Khalid Iqbal
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View article: Multi-filter stacking in inception V3 for enhanced Alzheimer’s severity classification
Multi-filter stacking in inception V3 for enhanced Alzheimer’s severity classification Open
Alzheimer's disease, a progressive neurodegenerative disorder, is characterized by a decline in brain volume and neuronal loss, with early symptoms often presenting as short-term memory impairment. Automated classification of Alzheimer's d…
View article: Valorization of Pomegranate and Banana By-products into Value-added Products: Influence on Physicochemical, Rheological, and Consumer Attributes
Valorization of Pomegranate and Banana By-products into Value-added Products: Influence on Physicochemical, Rheological, and Consumer Attributes Open
Fruits possess a variety of physiologically active compounds including polyphenols, vitamins, essential oils, terpenoids, and minerals, respectively that have ability to prevent disease and promote health. The production of different fruit…
View article: Using green finance to study energy elasticity, coal subsidy, energy transition and energy dependence in E7 economies: an efficiency analysis with data envelopment analysis
Using green finance to study energy elasticity, coal subsidy, energy transition and energy dependence in E7 economies: an efficiency analysis with data envelopment analysis Open
The inquiry examines the data envelopment analysis based efficiency analysis among green finance, energy transition, coal subsidy, energy elasticity and energy dependence in E7 economies. Accordingly, the research used E7 countries' data f…
View article: Approaches for harmonization of biomarker data from multiple studies: a narrative methodological review
Approaches for harmonization of biomarker data from multiple studies: a narrative methodological review Open
Research consortia frequently attempt co-analysis of biomarker data from multiple sources. However, limited guidance exists on the harmonization of biomarker data, which are prone to various sources of variation. This narrative review aime…
View article: Frequency of Hyperuricemia in Patients with Psoriasis
Frequency of Hyperuricemia in Patients with Psoriasis Open
Psoriasis is a chronic inflammatory skin disorder associated with systemic comorbidities, including metabolic syndrome and cardiovascular diseases. Hyperuricemia, characterized by elevated serum uric acid levels, has been implicated in sys…
View article: Effects of a ciliary neurotrophic factor (CNTF) small-molecule peptide mimetic in an in vitro and in vivo model of CDKL5 deficiency disorder
Effects of a ciliary neurotrophic factor (CNTF) small-molecule peptide mimetic in an in vitro and in vivo model of CDKL5 deficiency disorder Open
Background Mutations in the X-linked CDKL5 gene underlie a severe epileptic encephalopathy, CDKL5 deficiency disorder (CDD), characterized by gross motor impairment, autistic features and intellectual disability. Absence of Cdkl5 negativel…
View article: Diabetic Ketoacidosis Induces Tau Hyperphosphorylation in Rat Brain
Diabetic Ketoacidosis Induces Tau Hyperphosphorylation in Rat Brain Open
Background: Diabetes mellitus (DM) increases the risk for cognitive impairment and Alzheimer’s disease (AD). Diabetic ketoacidosis (DKA), a serious complication of DM, may also cause brain damage and further AD, but the underlying molecula…
View article: Methotrexate-Induced Lung Involvement in Psoriasis Patients: A single Centre Cross-Sectional Study
Methotrexate-Induced Lung Involvement in Psoriasis Patients: A single Centre Cross-Sectional Study Open
Background: Methotrexate is used for psoriasis as first-line disease-modifying drugs however it may cause lung complications. Objective: The aim of the current study was to find out the Prevalence of Methotrexate-Induced Lung Involvement i…
View article: Tau and Alzheimer's disease: Past, present and future
Tau and Alzheimer's disease: Past, present and future Open
My journey with tau started when in 1974 for the first time I isolated neurofibrillary tangles of paired helical filaments (PHFs) from autopsied Alzheimer's disease (AD) brains and discovered that they were made up of a ~50–70 KDa protein …
View article: Prophylactic effect of passive immunotherapy with tau antibody 43D in 3xTg‐AD mice
Prophylactic effect of passive immunotherapy with tau antibody 43D in 3xTg‐AD mice Open
Background Accumulation of abnormally hyperphosphorylated tau protein is a histopathological hallmark of Alzheimer’s disease (AD) and related tauopathies. Immunotherapy targeting tau represents a promising disease‐modifying therapeutic str…
View article: Does modulation of tau hyperphosphorylation represent a reasonable therapeutic strategy for Alzheimer’s disease? From preclinical studies to the clinical trials
Does modulation of tau hyperphosphorylation represent a reasonable therapeutic strategy for Alzheimer’s disease? From preclinical studies to the clinical trials Open
Protein kinases (PKs) have emerged as one of the most intensively investigated drug targets in current pharmacological research, with indications ranging from oncology to neurodegeneration. Tau protein hyperphosphorylation was the first pa…
View article: Two simple assays for assessing the seeding activity of proteopathic tau
Two simple assays for assessing the seeding activity of proteopathic tau Open
The regional distribution of neurofibrillary tangles of hyperphosphorylated tau aggregates is associated with the progression of Alzheimer’s disease (AD). Misfolded proteopathic tau recruits naïve tau and templates its misfolding and aggre…
