Edward Ki Yun Leung
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View article: Urine Organic Acid Testing in the Clinical Laboratory: The Past, Current, and Future
Urine Organic Acid Testing in the Clinical Laboratory: The Past, Current, and Future Open
Organic acidurias, a subgroup of inborn errors of metabolism (IEMs), are characterized by the accumulation of non-amine-containing, low-molecular-weight organic acids (OAs) in urine and/or plasma due to defects in specific metabolic pathwa…
View article: Method Evaluation of the QuidelOrtho Diagnostics Vitros NT-proBNP II Assay
Method Evaluation of the QuidelOrtho Diagnostics Vitros NT-proBNP II Assay Open
Background/Objectives: N-terminal-proBNP (NT-proBNP) is a biomarker released into the blood in response to heart failure, reflecting the extent of cardiac stress and damage. QuidelOrtho Diagnostics released its latest reformulation of its …
View article: Implementation and Assessment of a SmartZone Alert to Notify Clinicians of Critical Hyperbilirubinemia in Preterm Infants Less Than 35 Weeks Gestation
Implementation and Assessment of a SmartZone Alert to Notify Clinicians of Critical Hyperbilirubinemia in Preterm Infants Less Than 35 Weeks Gestation Open
Background Neonatal jaundice, also known as hyperbilirubinemia in term and preterm infants, is treated with phototherapy when bilirubin results exceed gestational age- and age-specific medical decision levels (MDL) to prevent kernicterus a…
View article: Clinical Laboratory Informatics and Analytics: Challenges and Opportunities
Clinical Laboratory Informatics and Analytics: Challenges and Opportunities Open
The American Medical Informatics Association defines biomedical and health informatics as the “science of how to use data, information, and knowledge to improve human health and the delivery of health care services.” More specifically with…
View article: Weak Precipitin Ring from A Fecal Specimen with Markedly Elevated Alpha-1 Antitrypsin Level Measured by Radial Immunodiffusion
Weak Precipitin Ring from A Fecal Specimen with Markedly Elevated Alpha-1 Antitrypsin Level Measured by Radial Immunodiffusion Open
Radial immunodiffusion (RID) is a classic methodology for antigen quantification that relies on the development of a distinct precipitin ring from precipitated antigen-antibody complex. As the precipitin ring grows, the precipitate at the …
View article: Evaluation of the Order SMARTT: An Initiative to Reduce Phlebotomy and Improve Sleep-Friendly Labs on General Medicine Services
Evaluation of the Order SMARTT: An Initiative to Reduce Phlebotomy and Improve Sleep-Friendly Labs on General Medicine Services Open
We assessed the effectiveness of a quality improvement project to reduce routine labs in clinically stable patients, while also promoting sleep-friendly lab timing. The electronic health record was modified with an “Order Sleep” shortcut t…
View article: Pharmacogenomic genotypes define genetic ancestry in patients and enable population-specific genomic implementation
Pharmacogenomic genotypes define genetic ancestry in patients and enable population-specific genomic implementation Open
View article: Evaluation of a New Generation Automated Assay for 25-Hydroxy Vitamin D Based on Competitive Protein Binding
Evaluation of a New Generation Automated Assay for 25-Hydroxy Vitamin D Based on Competitive Protein Binding Open
Background The interest for vitamin D has exponentially increased testing demand for 25-hydroxy vitamin D [25(OH)D]. Consequently, many laboratories are switching from LC-MS/MS methods to automated, high-throughput immunoassays. One of the…
View article: Analytical Differences in Intraoperative Parathyroid Hormone Assays
Analytical Differences in Intraoperative Parathyroid Hormone Assays Open
Background We compared the rates of intraoperative parathyroid hormone (PTH) decline using the Siemens Immulite® Turbo PTH and Roche Elecsys® short turnaround time PTH assays in 95 consecutive surgical patients to investigate analytical an…
View article: Validation of an Extensive <i>CYP2D6</i> Assay Panel Based on Invader and TaqMan Copy Number Assays
Validation of an Extensive <i>CYP2D6</i> Assay Panel Based on Invader and TaqMan Copy Number Assays Open
Background CYP2D6 is involved in the oxidative metabolism of approximately 20% of all clinically used medications. Genotyping cytochrome P450, family 2, subfamily D, polypeptide 6 (CYP2D6), is a challenge because of the high complexity of …
View article: High-Sensitivity Micro LC-MS/MS Assay for Serum Estradiol without Derivatization
High-Sensitivity Micro LC-MS/MS Assay for Serum Estradiol without Derivatization Open
Background There are considerable demands to accurately measure estradiol (E2) at low concentrations (<20 pg/mL) in postmenopausal women, men, pediatric patients, and patients receiving breast cancer treatment. Most current high-sensiti…
View article: Diiodothyropropionic acid (DITPA) cross-reacts with thyroid function assays on different immunoassay platforms
Diiodothyropropionic acid (DITPA) cross-reacts with thyroid function assays on different immunoassay platforms Open
View article: Transition State Features in the Hepatitis Delta Virus Ribozyme Reaction Revealed by Atomic Perturbations
Transition State Features in the Hepatitis Delta Virus Ribozyme Reaction Revealed by Atomic Perturbations Open
Endonucleolytic ribozymes constitute a class of non-coding RNAs that catalyze single-strand RNA scission. With crystal structures available for all of the known ribozymes, a major challenge involves relating functional data to the physical…