Karen C. Carroll
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View article: An update on novel taxa and revised taxonomic status of bacteria isolated from human clinical specimens described in 2024
An update on novel taxa and revised taxonomic status of bacteria isolated from human clinical specimens described in 2024 Open
Knowledge of novel and revised bacterial taxonomy facilitates routine operations in the medical microbiology laboratory and communication with important stakeholders. Notable new gram-positive taxa accepted in 2024 include the clinically s…
View article: Face Mask Use and Persistence of Livestock-associated Staphylococcus aureus Nasal Carriage among Industrial Hog Operation Workers and Household Contacts, USA
Face Mask Use and Persistence of Livestock-associated Staphylococcus aureus Nasal Carriage among Industrial Hog Operation Workers and Household Contacts, USA Open
BACKGROUND: Industrial hog operation (IHO) workers may persistently carry antibiotic-resistant, livestock-associated Staphylococcus aureus in their nasal cavities. It is unclear whether IHO work activities can alter IHO workers' and their …
View article: Multicenter evaluation of blood culture contamination and blood cultures practices in US acute care hospitals: time for standardization
Multicenter evaluation of blood culture contamination and blood cultures practices in US acute care hospitals: time for standardization Open
Clinical and Laboratory Standards Institute (CLSI) recommends a blood culture contamination (BCC) threshold of <3%, with ≤1% considered optimal. However, there is not a standardized definition of BCC, and the effect of multiple definitions…
View article: Crystalline lens dislocation as a presenting sign of Streptococcus pyogenes invasive infections
Crystalline lens dislocation as a presenting sign of Streptococcus pyogenes invasive infections Open
Introduction. To describe two cases of crystalline lens dislocation as a presenting feature of invasive group A Streptococcus (GAS) infection and its management. Case presentation. We report on a 58-year-old woman and a 36-year-old man who…
View article: Evaluation of long-read 16S rRNA next-generation sequencing for identification of bacterial isolates in a clinical diagnostic laboratory
Evaluation of long-read 16S rRNA next-generation sequencing for identification of bacterial isolates in a clinical diagnostic laboratory Open
Sanger sequencing of the first ~500 bp of the 16S rRNA gene is frequently used to identify bacterial pathogens that have ambiguous biochemical profiles or proteomic mass spectra. When diversity does not occur within that region, genus-leve…
View article: Crystalline lens dislocation as a presenting sign of Streptococcus pyogenes invasive infections
Crystalline lens dislocation as a presenting sign of Streptococcus pyogenes invasive infections Open
Introduction To describe two cases of crystalline lens dislocation as a presenting feature of invasive group A Streptococcus (GAS) infection and its management. Case presentation We report on a 58-year-old female and a 36-year-old male who…
View article: Crystalline lens dislocation as a presenting sign of Streptococcus pyogenes invasive infections
Crystalline lens dislocation as a presenting sign of Streptococcus pyogenes invasive infections Open
Introduction To describe two cases of crystalline lens dislocation as a presenting feature of invasive group A Streptococcus (GAS) infection and its management. Case presentation We report on a 58-year-old female and a 36-year-old male who…
View article: Blood Culture Use in Medical and Surgical Intensive Care Units and Wards
Blood Culture Use in Medical and Surgical Intensive Care Units and Wards Open
Importance Blood culture (BC) use benchmarks in US hospitals have not been defined. Objective To characterize BC use in adult intensive care units (ICUs) and wards in US hospitals. Design, Setting, and Participants A retrospective cross-se…
View article: Update on novel validly published and included bacterial taxa derived from human clinical specimens and taxonomic revisions published in 2023
Update on novel validly published and included bacterial taxa derived from human clinical specimens and taxonomic revisions published in 2023 Open
