Explanipedia

Functional analysis and the importance of ligament reconstruction after soft tissue sarcoma surgery around the knee joint -a Tokai musculoskeletal oncology consortium study Open

Hiroshi Koike, K. Ikuta, Akihito Nagano, Hisaki Aiba, Kunihiro Asanuma , et al. · 2025

Methotrexate, Doxorubicin, and Cisplatin Versus Methotrexate, Doxorubicin, and Cisplatin + Ifosfamide in Poor Responders to Preoperative Chemotherapy for Newly Diagnosed High-Grade Osteosarcoma (JCOG0905): A Multicenter, Open-Label, Randomized Trial Open

Hiroaki Hiraga, Ryunosuke Machida, Akira Kawai, Toshiyuki Kunisada, Tsukasa Yonemoto , et al. · 2025

PURPOSE Our previous NECO phase II studies on high-grade osteosarcoma suggested that administering ifosfamide (IF; 16 g/m 2 [4g/m 2 once on day 1, then 2g/m 2 once on days 2-7] × six) to patients showing a poor response (PrRsp) to preopera…

Skin and soft tissue disorders caused by trabectedin extravasation: A case report Open

Yumi Matsuyama, Tomoki Nakamura, Hiroto Yuasa, Tomohito Hagi, Kunihiro Asanuma , et al. · 2025

Trabectedin extravasation can cause significant soft tissue disorders. Early surgical intervention has been recommended in the event of chemotherapeutic extravasation; however, treatment tends to remain conservative. Trabectedin is a vesic…

Cryoablation for Malignant Bone and Soft Tissue Tumors and Histological Assessment of Ablated Tumors Open

Kunihiro Asanuma, Atsuhiro Nakatsuka, Tomoki Nakamura, Masashi Fujimori, Takashi Yamanaka , et al. · 2024

Cryoablation has shown good anti-tumor efficacy across various tumor types, including those affecting the bone. However, local control was inadequate for recurrent lesions and tumors larger than 4.0 cm in diameter. Further analysis of the …

Osteosarcoma Arising from Iliac Bone Lesions of Hereditary Multiple Osteochondromas: A Case Report Open

T. Handa, Kunihiro Asanuma, Hiroto Yuasa, Tomoki Nakamura, Tomohito Hagi , et al. · 2024

Introduction: Osteochondromas are benign tumors that arise primarily in the metaphyseal region of long bones. The malignant transformation rate is estimated to be less than 1% and 1–3% in solitary and multiple osteochondromas, respectively…

Complications of chest wall around malignant tumors: differences based on reconstruction strategy Open

Kunihiro Asanuma, Masaya Tsujii, Tomohito Hagi, Tomoki Nakamura, Takeshi Kataoka , et al. · 2024

Prediction of prognosis using artificial intelligence‐based histopathological image analysis in patients with soft tissue sarcomas Open

Tomohito Hagi, Tomoki Nakamura, Hiroto Yuasa, Katsunori Uchida, Kunihiro Asanuma , et al. · 2024

Background Prompt histopathological diagnosis with accuracy is required for soft tissue sarcomas (STSs) which are still challenging. In addition, the advances in artificial intelligence (AI) along with the development of pathology slides d…

The Combined Use of Inflammation Markers, Modified Glasgow Prognostic Score, and Sarculator Nomogram in Extremity Soft Tissue Sarcoma: A Multicenter Observational Study Open

Tomoki Nakamura, Satoshi Takenaka, Hidetatsu Outani, Tomohito Hagi, Hironari Tamiya , et al. · 2024

Background: Sarculator is a validated nomogram designed to predict overall survival (OS) in extremity soft tissue sarcoma (STS). Inflammation plays a critical role in cancer development and progression. There were no reports which investig…

Pedicled flap transfer after chest wall malignant tumor resection and potential risk of postoperative respiratory problems for patients with low FEV1.0% Open

Kunihiro Asanuma, Masaya Tsujii, Tomohito Hagi, Tomoki Nakamura, Teruya Uchiyama , et al. · 2024

Introduction Musculoskeletal transfer for chest wall tissue defects is a crucial method, and pedicled flaps around the chest wall are preferred in terms of location and simplicity of transfer. These require special care because of complica…

The Effect of Photodynamic Therapy Using 5-Aminolevulinic Acid in Bone and Soft Tissue Sarcoma Cells Open

Ryohei Adachi, Tomoki Nakamura, Kenta Nakata, Teruya Uchiyama, Tomohito Hagi , et al. · 2024

5-ALA PDT effectively inhibited proliferation of bone and soft tissue sarcoma cell lines. Further in vivo research using other subtypes of bone and soft tissue sarcoma is warranted to confirm the applicability in the clinical setting.

