Rakesh K. Jain
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View article: A European perspective on tardive dyskinesia
A European perspective on tardive dyskinesia Open
Tardive dyskinesia (TD) is a medication-induced movement disorder associated with long-term use of dopamine receptor-blocking agents, most frequently antipsychotics. Its clinical presentation comprises involuntary hyperkinetic movements of…
View article: Physiologically based pharmacokinetic model for CAR-T cell delivery and efficacy in solid tumors
Physiologically based pharmacokinetic model for CAR-T cell delivery and efficacy in solid tumors Open
Abnormal blood vessels limit the delivery and function of endogenous T cells as well as adoptively transferred Chimeric Antigen Receptor (CAR)-T cells in tumor microenvironment (TME). We recently showed that vascular normalization using an…
View article: CTNI-72. LONG-TERM EFFICACY AND SAFETY OF BEVACIZUMAB FOR PROGRESSIVE VESTIBULAR SCHWANNOMA IN PATIENTS WITH <i>NF2</i> -RELATED SCHWANNOMATOSIS ( <i>NF2</i> -SWN)
CTNI-72. LONG-TERM EFFICACY AND SAFETY OF BEVACIZUMAB FOR PROGRESSIVE VESTIBULAR SCHWANNOMA IN PATIENTS WITH <i>NF2</i> -RELATED SCHWANNOMATOSIS ( <i>NF2</i> -SWN) Open
PURPOSE To determine long-term outcomes for patients with NF2-SWN treated with bevacizumab. METHODS We retrospectively reviewed the records of NF2-SWN patient at Massachusetts General Hospital who received bevacizumab for ≥2 years. Bevaciz…
View article: TMIC-109. Wnt inhibition improves the efficacy of anti-PD-1 therapy in glioblastoma
TMIC-109. Wnt inhibition improves the efficacy of anti-PD-1 therapy in glioblastoma Open
Immune checkpoint blockade therapy, including anti-PD-1 antibody (αPD1), has shown limited success in glioblastoma (GBM), a lethal brain tumor with a median survival of under two years. The Wnt signaling pathway - known for its role in dev…
View article: Unravelling the mystery of Nipah virus: from virus to therapeutics: current insights and future frontiers
Unravelling the mystery of Nipah virus: from virus to therapeutics: current insights and future frontiers Open
Background Nipah virus (NiV) is a high-risk zoonotic infection that results in severe respiratory and neurological disease, with case fatality rates typically exceeding 70%. Driven by reservoir-host spillover and intermittent human-to-huma…
View article: Wnt inhibition alleviates resistance to anti-PD1 therapy and improves antitumor immunity in glioblastoma
Wnt inhibition alleviates resistance to anti-PD1 therapy and improves antitumor immunity in glioblastoma Open
Wnt signaling plays a crucial role for many developmental processes. It is also pivotal in the generation and limited treatment outcomes of glioblastoma (GBM). Here, we identified Wnt7b, which is markedly upregulated in GBM patients, as a …
View article: Physiologically-based pharmacokinetic model for CAR-T cells delivery and efficacy in solid tumors
Physiologically-based pharmacokinetic model for CAR-T cells delivery and efficacy in solid tumors Open
Abnormal blood vessels limit the delivery and function of endogenous T cells as well as adoptively transferred Chimeric Antigen Receptor (CAR)-T cells in the tumor microenvironment (TME). We recently showed that vascular normalization usin…
View article: Supplementary Table S3 from Mathematical Modeling and Association Analysis Decipher the Impact of the Gut Microbiome on Cancer Immunotherapy
Supplementary Table S3 from Mathematical Modeling and Association Analysis Decipher the Impact of the Gut Microbiome on Cancer Immunotherapy Open
The values of model parameters taken from the literature.
View article: Supplementary Fig. S6 from Mathematical Modeling and Association Analysis Decipher the Impact of the Gut Microbiome on Cancer Immunotherapy
Supplementary Fig. S6 from Mathematical Modeling and Association Analysis Decipher the Impact of the Gut Microbiome on Cancer Immunotherapy Open
Model validation with clinical dataset.
