Koichi Kyono
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View article: Application of Large Language Models in Data Analysis and Medical Education for Assisted Reproductive Technology: Comparative Study
Application of Large Language Models in Data Analysis and Medical Education for Assisted Reproductive Technology: Comparative Study Open
Background Recent studies have demonstrated that large language models exhibit exceptional performance in medical examinations. However, there is a lack of reports assessing their capabilities in specific domains or their application in pr…
View article: Successful Fertility Preservation Using <i>Ex vivo</i> Oocyte Retrieval and Transportation in a Case of Stage IB3 Cervical Cancer with a Risk of Ovarian Metastasis
Successful Fertility Preservation Using <i>Ex vivo</i> Oocyte Retrieval and Transportation in a Case of Stage IB3 Cervical Cancer with a Risk of Ovarian Metastasis Open
This case involved a 31-year-old woman with stage IB3 cervical cancer and suspected obturator lymph node metastasis. The cervical tumor size exceeded 4 cm. Ex vivo oocyte retrieval was performed to avoid puncturing the tumor during transva…
View article: First Report on Ovarian Tissue Cryopreservation for A 6-Year-Old Girl with Non-Mosaic Turner Syndrome (45, X) in Japan: A Case Report
First Report on Ovarian Tissue Cryopreservation for A 6-Year-Old Girl with Non-Mosaic Turner Syndrome (45, X) in Japan: A Case Report Open
View article: Large Language Models (Chat GPT, Claude, and Gemini) have potential to significantly transform data analysis and medical education in Assisted Reproductive Technology: Comparison Study. (Preprint)
Large Language Models (Chat GPT, Claude, and Gemini) have potential to significantly transform data analysis and medical education in Assisted Reproductive Technology: Comparison Study. (Preprint) Open
BACKGROUND Recent studies have demonstrated that large language models (LLMs) exhibit exceptional performance in medical examinations. However, there is a lack of reports assessing their capabilities in specific domains or their applicati…
View article: Clinical Outcomes of Frozen-Thawed Single Blastocyst Transfers in Relation to Blastocyst Diameter and Timing of Cryopreservation
Clinical Outcomes of Frozen-Thawed Single Blastocyst Transfers in Relation to Blastocyst Diameter and Timing of Cryopreservation Open
Background: It is important to select blastocysts based on their likelihood of leading to pregnancy. The purpose of this study was to focus on expansion time and blastocyst diameter as simple factors to assess blastocysts relative to clini…
View article: The utility of human two plus one small pronucleated zygotes (2.1PN) based on clinical outcomes and the focused ploidy analysis
The utility of human two plus one small pronucleated zygotes (2.1PN) based on clinical outcomes and the focused ploidy analysis Open
Purpose Are human embryos arising from two plus one small pronucleated zygotes, called 2.1 pronuclei (PN), clinically useful? Methods In a retrospective embryo cohort study and prospective experimental study, a total of 287 cycles in which…
View article: #146 : Low-Lactate Culture Medium Increases the Percentage of Usable Blastocysts from Advanced Maternal Age Patients: A Sibling-Oocyte, Monocentric Study
#146 : Low-Lactate Culture Medium Increases the Percentage of Usable Blastocysts from Advanced Maternal Age Patients: A Sibling-Oocyte, Monocentric Study Open
Background and Aims: Excess lactate in culture medium accumulates may adversely affect the embryo as metabolic stress. The purpose of this study is to investigate whether culture media with a low-lactate concentration have an effect on emb…
View article: Pregnancy and Delivery of a Healthy Baby Boy from a Patient Embryo Cryopreserved for Over 18 Years: A Case Report
Pregnancy and Delivery of a Healthy Baby Boy from a Patient Embryo Cryopreserved for Over 18 Years: A Case Report Open
Cryopreservation offers semipermanent embryo storage. Although there have been various reports on effects of cryopreservation, there are few regarding preservation for 10 years or more. Here, we describe the delivery of a healthy child to …
View article: Chlormadinone acetate in progestin‐primed ovarian stimulation does not negatively affect clinical results
Chlormadinone acetate in progestin‐primed ovarian stimulation does not negatively affect clinical results Open
Purpose To investigate whether progestin‐primed ovarian stimulation (PPOS) with chlormadinone acetate (CMA) adversely affects clinical results and neonatal outcomes, or causes congenital deformities. Methods This retrospective study was co…
View article: Clinical outcomes of personalized blastocyst embryo transfer after endometrial receptivity analysis: A multicenter, retrospective cohort study
Clinical outcomes of personalized blastocyst embryo transfer after endometrial receptivity analysis: A multicenter, retrospective cohort study Open
Purpose To evaluate clinical outcomes after endometrial receptivity analysis (ERA). Methods This was a multicenter, retrospective cohort study involving 861 women who underwent ERA testing at certified fertility clinics in Japan, and who r…