Cryoablation for malignant bone and soft tissue tumors and histological assessment of ablated tumors Open

Kunihiro Asanuma, Atsuhiro Nakatsuka, Tomoki Nakamura, Masashi Fujimori, Takashi Yamanaka , et al. · 2024

Background: Recurrent or metastatic disease after completion of initial therapy for primary sarcoma represents a substantial problem, along with as well as metastasis of cancer. Cryoablation is a new, minimally invasive option for local an…

C‑reactive protein and related predictors in soft tissue sarcoma (Review) Open

Tomoki Nakamura, Kunihiro Asanuma, Tomohito Hagi, Akihiro Sudo · 2023

C-reactive protein (CRP) is a useful predictor of poor survival in patients with several types of cancer because inflammation is strongly associated with cancer progression. The production of CRP in hepatocytes appears to be primarily indu…

Complications of chest wall around malignant tumors: differences based on reconstruction strategy Open

Kunihiro Asanuma, Masaya Tsujii, Tomohito Hagi, Tomoki Nakamura, Takeshi Kataoka , et al. · 2023

Background The chest wall around malignant tumors needs wide resection with tumor-free margins, and reconstruction methods differ according to tumor depth. This study evaluated differences in complications according to reconstruction strat…

1948P Concordance of the pathological diagnosis between local institutional and central judgment in high-grade non-round-cell sarcomas: A supplementary analysis of JCOG1306 Open

Eiji Kobayashi, Ryunosuke Machida, Nakao Konishi, Haruhiko Fukuda, Takayuki Nojima , et al. · 2023

A Novel Approach to Reducing Lung Metastasis in Osteosarcoma: Increasing Cell Stiffness with Carbenoxolone Open

Kouji Kita, Kunihiro Asanuma, Takayuki Okamoto, Eiji Kawamoto, Kōichi Nakamura , et al. · 2023

Aim: Primary malignant bone tumor osteosarcoma can metastasize to the lung. Diminishing lung metastasis would positively affect the prognosis of patients. Our previous studies demonstrated that highly metastatic osteosarcoma cell lines are…

Combination of Everolimus and Bortezomib Inhibits the Growth and Metastasis of Bone and Soft Tissue Sarcomas via JNK/p38/ERK MAPK and AKT Pathways Open

Kōichi Nakamura, Kunihiro Asanuma, Takayuki Okamoto, Takahiro Iino, Tomohito Hagi , et al. · 2023

The combination of the mammalian target of rapamycin and proteasome inhibitors is a new treatment strategy for various tumors. Herein, we investigated the synergistic effect of everolimus and bortezomib on tumor growth and metastasis in bo…

Full-thickness chest wall resection for malignant chest wall tumors and postoperative problems Open

Kunihiro Asanuma, Masaya Tsujii, Tomohito Hagi, Tomoki Nakamura, Kouji Kita , et al. · 2023

Background Chest wall malignant tumor (including primary and metastatic lesions) is rare, representing less than 5% of all thoracic malignancies. Local control of chest wall malignancies requires wide resection with tumor-free margins. The…

Protocol for the 2ND-STEP study, Japan Clinical Oncology Group study JCOG1802: a randomized phase II trial of second-line treatment for advanced soft tissue sarcoma comparing trabectedin, eribulin and pazopanib Open

Makoto Endo, Tomoko Kataoka, Toshifumi Fujiwara, Satoshi Tsukushi, Masanobu Takahashi , et al. · 2023

Background Soft tissue sarcomas (STS) are a rare type of malignancy comprising a variety of histological diagnoses. Chemotherapy constitutes the standard treatment for advanced STS. Doxorubicin-based regimens, which include the administrat…

New screw technique for posterior column and ischial fixation from the anterior approach for acetabular fractures Open

Kunihiro Asanuma, Gaku Miyamura, Yoshiaki Suzuki, Yoshinori Makino, Naoya Takada , et al. · 2023

Management of the ischial fragment in acetabular fractures is a considerable problem. In this report, we presented how to drill or screw around the posterior column and ischium from the anterior approach using a novel ‘sleeve guide techniq…

The Characteristics of magnetic resonance imaging and immunohistochemical findings in de-differentiated liposarcoma Open

Keisuke Yoshida, Tomoki Nakamura, Kōichi Nakamura, Yumi Matsuyama, Tomohito Hagi , et al. · 2023

