Sergey K. Filippov
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View article: Tensor network noise characterization for near-term quantum computers
Tensor network noise characterization for near-term quantum computers Open
Characterization of noise in current near-term quantum devices is of paramount importance to fully use their computational power. However, direct quantum process tomography becomes unfeasible for systems composed of tens of qubits. A promi…
View article: On the mucoadhesive properties of synthetic and natural polyampholytes
On the mucoadhesive properties of synthetic and natural polyampholytes Open
The mucoadhesive characteristics of amphoteric polymers (also known as polyampholytes) can vary and are influenced by factors such as the solution's pH and its relative position against their isoelectric point (pHIEP). Whilst th…
View article: Triblock Poly(2-Oxazoline)S with a Fluorinated Block as a New Platform for Advanced Self-Assembly: Cryo-Tem Study
Triblock Poly(2-Oxazoline)S with a Fluorinated Block as a New Platform for Advanced Self-Assembly: Cryo-Tem Study Open
View article: Emerging ctDNA detection strategies in clinical cancer theranostics
Emerging ctDNA detection strategies in clinical cancer theranostics Open
Circulating tumor DNA (ctDNA) is naked DNA molecules shed from the tumor cells into the peripheral blood circulation. They contain tumor‐specific gene mutations and other valuable information. ctDNA is considered to be one of the most sign…
View article: Scalable tensor-network error mitigation for near-term quantum computing
Scalable tensor-network error mitigation for near-term quantum computing Open
Until fault-tolerance becomes implementable at scale, quantum computing will heavily rely on noise mitigation techniques. While methods such as zero noise extrapolation with probabilistic error amplification (ZNE-PEA) and probabilistic err…
View article: New insights on the release and self-healing model of stimuli-sensitive liposomes
New insights on the release and self-healing model of stimuli-sensitive liposomes Open
View article: Dynamic light scattering and transmission electron microscopy in drug delivery: a roadmap for correct characterization of nanoparticles and interpretation of results
Dynamic light scattering and transmission electron microscopy in drug delivery: a roadmap for correct characterization of nanoparticles and interpretation of results Open
In this focus article, we provide a scrutinizing analysis of transmission electron microscopy and dynamic light scattering as the two common methods to study the sizes of nanoparticles with focus on the application in pharmaceutics and dru…
View article: Ultrasound‐mediated delivery of flexibility‐tunable polymer drug conjugates for treating glioblastoma
Ultrasound‐mediated delivery of flexibility‐tunable polymer drug conjugates for treating glioblastoma Open
Effective chemotherapy delivery for glioblastoma multiforme (GBM) is limited by drug transport across the blood–brain barrier and poor efficacy of single agents. Polymer–drug conjugates can be used to deliver drug combinations with a ratio…
View article: Maleimide-Decorated PEGylated Mucoadhesive Liposomes for Ocular Drug Delivery
Maleimide-Decorated PEGylated Mucoadhesive Liposomes for Ocular Drug Delivery Open
Liposomes are promising spherical vesicles for topical drug delivery to the eye. Several types of vesicles were formulated in this study, including conventional, PEGylated, and maleimide-decorated PEGylated liposomes. The physicochemical c…
View article: Enhancement of the Transdermal Delivery of Nonsteroidal Anti-inflammatory Drugs Using Liposomes Containing Cationic Surfactants
Enhancement of the Transdermal Delivery of Nonsteroidal Anti-inflammatory Drugs Using Liposomes Containing Cationic Surfactants Open
New hybrid liposomes based on cationic amphiphiles with different structures of the head group (cetyltrimethylammonium bromide (CTAB), 3-hexadecyl-1-hydroxyethylimidazolium bromide (IA-16(OH)), 1-(butylcarbamoyl)oxyethyl-3-hexadecylimidazo…
View article: Mucus-penetrating nanoparticles based on chitosan grafted with various non-ionic polymers: Synthesis, structural characterisation and diffusion studies
Mucus-penetrating nanoparticles based on chitosan grafted with various non-ionic polymers: Synthesis, structural characterisation and diffusion studies Open