View article: Supplementary Table S1 from Mathematical Modeling and Association Analysis Decipher the Impact of the Gut Microbiome on Cancer Immunotherapy
Supplementary Table S1 from Mathematical Modeling and Association Analysis Decipher the Impact of the Gut Microbiome on Cancer Immunotherapy Open
The list of variables that are calculated by the mathematical model.
View article: Supplementary Fig. S4 from Mathematical Modeling and Association Analysis Decipher the Impact of the Gut Microbiome on Cancer Immunotherapy
Supplementary Fig. S4 from Mathematical Modeling and Association Analysis Decipher the Impact of the Gut Microbiome on Cancer Immunotherapy Open
Global sensitivity analysis. The coefficients of significant predictors (p-value<0.05 ANOVA) on the tumor volume before treatment in equation (3) of the main paper.
View article: Supplementary Fig. S3 from Mathematical Modeling and Association Analysis Decipher the Impact of the Gut Microbiome on Cancer Immunotherapy
Supplementary Fig. S3 from Mathematical Modeling and Association Analysis Decipher the Impact of the Gut Microbiome on Cancer Immunotherapy Open
Representation of “Other” families with low relative abundances of less than 5% (murine training dataset) with their first 3 principal components.
View article: Supplementary Data from Mathematical Modeling and Association Analysis Decipher the Impact of the Gut Microbiome on Cancer Immunotherapy
Supplementary Data from Mathematical Modeling and Association Analysis Decipher the Impact of the Gut Microbiome on Cancer Immunotherapy Open
Supplementary raw data of the results of the paper
View article: Data from Mathematical Modeling and Association Analysis Decipher the Impact of the Gut Microbiome on Cancer Immunotherapy
Data from Mathematical Modeling and Association Analysis Decipher the Impact of the Gut Microbiome on Cancer Immunotherapy Open
The gut microbiome has emerged as a key regulator of response to cancer immunotherapy. However, a better understanding of the underlying mechanisms by which the microbiome influences immunotherapy is needed to identify strategies to optimi…
View article: Supplementary Fig. S1 from Mathematical Modeling and Association Analysis Decipher the Impact of the Gut Microbiome on Cancer Immunotherapy
Supplementary Fig. S1 from Mathematical Modeling and Association Analysis Decipher the Impact of the Gut Microbiome on Cancer Immunotherapy Open
Schematic of the mathematical model of tumor-immune system interactions, highlighting key immune components, their activation and cytolytic functions, and modulation by PD-1/PD-L1 signaling. The model also incorporates cytokine effects and…
View article: Supplementary Fig. S5 from Mathematical Modeling and Association Analysis Decipher the Impact of the Gut Microbiome on Cancer Immunotherapy
Supplementary Fig. S5 from Mathematical Modeling and Association Analysis Decipher the Impact of the Gut Microbiome on Cancer Immunotherapy Open
Local sensitivity analysis. The logarithm of total variance for each parameter and treatment.
View article: Supplementary Table S4 from Mathematical Modeling and Association Analysis Decipher the Impact of the Gut Microbiome on Cancer Immunotherapy
Supplementary Table S4 from Mathematical Modeling and Association Analysis Decipher the Impact of the Gut Microbiome on Cancer Immunotherapy Open
The values of model parameters that were determined by an optimization procedure.
View article: Supplementary Table S2 from Mathematical Modeling and Association Analysis Decipher the Impact of the Gut Microbiome on Cancer Immunotherapy
Supplementary Table S2 from Mathematical Modeling and Association Analysis Decipher the Impact of the Gut Microbiome on Cancer Immunotherapy Open
Comparison of the components incorporated in our modeling framework with those incorporated in previously published pertinent models.
View article: Supplementary Information from Mathematical Modeling and Association Analysis Decipher the Impact of the Gut Microbiome on Cancer Immunotherapy
Supplementary Information from Mathematical Modeling and Association Analysis Decipher the Impact of the Gut Microbiome on Cancer Immunotherapy Open
Supplementary Information file including supplementary methods and results.
View article: Supplementary Fig. S2 from Mathematical Modeling and Association Analysis Decipher the Impact of the Gut Microbiome on Cancer Immunotherapy
Supplementary Fig. S2 from Mathematical Modeling and Association Analysis Decipher the Impact of the Gut Microbiome on Cancer Immunotherapy Open
Comparison of experimental tumor growth curves with model predictions to define baseline values of model parameters.
