Kim F. Michaelsen
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View article: Concentration and Intakes of Macronutrients from Human Milk Do Not Differ by Infant Sex in Australian and Danish Cohorts
Concentration and Intakes of Macronutrients from Human Milk Do Not Differ by Infant Sex in Australian and Danish Cohorts Open
Background/Objectives: Human milk (HM) meets the nutritional needs of term-born infants. However, it remains unclear whether HM macronutrient concentrations and intakes differ by infant sex. We investigated sex- and country-specific differ…
View article: Hepcidin is low in children with moderate acute malnutrition and asymptomatic malaria: secondary analysis of a 2×2×3 factorial randomised trial in Burkina Faso
Hepcidin is low in children with moderate acute malnutrition and asymptomatic malaria: secondary analysis of a 2×2×3 factorial randomised trial in Burkina Faso Open
Children with moderate acute malnutrition (MAM) have an increased risk of iron deficiency, anaemia and death from infectious diseases. The iron-regulating hormone hepcidin is increased in inflammation and may be important in regulating iro…
View article: The Impact of Diabetes Mellitus on Treatment Outcomes of hospitalized Patients with Active Pulmonary Tuberculosis: A 5-Year Retrospective Study at the Laquintinie Hospital Douala
The Impact of Diabetes Mellitus on Treatment Outcomes of hospitalized Patients with Active Pulmonary Tuberculosis: A 5-Year Retrospective Study at the Laquintinie Hospital Douala Open
Background: Pulmonary tuberculosis–Diabetes mellitus (PTB-DM) co-morbidity is a rising global health concern. This study aimed to determine the prevalence of diabetes mellitus among pulmonary TB patients and assess its impact on treatment …
View article: Reference Values for Macronutrients in Human Milk: the Mothers, Infants and Lactation Quality (MILQ) Study
Reference Values for Macronutrients in Human Milk: the Mothers, Infants and Lactation Quality (MILQ) Study Open
This second article in the series establishing reference values (RVs) for nutrients in human milk describes RVs for protein, carbohydrate, fat, and energy. To establish RVs, the mothers, infants, and lactation quality (MILQ) and early-MILQ…
View article: Infections, Animal-Source Foods, and Micronutrient Status as Correlates of Serum IGF-1 in Children with Stunting: A Cross-sectional Study in Uganda
Infections, Animal-Source Foods, and Micronutrient Status as Correlates of Serum IGF-1 in Children with Stunting: A Cross-sectional Study in Uganda Open
Milk intake and vitamin A status were positively associated with serum IGF-1. In contrast to milk, vitamin A has not consistently been associated with growth. This requires further investigation.
View article: Reference Values for B Vitamins in Human Milk: The Mothers, Infants and Lactation Quality (MILQ) Study
Reference Values for B Vitamins in Human Milk: The Mothers, Infants and Lactation Quality (MILQ) Study Open
This third article in the series presenting reference values (RVs) for nutrients in human milk describes the values for B vitamins. The mothers, infants, and lactation quality (MILQ) and early-MILQ studies, conducted at sites in Bangladesh…
View article: The Mothers, Infants and Lactation Quality (MILQ) Study: Introduction and Study Design
The Mothers, Infants and Lactation Quality (MILQ) Study: Introduction and Study Design Open
The World Health Organization recommends exclusive breastfeeding for the first 6 mo of life and continued breastfeeding for 2 y or beyond. However, limited reliable, representative data on nutrient concentrations in milk from well-nourishe…
View article: Reference Values for Minerals in Human Milk: the Mothers, Infants and Lactation Quality (MILQ) Study
Reference Values for Minerals in Human Milk: the Mothers, Infants and Lactation Quality (MILQ) Study Open
This fifth article in the series presenting reference values for nutrients in human milk describes minerals. The Mothers, Infants and Lactation Quality (MILQ) and Early-MILQ studies collected human milk samples throughout the first 8.5 mo …
View article: Breast Milk Intake from 1 to 8.5 Months of Lactation in the Multisite Mothers, Infants and Lactation Quality (MILQ) Study
