Jens Kristoffer Hertel
YOU?
Author Swipe
View article: Global mapping of RNA N6-methyladenosine (m6A) in human subcutaneous and visceral adipose tissue reveals novel targets that correlate with clinical variables of obesity
Global mapping of RNA N6-methyladenosine (m6A) in human subcutaneous and visceral adipose tissue reveals novel targets that correlate with clinical variables of obesity Open
Background Obesity is a major health challenge and fat accumulation in visceral depots is more strongly associated with metabolic comorbidities than deposition in subcutaneous depots. Epitranscriptomic regulation of gene expression by N 6 …
View article: Gastric Bypass vs Diet and Cardiovascular Risk Factors
Gastric Bypass vs Diet and Cardiovascular Risk Factors Open
Importance Roux-en-Y gastric bypass (RYGB) is associated with reduced cardiovascular (CV) risk factors, morbidity, and mortality. Whether these effects are specifically induced by the surgical procedure or the weight loss is unclear. Objec…
View article: Comparison of Sleeve Gastrectomy vs Roux-en-Y Gastric Bypass
Comparison of Sleeve Gastrectomy vs Roux-en-Y Gastric Bypass Open
Importance Laparoscopic sleeve gastrectomy (SG) and laparoscopic Roux-en-Y gastric bypass (RYGB) are widely used bariatric procedures for which comparative efficacy and safety remain unclear. Objective To compare perioperative outcomes in …
View article: Single-centre, non-randomised clinical trial at a tertiary care centre to investigate 1-year changes in social experiences and biomarkers of well-being after bariatric surgery in individuals with severe obesity: protocol for the Bariatric Surgery and Social Experiences (BaSES) study
Single-centre, non-randomised clinical trial at a tertiary care centre to investigate 1-year changes in social experiences and biomarkers of well-being after bariatric surgery in individuals with severe obesity: protocol for the Bariatric Surgery and Social Experiences (BaSES) study Open
Introduction Obesity is linked to increased loneliness and less enjoyment of social interactions. While bariatric surgery is the most effective treatment targeting severe obesity, there is limited understanding as to whether patients exper…
View article: Rare variants in PLA2G7 are associated with the age of onset and disease burden of asthma
Rare variants in PLA2G7 are associated with the age of onset and disease burden of asthma Open
Understanding of the contributions of rare genetic variants in asthma is limited. In this study, we investigated this contribution in 121 asthma-associated genes to the age of onset and disease burden using targeted next-generation sequenc…
View article: A pilot study of implementation of endoscopic sleeve gastroplasty (ESG) in Norway
A pilot study of implementation of endoscopic sleeve gastroplasty (ESG) in Norway Open
This first Scandinavian clinical trial of ESG, documenting the implementation of the procedure at a Norwegian center, demonstrated acceptable feasibility and safety, with large variations in individual weight loss during the 52-week follow…
View article: Single-centre, non-randomised clinical trial at a tertiary care centre to investigate 1-year changes in social experiences and biomarkers of well-being after bariatric surgery in individuals with severe obesity: protocol for the Bariatric Surgery and Social Experiences (BaSES) study
Single-centre, non-randomised clinical trial at a tertiary care centre to investigate 1-year changes in social experiences and biomarkers of well-being after bariatric surgery in individuals with severe obesity: protocol for the Bariatric Surgery and Social Experiences (BaSES) study Open
Introduction Obesity is linked to increased loneliness and less enjoyment of social interactions. While bariatric surgery is the most effective treatment targeting severe obesity, there is limited understanding as to whether patients exper…
View article: Distinct T cell subsets in adipose tissue are associated with obesity
Distinct T cell subsets in adipose tissue are associated with obesity Open
Adipose tissue inflammation is a driving factor for the development of obesity‐associated metabolic disturbances, and a role of adipose tissue T cells in initiating the pro‐inflammatory signaling is emerging. However, data on human adipose…
View article: Impact of type 2 diabetes on in vivo activities and protein expressions of cytochrome <scp>P450</scp> in patients with obesity
Impact of type 2 diabetes on in vivo activities and protein expressions of cytochrome <span>P450</span> in patients with obesity Open
Previous studies have not accounted for the close link between type 2 diabetes mellitus (T2DM) and obesity when investigating the impact of T2DM on cytochrome P450 (CYP) activities. The aim was to investigate the effect of T2DM on in vivo …
View article: Association between hepatic steatosis and fibrosis with measures of insulin sensitivity in patients with severe obesity and type 2 diabetes - a cross-sectional study
Association between hepatic steatosis and fibrosis with measures of insulin sensitivity in patients with severe obesity and type 2 diabetes - a cross-sectional study Open
Background Obesity, non-alcoholic fatty liver disease (NAFLD) and insulin resistance are three pathological conditions highly correlated, but this relationship is not fully elucidated. Hence, we aimed to assess the association of hepatic s…
View article: Short‐ and long‐term effects of body weight, calorie restriction and gastric bypass on CYP1A2, CYP2C19 and CYP2C9 activity
Short‐ and long‐term effects of body weight, calorie restriction and gastric bypass on CYP1A2, CYP2C19 and CYP2C9 activity Open
