Kari E. North
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View article: Genome‐wide association study of periodontitis severity and progression
Genome‐wide association study of periodontitis severity and progression Open
Background To add to the knowledge base of periodontal genomics, we carried out a genome‐wide association study (GWAS) of periodontitis severity and progression among 416 mixed‐ethnicity adult participants of a periodontitis clinical study…
View article: Epigenome-wide association study meta-analysis of BMI in African Americans
Epigenome-wide association study meta-analysis of BMI in African Americans Open
Despite considerable advances in identifying risk factors for obesity, gaps remain in our understanding about its etiology. Genetic variants explain only a small portion of variation in obesity-related traits such as body mass index (BMI).…
View article: Genome-wide gene-sleep interaction study identifies novel lipid loci in 732,564 participants
Genome-wide gene-sleep interaction study identifies novel lipid loci in 732,564 participants Open
Collectively, the 17 (9 with short and 8 with long sleep) loci provided evidence into the biomolecular mechanisms underlying sleep-associated lipid changes, including potential involvement of the vitamin D receptor pathway. Collectively, t…
View article: Sex Modifies Metabolic Pathways Associated with Lipids in Untargeted Metabolomics: The Coronary Artery Risk Development in Young Adults (CARDIA) Study, 2005–2006
Sex Modifies Metabolic Pathways Associated with Lipids in Untargeted Metabolomics: The Coronary Artery Risk Development in Young Adults (CARDIA) Study, 2005–2006 Open
Background: There are differences in lipid metabolism by sex that are relevant for health, but metabolic pathways are not fully understood. We investigated sex differences in cross-sectional associations between metabolic pathways identifi…
View article: Proteomic signatures of pediatric cardiovascular and cardiometabolic traits demonstrate long-term modifiable drivers of adult disease
Proteomic signatures of pediatric cardiovascular and cardiometabolic traits demonstrate long-term modifiable drivers of adult disease Open
While the earliest pathological signs of cardiovascular disease (CVD) emerge before age 20, current adult-based risk thresholds fail to identify a substantial fraction of high-risk children. With the rising prevalence of childhood obesity,…
View article: Genetic underpinnings of the heterogeneous impact of obesity on lipid levels and cardiovascular disease
Genetic underpinnings of the heterogeneous impact of obesity on lipid levels and cardiovascular disease Open
Background Obesity is thought to increase cardiovascular disease (CVD) risk partly through dyslipidemia. Yet, obesity’s effects on dyslipidemia are not uniform. Understanding the shared genetic basis between obesity and lipid traits can pr…
View article: Body Mass Index Modifies Associations Between Diet Quality and Circulating Metabolites: The CARDIA Study, 2005 to 2006
Body Mass Index Modifies Associations Between Diet Quality and Circulating Metabolites: The CARDIA Study, 2005 to 2006 Open
Background Obesity perturbs metabolism, resulting in differential diet–disease associations, but metabolic pathways that differ by obesity remain unclear. We investigated whether cross‐sectional associations between metabolites and diet qu…
View article: Integrating genetic and transcriptomic data to identify genes underlying obesity risk loci
Integrating genetic and transcriptomic data to identify genes underlying obesity risk loci Open
Background Genome-wide association studies (GWAS) have identified numerous body mass index (BMI) loci. However, most underlying mechanisms from risk locus to BMI remain unknown. Leveraging omics data through integrative analyses could prov…
View article: Genetic subtyping of obesity reveals biological insights into the uncoupling of adiposity from its cardiometabolic comorbidities
Genetic subtyping of obesity reveals biological insights into the uncoupling of adiposity from its cardiometabolic comorbidities Open
Obesity is a heterogeneous condition not adequately captured by a single adiposity trait. We conducted a multi-trait genome-wide association analysis using individual-level data from 452,768 UK Biobank participants to study obesity in rela…
View article: Genetically determined body mass index is associated with diffuse large B‐cell lymphoma in polygenic and Mendelian randomization analyses
Genetically determined body mass index is associated with diffuse large B‐cell lymphoma in polygenic and Mendelian randomization analyses Open
