Kenneth Lyons Jones
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View article: STUDY DESIGN AND RECRUITMENT INTO THE BELIMUMAB MOTHERTOBABY PREGNANCY EXPOSURE STUDY: AN OTIS AUTOIMMUNE DISEASES IN PREGNANCY PROJECT
STUDY DESIGN AND RECRUITMENT INTO THE BELIMUMAB MOTHERTOBABY PREGNANCY EXPOSURE STUDY: AN OTIS AUTOIMMUNE DISEASES IN PREGNANCY PROJECT Open
PV187 / #637 Poster Topic: AS21 - Pregnancy and Reproductive Health Background/Purpose Belimumab is a human monoclonal antibody that inhibits B lymphocyte stimulator protein (BLyS). Among other countries, belimumab is approved in the Unite…
View article: Validation of the ND-PAE Diagnosis in Children with Heavy Prenatal Alcohol Exposure
Validation of the ND-PAE Diagnosis in Children with Heavy Prenatal Alcohol Exposure Open
This study evaluated criteria for Neurobehavioral Disorder Associated with Prenatal Alcohol Exposure (ND-PAE). Kable et al. (2022) assessed the validity of this diagnosis in a sample with low exposure to alcohol. The current study expanded…
View article: Predicting fetal alcohol spectrum disorders in preschool‐aged children from early life factors
Predicting fetal alcohol spectrum disorders in preschool‐aged children from early life factors Open
Background Early life factors, including parental sociodemographic characteristics, pregnancy exposures, and physical and neurodevelopmental features measured in infancy are associated with fetal alcohol spectrum disorders (FASD). The obje…
View article: Vision outcomes in children with fetal alcohol spectrum disorders
Vision outcomes in children with fetal alcohol spectrum disorders Open
Background Previous studies demonstrated that children with Fetal Alcohol Spectrum Disorders (FASD) are more likely to have vision impairments. However, existing human clinical and epidemiological investigations are few and include limited…
View article: Genomic analyses in Cornelia de Lange Syndrome and related diagnoses: Novel candidate genes, <scp>genotype–phenotype</scp> correlations and common mechanisms
Genomic analyses in Cornelia de Lange Syndrome and related diagnoses: Novel candidate genes, <span>genotype–phenotype</span> correlations and common mechanisms Open
Cornelia de Lange Syndrome (CdLS) is a rare, dominantly inherited multisystem developmental disorder characterized by highly variable manifestations of growth and developmental delays, upper limb involvement, hypertrichosis, cardiac, gastr…
View article: Results of a screening tool for fetal alcohol spectrum disorders are associated with neuropsychological and behavioral measures
Results of a screening tool for fetal alcohol spectrum disorders are associated with neuropsychological and behavioral measures Open
Purpose This study assessed whether the outcome of a screening tool for fetal alcohol spectrum disorders (FASD), the FASD‐Tree, was associated with neuropsychological and behavioral outcomes. Methods Data for this study were collected as p…
View article: Atypical developmental trajectories of white matter microstructure in prenatal alcohol exposure: Preliminary evidence from neurite orientation dispersion and density imaging
Atypical developmental trajectories of white matter microstructure in prenatal alcohol exposure: Preliminary evidence from neurite orientation dispersion and density imaging Open
Introduction Fetal alcohol spectrum disorder (FASD), a life-long condition resulting from prenatal alcohol exposure (PAE), is associated with structural brain anomalies and neurobehavioral differences. Evidence from longitudinal neuroimagi…
View article: Supplementary Figure 4 from Activity of Combined Androgen Receptor Antagonism and Cell Cycle Inhibition in Androgen Receptor Positive Triple Negative Breast Cancer
Supplementary Figure 4 from Activity of Combined Androgen Receptor Antagonism and Cell Cycle Inhibition in Androgen Receptor Positive Triple Negative Breast Cancer Open
Overlap between RNAseq datasets from MDA-MB-453 ARHigh cells and HCI-009 PDX mice treated with Sevi. scRNAseq was performed on untreated MDA-MB-453 cells cultured in full serum media. Cells were divided in groups based on their expression …
View article: Supplementary Figures 1-3 from Autophagy Supports Breast Cancer Stem Cell Maintenance by Regulating IL6 Secretion
Supplementary Figures 1-3 from Autophagy Supports Breast Cancer Stem Cell Maintenance by Regulating IL6 Secretion Open
Supplementary Figures 1-3. Supplementary Figure 1. MCF7 and MDA-MB-468 cells were transduced with lentiviruses containing shRNAs for ATG7 or BECN1. Supplementary Figure 2. Principal Component Analysis of RNA sequencing data in autophagy-de…
View article: Supplementary Table 3 from Autophagy Supports Breast Cancer Stem Cell Maintenance by Regulating IL6 Secretion
Supplementary Table 3 from Autophagy Supports Breast Cancer Stem Cell Maintenance by Regulating IL6 Secretion Open
Supplementary Table 3. Gene set enrichment analysis (GSEA) for RNA sequencing studies of MCF7 and MDA-MB-468 breast cancer cell lines expressing either a non-silencing (NS) shRNA or an ATG7 (A7) shRNA.