Aim Roux‐en‐Y gastric bypass (RYGB) may influence drug disposition due to surgery‐induced gastrointestinal alterations and/or subsequent weight loss. The objective was to compare short‐ and long‐term effects of RYGB and diet on the metabol…
View article: Effect of aerobic exercise intensity on health-related quality of life in severe obesity: a randomized controlled trial
Effect of aerobic exercise intensity on health-related quality of life in severe obesity: a randomized controlled trial Open
Background Aerobic exercise is an important part of obesity treatment and may improve health-related quality of life (HRQOL). The objective of this study was to compare the effect of two different exercise programs on health-related qualit…
View article: Drug Disposition Protein Quantification in Matched Human Jejunum and Liver From Donors With Obesity
Drug Disposition Protein Quantification in Matched Human Jejunum and Liver From Donors With Obesity Open
Mathematical models, such as physiologically‐based pharmacokinetic models, are used to predict, for example, drug disposition and toxicity. However, populations differ in the abundance of proteins involved in these processes. To improve th…
View article: Addendum to: Comparison of the effect of Roux‐en‐Y gastric bypass and sleeve gastrectomy on remission of type 2 diabetes: A systematic review and meta‐analysis of randomized controlled trials
Addendum to: Comparison of the effect of Roux‐en‐Y gastric bypass and sleeve gastrectomy on remission of type 2 diabetes: A systematic review and meta‐analysis of randomized controlled trials Open
After publication of our systematic review, one of the included studies (Ruiz-Tovar, Jaime et al. "Long-term follow-up after sleeve gastrectomy versus Roux-en-Y gastric bypass versus one-anastomosis gastric bypass: a prospective randomized…
View article: A novel intragastric balloon for treatment of obesity and type 2 diabetes. A two-center pilot trial
A novel intragastric balloon for treatment of obesity and type 2 diabetes. A two-center pilot trial Open
Obesity with type-2 diabetes is a global challenge. Lifestyle interventions have limited effect for most patients. Bariatric surgery is highly effective, but resource-demanding, invasive and associated with serious complications. Recently,…
View article: Influence of asthma and obesity on respiratory symptoms, work ability and lung function: findings from a cross-sectional Norwegian population study
Influence of asthma and obesity on respiratory symptoms, work ability and lung function: findings from a cross-sectional Norwegian population study Open
Background Although asthma and obesity are each associated with adverse respiratory outcomes, a possible interaction between them is less studied. This study assessed the extent to which asthma and overweight/obese status were independentl…
View article: Gastrointestinal Hormones and β-Cell Function After Gastric Bypass and Sleeve Gastrectomy: A Randomized Controlled Trial (Oseberg)
Gastrointestinal Hormones and β-Cell Function After Gastric Bypass and Sleeve Gastrectomy: A Randomized Controlled Trial (Oseberg) Open
Context Whether Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG) differentially affect postprandial gastrointestinal hormones and β-cell function in type 2 diabetes remains unclear. Objective We aimed to compare gastrointestinal…
View article: Effect of Aerobic Exercise Intensity on Energy Expenditure and Weight Loss in Severe Obesity—A Randomized Controlled Trial
Effect of Aerobic Exercise Intensity on Energy Expenditure and Weight Loss in Severe Obesity—A Randomized Controlled Trial Open
Objective This study aimed to compare the effects of two aerobic exercise programs of different intensities on energy expenditure. Methods This was a single‐center randomized controlled trial of patients with severe obesity allocated to a …
View article: Supplementary Figures and Tables Fatima et al. Gastrointestinal hormones and β-cell function after gastric bypass and sleeve gastrectomy: an RCT (Oseberg)
Supplementary Figures and Tables Fatima et al. Gastrointestinal hormones and β-cell function after gastric bypass and sleeve gastrectomy: an RCT (Oseberg) Open
Supplementary Figure 1. Patient flow (page 2) Supplementary Table 1. Baseline characteristics (page 3) Supplementary Figure 2. Insulin and C-peptide levels during an oral glucose tolerance test (page 4) Supplementary Figure 3. iAUC0-8min…
View article: Supplementary Figures and Tables Fatima et al. Gastrointestinal hormones and β-cell function after gastric bypass and sleeve gastrectomy: an RCT (Oseberg)
Supplementary Figures and Tables Fatima et al. Gastrointestinal hormones and β-cell function after gastric bypass and sleeve gastrectomy: an RCT (Oseberg) Open
Supplementary Figure 1. Patient flow (page 2) Supplementary Table 1. Baseline characteristics (page 3) Supplementary Figure 2. Insulin and C-peptide levels during an oral glucose tolerance test (page 4) Supplementary Figure 3. iAUC0-8min…
View article: Supplementary Figures and Tables Fatima et al. Gastrointestinal hormones and β-cell function after gastric bypass and sleeve gastrectomy in patients with morbid obesity and type 2 diabetes: a randomized controlled trial (Oseberg Study)
Supplementary Figures and Tables Fatima et al. Gastrointestinal hormones and β-cell function after gastric bypass and sleeve gastrectomy in patients with morbid obesity and type 2 diabetes: a randomized controlled trial (Oseberg Study) Open
Supplementary Figure 1. Patient flow (page 2) Supplementary Table 1. Baseline characteristics (page 3) Supplementary Figure 2. Insulin and C-peptide levels during an oral glucose tolerance test (page 4) Supplementary Figure 3. iAUC0-8min…