Obesity has been associated with non‐Hodgkin lymphoma (NHL), but the evidence is inconclusive. We examined the association between genetically determined adiposity and four common NHL subtypes: diffuse large B‐cell lymphoma (DLBCL), follic…
View article: An Efficient Lasso Framework for Admixture-Aware Polygenic Scores
An Efficient Lasso Framework for Admixture-Aware Polygenic Scores Open
Polygenic scores (PGS) have promising clinical applications for risk stratification, disease screening, and personalized medicine. However, most PGS are trained on predominantly European ancestry cohorts and have limited portability to ext…
View article: Mosaic Loss of Y chromosome associates with lung function, emphysema and epigenetic aging
Mosaic Loss of Y chromosome associates with lung function, emphysema and epigenetic aging Open
Mosaic loss of Y chromosome (mLOY) in blood cells is an age-related somatic mutation, but its relationship with pulmonary health remains undercharacterized. Leveraging mLOY assessment in over 12,000 men, including 5,097 from the COPDGene S…
View article: Genome-wide gene by sleepiness interaction analysis for sleep apnea
Genome-wide gene by sleepiness interaction analysis for sleep apnea Open
Study Objectives Excessive daytime sleepiness (EDS), influenced by environmental and social-behavioral factors, is reported by a subset of patients with sleep apnea—a group that may be at elevated cardiovascular risk. However, it is unclea…
View article: The Circulating Lipidome In Severe Obesity
The Circulating Lipidome In Severe Obesity Open
Background Severe obesity (SevO; BMI ≥40 kg/m²) is rapidly increasing globally and disproportionately affects minority populations. However, it remains understudied in mechanistic and omics literature. Lipid metabolism plays a central role…
View article: Genetic ancestry influences gene-environment interactions with sociocultural factors: Results from the Hispanic Community Health Study/Study of Latinos
Genetic ancestry influences gene-environment interactions with sociocultural factors: Results from the Hispanic Community Health Study/Study of Latinos Open
Often, studies will aggregate all participants identified as Hispanic/Latino, despite genetic and environmental substructures, preventing the meaningful interrogation of the roles of genetics and environment in human health. Using the Hisp…
View article: cellSTAAR: Incorporating single-cell-sequencing-based functional data to boost power in rare variant association testing of non-coding regions
cellSTAAR: Incorporating single-cell-sequencing-based functional data to boost power in rare variant association testing of non-coding regions Open
Whole genome sequencing (WGS) studies have identified hundreds of millions of rare variants (RVs) and have enabled RV association tests (RVATs) of these variants with complex traits and diseases. Analysis of non-coding variants is challeng…
View article: Alterations in DNA Methylation, Proteomic, and Metabolomic Profiles in African Ancestry Populations with APOL1 Risk Alleles
Alterations in DNA Methylation, Proteomic, and Metabolomic Profiles in African Ancestry Populations with APOL1 Risk Alleles Open
Key Points We aimed to elucidate potential methylation, proteomic, and metabolomic mechanisms by which APOL1 variants may be linked to kidney disease. We report distinct methylation profiling between APOL1 risk allele carriers and noncarri…
View article: A Gene-Acculturation Study of Obesity Among US Hispanic/Latinos: The Hispanic Community Health Study/Study of Latinos
A Gene-Acculturation Study of Obesity Among US Hispanic/Latinos: The Hispanic Community Health Study/Study of Latinos Open
OBJECTIVE: In the United States, Hispanic/Latino adults face a high burden of obesity; yet, not all individuals are equally affected, partly due in part to this ethnic group's marked sociocultural diversity. We sought to analyze the modifi…
View article: Molecular architecture of human atherosclerosis revealed through integrative human genetics
Molecular architecture of human atherosclerosis revealed through integrative human genetics Open
Current genetic discovery methods are largely restricted to profiling circulating molecules or genetic architecture, limited in use of tissue-based molecular genetics to identify pathogenic and therapeutic targets. Here, we leverage a mult…
View article: Insights from the largest diverse ancestry sex-specific disease map for genetically predicted height
Insights from the largest diverse ancestry sex-specific disease map for genetically predicted height Open
We performed ancestry and sex specific Phenome Wide Association Studies (PheWAS) to explore disease related outcomes associated with genetically predicted height. This is the largest PheWAS on genetically predicted height involving up to 8…