Transmucosal administration offers numerous advantages for drug delivery as it usually helps to avoid first pass metabolism, provides rapid onset of action, and is a non-invasive route. Mucosal surfaces are covered by a viscoelastic mucus …
View article: Interactions between polymeric nanoparticles and different buffers as investigated by zeta potential measurements and molecular dynamics simulations
Interactions between polymeric nanoparticles and different buffers as investigated by zeta potential measurements and molecular dynamics simulations Open
Zeta potential is an essential surface parameter in the characterization of nanoparticles, determined at the interface of loosely bound ions (diffuse layer) at the nanoparticle surface and free ions in solution. The ionic concentration and…
View article: Polymeric iodophors with poly(2-ethyl-2-oxazoline) and poly(N-vinylpyrrolidone): optical, hydrodynamic, thermodynamic, and antimicrobial properties
Polymeric iodophors with poly(2-ethyl-2-oxazoline) and poly(N-vinylpyrrolidone): optical, hydrodynamic, thermodynamic, and antimicrobial properties Open
Formation of iodophors by interactions of poly(2-ethyl-2-oxazoline) and poly(N-vinylpyrrolidone) with molecular iodine dissolved in aqueous solutions with addition of potassium iodide and ethanol has been studied using a range of physicoch…
View article: Hybrid Nanoparticles for Haloperidol Encapsulation: Quid Est Optimum?
Hybrid Nanoparticles for Haloperidol Encapsulation: Quid Est Optimum? Open
The choice of drug delivery carrier is of paramount importance for the fate of a drug in a human body. In this study, we have prepared the hybrid nanoparticles composed of FDA-approved Eudragit L100-55 copolymer and polymeric surfactant Br…
View article: Hyaluronic acid conjugates for topical treatment of skin cancer lesions
Hyaluronic acid conjugates for topical treatment of skin cancer lesions Open
Polymer-drug conjugates are developed for the topical ratiometric delivery of a synergistic drug pair to treat skin cancers.
View article: Understanding the temperature induced aggregation of silica nanoparticles decorated with temperature-responsive polymers: Can a small step in the chemical structure make a giant leap for a phase transition?
Understanding the temperature induced aggregation of silica nanoparticles decorated with temperature-responsive polymers: Can a small step in the chemical structure make a giant leap for a phase transition? Open
View article: Reversible Multilayered Vesicle-like Structures with Fluid Hydrophobic and Interpolyelectrolyte Layers
Reversible Multilayered Vesicle-like Structures with Fluid Hydrophobic and Interpolyelectrolyte Layers Open
Hydrophobic blocks of amphiphilic block copolymers usually form glassy micellar cores with a rigid structure that limits their applications as nanocapsules for targeted delivery. We report here on the core/shell micelles with a soft core f…
View article: Molecular Mechanisms of the Interactions of N-(2-Hydroxypropyl)methacrylamide Copolymers Designed for Cancer Therapy with Blood Plasma Proteins
Molecular Mechanisms of the Interactions of N-(2-Hydroxypropyl)methacrylamide Copolymers Designed for Cancer Therapy with Blood Plasma Proteins Open
The binding of plasma proteins to a drug carrier alters the circulation of nanoparticles (NPs) in the bloodstream, and, as a consequence, the anticancer efficiency of the entire nanoparticle drug delivery system. We investigate the possibl…
View article: Fluorophilic–Lipophilic–Hydrophilic Poly(2-oxazoline) Block Copolymers as MRI Contrast Agents: From Synthesis to Self-Assembly
Fluorophilic–Lipophilic–Hydrophilic Poly(2-oxazoline) Block Copolymers as MRI Contrast Agents: From Synthesis to Self-Assembly Open
This work focuses on the synthesis and self-assembly of triphilic poly(2-oxazoline) triblock copolymers with high fluorine content toward our future aim of developing poly(2-oxazoline) magnetic resonance imaging (MRI) contrast agents. A hi…
View article: Structural characterization of nanoparticles formed by fluorinated poly(2-oxazoline)-based polyphiles
Structural characterization of nanoparticles formed by fluorinated poly(2-oxazoline)-based polyphiles Open
View article: Comparative thermodynamic analysis in solution of a next generation antibody mimetic to VEGF
Comparative thermodynamic analysis in solution of a next generation antibody mimetic to VEGF Open
ITC illustrated similar binding thermodynamics for anti-VEGF IgG and FpFs. Bivalent FpFrani displayed larger enthalpy and entropy than monovalent ranibizumab.