Breast Milk Intake from 1 to 8.5 Months of Lactation in the Multisite Mothers, Infants and Lactation Quality (MILQ) Study Open
Human milk from healthy, well-nourished women is the optimal nutrition for infants and young children, and exclusive breastfeeding is recommended for the first 6 mo. In the context of poor diets, the quality of milk may be compromised, and…
View article: Future Applications of Human Milk Reference Values for Nutrients: A Global Resource for Maternal and Child Nutrition Research
Future Applications of Human Milk Reference Values for Nutrients: A Global Resource for Maternal and Child Nutrition Research Open
The World Health Organization recommends exclusive breastfeeding for the first 6 mo of life as human milk is considered to be the optimal form of nutrition to support infant health and development. Human milk provides many nutrient and non…
View article: Liver function tests among children with moderate acute malnutrition: A secondary analysis of a randomized trial from Burkina Faso
Liver function tests among children with moderate acute malnutrition: A secondary analysis of a randomized trial from Burkina Faso Open
Objectives Hepatic steatosis has been described in children with severe acute malnutrition, but the degree of liver damage in children with moderate acute malnutrition (MAM) is unknown. This study aimed to investigate the development of ma…
View article: Predictors of longitudinal changes in body composition and BMI in Brazilian lactating women during the first 8·5 months postpartum
Predictors of longitudinal changes in body composition and BMI in Brazilian lactating women during the first 8·5 months postpartum Open
Pregnancy and lactation change women’s body composition (BC), but few longitudinal studies have investigated postpartum BC trajectories. We aimed to investigate maternal and infant predictors of maternal body fat (BF), fat mass (FM), fat-f…
View article: The Role of Wolbachia-Based Interventions in Reducing Malaria Transmission: A Scoping Review of Field Trials and Modeling Studies
The Role of Wolbachia-Based Interventions in Reducing Malaria Transmission: A Scoping Review of Field Trials and Modeling Studies Open
Malaria continues to be a major global health threat, particularly in malaria-endemic regions such as sub-Saharan Africa and Southeast Asia. Despite significant advancements in vector control, including insecticide-treated nets and indoor …
View article: Cytokines and appetite-regulating hormones in human milk and associations with infant growth across four sites in a longitudinal cohort: The Mothers, Infants and Lactation Quality Study
Cytokines and appetite-regulating hormones in human milk and associations with infant growth across four sites in a longitudinal cohort: The Mothers, Infants and Lactation Quality Study Open
Introduction In resource-poor settings, mother-infant dyads are commonly exposed to environmental factors increasing the risk of infectious diseases and possibly influencing the cytokine profile of human milk (HM). Hormones in HM have been…
View article: Effects of lipid‐based nutrient supplements on gut markers in stunted children: Secondary analysis of a randomised trial
Effects of lipid‐based nutrient supplements on gut markers in stunted children: Secondary analysis of a randomised trial Open
Objectives To examine the effects of lipid‐based nutrient supplements (LNS) containing milk protein (MP) and/or whey permeate (WP) on markers of intestinal inflammation and enterocyte mass among stunted children. Furthermore, to explore wh…
View article: Effect of lipid-based nutrient supplements on micronutrient status and hemoglobin among children with stunting: secondary analysis of a randomized controlled trial in Uganda
Effect of lipid-based nutrient supplements on micronutrient status and hemoglobin among children with stunting: secondary analysis of a randomized controlled trial in Uganda Open
LNS supplementation increases Hb and improves iron, cobalamin, and folate status, but not vitamin A status among children with stunting. LNS should be considered for children with stunting. This trial was registered at ISRCTN as 13093195.