Purpose Radiological imaging in Dedifferentiated liposarcoma (DDLPS) often shows the coexistence of fatty and non-fatty solid components; however, it has been shown that when fatty components were not identified on magnetic resonance imagi…

Clinical Outcome in Patients With High-grade Soft-tissue Sarcoma Receiving Prosthetic Replacement After Tumor Resection of the Lower Extremities: Tokai Musculoskeletal Oncology Consortium Study Open

Tomoki Nakamura, Tomohisa Sakai, Satoshi Tsukushi, HIROAKI KIMURA, Junji Wasa , et al. · 2023

We identified a high rate of surgical complications and poor survival in patients with high-grade STS who underwent tumor resection and reconstruction using prosthetic replacement of the lower extremities, although limb salvage was achieve…

Is Lymphocyte C-Reactive Protein Ratio Useful for Predicting Survival in Patients with Non-Metastatic Soft Tissue Sarcoma? Open

Tomoki Nakamura, Tomohito Hagi, Kunihiro Asanuma, Akihiro Sudo · 2022

Background: Recently, the lymphocyte-to-CRP ratio (LCR) was found to have a prognostic role in many cancers. However, the clinical significance of LCR in patients with soft tissue sarcoma (STS) has not yet been established. This study aime…

Do coagulation or fibrinolysis reflect the disease condition in patients with soft tissue sarcoma? Open

Kunihiro Asanuma, Tomoki Nakamura, Takayuki Okamoto, Tomohito Hagi, Kouji Kita , et al. · 2022

Radiodynamic therapy with acridine orange local administration as a new treatment option for primary and secondary bone tumours Open

Yumi Matsuyama, Tomoki Nakamura, Keisuke Yoshida, Tomohito Hagi, Takahiro Iino , et al. · 2022

Aims Acridine orange (AO) demonstrates several biological activities. When exposed to low doses of X-ray radiation, AO increases the production of reactive radicals (radiodynamic therapy (AO-RDT)). We elucidated the efficacy of AO-RDT in b…

The role of soluble CD80 in patients with soft tissue tumors Open

Yumi Matsuyama, Kunihiro Asanuma, Keisuke Yoshida, Tomohito Hagi, Takahiro Iino , et al. · 2022

Macrophages and vimentin in tissues adjacent to megaprostheses and mesh in reconstructive surgeries Open

Kunihiro Asanuma, Tomoki Nakamura, Takahiro Iino, Tomohito Hagi, Akihiro Sudo · 2022

In reconstructive surgery using artificial materials after wide resection, soft tissues are usually adjacent to metal surfaces or mesh. The purpose of this study was to provide histological evaluation of the soft tissues adjacent to the me…

Perioperative Adriamycin plus ifosfamide vs. gemcitabine plus docetaxel for high-risk soft tissue sarcomas: randomised, phase II/III study JCOG1306 Open

Kazuhiro Tanaka, Ryunosuke Machida, Akira Kawai, Robert Nakayama, Satoshi Tsukushi , et al. · 2022

The Feasibility of Using the Direct Anterior Approach for Total Hip Arthroplasty or Bipolar Hemiarthroplasty to Treat Femoral Neck Fractures among the Elderly Open

Shigeo Ishiguro, Kunihiro Asanuma, Tomohito Hagi, Hidehiko Ohsumi, Hiroki Wakabayashi , et al. · 2022

Purpose. Femoral neck fractures (FNFs) are a significant cause of mortality and disability among the elderly. Total hip arthroplasty (THA) is the preferred treatment method in active, cognitively intact patients. In less active or cognitiv…

Modified Glasgow Prognostic Score is Better for Predicting Oncological Outcome in Patients with Soft Tissue Sarcoma, Compared to High-Sensitivity Modified Glasgow Prognostic Score Open

Tomoki Nakamura, Kunihiro Asanuma, Tomohito Hagi, Akihiro Sudo · 2022

mGPS is a reliable system for identifying patients at high risk for death in patients with STSs.

GPR64, Screened from Ewing Sarcoma Cells, Is a Potential Target for Antibody-Based Therapy for Various Sarcomas Open

Kōichi Nakamura, Kunihiro Asanuma, Takayuki Okamoto, Keisuke Yoshida, Yumi Matsuyama , et al. · 2022

Ewing sarcoma is an aggressive and the second most common bone tumor in adolescent and young adult patients. The 5-year survival rate is 60–70% for localized disease but 30% for patients with metastases. Here, we aimed to identify a therap…

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