Kyu‐Chang Wang
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View article: Fate of Brain metastasis with Cerebrospinal fluid space invasion based on MRI findings: Clinical features and factors affecting progression to overt leptomeningeal metastasis
Fate of Brain metastasis with Cerebrospinal fluid space invasion based on MRI findings: Clinical features and factors affecting progression to overt leptomeningeal metastasis Open
Purpose Parenchymal brain metastasis (BM), its extended growth into cerebrospinal fluid (CSF) pathways or surgical spillage could result in leptomeningeal metastasis (LM). We defined BM with epipial spread or dural attachment on MRI as BM …
View article: Development of the clinical practice guideline protocol registration program and its pilot application in Korea
Development of the clinical practice guideline protocol registration program and its pilot application in Korea Open
BackgroundIn the case of clinical practice guideline (CPG), the need for the prospective registration of protocols has been proposed several times. However, the registration of CPG protocols is not yet active. The objective of this study w…
View article: Exploratory profiling of metabolites in cerebrospinal fluid using a commercially available targeted LC-MS based metabolomics kit to discriminate leptomeningeal metastasis
Exploratory profiling of metabolites in cerebrospinal fluid using a commercially available targeted LC-MS based metabolomics kit to discriminate leptomeningeal metastasis Open
Using a commercial targeted liquid chromatography-mass spectrometry (LC-MS) metabolomics kit, we were able to differentiate LM from HC and PBT. Most of the discriminative metabolites among different diseases were lipid metabolites, for whi…
View article: Exploratory profiling of metabolites in cerebrospinal fluid using a commercially available targeted metabolomics kit to discriminate leptomeningeal metastasis
Exploratory profiling of metabolites in cerebrospinal fluid using a commercially available targeted metabolomics kit to discriminate leptomeningeal metastasis Open
Background: Early diagnosis is needed for patients with leptomeningeal metastasis (LM); however, cerebrospinal fluid (CSF) cytology has low sensitivity, and imaging approaches are ineffective. We explored targeted CSF metabolic profiling t…
View article: Leptomeningeal Metastasis in Gliomas : Clinical Characteristics and Risk Factors
Leptomeningeal Metastasis in Gliomas : Clinical Characteristics and Risk Factors Open
Objective : Our objective is to analyze the occurrence, clinical course and risk factors for glioma patients with leptomeningeal metastasis (LM) according to different metastasis patterns and clinical variables.Methods : We retrospectively…
View article: EPCO-38. TYPE B ULTRA LONG-RANGE INTERACTIONS IN PFAS (TULIPS) ARE RECURRENT EPIGENOMIC FEATURES OF PFA EPENDYMOMA
EPCO-38. TYPE B ULTRA LONG-RANGE INTERACTIONS IN PFAS (TULIPS) ARE RECURRENT EPIGENOMIC FEATURES OF PFA EPENDYMOMA Open
Posterior Fossa Group A (PFA) ependymomas are pediatric brain tumors with extremely poor survival outcomes. As protein-coding mutations in PFA are exceedingly rare, the underlying etiology of these tumors remains elusive. Elevated CpG isla…
View article: Clinical outcomes of pediatric cerebral cavernous malformation: an analysis of 124 consecutive cases
Clinical outcomes of pediatric cerebral cavernous malformation: an analysis of 124 consecutive cases Open
OBJECTIVE One-fourth of cerebral cavernous malformation (CCM) patients are children, but studies on these patients are scarce. This study aimed to identify the clinical presentation of pediatric CCM patients and to investigate clinical out…
View article: Complications of Endoscopic Skull Base Surgery for Sellar and Parasellar Tumors in Pediatric Population; Neurosurgical Perspectives
Complications of Endoscopic Skull Base Surgery for Sellar and Parasellar Tumors in Pediatric Population; Neurosurgical Perspectives Open
Background Advances in surgical techniques based on in-depth anatomical knowledge of the skull base have broadened the indications for endoscopic skull base surgery (ESS) with the advantage of wide and direct surgical exposure while minimi…
View article: We Are Cautious to Use the Term, ‘Split Cord Malformation Type 1.5’
We Are Cautious to Use the Term, ‘Split Cord Malformation Type 1.5’ Open
See the reply "We Are Cautious to Use the Term, âSplit Cord Malformation Type 1.5â" in Volume 65 on page 763.
