Kay Huebner
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View article: Zinc treatment reverses and anti-Zn-regulated miRs suppress esophageal carcinomas in vivo
Zinc treatment reverses and anti-Zn-regulated miRs suppress esophageal carcinomas in vivo Open
Esophageal squamous cell carcinoma (ESCC) is a deadly disease with few prevention or treatment options. ESCC development in humans and rodents is associated with Zn deficiency (ZD), inflammation, and overexpression of oncogenic microRNAs: …
View article: Data from Protein Expression Profiling Identifies Cyclophilin A as a Molecular Target in Fhit-Mediated Tumor Suppression
Data from Protein Expression Profiling Identifies Cyclophilin A as a Molecular Target in Fhit-Mediated Tumor Suppression Open
Loss of fragile histidine triad (Fhit) expression is often associated with human malignancies, and Fhit functions as a tumor suppressor in controlling cell growth and apoptosis, although specific signal pathways are still undefined. We hav…
View article: Data from Wwox Suppresses Prostate Cancer Cell Growth through Modulation of ErbB2-Mediated Androgen Receptor Signaling
Data from Wwox Suppresses Prostate Cancer Cell Growth through Modulation of ErbB2-Mediated Androgen Receptor Signaling Open
The expression of the WWOX tumor suppressor gene is lost or reduced in a large fraction of various cancers, including prostate cancer. We previously reported that Wwox overexpression induced apoptosis and suppressed prostate cancer …
View article: Data from Protein Expression Profiling Identifies Cyclophilin A as a Molecular Target in Fhit-Mediated Tumor Suppression
Data from Protein Expression Profiling Identifies Cyclophilin A as a Molecular Target in Fhit-Mediated Tumor Suppression Open
Loss of fragile histidine triad (Fhit) expression is often associated with human malignancies, and Fhit functions as a tumor suppressor in controlling cell growth and apoptosis, although specific signal pathways are still undefined. We hav…
View article: Supplementary Figure S1 from Protein Expression Profiling Identifies Cyclophilin A as a Molecular Target in Fhit-Mediated Tumor Suppression
Supplementary Figure S1 from Protein Expression Profiling Identifies Cyclophilin A as a Molecular Target in Fhit-Mediated Tumor Suppression Open
Supplementary Figure S1 from Protein Expression Profiling Identifies Cyclophilin A as a Molecular Target in Fhit-Mediated Tumor Suppression
View article: Supplementary Figures S1-S2 from Wwox Suppresses Prostate Cancer Cell Growth through Modulation of ErbB2-Mediated Androgen Receptor Signaling
Supplementary Figures S1-S2 from Wwox Suppresses Prostate Cancer Cell Growth through Modulation of ErbB2-Mediated Androgen Receptor Signaling Open
Supplementary Figures S1-S2 from Wwox Suppresses Prostate Cancer Cell Growth through Modulation of ErbB2-Mediated Androgen Receptor Signaling
View article: Supplementary Figures S1-S2 from Wwox Suppresses Prostate Cancer Cell Growth through Modulation of ErbB2-Mediated Androgen Receptor Signaling
Supplementary Figures S1-S2 from Wwox Suppresses Prostate Cancer Cell Growth through Modulation of ErbB2-Mediated Androgen Receptor Signaling Open
Supplementary Figures S1-S2 from Wwox Suppresses Prostate Cancer Cell Growth through Modulation of ErbB2-Mediated Androgen Receptor Signaling
View article: Supplementary Figure S1 from Protein Expression Profiling Identifies Cyclophilin A as a Molecular Target in Fhit-Mediated Tumor Suppression
Supplementary Figure S1 from Protein Expression Profiling Identifies Cyclophilin A as a Molecular Target in Fhit-Mediated Tumor Suppression Open
Supplementary Figure S1 from Protein Expression Profiling Identifies Cyclophilin A as a Molecular Target in Fhit-Mediated Tumor Suppression
View article: Data from Wwox Suppresses Prostate Cancer Cell Growth through Modulation of ErbB2-Mediated Androgen Receptor Signaling
Data from Wwox Suppresses Prostate Cancer Cell Growth through Modulation of ErbB2-Mediated Androgen Receptor Signaling Open
The expression of the WWOX tumor suppressor gene is lost or reduced in a large fraction of various cancers, including prostate cancer. We previously reported that Wwox overexpression induced apoptosis and suppressed prostate cancer …
View article: Supplementary Data Figure 1 from Inhibition of Breast Cancer Cell Growth <i>In vitro</i> and <i>In vivo</i>: Effect of Restoration of Wwox Expression
Supplementary Data Figure 1 from Inhibition of Breast Cancer Cell Growth <i>In vitro</i> and <i>In vivo</i>: Effect of Restoration of Wwox Expression Open
