Kai Cao
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View article: Mn<sub>3</sub>O<sub>4</sub> nanozyme-based anti-inflammatory therapy modulates microglial phenotype by downregulating TLR4/NOX2 expression and further alleviates Alzheimer's disease pathology
Mn<sub>3</sub>O<sub>4</sub> nanozyme-based anti-inflammatory therapy modulates microglial phenotype by downregulating TLR4/NOX2 expression and further alleviates Alzheimer's disease pathology Open
Rationale: Evidence shows that neuroinflammation mediated by microglial activation plays an important role in Alzheimer's disease (AD) pathogenesis. However, the relationship between microglial phenotype and fibrillar β-amyloid (fAβ) patho…
View article: Nutrient Solution Selection Modulates Growth Patterns and Leaf Elemental Accumulation in Alfalfa (Medicago sativa) Grown
Nutrient Solution Selection Modulates Growth Patterns and Leaf Elemental Accumulation in Alfalfa (Medicago sativa) Grown Open
While forage grasses in southern China exhibit yield and nutritional advantages, the impact of nutrient solutions on alfalfa (Medicago sativa BC4) growth and elemental accumulation remains understudied. We conducted a pot-based controlled …
View article: Advances in gut microbiota-related treatment strategies for managing colorectal cancer in humans
Advances in gut microbiota-related treatment strategies for managing colorectal cancer in humans Open
Colorectal cancer (CRC) is a major contributor to global cancer-related mortality with increasing incidence rates in both developed and developing regions. Therefore, CRC presents a significant challenge to global health. The development o…
View article: Polydopamine Nanocomposite Hydrogel for Drug Slow-Release in Bone Defect Repair: A Review of Research Advances
Polydopamine Nanocomposite Hydrogel for Drug Slow-Release in Bone Defect Repair: A Review of Research Advances Open
In recent years, hydrogels have emerged as promising candidates for bone defect repair due to their excellent biocompatibility, high porosity, and water-retentive properties. However, conventional hydrogels face significant challenges in c…
View article: IRAK2 overexpression restrains prostate cancer progression by regulation of TRAF6 ubiquitination
IRAK2 overexpression restrains prostate cancer progression by regulation of TRAF6 ubiquitination Open
Prostate cancer is recognized as one of the most common tumors among men worldwide, yet the molecular mechanisms underlying its progression remain to be fully understood. In this study, we explored the role of interleukin-1 receptor-associ…
View article: Induction of Non-Canonical Ferroptosis by Targeting Clusters Suppresses Glioblastoma
Induction of Non-Canonical Ferroptosis by Targeting Clusters Suppresses Glioblastoma Open
Glioblastoma multiforme (GBM) is the most aggressive brain tumor. There is a pressing need to develop novel treatment strategies due to the poor targeting effect of current therapeutics. Here, a gold cluster coated with optimized GBM-targe…
View article: Enhanced Production of High-Value Porphyrin Compound Heme by Metabolic Engineering Modification and Mixotrophic Cultivation of Synechocystis sp. PCC6803
Enhanced Production of High-Value Porphyrin Compound Heme by Metabolic Engineering Modification and Mixotrophic Cultivation of Synechocystis sp. PCC6803 Open
Heme, as an essential cofactor and source of iron for cells, holds great promise in various areas, e.g., food and medicine. In this study, the model cyanobacteria Synechocystis sp. PCC6803 was used as a host for heme synthesis. The heme sy…
View article: Biomass Estimation of Milk Vetch Using UAV Hyperspectral Imagery and Machine Learning
Biomass Estimation of Milk Vetch Using UAV Hyperspectral Imagery and Machine Learning Open
Milk vetch (Astragalus sinicus L.) is a winter-growing plant that can enhance soil fertility and provide essential nutrients for subsequent season crops. The fertilizing capacity of milk vetch is closely related to its above-ground biomass…
View article: A probe for NIR-II imaging and multimodal analysis of early Alzheimer’s disease by targeting CTGF
A probe for NIR-II imaging and multimodal analysis of early Alzheimer’s disease by targeting CTGF Open
To date, earlier diagnosis of Alzheimer’s disease (AD) is still challenging. Recent studies revealed the elevated expression of connective tissue growth factor (CTGF) in AD brain is an upstream regulator of amyloid-beta (Aβ) plaque, thus C…
View article: EPL-based medium- and long-term end-use energy service demand forecasting model for parks
EPL-based medium- and long-term end-use energy service demand forecasting model for parks Open
Aiming at the problem of medium and long-term energy demand forecast in parks, which is limited by meteorological factors, industry production plans, energy policies, energy prices, and other uncertainties which has low accuracy, this pape…
View article: The war between the immune system and the tumor - using immune biomarkers as tracers
The war between the immune system and the tumor - using immune biomarkers as tracers Open
Nowadays, immunotherapy is one of the most promising anti-tumor therapeutic strategy. Specifically, immune-related targets can be used to predict the efficacy and side effects of immunotherapy and monitor the tumor immune response. In the …
View article: Continuous and low-carbon production of biomass flash graphene
Continuous and low-carbon production of biomass flash graphene Open