View article: Non‐medical oocyte cryopreservation at a single center in Japan: 8 years of experience
Non‐medical oocyte cryopreservation at a single center in Japan: 8 years of experience Open
Purpose Increasing numbers of women are opting to undergo non‐medical oocyte cryopreservation (NMOC). In this report, we present experience at our clinic and discuss NMOC in Japan. Methods We followed the progress of 403 women who underwen…
View article: P-763 effect of duration of cryo-storage of vitrified embryos on obstetric and perinatal outcomes
P-763 effect of duration of cryo-storage of vitrified embryos on obstetric and perinatal outcomes Open
Study question Does the duration of cryo-storage of vitrified embryos affect obstetric and perinatal outcomes? Summary answer Duration of cryo-storage with an open vitrification system did not affect obstetric and perinatal outcomes. What …
View article: Obstetrical and Neonatal Outcomes of 3,028 Singletons Born After Advanced ART Techniques: Ejaculated Sperm Intracytoplasmic Sperm Injection, Artificial Oocyte Activation, in Vitro Maturation and Testicular Sperm Extraction
Obstetrical and Neonatal Outcomes of 3,028 Singletons Born After Advanced ART Techniques: Ejaculated Sperm Intracytoplasmic Sperm Injection, Artificial Oocyte Activation, in Vitro Maturation and Testicular Sperm Extraction Open
Background: To evaluate obstetrical and neonatal outcomes of singletons conceived after advanced assisted reproductive technology (ART) techniques: conventional IVF pregnancies (C-IVF), ejaculated sperm intracytoplasmic sperm injection (IC…
View article: Six-year follow-up of children born from vitrified oocytes
Six-year follow-up of children born from vitrified oocytes Open
This is the first follow-up report of children born from vitrified-warmed oocytes followed by ICSI. The data suggested that the responses from the study participants on the mental and physical development of children were comparable to the…
View article: Two Successful Deliveries after 6 and 13 Years from 10 Oocytes Vitrified for Fertility Preservation in a Then 20-Year-Old Patient with PH-Positive Acute Lymphoid Leukemia
Two Successful Deliveries after 6 and 13 Years from 10 Oocytes Vitrified for Fertility Preservation in a Then 20-Year-Old Patient with PH-Positive Acute Lymphoid Leukemia Open
Oocyte vitrification is one of the methods for preserving fertility of cancer patients. In 2013, we reported a successful live birth using cryopreserved oocytes from a patient who contracted Ph-positive acute lymphoid leukemia at the retri…
View article: Dose-Dependent Chlormadinone Acetate Can Suppress Premature LH Surge in Parallel with LH Value Reduction
Dose-Dependent Chlormadinone Acetate Can Suppress Premature LH Surge in Parallel with LH Value Reduction Open
Background: Progestin-primed ovarian stimulation (PPOS) protocol is reported as an alternative method of premature luteinizing hormone (LH) surge suppression. How much dosage of chlormadinone acetate (CMA), a synthetic progestin, is approp…
View article: Effectiveness and optimal dose of chlormadinone acetate (CMA) as progestin-primed ovarian stimulation
Effectiveness and optimal dose of chlormadinone acetate (CMA) as progestin-primed ovarian stimulation Open
View article: Association of four imprinting disorders and ART
Association of four imprinting disorders and ART Open
We reconfirmed the association between ART and imprinting disorders. In addition, we found unique methylation patterns in ART-SRS patients, therefore, concluded that the imprinting disorders related to ART might tend to take place just aft…
View article: Additional file 4: of Association of four imprinting disorders and ART
Additional file 4: of Association of four imprinting disorders and ART Open
Frequency of different prevalence of UPD(15)mat and DNA methylation error in ART-patients and Sp-patients with PWS according to maternal age. All data were obtained from the questionnaire. DNA methylation error indicates gain of methylatio…
View article: Additional file 9: of Association of four imprinting disorders and ART
Additional file 9: of Association of four imprinting disorders and ART Open
Lists of DMVs in various genomic regions. N.A. indicates that data was not available. (XLSX 1005 kb)
View article: Additional file 6: of Association of four imprinting disorders and ART
Additional file 6: of Association of four imprinting disorders and ART Open
Sequencing information. (XLSX 10 kb)
View article: Effects of melatonin and resveratrol on embryo development and clinical outcomes in poor-prognosis IVF patients
Effects of melatonin and resveratrol on embryo development and clinical outcomes in poor-prognosis IVF patients Open
View article: Does in vitro maturation (IVM) have an impact on morphokinetic parameters in comparison with IVF?
Does in vitro maturation (IVM) have an impact on morphokinetic parameters in comparison with IVF? Open
View article: Follow-up of child growth regarding new technologies: testicular sperm extraction (TESE), in vitro maturation (IVM), and assisted oocyte activation (AOA)
Follow-up of child growth regarding new technologies: testicular sperm extraction (TESE), in vitro maturation (IVM), and assisted oocyte activation (AOA) Open