View article: Preoperative Videourodynamic Study Is Helpful in Predicting Long-term Postoperative Voiding Function in Asymptomatic Patients With Closed Spinal Dysraphism
Preoperative Videourodynamic Study Is Helpful in Predicting Long-term Postoperative Voiding Function in Asymptomatic Patients With Closed Spinal Dysraphism Open
Purpose: Controversy exists regarding the role preoperative urodynamic study for asymptomatic closed spinal dysraphism as it has failed to reveal the benefit in surgical decision and expectation of urological outcomes. We explore the relat…
View article: Three‐dimensional visualization of secondary neurulation in chick embryos using <scp>microCT</scp>
Three‐dimensional visualization of secondary neurulation in chick embryos using <span>microCT</span> Open
Background Defects in secondary neurulation play an important role in neural tube defects. Researchers have investigated the processes of secondary neurulation and caudal body formation mainly by microscopic observations and molecular expe…
View article: Dosimetric Parameters Associated with the Long-Term Oncologic Outcomes of Gamma Knife Surgery for Sellar and Parasellar Tumors in Pediatric Patients
Dosimetric Parameters Associated with the Long-Term Oncologic Outcomes of Gamma Knife Surgery for Sellar and Parasellar Tumors in Pediatric Patients Open
Purpose We aimed to investigate the dosimetric parameter and the minimally required dose associated with long-term control of sellar and parasellar tumors after gamma knife surgery (GKS) in children. Methods A retrospective analysis was pe…
View article: Disorders of Secondary Neurulation : Mainly Focused on Pathoembryogenesis
Disorders of Secondary Neurulation : Mainly Focused on Pathoembryogenesis Open
Recent advancements in basic research on the process of secondary neurulation and increased clinical experience with caudal spinal anomalies with associated abnormalities in the surrounding and distal structures shed light on further under…
View article: Caudal Agenesis : Understanding the Base of the Wide Clinical Spectrum
Caudal Agenesis : Understanding the Base of the Wide Clinical Spectrum Open
Caudal agenesis refers to the congenital malformation with the essential feature of the agenesis of the sacrococcygeal bone. It is associated with various types of spinal cord anomaly as well as with complex anomalies of genitourinary or g…
View article: Perspectives : The Role of Clinicians in Understanding Secondary Neurulation
Perspectives : The Role of Clinicians in Understanding Secondary Neurulation Open
During the last two decades, there have been remarkable advances in knowledge regarding secondary neurulation. An increased number of cases of occult spinal dysraphism and progress in basic embryology research have provoked the continuous …
View article: Clinicopathological Features of Primary Solitary Spinal Cord Tumors in Pediatric Patients : A 32-Year Single Institution Experience
Clinicopathological Features of Primary Solitary Spinal Cord Tumors in Pediatric Patients : A 32-Year Single Institution Experience Open
Approximately half of PSCTs were malignant, and ED tumors were most common. The most common pathologies were schwannomas and neuroblastomas. Both the pathology and extent of resection had a decisive effect on OS. For IM tumors, pathology w…
View article: Long-Term Outcomes and Sequelae Analysis of Intracranial Germinoma: Need to Reduce the Extended-Field Radiotherapy Volume and Dose to Minimize Late Sequelae
Long-Term Outcomes and Sequelae Analysis of Intracranial Germinoma: Need to Reduce the Extended-Field Radiotherapy Volume and Dose to Minimize Late Sequelae Open
Purpose We aimed to refine the radiotherapy (RT) volume and dose for intracranial germinoma considering recurrences and long-term toxicities.Materials and Methods Total 189 patients with intracranial germinoma were treated with RT alone (n…
View article: GCT-12. INTRACRANIAL GROWING TERATOMA SYNDROME: CLINICAL IMPLICATION FROM SINGLE UNIVERSITY EXPERIENCES
GCT-12. INTRACRANIAL GROWING TERATOMA SYNDROME: CLINICAL IMPLICATION FROM SINGLE UNIVERSITY EXPERIENCES Open
In general, intracranial germ cell tumors (GCT) are sensitive to chemotherapy, radiation therapy, and have favorable outcomes. However, a rare chemotherapeutic retro conversion phenomenon, known as intracranial growing teratoma syndrome (i…
View article: GCT-02. THE LONG-TERM OUTCOMES AND SEQUELAE ANALYSIS OF INTRACRANIAL GERMINOMA FROM 187 PATIENTS IN THE SINGLE INSTITUTE: NECESSITY FOR THE ADAPTATION OF RADIOTHERAPY DOSE AND VOLUME
GCT-02. THE LONG-TERM OUTCOMES AND SEQUELAE ANALYSIS OF INTRACRANIAL GERMINOMA FROM 187 PATIENTS IN THE SINGLE INSTITUTE: NECESSITY FOR THE ADAPTATION OF RADIOTHERAPY DOSE AND VOLUME Open
PURPOSE We aimed to refine the radiotherapy (RT) volume and dose determinant for disease failures and long-term sequelae in the intracranial germinoma. METHODS The main treatment for intracranial germinoma was craniospinal RT only (n=51) d…
View article: Long-term outcome of large sylvian arachnoid cysts: the role of surgery has been exaggerated
Long-term outcome of large sylvian arachnoid cysts: the role of surgery has been exaggerated Open
OBJECTIVE The surgical indications for some arachnoid cysts (ACs) are controversial. While surgical procedures can be effective when an AC is a definite cause of hydrocephalus or papilledema, most ACs do not cause any symptoms or signs. So…
View article: Terminal Myelocystocele : Pathoembryogenesis and Clinical Features
Terminal Myelocystocele : Pathoembryogenesis and Clinical Features Open
There has been confusion in the classification of terminal myelocystocele (TMCC) due to its diverse morphology and vague pathoembryogenesis. TMCC could be summarized as having the essential features of an elongated caudal spinal cord extru…
View article: Retethering : A Neurosurgical Viewpoint
Retethering : A Neurosurgical Viewpoint Open
During the follow-up period after surgery for spinal dysraphism, a certain portion of patients show neurological deterioration and its secondary phenomena, such as motor, sensory or sphincter changes, foot and spinal deformities, pain, and…