Taxonomy is a systematic practice in which microorganisms are granted names to facilitate and standardize multi-disciplinary communication. We summarize novel bacterial taxa derived from human clinical material that were published in peer-…
View article: Host heterogeneity in humoral bactericidal activity can be complement independent
Host heterogeneity in humoral bactericidal activity can be complement independent Open
Background Humoral bactericidal activity was first recognized nearly a century ago. However, the extent of inter-individual heterogeneity and the mechanisms underlying such heterogeneity beyond antibody or complement systems have not been …
View article: Crystalline lens dislocation as a presenting sign of Streptococcus pyogenes invasive infections
Crystalline lens dislocation as a presenting sign of Streptococcus pyogenes invasive infections Open
Introduction To describe two cases of crystalline lens dislocation as a presenting feature of invasive group A Streptococcus (GAS) infection and its management. Case presentation We report on a 58-year-old female and a 36-year-old male who…
View article: A rapid host–protein test for differentiating bacterial from viral infection: Apollo diagnostic accuracy study
A rapid host–protein test for differentiating bacterial from viral infection: Apollo diagnostic accuracy study Open
MMBV had a high sensitivity and specificity relative to reference standard for differentiating bacterial from viral infections. Future implementation of MMBV for patients with suspected acute infections could potentially aid with appropria…
View article: Guide to Utilization of the Microbiology Laboratory for Diagnosis of Infectious Diseases: 2024 Update by the Infectious Diseases Society of America (IDSA) and the American Society for Microbiology (ASM)
Guide to Utilization of the Microbiology Laboratory for Diagnosis of Infectious Diseases: 2024 Update by the Infectious Diseases Society of America (IDSA) and the American Society for Microbiology (ASM) Open
The critical nature of the microbiology laboratory in infectious disease diagnosis calls for a close, positive working relationship between the physician and the microbiologists who provide enormous value to the healthcare team. This docum…
View article: Usual light touch osteopathic treatment versus simple light touch without intent in the reduction of infantile colic crying time: A randomised controlled trial
Usual light touch osteopathic treatment versus simple light touch without intent in the reduction of infantile colic crying time: A randomised controlled trial Open
Background: Many parents seek osteopathic care for their infants with colic. Our aim was to test the effectiveness of usual light touch osteopathic treatment on crying time for infants with ‘colic’. Methods: A superiority, two arm, single …
View article: Impact of Blood Culture Contamination on Antibiotic Use, Resource Utilization, and Clinical Outcomes: A Retrospective Cohort Study in Dutch and US Hospitals
Impact of Blood Culture Contamination on Antibiotic Use, Resource Utilization, and Clinical Outcomes: A Retrospective Cohort Study in Dutch and US Hospitals Open
Background Blood culture contamination (BCC) has been associated with prolonged antibiotic use (AU) and increased health care utilization; however, this has not been widely reevaluated in the era of increased attention to antibiotic stewar…
View article: 1449. Evaluation of Cloud-Based Automated Analytic Pipelines for Whole Genome Sequencing Analysis of Multidrug-Resistant Gram-Negative Organism Outbreaks
1449. Evaluation of Cloud-Based Automated Analytic Pipelines for Whole Genome Sequencing Analysis of Multidrug-Resistant Gram-Negative Organism Outbreaks Open
Background Clinical implementation of whole genome sequencing (WGS) has been identified as the optimal approach to identify transmission of multidrug-resistant (MDR) organisms in the healthcare setting. Although WGS capabilities are becomi…
View article: A diagnostic stewardship approach to prevent unnecessary testing of an enteric bacterial molecular panel
A diagnostic stewardship approach to prevent unnecessary testing of an enteric bacterial molecular panel Open
