Karl Wah Keung Tsim
YOU?
Author Swipe
View article: Proteomic study of Akkermansia muciniphila and Bifidobacterium species co-culture under different carbon sources
Proteomic study of Akkermansia muciniphila and Bifidobacterium species co-culture under different carbon sources Open
Akkermansia muciniphila and Bifidobacterium spp. are major probiotic strains that have been shown to improve host metabolism and treat metabolic diseases. Previous studies have proposed formulating these probiotics as a therapeutic product…
View article: Profiling Class-Wide Bioactivities of Flavonoids While Minimizing Compound-Specific Effects Using an Equimolar Mixture Strategy
Profiling Class-Wide Bioactivities of Flavonoids While Minimizing Compound-Specific Effects Using an Equimolar Mixture Strategy Open
Flavonoids share a C6-C3-C6 core yet vary in side-chain decorations. Here, we tested whether an equimolar cross-subclass mixture could serve as a "class reference" by capturing class-wide bioactivities and …
View article: The Hepatoprotective Properties of the Revised Formulation of Dahuang Xiaoshi Tang, an Ancient Chinese Herbal Decoction, Are Probed by Integrated Metabolomics and Network Pharmacology
The Hepatoprotective Properties of the Revised Formulation of Dahuang Xiaoshi Tang, an Ancient Chinese Herbal Decoction, Are Probed by Integrated Metabolomics and Network Pharmacology Open
Background: Dahuang Xiaoshi Tang (DXT), an ancient Chinese herbal remedy dating back to 220 AD, as documented initially in “Treatise on Febrile and Miscellaneous Diseases,” is used to treat damp-heat jaundice with interior sthenia syndrome…
View article: The Mechanistic Evaluation of Danggui Buxue Tang, an Ancient Chinese Herbal Decoction Containing Astragali Radix and Angelicae Sinensis Radix, by Network Pharmacology
The Mechanistic Evaluation of Danggui Buxue Tang, an Ancient Chinese Herbal Decoction Containing Astragali Radix and Angelicae Sinensis Radix, by Network Pharmacology Open
Background/Objectives: Danggui Buxue Tang (DBT), an herbal formula deriving from traditional Chinese medicine (TCM), is widely recognized for its therapeutic effectiveness in clinical practice. To uncover the molecular mechanisms underlyin…
View article: The Identification of Gyrophoric Acid, a Phytochemical Derived from Lichen, as a Potent Inhibitor for Aggregation of Amyloid Beta Peptide: In Silico and Biochemical Evaluation
The Identification of Gyrophoric Acid, a Phytochemical Derived from Lichen, as a Potent Inhibitor for Aggregation of Amyloid Beta Peptide: In Silico and Biochemical Evaluation Open
Alzheimer’s disease (AD) is characterized by amyloid-beta (Aβ) plaque accumulation and neurodegeneration. This study identifies gyrophoric acid, a lichen-derived phenolic metabolite, as a dual-action Aβ42 inhibitor preventing aggregation a…
View article: Pan-cancer analysis of acetylcholinesterase (AChE) expression by a data-driven approach: future directions of AChE in cancer neuroscience
Pan-cancer analysis of acetylcholinesterase (AChE) expression by a data-driven approach: future directions of AChE in cancer neuroscience Open
There is evidence that the expression of acetylcholinesterase (AChE) is associated with the development of certain cancers. However, there are still insufficient studies to reveal the correlation between AChE expression and cancer developm…
View article: Camelia seed and its functional properties promising for dermatological applications
Camelia seed and its functional properties promising for dermatological applications Open
Tea or camelia (Camelia spp.) is considered as the important crop of the world with several health benefits. The leaves are processed and consumed as the popular beverage, as well as in varieties of consumer products. While camellia leaves…
View article: PT109B, a Multikinase Inhibitor, Converts Astrocytes into Dopaminergic Neurons and Alleviates Parkinson's Disease in Mice
PT109B, a Multikinase Inhibitor, Converts Astrocytes into Dopaminergic Neurons and Alleviates Parkinson's Disease in Mice Open
Background Parkinson’s disease (PD) is characterized by the progressive loss of dopaminergic neurons (DANs), leading to motor dysfunction, while current treatments fail to restore neuronal loss. Reprogramming astrocytes into induced DANs b…
View article: Drug Screening of Flavonoids as Potential VEGF Inhibitors Through Computational Docking and Cell Models
Drug Screening of Flavonoids as Potential VEGF Inhibitors Through Computational Docking and Cell Models Open
Vascular endothelial growth factor (VEGF), also known as VEGF-A, has been linked to various diseases, such as wet age-related macular degeneration (wAMD) and cancer. Even though there are VEGF inhibitors that are currently commercially ava…
View article: Disruption of Copper Redox Balance and Dysfunction under <i>In Vivo</i> and <i>In Vitro</i> Alzheimer’s Disease Models
Disruption of Copper Redox Balance and Dysfunction under <i>In Vivo</i> and <i>In Vitro</i> Alzheimer’s Disease Models Open
Alzheimer's disease (AD) is a neurodegenerative disorder disease mainly caused by extracellular senile plaques (SP) formed by β-amyloid (Aβ1-42) protein deposits. Copper (Cu) is an essential metal involved in neural system, and its homeost…