Flash Joule heating (FJH) is an emerging and profitable technology for converting inexhaustible biomass into flash graphene (FG). However, it is challenging to produce biomass FG continuously due to the lack of an integrated device. Furthe…
View article: Results of a phase I trial with Haploidentical <scp>mbIL</scp>‐21 ex vivo expanded <scp>NK</scp> cells for patients with multiply relapsed and refractory <scp>AML</scp>
Results of a phase I trial with Haploidentical <span>mbIL</span>‐21 ex vivo expanded <span>NK</span> cells for patients with multiply relapsed and refractory <span>AML</span> Open
Natural killer (NK)‐cells have potent anti‐tumor effects, yet it remains unclear if they are effective for patients with relapsed acute myeloid leukemia (AML). In a phase I clinical trial, we treated 12 patients (median age 60 years) with …
View article: The role of novel adipokines in hepatocellular carcinoma progression: a mini review
The role of novel adipokines in hepatocellular carcinoma progression: a mini review Open
Hepatocellular carcinoma (HCC), which originates from hepatocytes, accounts for the majority of primary liver cancers. Globally, HCC ranks among the most common cancers and is a leading cause of cancer-related deaths. Obesity, a growing he…
View article: Identification of ECM and EMT relevant genes involved in the progression of bladder cancer through bioinformatics analysis
Identification of ECM and EMT relevant genes involved in the progression of bladder cancer through bioinformatics analysis Open
Taken together, most of hub genes involved in the progression of BC were related to ECM and EMT. In addition, 3 hub genes (DCN, JUN, THBS1) were strongly related with clinical stages and OS of BC patients. This study can enhance our compre…
View article: Reviewer #2 (Public Review): Akkermansia muciniphila identified as key strain to function in pathogen invasion and intestinal stem cell proliferation through Wnt signaling pathway
Reviewer #2 (Public Review): Akkermansia muciniphila identified as key strain to function in pathogen invasion and intestinal stem cell proliferation through Wnt signaling pathway Open
As the largest mucosal surface, the gut has built a physical, chemical, microbial and immune barrier to protect the body against pathogen invasion. The disturbance of gut microbiota aggravates pathogenic bacteria invasion and gut barrier i…
View article: Reviewer #3 (Public Review): Akkermansia muciniphila identified as key strain to function in pathogen invasion and intestinal stem cell proliferation through Wnt signaling pathway
Reviewer #3 (Public Review): Akkermansia muciniphila identified as key strain to function in pathogen invasion and intestinal stem cell proliferation through Wnt signaling pathway Open
As the largest mucosal surface, the gut has built a physical, chemical, microbial and immune barrier to protect the body against pathogen invasion. The disturbance of gut microbiota aggravates pathogenic bacteria invasion and gut barrier i…
View article: Reviewer #1 (Public Review): Akkermansia muciniphila identified as key strain to function in pathogen invasion and intestinal stem cell proliferation through Wnt signaling pathway
Reviewer #1 (Public Review): Akkermansia muciniphila identified as key strain to function in pathogen invasion and intestinal stem cell proliferation through Wnt signaling pathway Open
As the largest mucosal surface, the gut has built a physical, chemical, microbial and immune barrier to protect the body against pathogen invasion. The disturbance of gut microbiota aggravates pathogenic bacteria invasion and gut barrier i…
View article: Akkermansia muciniphila identified as key strain to function in pathogen invasion and intestinal stem cell proliferation through Wnt signaling pathway
Akkermansia muciniphila identified as key strain to function in pathogen invasion and intestinal stem cell proliferation through Wnt signaling pathway Open
As the largest mucosal surface, the gut has built a physical, chemical, microbial and immune barrier to protect the body against pathogen invasion. The disturbance of gut microbiota aggravates pathogenic bacteria invasion and gut barrier i…
View article: Various green manure-fertilizer combinations affect the soil microbial community and function in immature red soil
Various green manure-fertilizer combinations affect the soil microbial community and function in immature red soil Open
Green manure application is a common practice to improve soil fertility in China. However, the impact of different green manure-fertilizer combinations on the soil microbial communities in the low-fertility immature red soil in southern Ch…
View article: Aβ42 and ROS Dual-targeted Multifunctional Nanocomposite for Combination Therapy of Alzheimer’s Disease
Aβ42 and ROS Dual-targeted Multifunctional Nanocomposite for Combination Therapy of Alzheimer’s Disease Open
Amyloid-β (Aβ) is prone to misfolding into neurotoxic aggregates that generate high levels of reactive oxygen species (ROS), leading to progressive oxidative damage and ultimately cell death. Therefore, simultaneous inhibition of Aβ aggreg…
View article: Large-scale pancreatic cancer detection via non-contrast CT and deep learning
Large-scale pancreatic cancer detection via non-contrast CT and deep learning Open
Pancreatic ductal adenocarcinoma (PDAC), the most deadly solid malignancy, is typically detected late and at an inoperable stage. Early or incidental detection is associated with prolonged survival, but screening asymptomatic individuals f…