Richard J. Simpson
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View article: Oncogenic H‐Ras Reprograms Madin‐Darby Canine Kidney (MDCK) Cell‐Derived Midbody Remnant Proteome Following Epithelial‐Mesenchymal Transition
Oncogenic H‐Ras Reprograms Madin‐Darby Canine Kidney (MDCK) Cell‐Derived Midbody Remnant Proteome Following Epithelial‐Mesenchymal Transition Open
Epithelial‐mesenchymal transition (EMT) is a fundamental, dynamic cellular process involved in embryonic development, metastasis, organ fibrosis, and tissue regeneration. To define the molecular landscape of secreted midbody remnants (MBRs…
View article: Oncogenic H-Ras Reprograms Madin-Darby Canine Kidney (MDCK) Cell-derived Midbody Remnant Proteins Following Epithelial-Mesenchymal Transition
Oncogenic H-Ras Reprograms Madin-Darby Canine Kidney (MDCK) Cell-derived Midbody Remnant Proteins Following Epithelial-Mesenchymal Transition Open
Epithelial-mesenchymal transition (EMT) is a highly conserved morphogenic process that allows highly polarized, immotile epithelial cells to transform into motile mesenchymal cells: it is a fundamental cellular process involved in embryoni…
View article: Capacity for Compensatory Cyclin D2 Response Confers Trametinib Resistance in Canine Mucosal Melanoma
Capacity for Compensatory Cyclin D2 Response Confers Trametinib Resistance in Canine Mucosal Melanoma Open
Background/objective: Mucosal melanoma (MM) is a poorly responsive, rare and aggressive subtype with few cases having targetable recurrent driver mutations, although Ras/MAPK and PI3K/AKT/mTOR signaling pathway activations are common. Even…
View article: Capacity for compensatory cyclin D2 response confers trametinib resistance in canine mucosal melanoma
Capacity for compensatory cyclin D2 response confers trametinib resistance in canine mucosal melanoma Open
Background/objective Mucosal melanoma (MM) is a poorly responsive, rare and aggressive subtype with paucity of targetable recurrent driver mutations, although Ras/MAPK and PI3K/AKT/mTOR signaling pathway activations are common. Eventual tu…
View article: Unlinking sudden death from coronary artery disease - a systematic scoping review of the association of low-density lipoprotein cholesterol and sudden death
Unlinking sudden death from coronary artery disease - a systematic scoping review of the association of low-density lipoprotein cholesterol and sudden death Open
Background Sudden death (SD) is a common first manifestation of cardiovascular disease (CVD) and accounts for more than 350 000 deaths per year in the U.S. (1) Coronary artery disease is held accounted for up to 80% of SD cases. (2) Whilst…
View article: Editorial Board: Proteomics 7'24
Editorial Board: Proteomics 7'24 Open
View article: Transcriptomic analysis and fusion gene identifications of midbody remnants released from colorectal cancer cells reveals they are molecularly distinct from exosomes and microparticles
Transcriptomic analysis and fusion gene identifications of midbody remnants released from colorectal cancer cells reveals they are molecularly distinct from exosomes and microparticles Open
Previously, we reported that human primary (SW480) and metastatic (SW620) colorectal (CRC) cells release three classes of membrane‐encapsulated extracellular vesicles (EVs); midbody remnants (MBRs), exosomes (Exos), and microparticles (MPs…
View article: Editorial Board: Proteomics 3–4'24
Editorial Board: Proteomics 3–4'24 Open
View article: Characterisation is key: Composition and structure of oxalate kidney stones
Characterisation is key: Composition and structure of oxalate kidney stones Open
View article: Laboratory realization of relativistic pair-plasma beams
Laboratory realization of relativistic pair-plasma beams Open
Relativistic electron-positron plasmas are ubiquitous in extreme astrophysical environments such as black holes and neutron star magnetospheres, where accretion-powered jets and pulsar winds are expected to be enriched with such pair plasm…
View article: An extract from the frass of swallowtail butterfly (Papilio machaon) larvae inhibits HCT116 colon cancer cell proliferation but not other cancer cell types
An extract from the frass of swallowtail butterfly (Papilio machaon) larvae inhibits HCT116 colon cancer cell proliferation but not other cancer cell types Open
View article: Fusion-negative rhabdomyosarcoma orthotopic tongue xenografts for study of invasion, intravasation and metastasis in live animals
Fusion-negative rhabdomyosarcoma orthotopic tongue xenografts for study of invasion, intravasation and metastasis in live animals Open
PAX3/7 Fusion-negative rhabdomyosarcoma (FN-RMS) is a childhood mesodermal lineage malignancy with a poor prognosis for metastatic or relapsed cases. Towards achieving a more complete understanding of advanced FN-RMS, we developed an ortho…
View article: Editorial Board: Proteomics 18'23
Editorial Board: Proteomics 18'23 Open
View article: Editorial Board: Proteomics 17'23
Editorial Board: Proteomics 17'23 Open
View article: Editorial Board: Proteomics 16'23
Editorial Board: Proteomics 16'23 Open