View article: 612. EFFICACY OF LUMATEPERONE 42 MG IN THE TREATMENT OF MAJOR DEPRESSIVE DISORDER: A POOLED ANALYSIS OF PHASE 3 RANDOMIZED CONTROLLED TRIALS
612. EFFICACY OF LUMATEPERONE 42 MG IN THE TREATMENT OF MAJOR DEPRESSIVE DISORDER: A POOLED ANALYSIS OF PHASE 3 RANDOMIZED CONTROLLED TRIALS Open
Background Major depressive disorder (MDD) is a common and complex mental illness that is associated with multiple comorbidities, impaired functioning, and a heightened risk of suicide. Current treatments have limited response and remissio…
View article: Challenges and opportunities for the next generation of computational tumor models
Challenges and opportunities for the next generation of computational tumor models Open
Mathematical models have become essential tools for exploring the complex interplay between cancer cells and their microenvironment, but require multidisciplinary expertise and abundant biological data to develop. AI is leading the way tow…
View article: Health-related behavioral changes following the use of psychedelics in naturalistic settings
Health-related behavioral changes following the use of psychedelics in naturalistic settings Open
These findings suggest that psychedelic use is associated with broad behavioral adaptations beyond mental health, including important areas such diet, and alcohol and tobacco use. Compared with those who use full doses, participants who mi…
View article: Biomarkers of mRNA vaccine efficacy derived from mechanistic modeling of tumor-immune interactions
Biomarkers of mRNA vaccine efficacy derived from mechanistic modeling of tumor-immune interactions Open
The success of mRNA vaccines against infectious diseases such as COVID-19 has opened new avenues for their application in oncology. In cancer immunotherapy, mRNA vaccines—typically encapsulated in lipid nanoparticles (LNPs) 100–200 nm in s…
View article: Solid Stress Estimations via Intraoperative 3D Navigation in Patients with Brain Tumors
Solid Stress Estimations via Intraoperative 3D Navigation in Patients with Brain Tumors Open
Purpose: Physical forces exerted by expanding brain tumors—specifically the compressive stresses propagated through solid tissue structures—reduce brain perfusion and neurologic function but heretofore have not been directly measured in pa…
View article: Mathematical Modeling and Association Analysis Decipher the Impact of the Gut Microbiome on Cancer Immunotherapy
Mathematical Modeling and Association Analysis Decipher the Impact of the Gut Microbiome on Cancer Immunotherapy Open
The gut microbiome has emerged as a key regulator of response to cancer immunotherapy. However, a better understanding of the underlying mechanisms by which the microbiome influences immunotherapy is needed to identify strategies to optimi…
View article: Reimagining Auto Insurance with LiDAR: A Review of Applications, Challenges, and Opportunities
Reimagining Auto Insurance with LiDAR: A Review of Applications, Challenges, and Opportunities Open
The acceptance of LiDAR (Light Detection and Ranging) technology in self-driven vehicles and urban mapping is substantial. In the auto insurance domain, LiDAR’s accurate depth-sensing potential proposes its unexploited opportunity, which c…
View article: IL-1β blockade prevents cardiotoxicity and improves the efficacy of immune checkpoint blockers and chemotherapy against pancreatic cancer in mice with obesity
IL-1β blockade prevents cardiotoxicity and improves the efficacy of immune checkpoint blockers and chemotherapy against pancreatic cancer in mice with obesity Open
Background Immune checkpoint blockers (ICBs) have revolutionized cancer therapy, yet they remain largely ineffective in treating pancreatic ductal adenocarcinoma (PDAC). Moreover, ICBs can cause severe immune-related adverse events (irAEs)…
View article: Targeting EPHB2/ABL1 restores antitumor immunity in preclinical models of ependymoma
Targeting EPHB2/ABL1 restores antitumor immunity in preclinical models of ependymoma Open
Ependymoma (EPN) is a common form of brain tumor in children, often resistant to available cytotoxic therapies. Molecular profiling studies have led to a better understanding of EPN subtypes and revealed a critical role of oncogenes ZFTA–R…