Karleyton C. Evans
YOU?
Author Swipe
View article: An in vivo PET/CT investigation of mitochondrial complex 1, sigma 1, and synaptic vesicle 2 A in patients with amyotrophic lateral sclerosis
An in vivo PET/CT investigation of mitochondrial complex 1, sigma 1, and synaptic vesicle 2 A in patients with amyotrophic lateral sclerosis Open
Our findings reveal loss of MC1 and S1R in ALS, suggesting mitochondrial dysfunction associated with disease progression. This work provides initial insights of mitochondrial and receptor pathology in ALS, potentially guiding future biomar…
View article: Cinpanemab in Early Parkinson Disease
Cinpanemab in Early Parkinson Disease Open
NCT03318523 (clinicaltrials.gov/ct2/show/NCT03318523); Submitted October 24, 2017; First patient enrolled January 2018.
View article: Neuromelanin and T2*-MRI for the assessment of genetically at-risk, prodromal, and symptomatic Parkinson’s disease
Neuromelanin and T2*-MRI for the assessment of genetically at-risk, prodromal, and symptomatic Parkinson’s disease Open
MRI was suggested as a promising method for the diagnosis and assessment of Parkinson’s Disease (PD). We aimed to assess the sensitivity of neuromelanin-MRI and T 2 * with radiomics analysis for detecting PD, identifying individuals at ris…
View article: Trial of Cinpanemab in Early Parkinson’s Disease
Trial of Cinpanemab in Early Parkinson’s Disease Open
In participants with early Parkinson's disease, the effects of cinpanemab on clinical measures of disease progression and changes in DaT-SPECT imaging did not differ from those of placebo over a 52-week period. (Funded by Biogen; SPARK Cli…
View article: Synaptic PET imaging using [<sup>11</sup>C]UCB‐J in frontotemporal dementia
Synaptic PET imaging using [<sup>11</sup>C]UCB‐J in frontotemporal dementia Open
Background A number of pathophysiological mechanisms are associated with neurodegeneration, including synaptic dysfunction and/or loss. Novel radiotracers which enable the quantification of synaptic proteins in vivo have not previously bee…
View article: Evaluating dopamine transporter imaging as an enrichment biomarker in a phase 2 Parkinson’s disease trial
Evaluating dopamine transporter imaging as an enrichment biomarker in a phase 2 Parkinson’s disease trial Open
Background Dopamine transporter single-photon emission computed tomography (DaT-SPECT) can quantify the functional integrity of the dopaminergic nerve terminals and has been suggested as an imaging modality to verify the clinical diagnosis…
View article: A randomized study of natalizumab dosing regimens for relapsing–remitting multiple sclerosis
A randomized study of natalizumab dosing regimens for relapsing–remitting multiple sclerosis Open
Background: REFINE was an exploratory, dose- and frequency-blinded, prospective, randomized, dose-ranging study in relapsing–remitting multiple sclerosis (RRMS) patients. Objective: To examine the efficacy, safety, and tolerability of nata…
View article: Dynamic brain-body coupling of breath-by-breath O2-CO2 exchange ratio with resting state cerebral hemodynamic fluctuations
Dynamic brain-body coupling of breath-by-breath O2-CO2 exchange ratio with resting state cerebral hemodynamic fluctuations Open
Although the physiological mechanisms underlying the strong correlation between bER and CHF are unclear, our findings suggest the contribution of bER to low frequency resting state CHF, providing a novel insight of brain-body interaction v…
View article: Cerebrovascular reactivity assessment with O2-CO2 exchange ratio under brief breath hold challenge
Cerebrovascular reactivity assessment with O2-CO2 exchange ratio under brief breath hold challenge Open
Our findings provide a novel insight on the potential of using bER to better quantify CVR changes under BH challenge.
View article: Functional magnetic resonance imaging of regional impaired cerebrovascular reactivity for migraineurs in the interictal state
Functional magnetic resonance imaging of regional impaired cerebrovascular reactivity for migraineurs in the interictal state Open
There is still an unmet need of mapping the potential impairment of cerebrovascular reactivity (CVR) in episodic migraineurs in the interictal state. We mapped CVR of 6 episodic migraineurs and 5 headache-free controls (HC) with blood oxyg…
View article: Cerebrovascular reactivity assessment with O<sub>2</sub>-CO<sub>2</sub> exchange ratio under brief breath hold challenge
Cerebrovascular reactivity assessment with O<sub>2</sub>-CO<sub>2</sub> exchange ratio under brief breath hold challenge Open
Hypercapnia during breath holding is believed to be the dominant driver behind the modulation of cerebral blood flow (CBF). Here we showed that the cerebrovascular responses to brief breath hold epochs were coupled not only with increased …
View article: Dynamic Brain-Body Coupling of Breath-by-Breath O<sub>2</sub>-CO<sub>2</sub>Exchange Ratio with Resting State Cerebral Hemodynamic Fluctuations
Dynamic Brain-Body Coupling of Breath-by-Breath O<sub>2</sub>-CO<sub>2</sub>Exchange Ratio with Resting State Cerebral Hemodynamic Fluctuations Open
The origin of low frequency cerebral hemodynamic fluctuations (CHF) in resting state remains unknown. Here we studied the contribution of respiratory gas exchange (RGE) metrics to CHF during spontaneous breathing. RGE metrics include the b…
View article: FDG PET Parkinson’s disease-related pattern as a biomarker for clinical trials in early stage disease
FDG PET Parkinson’s disease-related pattern as a biomarker for clinical trials in early stage disease Open
Two independent analyses performed in a cohort of mild PD patients replicated key features of the PDRP, confirming that FDG-PET and multivariate classification can provide an objective, sensitive biomarker of disease stage with the potenti…
View article: Reversibility of the effects of natalizumab on peripheral immune cell dynamics in MS patients
Reversibility of the effects of natalizumab on peripheral immune cell dynamics in MS patients Open
This study provides Class III evidence that the pharmacodynamic markers of natalizumab are reversed ≈16 weeks after stopping natalizumab.
View article: The pulsatility volume index: an indicator of cerebrovascular compliance based on fast magnetic resonance imaging of cardiac and respiratory pulsatility
The pulsatility volume index: an indicator of cerebrovascular compliance based on fast magnetic resonance imaging of cardiac and respiratory pulsatility Open
The influence of cardiac activity on the viscoelastic properties of intracranial tissue is one of the mechanisms through which brain–heart interactions take place, and is implicated in cerebrovascular disease. Cerebrovascular disease risk …
View article: Acute deep brain stimulation changes in regional cerebral blood flow in obsessive-compulsive disorder
Acute deep brain stimulation changes in regional cerebral blood flow in obsessive-compulsive disorder Open
OBJECTIVE Deep brain stimulation (DBS) is a reversible, nonlesion-based treatment for patients with intractable obsessive-compulsive disorder (OCD). The first studies on DBS for OCD stimulating the ventral capsule/ventral striatum (VC/VS) …