View article: Editorial Board: Proteomics 15'23
Editorial Board: Proteomics 15'23 Open
View article: Comparative proteomic analysis of three major extracellular vesicle classes secreted from human primary and metastatic colorectal cancer cells: Exosomes, microparticles, and shed midbody remnants
Comparative proteomic analysis of three major extracellular vesicle classes secreted from human primary and metastatic colorectal cancer cells: Exosomes, microparticles, and shed midbody remnants Open
Cell‐derived extracellular vesicles (EVs) are evolutionary‐conserved secretory organelles that, based on their molecular composition, are important intercellular signaling regulators. At least three classes of circulating EVs are known bas…
View article: Drug combinations identified by high-throughput screening promote cell cycle transition and upregulate Smad pathways in myeloma
Drug combinations identified by high-throughput screening promote cell cycle transition and upregulate Smad pathways in myeloma Open
View article: Editorial Board: Proteomics 12'23
Editorial Board: Proteomics 12'23 Open
View article: Editorial Board: Proteomics 11'23
Editorial Board: Proteomics 11'23 Open
View article: Comparative proteomic analysis of three major extracellular classes secreted from human adenocarcinoma and metastatic colorectal cancer cells: exosomes, microparticles and shed midbody remnants
Comparative proteomic analysis of three major extracellular classes secreted from human adenocarcinoma and metastatic colorectal cancer cells: exosomes, microparticles and shed midbody remnants Open
Cell-derived extracellular vesicles (EVs) are evolutionary-conserved secretory organelles that, based on their molecular composition, are important intercellular signaling regulators. At least three classes of circulating EVs are known bas…
View article: Editorial Board: Proteomics 10'23
Editorial Board: Proteomics 10'23 Open
View article: Editorial Board: Proteomics 9'23
Editorial Board: Proteomics 9'23 Open
View article: Supplementary Methods, Figure Legends from Loss of MIG6 Accelerates Initiation and Progression of Mutant Epidermal Growth Factor Receptor–Driven Lung Adenocarcinoma
Supplementary Methods, Figure Legends from Loss of MIG6 Accelerates Initiation and Progression of Mutant Epidermal Growth Factor Receptor–Driven Lung Adenocarcinoma Open
Supplementary Methods, Figure Legends
View article: Data from The Protein Phosphatase 2A Inhibitor LB100 Sensitizes Ovarian Carcinoma Cells to Cisplatin-Mediated Cytotoxicity
Data from The Protein Phosphatase 2A Inhibitor LB100 Sensitizes Ovarian Carcinoma Cells to Cisplatin-Mediated Cytotoxicity Open
Despite early positive response to platinum-based chemotherapy, the majority of ovarian carcinomas develop resistance and progress to fatal disease. Protein phosphatase 2A (PP2A) is a ubiquitous phosphatase involved in the regulation of DN…
View article: Data from Loss of MIG6 Accelerates Initiation and Progression of Mutant Epidermal Growth Factor Receptor–Driven Lung Adenocarcinoma
Data from Loss of MIG6 Accelerates Initiation and Progression of Mutant Epidermal Growth Factor Receptor–Driven Lung Adenocarcinoma Open
Somatic mutations in the EGFR kinase domain drive lung adenocarcinoma. We have previously identified MIG6, an inhibitor of ERBB signaling and a potential tumor suppressor, as a target for phosphorylation by mutant EGFRs. Here, we demonstra…
View article: SupplementalFigures 1-4, Tables from Hypomorphic mTOR Downregulates CDK6 and Delays Thymic Pre-T LBL Tumorigenesis
SupplementalFigures 1-4, Tables from Hypomorphic mTOR Downregulates CDK6 and Delays Thymic Pre-T LBL Tumorigenesis Open
Supplemental Figures S1-S4 + two supp. tables
View article: Supplementary figure legends from The Protein Phosphatase 2A Inhibitor LB100 Sensitizes Ovarian Carcinoma Cells to Cisplatin-Mediated Cytotoxicity
Supplementary figure legends from The Protein Phosphatase 2A Inhibitor LB100 Sensitizes Ovarian Carcinoma Cells to Cisplatin-Mediated Cytotoxicity Open
Supplementary figure legends
View article: Supplementary Table 1 from Loss of MIG6 Accelerates Initiation and Progression of Mutant Epidermal Growth Factor Receptor–Driven Lung Adenocarcinoma
Supplementary Table 1 from Loss of MIG6 Accelerates Initiation and Progression of Mutant Epidermal Growth Factor Receptor–Driven Lung Adenocarcinoma Open
Supplementary Table 1. Identification of mice used is Western blots and immunoprecipitation experiments (M1-M20) and the mice used for the early time periods upon doxycycline induction.
View article: Supplementary figures S1-S5 from The Protein Phosphatase 2A Inhibitor LB100 Sensitizes Ovarian Carcinoma Cells to Cisplatin-Mediated Cytotoxicity
Supplementary figures S1-S5 from The Protein Phosphatase 2A Inhibitor LB100 Sensitizes Ovarian Carcinoma Cells to Cisplatin-Mediated Cytotoxicity Open
Supplementary figures S1-S5. Supplementary Figure S1. Western blot showing differential expression of PP2A-C (catalytic subunit) and PP2A-A (scaffold subunit) in different ovarian cancer cell lines; Supplementary Figure S2. LB100 is not a …