Keith T. Ballingall
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Randomised controlled field trial to assess the safety and efficacy of a killed autologous vaccine against <i>Streptococcus dysgalactiae</i> subspecies <i>dysgalactiae</i> in a sheep flock Open
Introduction Joint‐ill in neonatal lambs, primarily caused by Streptococcus dysgalactiae subspecies dysgalactiae (SDSD), results in increased mortality and morbidity. An effective vaccine is needed to prevent the disease. Methods A blinded…
Genomic Analysis of Hair Sheep From West/Central Africa Reveals Unique Genetic Diversity and Ancestral Links to Breed Formation in the Caribbean Open
Cameroon Blackbelly sheep are a domestic breed of hair sheep from West/Central Africa. They are popular with small‐holder farmers in Cameroon as they are highly resilient to local environmental challenges and are prolific a‐seasonal breede…
The development, validation and application of an indirect enzyme-linked immunosorbent assay (ELISA) for the detection of antibodies to Streptococcus dysgalactiae subspecies dysgalactiae in lamb and ewe sera Open
This ELISA assay could be applied to estimate flock sero-prevalences for SDSD and changing SDSD antibody titres in vaccine trials.
Mastitis Pathogens Mannheimia haemolytica, Staphylococcus aureus, and Streptococcus uberis Selectively Alter TLR Gene Transcription in Sheep Mammary Epithelial Cells Open
Despite the impact of mastitis on sheep production worldwide, the pathogenesis and host response to bacterial infection of the ovine mammary gland are poorly characterized. Studies in cattle highlight the significance of the mammary epithe…
Novel sequence types and low levels of antimicrobial resistance associated with clinical mastitis in sheep flocks across Scotland Open
This research paper aimed to demonstrate that mammary secretions provided by sheep farmers across Scotland from cases of clinical mastitis are free from environmental contamination, as well as to provide information on the major bacterial …
Genomic analysis of hair sheep from West/Central Africa reveals unique genetic diversity and ancestral links to breed formation in the Caribbean Open
Cameroon Blackbelly sheep are a domestic breed of hair sheep from West/Central Africa. They are popular with small holder farmers in Cameroon as they are highly resilient to local environmental challenges and are prolific aseasonal breeder…
Large scale transcriptional analysis of <span>MHC</span> class I haplotype diversity in sheep Open
Domestic sheep ( Ovis aries ) have been an important component of livestock agricultural production for thousands of years. Preserving genetic diversity within livestock populations maintains a capacity to respond to changing environments …
Immune markers in goats selected for reduced gastrointestinal nematode egg count under artificial infection conditions Open
This study aimed to further investigate the mechanisms responsible for inhibition of gastrointestinal nematode egg production in a line of Scottish Cashmere Goat selected for low faecal egg count. Animals were chosen as the lowest egg prod…
Presence of Anaplasma phagocytophilum Ecotype I in UK Ruminants and Associated Zoonotic Risk Open
Anaplasma phagocytophilum is the causative agent of tick-borne fever in sheep, pasture fever in cattle, and granulocytic anaplasmosis in humans. The increasing prevalence and transboundary spread of A. phagocytophilum in livestock, ticks, …
Contemporary selection on MHC genes in a free‐living ruminant population Open
Genes within the major histocompatibility complex (MHC) are the most variable identified in vertebrates. Pathogen‐mediated selection is believed to be the main force maintaining MHC diversity. However, relatively few studies have demonstra…
Associations between MHC class II variation and phenotypic traits in a free‐living sheep population Open
Pathogen‐mediated selection (PMS) is thought to maintain the high level of allelic diversity observed in the major histocompatibility complex (MHC) class II genes. A comprehensive way to demonstrate contemporary selection is to examine ass…
Development of a Potential Yeast-Based Vaccine Platform for Theileria parva Infection in Cattle Open
East Coast Fever (ECF), caused by the tick-borne apicomplexan parasite Theileria parva , remains one of the most important livestock diseases in sub-Saharan Africa with more than 1 million cattle dying from infection every year. Disease pr…
