K. Bailey Freund
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View article: Peripapillary Retinoschisis: The Expanded Spectrum and New Insights From Multimodal Imaging
Peripapillary Retinoschisis: The Expanded Spectrum and New Insights From Multimodal Imaging Open
The 9 aetiologies of peripapillary retinoschisis can be classified into 5 groups: non-glaucomatous optic disc abnormalities (CDA, PP-coloboma, PP-atrophy), glaucomatous optic disc abnormalities, peripapillary choroidal diseases (PPS and PP…
View article: International consensuses and guidelines on central serous chorioretinopathy (CSC) by the Asia Pacific Vitreo-retina Society (APVRS), the Academy of Asia-Pacific Professors of Ophthalmology (AAPPO) and the Academia Retina Internationalis (ARI)
International consensuses and guidelines on central serous chorioretinopathy (CSC) by the Asia Pacific Vitreo-retina Society (APVRS), the Academy of Asia-Pacific Professors of Ophthalmology (AAPPO) and the Academia Retina Internationalis (ARI) Open
This consensus initiative provides a robust, evidence-based framework for the diagnosis and management of CSC, promoting standardization across clinical practices and guiding future research directions to address persistent gaps in CSC car…
View article: Evidence and Consensus Based Imaging Guidelines in Multiple Evanescent White Dot Syndrome Multimodal imaging in Uveitis (MUV) Taskforce Report 6
Evidence and Consensus Based Imaging Guidelines in Multiple Evanescent White Dot Syndrome Multimodal imaging in Uveitis (MUV) Taskforce Report 6 Open
Multimodal imaging is essential for diagnosing MEWDS and differentiating it from other non-infectious uveitis types, extending the Standardization of Uveitis Nomenclature (SUN) classification. These imaging criteria enable detailed assessm…
View article: En face OCT: Breakthroughs in understanding the pathoanatomy of retinal disease and clinical applications
En face OCT: Breakthroughs in understanding the pathoanatomy of retinal disease and clinical applications Open
En face optical coherence tomography (OCT) is a practical and informative imaging modality to noninvasively visualize distinct retinal and choroidal layers by providing coronal images using boundary-specific segmentation. Ongoing research …
View article: Standardization of OCT Angiography Nomenclature in Retinal Vascular Diseases
Standardization of OCT Angiography Nomenclature in Retinal Vascular Diseases Open
Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.
View article: Fundus Autofluorescence Variation in Geographic Atrophy of Age-Related Macular Degeneration: A Clinicopathologic Correlation
Fundus Autofluorescence Variation in Geographic Atrophy of Age-Related Macular Degeneration: A Clinicopathologic Correlation Open
FAF in GA is locally multifactorial, with photoreceptor shortening potentially promoting hyperFAF by increasing incoming excitation light available to RPE fluorophores. RPE dysmorphia may lead to either longer or shorter pathlength for exc…
View article: De novo and inherited dominant variants in U4 and U6 snRNAs cause retinitis pigmentosa
De novo and inherited dominant variants in U4 and U6 snRNAs cause retinitis pigmentosa Open
The U4 small nuclear RNA (snRNA) forms a duplex with the U6 snRNA and, together with U5 and ∼30 proteins, is part of the U4/U6.U5 tri-snRNP complex, located at the core of the major spliceosome. Recently, recurrent de novo variants in the …
View article: Pachychoroid disease: review and update
Pachychoroid disease: review and update Open
The pachychoroid disease spectrum is a phenotype characterized by alterations in choroidal vasculature which result in outer retinal and choriocapillaris damage and visual loss. The presence of pachyvessels is one of the key features of th…
View article: Intraocular Pressure Outcomes After Lampalizumab Injections in Patients With Geographic Atrophy
Intraocular Pressure Outcomes After Lampalizumab Injections in Patients With Geographic Atrophy Open
Importance Intraocular pressure (IOP) elevations of clinical relevance have been observed after the commonly used 0.05-mL volume for intravitreous injections. However, more recently approved intravitreous agents involve volumes from 0.07 t…
View article: Imaging Histology Correlations of Intraretinal Fluid in Neovascular Age-Related Macular Degeneration
Imaging Histology Correlations of Intraretinal Fluid in Neovascular Age-Related Macular Degeneration Open
OCT and histological features of different fluid types can inform clinical decision-making and assist in the interpretation of newly available automated fluid detection algorithms.