View article: Macronutrient Content in Human Milk Is Not Affected by Infant’s Sex
Macronutrient Content in Human Milk Is Not Affected by Infant’s Sex Open
Human milk contains macronutrients possibly affecting infant and early childhood growth. Most studies suggest a sex-specific difference in macronutrient levels in favor of males, with a higher energy content from fat, lactose, and protein.…
View article: Correlates of Plasma Citrulline, a Potential Marker of Enterocyte Mass, among Children with Stunting: A Cross-Sectional Study in Uganda
Correlates of Plasma Citrulline, a Potential Marker of Enterocyte Mass, among Children with Stunting: A Cross-Sectional Study in Uganda Open
Many of the correlates of p-cit are characteristic of populations with a high EED prevalence. Systemic inflammation is strongly associated with p-cit and is implicated in EED and stunting. Adjustment for systemic inflammation attenuates ma…
View article: Serum insulin-like growth factor 1 in young children with moderate acute malnutrition: secondary analysis of a randomized trial in Burkina Faso
Serum insulin-like growth factor 1 in young children with moderate acute malnutrition: secondary analysis of a randomized trial in Burkina Faso Open
Background/objectives Insulin-like growth factor 1 (IGF-1) is an important growth factor in childhood. We aimed to investigate the impact of food supplements for treatment of moderate acute malnutrition (MAM) on serum IGF-1 (sIGF-1). Subje…
View article: The Associations of Breastfeeding Status at 6 Months with Anthropometry, Body Composition, and Cardiometabolic Markers at 5 Years in the Ethiopian Infant Anthropometry and Body Composition Birth Cohort
The Associations of Breastfeeding Status at 6 Months with Anthropometry, Body Composition, and Cardiometabolic Markers at 5 Years in the Ethiopian Infant Anthropometry and Body Composition Birth Cohort Open
(1) Background: Breastfeeding (BF) has been shown to lower the risk of overweight and cardiometabolic disease later in life. However, evidence from low-income settings remains sparse. We examined the associations of BF status at 6 months w…
View article: A literature review of evidence for primary prevention of overweight and obesity in healthy weight children and adolescents: A report produced by a working group of the Danish Council on Health and Disease Prevention
A literature review of evidence for primary prevention of overweight and obesity in healthy weight children and adolescents: A report produced by a working group of the Danish Council on Health and Disease Prevention Open
Summary Primary prevention targets development of overweight in individuals with healthy weight and is a great challenge. This paper summarizes the main findings of a working group of the Danish Council on Health and Disease Prevention tha…
View article: Maternal inflammatory, lipid and metabolic markers and associations with birth and breastfeeding outcomes
Maternal inflammatory, lipid and metabolic markers and associations with birth and breastfeeding outcomes Open
Background Conditions in utero influence intrauterine and postnatal infant growth and a few studies indicate that maternal inflammation and insulin resistance might affect birth and breastfeeding outcomes. Furthermore, hormones in human mi…
View article: Effect of maternal fish oil supplementation during lactation on socioemotional wellbeing and physical activity in 13-year-old children: A randomized clinical trial
Effect of maternal fish oil supplementation during lactation on socioemotional wellbeing and physical activity in 13-year-old children: A randomized clinical trial Open
Early dietary long-chain n-3PUFA (n-3LCPUFA) may affect brain development. We investigated if fish oil supplementation of lactating mothers affected socioemotional wellbeing in adolescents in a potentially gender-specific manner. At age 13…
View article: Infancy weight faltering and childhood neuro-developmental disorders: A general population birth-cohort study:a general population birth-cohort study
Infancy weight faltering and childhood neuro-developmental disorders: A general population birth-cohort study:a general population birth-cohort study Open
While it is known that intrauterine growth restriction is associated with later mental disorders, it is still unclear whether similar associations exists for postnatal weight faltering, also known as ‘failure to thrive’ in infancy. This st…
View article: Effect of Milk Protein and Whey Permeate in Large-Quantity Lipid-Based Nutrient Supplement on Early Child Development among Children with Stunting: A Randomized 2 × 2 Factorial Trial in Uganda
Effect of Milk Protein and Whey Permeate in Large-Quantity Lipid-Based Nutrient Supplement on Early Child Development among Children with Stunting: A Randomized 2 × 2 Factorial Trial in Uganda Open
Stunting affects 22% children globally, putting them at risk of adverse outcomes including delayed development. We investigated the effect of milk protein (MP) vs. soy and whey permeate (WP) vs. maltodextrin in large-quantity, lipid-based …
View article: Effect of milk protein and whey permeate in large quantity lipid-based nutrient supplement on linear growth and body composition among stunted children: A randomized 2 × 2 factorial trial in Uganda
Effect of milk protein and whey permeate in large quantity lipid-based nutrient supplement on linear growth and body composition among stunted children: A randomized 2 × 2 factorial trial in Uganda Open
Background Despite possible benefits for growth, milk is costly to include in foods for undernourished children. Furthermore, the relative effects of different milk components, milk protein (MP), and whey permeate (WP) are unclear. We aime…