View article: Gut Microbiota and Immunotherapy for Alzheimer’s Disease
Gut Microbiota and Immunotherapy for Alzheimer’s Disease Open
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder that eventually leads to dementia and death of the patient. Currently, no effective treatment is available that can slow or halt the progression of the disease. The gut m…
View article: Alzheimer’s Disease: Challenges and a Therapeutic Opportunity to Treat It with a Neurotrophic Compound
Alzheimer’s Disease: Challenges and a Therapeutic Opportunity to Treat It with a Neurotrophic Compound Open
Alzheimer’s disease (AD) is a progressive neurodegenerative disease with an insidious onset and multifactorial nature. A deficit in neurogenesis and synaptic plasticity are considered the early pathological features associated with neurofi…
View article: Tau antibody <scp>77G7</scp> targeting microtubule binding domain suppresses proteopathic tau to seed tau aggregation
Tau antibody <span>77G7</span> targeting microtubule binding domain suppresses proteopathic tau to seed tau aggregation Open
Introduction Neurofibrillary tangle (NFT) of hyperphosphorylated tau is a hallmark of Alzheimer's disease (AD) and related tauopathies. Tau lesion starts in the trans‐entorhinal cortex, from where it spreads to limbic regions, followed by …
View article: Tau seeding activity in various regions of down syndrome brain assessed by two novel assays
Tau seeding activity in various regions of down syndrome brain assessed by two novel assays Open
Propagation of tau pathology via the seeding of naive tau aggregation underlies the progression of Alzheimer’s disease (AD) and related tauopathies. Individuals with Down syndrome (DS) develop tau pathology at the fourth decade of life, bu…
View article: COVID-19 and Neurodegenerative Diseases: Prion-Like Spread and Long-Term Consequences
COVID-19 and Neurodegenerative Diseases: Prion-Like Spread and Long-Term Consequences Open
COVID-19 emerged as a global pandemic starting from Wuhan in China and spread at a lightning speed to the rest of the world. One of the potential long-term outcomes that we speculate is the development of neurodegenerative diseases as a lo…
View article: Heightened Tameness and Accelerated Handling-Habituation in 3×Tg-AD Mice on a B6;129 Genetic Background
Heightened Tameness and Accelerated Handling-Habituation in 3×Tg-AD Mice on a B6;129 Genetic Background Open
Background: The triple transgenic mouse model of Alzheimer’s disease (3×Tg-AD) has gained popularity in Alzheimer’s research owing to the progressive development of both amyloid- β and tau pathologies in its brain. Prior handling-habituati…
View article: Multi-Targets: An Unconventional Drug Development Strategy for Alzheimer’s Disease
Multi-Targets: An Unconventional Drug Development Strategy for Alzheimer’s Disease Open
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder that eventually leads to dementia and death of the patient. Despite the enormous amounts of resources and efforts for AD drug development during the last three decades, n…
View article: Neurotrophic Treatment Initiated During Early Postnatal Development Prevents the Alzheimer-Like Behavior and Synaptic Dysfunction
Neurotrophic Treatment Initiated During Early Postnatal Development Prevents the Alzheimer-Like Behavior and Synaptic Dysfunction Open
Background: Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by impairments in synaptic plasticity and cognitive performance. Cognitive dysfunction and loss of neuronal plasticity are known to begin decade…
View article: Alzheimer’s disease brain contains tau fractions with differential prion-like activities
Alzheimer’s disease brain contains tau fractions with differential prion-like activities Open
Neurofibrillary tangles (NFTs) made of abnormally hyperphosphorylated tau are a hallmark of Alzheimer’s disease (AD) and related tauopathies. Regional distribution of NFTs is associated with the progression of the disease and has been prop…
View article: Socio-Economic Barriers to Women's Higher Education: A Study of Tribal Area Barthi
Socio-Economic Barriers to Women's Higher Education: A Study of Tribal Area Barthi Open
The aim of the present had to identify the various barriers females face in their higher education.The main issue women are facing in their higher education is a tradition of that culture.Education improves the socio-economic status of wom…
View article: Tau immunotherapy rescues cognitive impairment by clearing extracellular tau
Tau immunotherapy rescues cognitive impairment by clearing extracellular tau Open
Background Alzheimer’s disease (AD) is histopathologically characterized by loss of neuronal connectivity associated with extensive tau and Abeta pathologies. Tau immunization can inhibit the seeding and spread of tau pathology and reduce …
View article: Anesthesia with sevoflurane or isoflurane induces severe hypoglycemia in neonatal mice
Anesthesia with sevoflurane or isoflurane induces severe hypoglycemia in neonatal mice Open
Sevoflurane and isoflurane are among the most commonly used general anesthetics for children including infants, but their impact on metabolism, especially on blood glucose level, in children is not well understood. We investigated the impa…
View article: Inhibition of AMD-Like Pathology With a Neurotrophic Compound in Aged Rats and 3xTg-AD Mice
Inhibition of AMD-Like Pathology With a Neurotrophic Compound in Aged Rats and 3xTg-AD Mice Open
Age-associated macular degeneration (AMD), which leads to loss of vision at its end stage, is one of the most common neurodegenerative diseases among the elderly. However, to date, no effective drug therapy is available for the prevention …