View article: Ultrasound Assessment of Gaze-induced Posterior Eyewall Deformation in Highly Myopic Eyes
Ultrasound Assessment of Gaze-induced Posterior Eyewall Deformation in Highly Myopic Eyes Open
Downward gaze results in a significant increase in posterior eyewall concavity in highly myopic eyes after accounting for AL and staphyloma presence. In comparison with downward gaze, upgaze resulted in a lower magnitude, but significant c…
View article: Variability in Capillary Perfusion Is Increased in Regions of Retinal Ischemia Due to Branch Retinal Vein Occlusion
Variability in Capillary Perfusion Is Increased in Regions of Retinal Ischemia Due to Branch Retinal Vein Occlusion Open
Greater variability in microvasculature perfusion occurs at sites of macular ischemia due to BRVO. We report a novel way for quantifying macular perfusion variability using OCTA. This technique may have applicability for studying the patho…
View article: MULTIZONAL OUTER RETINOPATHY AND RETINAL PIGMENT EPITHELIOPATHY (MORR)
MULTIZONAL OUTER RETINOPATHY AND RETINAL PIGMENT EPITHELIOPATHY (MORR) Open
Purpose: To describe specific clinical, multimodal imaging, and natural history features of an unusual variant of acute zonal occult outer retinopathy. Methods: Retrospective, observational, longitudinal, multicenter case series. Patients …
View article: Multiple Small Floaters Associated With Silicone Oil Droplets Following Intravitreal Pegcetacoplan Injection
Multiple Small Floaters Associated With Silicone Oil Droplets Following Intravitreal Pegcetacoplan Injection Open
This case series analyzes the presence of floaters associated with silicone oil droplets after intravitreal pegcetacoplan injection.
View article: INFLAMMATORY CELL ACTIVITY IN TREATED NEOVASCULAR AGE-RELATED MACULAR DEGENERATION
INFLAMMATORY CELL ACTIVITY IN TREATED NEOVASCULAR AGE-RELATED MACULAR DEGENERATION Open
Background: Imaging indicators of macular neovascularization risk can help determine patient eligibility for new treatments for geographic atrophy secondary to age-related macular degeneration. Because type 1 macular neovascularization inc…
View article: HISTOLOGY, DIMENSIONS, AND FLUORESCEIN STAINING CHARACTERISTICS OF NODULAR AND CUTICULAR DRUSEN IN AGE-RELATED MACULAR DEGENERATION
HISTOLOGY, DIMENSIONS, AND FLUORESCEIN STAINING CHARACTERISTICS OF NODULAR AND CUTICULAR DRUSEN IN AGE-RELATED MACULAR DEGENERATION Open
Purpose: To enable in vivo analysis of drusen composition and lifecycle, the macular nodular and cuticular drusen were assessed using histology. Methods: Median and interquartile range of base widths of single (nonconfluent) nodular drusen…
View article: <em>Ex Vivo</em> OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration
<em>Ex Vivo</em> OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration Open
A progression sequence for age-related macular degeneration (AMD) learned from optical coherence tomography (OCT)-based multimodal (MMI) clinical imaging could add prognostic value to laboratory findings. In this work, ex vivo OCT and MMI …
View article: Quantitative assessment of choriocapillaris flow deficits and type 1 macular neovascularization growth in age-related macular degeneration
Quantitative assessment of choriocapillaris flow deficits and type 1 macular neovascularization growth in age-related macular degeneration Open
During the past 15 years, new treatment paradigms for neovascular age-related macular degeneration (nvAMD) have evolved due to the advent of intravitreal anti-vascular endothelial growth factor (VEGF) therapy and rapid advances in retinal …
View article: Angiographic biomarkers are significant predictors of treatment response to intravitreal aflibercept in diabetic macular edema
Angiographic biomarkers are significant predictors of treatment response to intravitreal aflibercept in diabetic macular edema Open
This prospective single-center study aims to identify biomarkers that predict improvement in best-corrected visual acuity (BCVA) and central retinal thickness (CRT) at 6 months, in 76 eyes with diabetic macular edema (DME) treated monthly …
View article: STELLATE MULTIFORM AMELANOTIC CHOROIDOPATHY
STELLATE MULTIFORM AMELANOTIC CHOROIDOPATHY Open
Purpose: To describe the clinical and multimodal imaging features of stellate multiform amelanotic choroidopathy (SMACH; also known as serous maculopathy due to aspecific choroidopathy). Methods: Retrospective observational case series of …
View article: THE CHRYSANTHEMUM PHENOTYPE OF IDIOPATHIC MULTIFOCAL CHOROIDITIS
THE CHRYSANTHEMUM PHENOTYPE OF IDIOPATHIC MULTIFOCAL CHOROIDITIS Open
Purpose: To describe the clinical characteristics and multimodal imaging features of a distinctive subtype of active idiopathic multifocal choroiditis (iMFC) lesions with grey–yellow chorioretinal lesions surrounded by smaller satellite do…
View article: Foveal Development and Posterior Precortical Vitreous Pocket Formation
Foveal Development and Posterior Precortical Vitreous Pocket Formation Open
Oh, Daniel MD1,2,3; Esselfie, Juliet MD1,2; Tsang, Stephen MD PhD1,2,3; Freund, Kenneth Bailey MD1,2; Engelbert, Michael MD PhD1,2,a Author Information
View article: Histology of Type 3 Macular Neovascularization and Microvascular Anomalies in Treated Age-Related Macular Degeneration
Histology of Type 3 Macular Neovascularization and Microvascular Anomalies in Treated Age-Related Macular Degeneration Open
Proprietary or commercial disclosure may be found after the references.