodegeneration associated with Alzheimer’s disease biomarkers
Medial temporal lobe gray matter microstructure alterations provide improved sensitivity to detect neurodegeneration associated with Alzheimer’s disease biomarkers Open
Background Despite the strengths conventional structural imaging measures to detect atrophy, cross‐sectional relationships between neurodegeneration and Alzheimer’s disease (AD) biomarkers in early stages is limited. Neurite orientation di…
View article: Effects of Lockdown Restrictions and Impact of Anxiety and Depression Symptoms in People With Chronic Pain During the Covid-19 Pandemic: A 13-Wave Longitudinal Study
Effects of Lockdown Restrictions and Impact of Anxiety and Depression Symptoms in People With Chronic Pain During the Covid-19 Pandemic: A 13-Wave Longitudinal Study Open
In early 2020, countries across the world imposed lockdown restrictions to curb the spread of the Covid-19 coronavirus. Lockdown conditions, including social and physical distancing measures and recommended self-isolation for clinically vu…
View article: External Validation of Machine Learning and EEG for Continuous Pain Intensity Prediction in Healthy Individuals
External Validation of Machine Learning and EEG for Continuous Pain Intensity Prediction in Healthy Individuals Open
Previous research has predicted subjective pain intensity from electroencephalographic (EEG) data using machine learning (ML) models. However, there is a paucity of externally validated ML models for pain assessment, particularly for conti…
View article: Test–retest reliability of Bayesian estimations of the effects of stimulation, prior information and individual traits on pain perception
Test–retest reliability of Bayesian estimations of the effects of stimulation, prior information and individual traits on pain perception Open
Background There is inter‐individual variability in the influence of different components (e.g. nociception and expectations) on pain perception. Identifying the individual effect of these components could serve for patient stratification,…
View article: Analysing transitions from a Turing instability to large periodic patterns in a reaction-diffusion system
Analysing transitions from a Turing instability to large periodic patterns in a reaction-diffusion system Open
Analytically tracking patterns emerging from a small amplitude Turing instability to large amplitude remains a challenge as no general theory exists. In this paper, we consider a three component reaction-diffusion system with one of its co…
View article: A systematic review of quantitative EEG findings in Long COVID, Fibromyalgia and Chronic Fatigue Syndrome
A systematic review of quantitative EEG findings in Long COVID, Fibromyalgia and Chronic Fatigue Syndrome Open
Long COVID (LC) is a multisymptom clinical syndrome with similarities to Fibromyalgia Syndrome (FMS) and Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME). All these conditions are believed to be associated with centrally driven …