Bente Klarlund Pedersen
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View article: Large‐Scale Study Comparing Analytical and Diagnostic Quality of Three <scp>HPV</scp> Self‐Sampling Devices for At‐Home Cervical Cancer Screening
Large‐Scale Study Comparing Analytical and Diagnostic Quality of Three <span>HPV</span> Self‐Sampling Devices for At‐Home Cervical Cancer Screening Open
Elimination of cervical cancer requires broad access to and participation in cervical screening. Self‐sampling has emerged as a robust technology that simplifies access; however, few self‐sampling devices are independently validated regard…
View article: Influence of Obesity and IL-6 on Human Postprandial Amino Acid and Protein Metabolism at Whole-body and Tissue Level
Influence of Obesity and IL-6 on Human Postprandial Amino Acid and Protein Metabolism at Whole-body and Tissue Level Open
Context Sarcopenic obesity, the loss of muscle mass and function in people with obesity, may result from altered muscle protein synthesis and degradation. Chronic low-grade inflammation, particularly IL-6, has been implicated. Objective To…
View article: Body Fluid Proteomic Landscape of Acute Exercise
Body Fluid Proteomic Landscape of Acute Exercise Open
Physical activity improves health, yet the molecular mechanisms remain partially understood. This study presents a high-resolution, time-resolved atlas profiling 10,127 proteins across plasma, saliva, and urine from healthy adults post-acu…
View article: Physical activity promotes gut adaptation, responses to nutrients, and sensitivity to gut peptides
Physical activity promotes gut adaptation, responses to nutrients, and sensitivity to gut peptides Open
SUMMARY Physical activity is essential for body weight maintenance after body weight-loss, partly by promoting the coupling between energy intake and expenditure. However, the underlying mechanisms remain largely unknown. Here we demonstra…
View article: Inhibition of basal IL-6 activity promotes subcutaneous fat retention in humans during fasting and postprandial states
Inhibition of basal IL-6 activity promotes subcutaneous fat retention in humans during fasting and postprandial states Open
Interleukin-6 (IL-6) knockout mice and humans treated with IL-6 receptor blockade gain adipose tissue mass. This study investigates whether basal IL-6 activity (resting IL-6 levels) influences fat storage during fasting and postprandial st…
View article: Sex Hormone Binding Globulin Controls Gender Specific Lipolytic Activity in Human Abdominal Subcutaneous Adipocytes
Sex Hormone Binding Globulin Controls Gender Specific Lipolytic Activity in Human Abdominal Subcutaneous Adipocytes Open
Regulation of lipid metabolism is fundamental for metabolic health, and adipose tissue is a central component in this process. Adipose tissue differs dramatically between women and men with a higher subcutaneous capacity for storage and he…
View article: Prevalence of cardiometabolic co-morbidities in patients with <i>vs</i> persons without chronic hepatitis B: The FitLiver cohort study
Prevalence of cardiometabolic co-morbidities in patients with <i>vs</i> persons without chronic hepatitis B: The FitLiver cohort study Open
BACKGROUND Chronic hepatitis B (CHB) affects > 300 million people worldwide. The combination of CHB and cardiometabolic co-morbidities increases the risk of liver-related morbidity and mortality. However, international guidelines for CHB t…
View article: Participation and relative cost of attendance by direct‐mail compared to opt‐in invitation strategy for <scp>HPV</scp> self‐sampling targeting cervical screening non‐attenders: A large‐scale, randomized, pragmatic study
Participation and relative cost of attendance by direct‐mail compared to opt‐in invitation strategy for <span>HPV</span> self‐sampling targeting cervical screening non‐attenders: A large‐scale, randomized, pragmatic study Open
Broad accessibility to cervical cancer screening and high participation rate is essential to reduce cervical cancer incidence. HPV self‐sampling is an alternative to clinician collected cervical samples to increase accessibility and screen…
View article: Effects of caloric restriction with different doses of exercise on fat loss in people living with type 2 diabetes: A secondary analysis of the DOSE-EX randomized clinical trial
Effects of caloric restriction with different doses of exercise on fat loss in people living with type 2 diabetes: A secondary analysis of the DOSE-EX randomized clinical trial Open
All interventions were superior in reducing FM% compared to standard care. Adding exercise to a caloric restriction was superior in reducing FM% compared to a caloric restriction alone.