View article: Conformational properties of biocompatible poly(2-ethyl-2-oxazoline)s in phosphate buffered saline
Conformational properties of biocompatible poly(2-ethyl-2-oxazoline)s in phosphate buffered saline Open
The Kuhn segment length of PEtOx as a flexible macromolecule under physiological conditions is undoubtedly decreasing when approaching the LCST.
View article: Fluorinated 2-Alkyl-2-oxazolines of High Reactivity: Spacer-Length-Induced Acceleration for Cationic Ring-Opening Polymerization As a Basis for Triphilic Block Copolymer Synthesis
Fluorinated 2-Alkyl-2-oxazolines of High Reactivity: Spacer-Length-Induced Acceleration for Cationic Ring-Opening Polymerization As a Basis for Triphilic Block Copolymer Synthesis Open
The synthesis of defined triphilic terpolymers with hydrophilic, lyophilic, and fluorophilic blocks is an important challenge as a basis for the development of multicompartment self-assembled structures with potential for, e.g., cascade ca…
View article: Synthesis and supramolecular properties of regioisomers of mononaphthylallyl derivatives of γ-cyclodextrin
Synthesis and supramolecular properties of regioisomers of mononaphthylallyl derivatives of γ-cyclodextrin Open
Monosubstituted derivatives of γ-cyclodextrin (γ-CD) are suitable building blocks for supramolecular polymers, and can also serve as precursors for the synthesis of other regioselectively monosubstituted γ-CD derivatives. We prepared a set…
View article: Special issue: Petr Štěpánek
Special issue: Petr Štěpánek Open
View article: Synthesis and solution properties of a temperature-responsive PNIPAM–b-PDMS–b-PNIPAM triblock copolymer
Synthesis and solution properties of a temperature-responsive PNIPAM–b-PDMS–b-PNIPAM triblock copolymer Open
View article: Supramolecular Structures and Self-Association Processes in Polymer Systems
Supramolecular Structures and Self-Association Processes in Polymer Systems Open
Self-organization in a polymer system appears when a balance is achieved between long-range repulsive and short-range attractive forces between the chemically different building blocks. Block copolymers forming supramolecular assemblies in…
View article: Internal Nanoparticle Structure of Temperature-Responsive Self-Assembled PNIPAM-<i>b</i>-PEG-<i>b</i>-PNIPAM Triblock Copolymers in Aqueous Solutions: NMR, SANS, and Light Scattering Studies
Internal Nanoparticle Structure of Temperature-Responsive Self-Assembled PNIPAM-<i>b</i>-PEG-<i>b</i>-PNIPAM Triblock Copolymers in Aqueous Solutions: NMR, SANS, and Light Scattering Studies Open
In this study, we report detailed information on the internal structure of PNIPAM-b-PEG-b-PNIPAM nanoparticles formed from self-assembly in aqueous solutions upon increase in temperature. NMR spectroscopy, light scattering, and small-angle…
View article: Micelle-forming HPMA copolymer conjugates of ritonavir bound via a pH-sensitive spacer with improved cellular uptake designed for enhanced tumor accumulation
Micelle-forming HPMA copolymer conjugates of ritonavir bound via a pH-sensitive spacer with improved cellular uptake designed for enhanced tumor accumulation Open
We describe design, synthesis, physico-chemical characterization and preliminary biological evaluation of micelle-forming polymer drug conjugates with controlled drug release intended for tumor treatment.
View article: Properties of cationic monosubstituted tetraalkylammonium cyclodextrin derivatives – their stability, complexation ability in solution or when deposited on solid anionic surface
Properties of cationic monosubstituted tetraalkylammonium cyclodextrin derivatives – their stability, complexation ability in solution or when deposited on solid anionic surface Open
The thermal stability of the monosubstituted cationic cyclodextrin (CD) derivatives PEMEDA-β-CD and PEMPDA-β-CD, which differ in their substituent linker length (ethylene and propylene, respectively), was studied via 1 H NMR experiments. P…