Supplementary Data Figure 1 from Inhibition of Breast Cancer Cell Growth In vitro and In vivo: Effect of Restoration of Wwox Expression
View article: Data from Inhibition of Breast Cancer Cell Growth <i>In vitro</i> and <i>In vivo</i>: Effect of Restoration of Wwox Expression
Data from Inhibition of Breast Cancer Cell Growth <i>In vitro</i> and <i>In vivo</i>: Effect of Restoration of Wwox Expression Open
Purpose: The WWOX gene is down-regulated in breast cancer and loss of Wwox expression correlates with important clinical features of breast cancer. Thus, we have examined the effect of restoration of Wwox expression in breast…
View article: Supplementary Data Figure 1 from Inhibition of Breast Cancer Cell Growth <i>In vitro</i> and <i>In vivo</i>: Effect of Restoration of Wwox Expression
Supplementary Data Figure 1 from Inhibition of Breast Cancer Cell Growth <i>In vitro</i> and <i>In vivo</i>: Effect of Restoration of Wwox Expression Open
Supplementary Data Figure 1 from Inhibition of Breast Cancer Cell Growth In vitro and In vivo: Effect of Restoration of Wwox Expression
View article: Data from Inhibition of Breast Cancer Cell Growth <i>In vitro</i> and <i>In vivo</i>: Effect of Restoration of Wwox Expression
Data from Inhibition of Breast Cancer Cell Growth <i>In vitro</i> and <i>In vivo</i>: Effect of Restoration of Wwox Expression Open
Purpose: The WWOX gene is down-regulated in breast cancer and loss of Wwox expression correlates with important clinical features of breast cancer. Thus, we have examined the effect of restoration of Wwox expression in breast…
View article: Data from A Role for the <i>WWOX</i> Gene in Prostate Cancer
Data from A Role for the <i>WWOX</i> Gene in Prostate Cancer Open
Expression of the WWOX gene, encompassing the common chromosome fragile site FRA16D, is altered in a large fraction of cancers of various types, including prostate cancer. We have examined expression and biological functions of WWOX…
View article: Supplementary Figure S4 from TWIST1-Induced miR-424 Reversibly Drives Mesenchymal Programming while Inhibiting Tumor Initiation
Supplementary Figure S4 from TWIST1-Induced miR-424 Reversibly Drives Mesenchymal Programming while Inhibiting Tumor Initiation Open
Supplementary Figure S4 Inducible miR-424 recapitulates constitutive miR-424 EMT and TIC phenotypes reversibly. SUM149PT clones with i-EV or i-miR-424 constructs were assayed for a variety of EMT parameters: (A) 3' UTR luciferase reporter …
View article: Supplementary Figure S6 from TWIST1-Induced miR-424 Reversibly Drives Mesenchymal Programming while Inhibiting Tumor Initiation
Supplementary Figure S6 from TWIST1-Induced miR-424 Reversibly Drives Mesenchymal Programming while Inhibiting Tumor Initiation Open
Supplementary Figure S6 MiR-424 is post-transcriptionally regulated in vitro. Primary and mature miR-424 levels, by qPCR, in (A) HMLE cells constitutively expressing SNAI1 and in (B) HMLER cells constitutively expressing TWIST1 or SNAI1, a…
View article: Supplementary Figure S7 from TWIST1-Induced miR-424 Reversibly Drives Mesenchymal Programming while Inhibiting Tumor Initiation
Supplementary Figure S7 from TWIST1-Induced miR-424 Reversibly Drives Mesenchymal Programming while Inhibiting Tumor Initiation Open
Supplementary Figure S7 MiR-424 regulates many genes associated with EMT and cancer stemness. Effects of MCF12A cells stably expressing constitutive miR-424 on (A) known downregulated genes in an EMT signature (1) and on (B) known upregula…
View article: Supplementary Figure 1 from A Role for the <i>WWOX</i> Gene in Prostate Cancer
Supplementary Figure 1 from A Role for the <i>WWOX</i> Gene in Prostate Cancer Open
Supplementary Figure 1 from A Role for the WWOX Gene in Prostate Cancer
View article: Supplementary Figure S3 from TWIST1-Induced miR-424 Reversibly Drives Mesenchymal Programming while Inhibiting Tumor Initiation
Supplementary Figure S3 from TWIST1-Induced miR-424 Reversibly Drives Mesenchymal Programming while Inhibiting Tumor Initiation Open
Supplementary Figure S3 MiR-424 increases classical EMT phenotypes while decreasing TIC phenotypes. Stable miR-424 expressing MCF12A cells displaying: (A) distance migrated over 8 hours; (B) cell cycle analysis, by BrdU/PI staining; (C) ad…
View article: Supplementary Figure S3 from TWIST1-Induced miR-424 Reversibly Drives Mesenchymal Programming while Inhibiting Tumor Initiation
Supplementary Figure S3 from TWIST1-Induced miR-424 Reversibly Drives Mesenchymal Programming while Inhibiting Tumor Initiation Open