MHC class IIa haplotypes derived by high-throughput SNP screening in an isolated sheep population Open
Investigating the current evolutionary processes acting on a highly polymorphic gene region, such as the major histocompatibility complex (MHC), requires extensive population data for both genotypes and phenotypes. The MHC consists of seve…
Intramammary Immunisation Provides Short Term Protection Against Mannheimia haemolytica Mastitis in Sheep Open
Mastitis affects both dairy and meat/wool sheep industries with losses due to reductions in milk quality and quantity, increased treatment costs and restricted lamb growth. Effective vaccines would be important tools for mastitis control. …
Associations between MHC class II variation and phenotypic traits in a free-living sheep population Open
Pathogen-mediated selection (PMS) is thought to maintain the high level of allelic diversity observed in the major histocompatibility complex (MHC) class II genes. A comprehensive way to demonstrate contemporary selection is to examine ass…
Associations between MHC class II variation and phenotypic traits in a free-living sheep population Open
Pathogen-mediated selection (PMS) is thought to maintain the high level of allelic diversity observed in the major histocompatibility complex (MHC) class II genes. A comprehensive way to demonstrate contemporary selection is to examine ass…
Development of a yeast-based vaccine for<i>Theileria parva</i>infection in cattle Open
East Coast Fever (ECF), caused by the tick-borne apicomplexan parasite Theileria parva, remains one of the most important livestock diseases in sub-Saharan Africa with more than 1 million cattle dying from infection every year. Disease pre…
Antimicrobial resistance in ovine bacteria: A sheep in wolf’s clothing? Open
The apparent prevalence of AMR in bacteria isolated from sheep is highly dependent on interpretation criteria. The sheep industry may want to establish bespoke cut-off values for AMR monitoring to avoid the use of cut-offs developed for ot…
MHC class IIa haplotypes derived by high throughput SNP screening in an isolated sheep population Open
Investigating the current evolutionary processes acting on a highly polymorphic gene region, such as the major histocompatibility complex (MHC), requires extensive population data for both genotypes and phenotypes. The MHC consists of seve…
Age-dependent selection on MHC class 2 variation in a free-living ruminant Open
Genes within the major histocompatibility complex (MHC) are the most variable identified in vertebrates. Pathogen-mediated selection (PMS) is believed to be the main force maintaining diversity at MHC class I and II genes, but it has prove…
View article: Immunological Homeostasis at the Ovine Placenta May Reflect the Degree of Maternal Fetal Interaction
Immunological Homeostasis at the Ovine Placenta May Reflect the Degree of Maternal Fetal Interaction Open
Successful mammalian pregnancies are a result of complex physiological, endocrinological, and immunological processes that combine to create an environment where the mother is tolerant to the semi-allogeneic fetus. Our knowledge of the mec…
IPD-MHC: nomenclature requirements for the non-human major histocompatibility complex in the next-generation sequencing era Open
The IPD-MHC Database is the official repository for non-human MHC sequences, overseen and supported by the Comparative MHC Nomenclature Committee, providing access to curated MHC data and associated analysis tools. To address the increasin…
IPD-MHC 2.0: an improved inter-species database for the study of the major histocompatibility complex Open
This FAIRsharing record describes: The IPD-MHC Database provides a centralised repository for sequences of the Major Histocompatibility Complex (MHC) from a number of different species. Through a number of international collaborations IPD …
View article: Identification of Theileria lestoquardi Antigens Recognized by CD8+ T Cells
Identification of Theileria lestoquardi Antigens Recognized by CD8+ T Cells Open
As part of an international effort to develop vaccines for Theileria lestoquardi, we undertook a limited screen to test T. lestoquardi orthologues of antigens recognised by CD8+ T lymphocyte responses against T. annulata and T. parva in ca…