Karina Cuevas-Mora
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View article: PD 102807 Induces M3 mAChR-Dependent GRK-/Arrestin-Biased Signaling in Airway Smooth Muscle Cells
PD 102807 Induces M3 mAChR-Dependent GRK-/Arrestin-Biased Signaling in Airway Smooth Muscle Cells Open
G protein-coupled receptors (GPCRs) not only are turned on or off to control canonical G protein signaling but also may be fine-tuned to promote qualitative/biased signaling. Qualitative signaling by M3 muscarinic acetylcholine receptors (…
View article: A model of the aged lung epithelium in idiopathic pulmonary fibrosis
A model of the aged lung epithelium in idiopathic pulmonary fibrosis Open
Idiopathic pulmonary fibrosis (IPF) is an age-related disorder that carries a universally poor prognosis and is thought to arise from repetitive micro injuries to the alveolar epithelium. To date, a major factor limiting our understanding …
View article: Senescent Alveolar Type 2 Cells Exhibit an Unique Metabolomics Profile
Senescent Alveolar Type 2 Cells Exhibit an Unique Metabolomics Profile Open
View article: TP53 Expression Is Altered in the Alveolar Epithelium in Hermansky-Pudlak Syndrome
TP53 Expression Is Altered in the Alveolar Epithelium in Hermansky-Pudlak Syndrome Open
View article: Hermansky-Pudlak syndrome-2 alters mitochondrial homeostasis in the alveolar epithelium of the lung
Hermansky-Pudlak syndrome-2 alters mitochondrial homeostasis in the alveolar epithelium of the lung Open
View article: Transcriptomics, metabolomics and lipidomics of chronically injured alveolar epithelial cells reveals similar features of IPF lung epithelium
Transcriptomics, metabolomics and lipidomics of chronically injured alveolar epithelial cells reveals similar features of IPF lung epithelium Open
The current hypothesis suggests that Idiopathic pulmonary fibrosis (IPF) arises as a result of chronic injury to alveolar epithelial cells and aberrant activation of multiple signaling pathways. Dysfunctional IPF lung epithelium manifests …
View article: Mitochondrial Quality Control in Age-Related Pulmonary Fibrosis
Mitochondrial Quality Control in Age-Related Pulmonary Fibrosis Open
Idiopathic pulmonary fibrosis (IPF) is age-related interstitial lung disease of unknown etiology. About 100,000 people in the U.S have IPF, with a 3-year median life expectancy post-diagnosis. The development of an effective treatment for …
View article: Matrix metalloproteinase activity in the lung is increased in Hermansky-Pudlak syndrome
Matrix metalloproteinase activity in the lung is increased in Hermansky-Pudlak syndrome Open
In summary, our findings indicate that MMP activity is dysregulated in the HPS lung, suggesting a role for these proteases as biological markers or pathogenic players in HPS lung disease.
View article: Activation of the mTORC1/PGC-1 axis promotes mitochondrial biogenesis and induces cellular senescence in the lung epithelium
Activation of the mTORC1/PGC-1 axis promotes mitochondrial biogenesis and induces cellular senescence in the lung epithelium Open
Cellular senescence is a biological process by which cells lose their capacity to proliferate yet remain metabolically active. Although originally considered a protective mechanism to limit the formation of cancer, it is now appreciated th…
View article: Hermansky-Pudlak Syndrome 1 and 2 Have Differential Effects on Lung Fibroblast Behavior
Hermansky-Pudlak Syndrome 1 and 2 Have Differential Effects on Lung Fibroblast Behavior Open
Objective To determine whether mitochondrial function and/or the proteasome system is altered in fibroblasts from the HPS mouse lung.