Supplementary Figure S3 MiR-424 increases classical EMT phenotypes while decreasing TIC phenotypes. Stable miR-424 expressing MCF12A cells displaying: (A) distance migrated over 8 hours; (B) cell cycle analysis, by BrdU/PI staining; (C) ad…
View article: Supplementary Figure S4 from TWIST1-Induced miR-424 Reversibly Drives Mesenchymal Programming while Inhibiting Tumor Initiation
Supplementary Figure S4 from TWIST1-Induced miR-424 Reversibly Drives Mesenchymal Programming while Inhibiting Tumor Initiation Open
Supplementary Figure S4 Inducible miR-424 recapitulates constitutive miR-424 EMT and TIC phenotypes reversibly. SUM149PT clones with i-EV or i-miR-424 constructs were assayed for a variety of EMT parameters: (A) 3' UTR luciferase reporter …
View article: Data from TWIST1-Induced miR-424 Reversibly Drives Mesenchymal Programming while Inhibiting Tumor Initiation
Data from TWIST1-Induced miR-424 Reversibly Drives Mesenchymal Programming while Inhibiting Tumor Initiation Open
Epithelial-to-mesenchymal transition (EMT) is a dynamic process that relies on cellular plasticity. Recently, the process of an oncogenic EMT, followed by a reverse mesenchymal-to-epithelial transition (MET), has been implicated as critica…
View article: Supplementary Table S1 - S2 from TWIST1-Induced miR-424 Reversibly Drives Mesenchymal Programming while Inhibiting Tumor Initiation
Supplementary Table S1 - S2 from TWIST1-Induced miR-424 Reversibly Drives Mesenchymal Programming while Inhibiting Tumor Initiation Open
MicroRNA microarray table results after (Table S1) 4 days and (Table S2) 12 days of TWIST1 induction.
View article: Data from Fhit-Deficient Hematopoietic Stem Cells Survive Hydroquinone Exposure Carrying Precancerous Changes
Data from Fhit-Deficient Hematopoietic Stem Cells Survive Hydroquinone Exposure Carrying Precancerous Changes Open
The fragile FHIT gene is among the first targets of DNA damage in preneoplastic lesions, and recent studies have shown that Fhit protein is involved in surveillance of genome integrity and checkpoint response after genotoxin exposur…
View article: Supplementary Figure 1 from Fhit-Deficient Hematopoietic Stem Cells Survive Hydroquinone Exposure Carrying Precancerous Changes
Supplementary Figure 1 from Fhit-Deficient Hematopoietic Stem Cells Survive Hydroquinone Exposure Carrying Precancerous Changes Open
Supplementary Figure 1 from Fhit-Deficient Hematopoietic Stem Cells Survive Hydroquinone Exposure Carrying Precancerous Changes
View article: Supplementary Figure S1 from TWIST1-Induced miR-424 Reversibly Drives Mesenchymal Programming while Inhibiting Tumor Initiation
Supplementary Figure S1 from TWIST1-Induced miR-424 Reversibly Drives Mesenchymal Programming while Inhibiting Tumor Initiation Open
Supplementary Figure S1 SNAI1 induces mesenchymal genes prior to repression of epithelial genes, concomitant with miR-424 upregulation. (A) Phase contrast images of HMLE Empty Vector and HMLE SNAI1-inducible cells after 4 and 12 days of SN…
View article: Supplementary Figure 2 from Fhit-Deficient Hematopoietic Stem Cells Survive Hydroquinone Exposure Carrying Precancerous Changes
Supplementary Figure 2 from Fhit-Deficient Hematopoietic Stem Cells Survive Hydroquinone Exposure Carrying Precancerous Changes Open
Supplementary Figure 2 from Fhit-Deficient Hematopoietic Stem Cells Survive Hydroquinone Exposure Carrying Precancerous Changes
View article: Supplementary Figure S8 from TWIST1-Induced miR-424 Reversibly Drives Mesenchymal Programming while Inhibiting Tumor Initiation
Supplementary Figure S8 from TWIST1-Induced miR-424 Reversibly Drives Mesenchymal Programming while Inhibiting Tumor Initiation Open
Supplementary Figure S8 Working model. MiR-424 can drive an intermediate EMT in primary breast tumors by downregulating TGFBR3, leading to increased mesenchymal characteristics concomitant with unaffected epithelial content. Experimental m…
View article: Supplementary Table S1 - S2 from TWIST1-Induced miR-424 Reversibly Drives Mesenchymal Programming while Inhibiting Tumor Initiation
Supplementary Table S1 - S2 from TWIST1-Induced miR-424 Reversibly Drives Mesenchymal Programming while Inhibiting Tumor Initiation Open
MicroRNA microarray table results after (Table S1) 4 days and (Table S2) 12 days of TWIST1 induction.
View article: Supplementary Figure 3 from Fhit-Deficient Hematopoietic Stem Cells Survive Hydroquinone Exposure Carrying Precancerous Changes
Supplementary Figure 3 from Fhit-Deficient Hematopoietic Stem Cells Survive Hydroquinone Exposure Carrying Precancerous Changes Open
Supplementary Figure 3 from Fhit-Deficient Hematopoietic Stem Cells Survive Hydroquinone Exposure Carrying Precancerous Changes