View article: Longevity biotechnology: bridging AI, biomarkers, geroscience and clinical applications for healthy longevity
Longevity biotechnology: bridging AI, biomarkers, geroscience and clinical applications for healthy longevity Open
The recent unprecedented progress in ageing research and drug discovery brings together fundamental research and clinical applications to advance the goal of promoting healthy longevity in the human population. We, from the gathering at th…
View article: Impact of sarcopenia and muscle strength on postoperative complication risk following pancreatic resection
Impact of sarcopenia and muscle strength on postoperative complication risk following pancreatic resection Open
Sarcopenia defined according to the EWGSOP criteria and with international cut-off points is associated with an increased risk of postoperative complications following pancreatic resection. Using regionally based cut-off points, the preval…
View article: Impact of a 12‐week high‐intensity interval training intervention on cardiac structure and function after COVID‐19 at 12‐month follow‐up
Impact of a 12‐week high‐intensity interval training intervention on cardiac structure and function after COVID‐19 at 12‐month follow‐up Open
In patients previously hospitalised for COVID‐19, a 12‐week high‐intensity interval training (HIIT) intervention has previously been shown to increase left ventricular mass (LVM) immediately after the intervention. In the present study, we…
View article: Exercise‐induced changes in left ventricular strain are affected by interleukin‐6 activity: An exploratory analysis of a randomised‐controlled trial in humans with abdominal obesity
Exercise‐induced changes in left ventricular strain are affected by interleukin‐6 activity: An exploratory analysis of a randomised‐controlled trial in humans with abdominal obesity Open
Whilst the exercise‐induced myokine interleukin‐6 (IL‐6) plays a beneficial role in cardiac structural adaptations, its influence on exercise‐induced functional cardiac outcomes remains unknown. We hypothesised that IL‐6 activity is requir…
View article: An ultrasound-guided biopsy technique for obtaining supraclavicular brown fat biopsies and preadipocytes
An ultrasound-guided biopsy technique for obtaining supraclavicular brown fat biopsies and preadipocytes Open
Studying activated human brown adipose tissue (BAT) in vivo poses challenges due to its intricate anatomical positioning. Through the implementation of an ultrasound-guided biopsy technique, we successfully collected BAT samples from the s…
View article: Effect of Exercise Training on Prognosis in Community-acquired Pneumonia: A Randomized Controlled Trial
Effect of Exercise Training on Prognosis in Community-acquired Pneumonia: A Randomized Controlled Trial Open
Objective To investigate the effect of standard care (SoC) combined with supervised in-bed cycling (Bed-Cycle) or booklet exercises (Book-Exe) versus SoC in community-acquired pneumonia (CAP). Methods In this randomized controlled trial, 1…
View article: Type I interferon induced differences in exercise adaptations of aerobic capacity and fatigue in systemic lupus erythematosus – A randomised controlled single-centre trial v1.0
Type I interferon induced differences in exercise adaptations of aerobic capacity and fatigue in systemic lupus erythematosus – A randomised controlled single-centre trial v1.0 Open
Impaired exercise capacity and persistent fatigue are common manifestations in patients with systemic lupus erythematosus (SLE) even during disease remission. Knowledge on pathophysiologic mechanisms causing these disease manifestations is…
View article: Cervical cancer screening activity in the Capital Region of Denmark before, during and after the COVID-19 pandemic
Cervical cancer screening activity in the Capital Region of Denmark before, during and after the COVID-19 pandemic Open
The activity of cervical cancer screening was initially affected by the pandemic lockdowns, but increased activity during summer 2020 partly compensated this effect. Regular screening activity decreased 8.4% in 2020 and returned to pre-pan…
View article: Editorial: Integrative exercise endocrinology
Editorial: Integrative exercise endocrinology Open
EDITORIAL article Front. Endocrinol., 09 January 2024Sec. Translational Endocrinology Volume 14 - 2023 | https://doi.org/10.3389/fendo.2023.1350462
View article: Impact of high-intensity interval training on cardiac structure and function after COVID-19: an investigator-blinded randomized controlled trial
Impact of high-intensity interval training on cardiac structure and function after COVID-19: an investigator-blinded randomized controlled trial Open
In this randomized clinical trial on individuals previously hospitalized for COVID-19, a 12 wk supervised high-intensity interval training (HIIT) scheme was found to increase left ventricular mass, whereas pulmonary diffusing capacity was …
View article: Adding Different Exercise Training Volumes to a Diet-Induced Weight Loss Facilitates Fat Loss and Maintains Fat-Free Mass in a Dose-Depending Fashion in Persons with Newly Diagnosed Type 2 Diabetes: Secondary Findings from the DOSE-EX Multi-Arm, Parallel-Group, Randomized Trial
Adding Different Exercise Training Volumes to a Diet-Induced Weight Loss Facilitates Fat Loss and Maintains Fat-Free Mass in a Dose-Depending Fashion in Persons with Newly Diagnosed Type 2 Diabetes: Secondary Findings from the DOSE-EX Multi-Arm, Parallel-Group, Randomized Trial Open
OBJECTIVE To assess the dose-response effects of exercise in combination with a diet-induced weight loss on fat mass (FM) percentage (FM%) in persons with diagnosed type 2 diabetes. RESEARCH DESIGN AND METHODS In this secondary analysis of…
View article: Effect of a 12-week high-intensity exercise intervention: a comparison of cardiac exercise adaptations during biological disease-modifying antirheumatic drug treatment (TNF inhibitors vs IL-6 signalling inhibitors) in patients with rheumatoid arthritis – study protocol for a randomised controlled trial
Effect of a 12-week high-intensity exercise intervention: a comparison of cardiac exercise adaptations during biological disease-modifying antirheumatic drug treatment (TNF inhibitors vs IL-6 signalling inhibitors) in patients with rheumatoid arthritis – study protocol for a randomised controlled trial Open
Introduction The chronic inflammatory state in rheumatoid arthritis (RA) augments the risk of cardiovascular disease (CVD), with pro-inflammatory cytokines tumour necrosis factor (TNF) and interleukin 6 (IL-6) playing a vital role. Consequ…
View article: Effects of different doses of exercise and diet-induced weight loss on beta-cell function in type 2 diabetes (DOSE-EX): a randomized clinical trial
Effects of different doses of exercise and diet-induced weight loss on beta-cell function in type 2 diabetes (DOSE-EX): a randomized clinical trial Open
Diet-induced weight loss is associated with improved beta-cell function in people with type 2 diabetes (T2D) with remaining secretory capacity. It is unknown if adding exercise to diet-induced weight loss improves beta-cell function and if…
View article: Data from Voluntary Wheel Running Reduces the Acute Inflammatory Response to Liver Carcinogen in a Sex-specific Manner
Data from Voluntary Wheel Running Reduces the Acute Inflammatory Response to Liver Carcinogen in a Sex-specific Manner Open
Inflammation contributes to the development of cancer, yet acute inflammatory responses are also needed to eradicate tumorigenic cells and activate adaptive immune responses to combat cancer. Physical exercise has direct immunomodulatory e…