Kolin C. Hribar
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View article: 842 High-throughput screening of cancer immunotherapy combinations using a hydrogel-based 3D in vitro tumor platform
842 High-throughput screening of cancer immunotherapy combinations using a hydrogel-based 3D in vitro tumor platform Open
Background Immunotherapies such as immune checkpoint inhibitors and CAR-T therapies have revolutionized cancer treatment in recent years. However, the success of the immunotherapies has been only limited to a small percentage of patients a…
View article: A Novel Hydrogel-Based 3D In Vitro Tumor Panel of 30 PDX Models Incorporates Tumor, Stromal and Immune Cell Compartments of the TME for the Screening of Oncology and Immuno-Therapies
A Novel Hydrogel-Based 3D In Vitro Tumor Panel of 30 PDX Models Incorporates Tumor, Stromal and Immune Cell Compartments of the TME for the Screening of Oncology and Immuno-Therapies Open
Human-relevant systems that mimic the 3D tumor microenvironment (TME), particularly the complex mechanisms of immuno-modulation in the tumor stroma, in a reproducible and scalable format are of high interest for the drug discovery industry…
View article: Data from A Simple Three-dimensional Hydrogel Platform Enables <i>Ex Vivo</i> Cell Culture of Patient and PDX Tumors for Assaying Their Response to Clinically Relevant Therapies
Data from A Simple Three-dimensional Hydrogel Platform Enables <i>Ex Vivo</i> Cell Culture of Patient and PDX Tumors for Assaying Their Response to Clinically Relevant Therapies Open
A cell culture platform that enables ex vivo tissue growth from patients or patient-derived xenograft (PDX) models and assesses sensitivity to approved therapies (e.g., temozolomide) in a clinically relevant time frame would be very useful…
View article: Supplementary Figures 1-2 from A Simple Three-dimensional Hydrogel Platform Enables <i>Ex Vivo</i> Cell Culture of Patient and PDX Tumors for Assaying Their Response to Clinically Relevant Therapies
Supplementary Figures 1-2 from A Simple Three-dimensional Hydrogel Platform Enables <i>Ex Vivo</i> Cell Culture of Patient and PDX Tumors for Assaying Their Response to Clinically Relevant Therapies Open
Supplementary Figure 1: spheroid growth in VersaGel using tumor cell lines. A) HepG2 hepatocarcinoma cell line; B) LN18 glioblastoma cell line. Scale bar = 1 millimeter. Supplementary Figure 2: VersaGel vs. BME (Matrigel) for Patient 4, Pa…
View article: Data from A Simple Three-dimensional Hydrogel Platform Enables <i>Ex Vivo</i> Cell Culture of Patient and PDX Tumors for Assaying Their Response to Clinically Relevant Therapies
Data from A Simple Three-dimensional Hydrogel Platform Enables <i>Ex Vivo</i> Cell Culture of Patient and PDX Tumors for Assaying Their Response to Clinically Relevant Therapies Open
A cell culture platform that enables ex vivo tissue growth from patients or patient-derived xenograft (PDX) models and assesses sensitivity to approved therapies (e.g., temozolomide) in a clinically relevant time frame would be very useful…
View article: Supplementary Figures 1-2 from A Simple Three-dimensional Hydrogel Platform Enables <i>Ex Vivo</i> Cell Culture of Patient and PDX Tumors for Assaying Their Response to Clinically Relevant Therapies
Supplementary Figures 1-2 from A Simple Three-dimensional Hydrogel Platform Enables <i>Ex Vivo</i> Cell Culture of Patient and PDX Tumors for Assaying Their Response to Clinically Relevant Therapies Open
Supplementary Figure 1: spheroid growth in VersaGel using tumor cell lines. A) HepG2 hepatocarcinoma cell line; B) LN18 glioblastoma cell line. Scale bar = 1 millimeter. Supplementary Figure 2: VersaGel vs. BME (Matrigel) for Patient 4, Pa…
View article: 1447 A 30 PDX panel of 3D in vitro tumor models identifies responders to pembrolizumab and solitomab
1447 A 30 PDX panel of 3D in vitro tumor models identifies responders to pembrolizumab and solitomab Open
Background Immunotherapies are emerging as a novel approach to combat cancer. Among them, checkpoint inhibitor treatment has found success in a subset of cancer patients by reversing T cell dysfunction and unleashing their cytolytic potent…
View article: 299 3D <i>in vitro</i> tumor microenvironment models for screening CAR-T cell therapy efficacy
299 3D <i>in vitro</i> tumor microenvironment models for screening CAR-T cell therapy efficacy Open
Background T cells that are genetically modified to express chimeric antigen receptors (CARs) show promising results for treating hematological tumors, however CAR-T cell therapy have thus far demonstrated limited anti-tumor activity in so…
View article: 943 3D in vitro tumor model platform rapidly assays immunotherapy efficacy with high content imaging and downstream phenotypic changes with flow cytometry and cytokine analysis
943 3D in vitro tumor model platform rapidly assays immunotherapy efficacy with high content imaging and downstream phenotypic changes with flow cytometry and cytokine analysis Open
Background Cancer immunotherapy represents a burgeoning new direction for oncology therapeutic innovation, with the principal thesis of activating one's own immune system to irradicate cancer as opposed to the injection of foreign cytotoxi…
View article: Abstract 4522: An in vitro 3D immune exclusion tumor model engineered in a layer-by-layer fashion
Abstract 4522: An in vitro 3D immune exclusion tumor model engineered in a layer-by-layer fashion Open
Recent immunotherapy failures in clinical trials have elucidated the affects of the tumor stroma on attenuating therapeutic response. In some cancers, the stroma consists of a collagen-rich fibrotic zone on the tumor periphery that traps i…
View article: Three-dimensional direct cell patterning in collagen hydrogels with near-infrared femtosecond laser
Three-dimensional direct cell patterning in collagen hydrogels with near-infrared femtosecond laser Open
We report a methodology for three-dimensional (3D) cell patterning in a hydrogel in situ . Gold nanorods within a cell-encapsulating collagen hydrogel absorb a focused near-infrared femtosecond laser beam, locally denaturing the collagen a…