After stool culture was replaced by an enteric bacterial panel (EBP) at the Johns Hopkins Hospital (JHH), many EBPs were ordered >3 days after admission (EBP >3 days) with low yield. To reduce unnecessary testing, a hard stop for ordering …
View article: Valid and accepted novel bacterial taxa derived from human clinical specimens and taxonomic revisions published in 2022
Valid and accepted novel bacterial taxa derived from human clinical specimens and taxonomic revisions published in 2022 Open
Although some nomenclature changes have caused consternation among clinical microbiologists, the discovery of novel taxa and improving classification of existing groups of organisms is exciting and adds to our understanding of microbial pa…
View article: Clinical significance of <i>Nosocomiicoccus ampullae</i> isolated from blood cultures
Clinical significance of <i>Nosocomiicoccus ampullae</i> isolated from blood cultures Open
Nosocomiicoccus species are infrequently isolated from clinical specimens and their clinical significance has not been evaluated. We retrospectively reviewed five cases in which Nosocomiicoccus ampullae was identified in a single blood cul…
View article: A US-based national surveillance study for the susceptibility and epidemiology of <i>Clostridioides difficile</i> isolates with special reference to ridinilazole: 2020–2021
A US-based national surveillance study for the susceptibility and epidemiology of <i>Clostridioides difficile</i> isolates with special reference to ridinilazole: 2020–2021 Open
We have previously reported on the susceptibility and epidemiology of Clostridioides difficile isolates from six geographically dispersed medical centers in the United States. This current survey was conducted with isolates collected in 20…
View article: Multicentre genetic diversity study of carbapenem-resistant Enterobacterales: predominance of untypeable pUVA-like <i>bla</i>KPC bearing plasmids
Multicentre genetic diversity study of carbapenem-resistant Enterobacterales: predominance of untypeable pUVA-like <i>bla</i>KPC bearing plasmids Open
Objectives Carbapenem-resistant Enterobacterales (CRE) are an urgent public health threat. A better understanding of the molecular epidemiology and transmission dynamics of CRE is necessary to limit their dissemination within healthcare se…
View article: Data from Human Colon Cancer–Derived <i>Clostridioides difficile</i> Strains Drive Colonic Tumorigenesis in Mice
Data from Human Colon Cancer–Derived <i>Clostridioides difficile</i> Strains Drive Colonic Tumorigenesis in Mice Open
Defining the complex role of the microbiome in colorectal cancer and the discovery of novel, protumorigenic microbes are areas of active investigation. In the present study, culturing and reassociation experiments revealed that toxigenic s…
View article: Supplementary Table from Human Colon Cancer–Derived <i>Clostridioides difficile</i> Strains Drive Colonic Tumorigenesis in Mice
Supplementary Table from Human Colon Cancer–Derived <i>Clostridioides difficile</i> Strains Drive Colonic Tumorigenesis in Mice Open
Supplementary Table from Human Colon Cancer–Derived Clostridioides difficile Strains Drive Colonic Tumorigenesis in Mice
View article: Supplementary Table from Human Colon Cancer–Derived <i>Clostridioides difficile</i> Strains Drive Colonic Tumorigenesis in Mice
Supplementary Table from Human Colon Cancer–Derived <i>Clostridioides difficile</i> Strains Drive Colonic Tumorigenesis in Mice Open
Supplementary Table from Human Colon Cancer–Derived Clostridioides difficile Strains Drive Colonic Tumorigenesis in Mice
View article: Supplementary Table from Human Colon Cancer–Derived <i>Clostridioides difficile</i> Strains Drive Colonic Tumorigenesis in Mice
Supplementary Table from Human Colon Cancer–Derived <i>Clostridioides difficile</i> Strains Drive Colonic Tumorigenesis in Mice Open
Supplementary Table from Human Colon Cancer–Derived Clostridioides difficile Strains Drive Colonic Tumorigenesis in Mice
View article: Supplementary Table from Human Colon Cancer–Derived <i>Clostridioides difficile</i> Strains Drive Colonic Tumorigenesis in Mice
Supplementary Table from Human Colon Cancer–Derived <i>Clostridioides difficile</i> Strains Drive Colonic Tumorigenesis in Mice Open
Supplementary Table from Human Colon Cancer–Derived Clostridioides difficile Strains Drive Colonic Tumorigenesis in Mice