View article: Cholinergic Signaling Mediated by Muscarinic Receptors Triggers the Ultraviolet‐Induced Release of Melanosome in Cultured Melanoma Cells
Cholinergic Signaling Mediated by Muscarinic Receptors Triggers the Ultraviolet‐Induced Release of Melanosome in Cultured Melanoma Cells Open
In skin, melanin is synthesized and stored in melanosomes. In epidermal melanocytes, melanosomes are transported to and internalized by the neighboring keratinocytes, subsequently leading to skin pigmentation. Ultraviolet (UV) radiation in…
View article: Plant growth-promoting rhizobacteria enhance active ingredient accumulation in medicinal plants at elevated CO2 and are associated with indigenous microbiome
Plant growth-promoting rhizobacteria enhance active ingredient accumulation in medicinal plants at elevated CO2 and are associated with indigenous microbiome Open
Introduction Plant growth-promoting rhizobacteria (PGPR) and elevated CO 2 (eCO 2 ) have demonstrated their individual potential to enhance plant yield and quality through close interaction with rhizosphere microorganisms and plant growth.…
View article: Unveiling the therapeutic potential of Lobaria extract and its depsides/depsidones in combatting Aβ42 peptides aggregation and neurotoxicity in Alzheimer’s disease
Unveiling the therapeutic potential of Lobaria extract and its depsides/depsidones in combatting Aβ42 peptides aggregation and neurotoxicity in Alzheimer’s disease Open
Background: The development of effective inhibitors that can inhibit amyloid β (A β ) peptides aggregation and promote neurite outgrowth is crucial for the possible treatment of Alzheimer’s disease (AD). Lobaria (Schreb.) Hoffm., a traditi…
View article: Acetylcholine regulates the melanogenesis of retinal pigment epithelia cells via a cAMP-dependent pathway: A non-neuronal function of cholinergic system in retina
Acetylcholine regulates the melanogenesis of retinal pigment epithelia cells via a cAMP-dependent pathway: A non-neuronal function of cholinergic system in retina Open
View article: Synergy of botanical drug extracts from Dracaena cochinchinensis stemwood and Ardisia elliptica fruit in multifunctional effects on neuroprotection and anti-inflammation
Synergy of botanical drug extracts from Dracaena cochinchinensis stemwood and Ardisia elliptica fruit in multifunctional effects on neuroprotection and anti-inflammation Open
Combination therapy is one of the promising approaches in developing therapeutics to cure complex diseases, such as Alzheimer’s disease (AD). In Thai traditional medicines, the clinical application often comprises multiple botanical drugs …
View article: The Extracts of Evodiae Fructus and Stephaniae Tetrandrae Radix Show Synergy in Blocking the Entry of SARS-CoV-2
The Extracts of Evodiae Fructus and Stephaniae Tetrandrae Radix Show Synergy in Blocking the Entry of SARS-CoV-2 Open
Given the fact that herbal extracts have been effectively used in clinical applications and have well-established safety records, our current findings suggest that these drug combinations might be considered as potential anti-COVID-19 trea…
View article: The muscarinic acetylcholine receptor in dermal papilla cells regulates hair growth
The muscarinic acetylcholine receptor in dermal papilla cells regulates hair growth Open
The role of cholinergic system in hair biology is poorly understood. In M4 muscarinic receptor (mAChR) knockout mice, the hair follicles have a prolonged telogen phase and failed to produce hair shafts. Here, we reported that hair growth w…
View article: Luteolin, a common flavone in vegetables, acts as a hormetin possessing neurotrophic function: signaling mediated by inducing mitochondrial stress
Luteolin, a common flavone in vegetables, acts as a hormetin possessing neurotrophic function: signaling mediated by inducing mitochondrial stress Open
This study aims to uncover the hormetic process of luteolin, a common dietary flavone, in neuronal cells through its role in inducing mitochondrial stress. In rat pheochromocytoma PC12 cells, luteolin at low concentrations caused a mild an…
View article: Acetylcholine Regulates the Melanogenesis of Retinal Pigment Epithelia Cells Via a CAMP-Dependent Pathway: A Non-Neuronal Function of Cholinergic System in Retina
Acetylcholine Regulates the Melanogenesis of Retinal Pigment Epithelia Cells Via a CAMP-Dependent Pathway: A Non-Neuronal Function of Cholinergic System in Retina Open
View article: Review of: "Bisphosphonate-Related Osteonecrosis of the Jaws Treated with Platelet-Rich Plasma: Preliminary Results from a Case Series"
Review of: "Bisphosphonate-Related Osteonecrosis of the Jaws Treated with Platelet-Rich Plasma: Preliminary Results from a Case Series" Open
View article: Isolation and characterization of ZK002, a novel dual function snake venom protein from Deinagkistrodon acutus with anti-angiogenic and anti-inflammatory properties
Isolation and characterization of ZK002, a novel dual function snake venom protein from Deinagkistrodon acutus with anti-angiogenic and anti-inflammatory properties Open
Introduction: Pathological angiogenesis, the abnormal or excessive generation of blood vessels, plays an important role in many diseases including cancer, diabetic retinopathy, psoriasis, and arthritis. Additionally, increasing evidence su…
View article: Reproductive characteristics of the hermaphroditic four-finger threadfin, Eleutheronema tetradactylum (Shaw, 1804), in tropical coastal waters
Reproductive characteristics of the hermaphroditic four-finger threadfin, Eleutheronema tetradactylum (Shaw, 1804), in tropical coastal waters Open
This study investigated the reproductive traits of the hermaphroditic four-finger threadfin, Eleutheronema tetradactylum , along the coasts of Thailand during January to December 2021. Fish samples were collected from Pattani Bay, Thailand…
View article: Herbicide propisochlor exposure induces intestinal barrier impairment, microbiota dysbiosis and gut pyroptosis
Herbicide propisochlor exposure induces intestinal barrier impairment, microbiota dysbiosis and gut pyroptosis Open
Propisochlor is a chloroacetamide herbicide causing liver toxicity and suppressing immunity in human and animal. Although the herbicide has been used for years, the effects of propisochlor on intestinal health remain poorly understood. Hen…
View article: The extracts of Lobaria pindarensis, an edible lichen from Himalayas, suppress inflammatory response and fibrillation of amyloid β-protein in cultured microglial cells: Active depsidones, norstictic acid and stictic acid, are responsible for the functions
The extracts of Lobaria pindarensis, an edible lichen from Himalayas, suppress inflammatory response and fibrillation of amyloid β-protein in cultured microglial cells: Active depsidones, norstictic acid and stictic acid, are responsible for the functions Open
Lobaria pindarensis Räsänen is an edible and medicinal lichen found in the Himalayas that has been used as ethnomedicine for years to combat inflammation. The study aimed to evaluate the ability of L. pindarensis extracts and its main deps…
View article: Review of: "Natural Polyphenols of Pomegranate and Black Tea Juices can Combat COVID-19 through their SARS-CoV-2 3C-like Protease-inhibitory Activity"
Review of: "Natural Polyphenols of Pomegranate and Black Tea Juices can Combat COVID-19 through their SARS-CoV-2 3C-like Protease-inhibitory Activity" Open
The authors claimed that HIV-1 protease inhibitors and some herbal teas could potentially combat the COVID-19.There are some issues below that are needed to be considered.1.
View article: Reproductive characteristics of the hermaphroditic four-finger threadfin, Eleutheronema tetradactylum (Shaw, 1804), in tropical coastal waters
Reproductive characteristics of the hermaphroditic four-finger threadfin, Eleutheronema tetradactylum (Shaw, 1804), in tropical coastal waters Open
This study investigates reproductive traits of the hermaphroditic four-finger threadfin, Eleutheronema tetradactylum , along the coasts of Thailand during January 2021 and January 2022. Fish sample from Pattani Bay, Thailand was collected …
View article: How fish cells responded to zinc challenges: Insights from bioimaging
How fish cells responded to zinc challenges: Insights from bioimaging Open
View article: Peer Review #2 of "Feeding habits of four-finger threadfin fish, Eleutheronema tetradactylum, and its diet interaction with co-existing fish species in the coastal waters of Thailand (v0.1)"
Peer Review #2 of "Feeding habits of four-finger threadfin fish, Eleutheronema tetradactylum, and its diet interaction with co-existing fish species in the coastal waters of Thailand (v0.1)" Open
This study assessed feeding habits of four-finger threadfin fish, Eleutheronema tetradactylum, and its diet relationship with other fish species in the tropics.General fish samples were collected from four localities along the coastal regi…
View article: Peer Review #2 of "Feeding habits of four-finger threadfin fish, Eleutheronema tetradactylum, and its diet interaction with co-existing fish species in the coastal waters of Thailand (v0.2)"
Peer Review #2 of "Feeding habits of four-finger threadfin fish, Eleutheronema tetradactylum, and its diet interaction with co-existing fish species in the coastal waters of Thailand (v0.2)" Open
This study assessed feeding habits of four-finger threadfin fish, Eleutheronema tetradactylum, and its diet relationship with other fish species in the tropics.General fish samples were collected from four localities along the coastal regi…
View article: Feeding habits of four-finger threadfin fish, <i>Eleutheronema tetradactylum,</i> and its diet interaction with co-existing fish species in the coastal waters of Thailand
Feeding habits of four-finger threadfin fish, <i>Eleutheronema tetradactylum,</i> and its diet interaction with co-existing fish species in the coastal waters of Thailand Open
This study assessed the feeding habits of four-finger threadfin fish, Eleutheronema tetradactylum , and its diet relationship with other fish species in the tropics. Fish samples were collected from four locations along the coastal regions…