View article: Data from PARP Inhibition Enhances Radiotherapy of SMAD4-Deficient Human Head and Neck Squamous Cell Carcinomas in Experimental Models
Data from PARP Inhibition Enhances Radiotherapy of SMAD4-Deficient Human Head and Neck Squamous Cell Carcinomas in Experimental Models Open
Purpose:SMAD4 loss causes genomic instability and the initiation/progression of head and neck squamous cell carcinoma (HNSCC). Here, we study whether SMAD4 loss sensitizes HNSCCs to olaparib (PARP inhibitor) in combination with radiotherap…
View article: Supplementary Figure S6 from PARP Inhibition Enhances Radiotherapy of SMAD4-Deficient Human Head and Neck Squamous Cell Carcinomas in Experimental Models
Supplementary Figure S6 from PARP Inhibition Enhances Radiotherapy of SMAD4-Deficient Human Head and Neck Squamous Cell Carcinomas in Experimental Models Open
Supplementary Figure S6 demonstrates the influence of SMAD4 status on DNA damage response to RT + olaparib
View article: Supplementary Figure S6 from PARP Inhibition Enhances Radiotherapy of SMAD4-Deficient Human Head and Neck Squamous Cell Carcinomas in Experimental Models
Supplementary Figure S6 from PARP Inhibition Enhances Radiotherapy of SMAD4-Deficient Human Head and Neck Squamous Cell Carcinomas in Experimental Models Open
Supplementary Figure S6 demonstrates the influence of SMAD4 status on DNA damage response to RT + olaparib
View article: Supplementary Figure S5 from PARP Inhibition Enhances Radiotherapy of SMAD4-Deficient Human Head and Neck Squamous Cell Carcinomas in Experimental Models
Supplementary Figure S5 from PARP Inhibition Enhances Radiotherapy of SMAD4-Deficient Human Head and Neck Squamous Cell Carcinomas in Experimental Models Open
Supplementary Figure S5 demonstrates the influence of SMAD4 status on proliferation (with and without treatment)
View article: Supplementary Table S1 from PARP Inhibition Enhances Radiotherapy of SMAD4-Deficient Human Head and Neck Squamous Cell Carcinomas in Experimental Models
Supplementary Table S1 from PARP Inhibition Enhances Radiotherapy of SMAD4-Deficient Human Head and Neck Squamous Cell Carcinomas in Experimental Models Open
Supplementary Table S1 lists reagents used
View article: Validation of the <scp>FASD‐Tree</scp> as a screening tool for fetal alcohol spectrum disorders
Validation of the <span>FASD‐Tree</span> as a screening tool for fetal alcohol spectrum disorders Open
Background As many as 80% of individuals with fetal alcohol spectrum disorders (FASD) are misdiagnosed or not diagnosed. This study tests the accuracy and validity of a web‐based screening tool (the FASD‐Tree) for identifying children and …
View article: Identifying Prenatal Alcohol Exposure and Children Affected by It: A Review of Biomarkers and Screening Tools
Identifying Prenatal Alcohol Exposure and Children Affected by It: A Review of Biomarkers and Screening Tools Open
Biomarkers and screening tools of PAE and its impact fall short of ideal predictive validity characteristics. Higher specificity than sensitivity was found for many of the biomarkers and screening tools used to identify PAE and its impact,…
View article: Alcohol‐related dysmorphic features as predictors of neurodevelopmental delay in infants and preschool‐aged children: Results from a birth cohort in Ukraine
Alcohol‐related dysmorphic features as predictors of neurodevelopmental delay in infants and preschool‐aged children: Results from a birth cohort in Ukraine Open
Background Cardinal and non‐cardinal dysmorphic features are associated with prenatal alcohol exposure (PAE); however, their association with neurodevelopment is less clear. The objective of this study was to determine whether alcohol‐rela…
View article: Fetal alcohol spectrum disorders and access to regional center services in San Diego County
Fetal alcohol spectrum disorders and access to regional center services in San Diego County Open
Background Fetal alcohol spectrum disorders (FASD) are developmental disabilities that are estimated to occur in 2–5% of elementary school children and that negatively impact a child's ability to function without support. Timely diagnosis‐…
View article: Prenatal alcohol exposure can be determined from baby teeth: Proof of concept
Prenatal alcohol exposure can be determined from baby teeth: Proof of concept Open
Background Prenatal alcohol exposure (PAE), leading to fetal alcohol spectrum disorders (FASD), is a serious public health issue in the United States and globally. Diagnosis of FASD is crucial in obtaining appropriate care, but it is not a…
View article: Development and validation of a postnatal risk score that identifies children with prenatal alcohol exposure
Development and validation of a postnatal risk score that identifies children with prenatal alcohol exposure Open
Background This study aimed to develop an efficient and easily calculable risk score that can be used to identify an individual's risk of having been exposed to alcohol prenatally. Methods Data for this study were collected as part of the …
View article: Validity and Reliability of Executive Function Measures in Children With Heavy Prenatal Alcohol Exposure: Correspondence Between Multiple Raters and Laboratory Measures
Validity and Reliability of Executive Function Measures in Children With Heavy Prenatal Alcohol Exposure: Correspondence Between Multiple Raters and Laboratory Measures Open
Background Rating scales are designed to complement traditional performance‐based measures, and both can provide useful information about the functioning of youth with histories of prenatal alcohol exposure. Few studies, however, have comp…
View article: Executive and Social Functioning Across Development in Children and Adolescents With Prenatal Alcohol Exposure
Executive and Social Functioning Across Development in Children and Adolescents With Prenatal Alcohol Exposure Open
Background Prenatal alcohol exposure (PAE) is linked to a variety of neurodevelopmental challenges, including social functioning (SF) and executive functioning (EF) deficits. These deficits present differently across developmental stages f…
View article: Use of Telemedicine for the Physical Examination of Children With Fetal Alcohol Spectrum Disorders
Use of Telemedicine for the Physical Examination of Children With Fetal Alcohol Spectrum Disorders Open
Background The fetal alcohol spectrum disorders (FASD) are among the most prevalent causes of neurodevelopmental disorders. The diagnosis is based on assessment of prenatal alcohol exposure, specific physical features identified with a dys…
View article: Infant Cardiac Orienting Responses Predict Later FASD in the Preschool Period
Infant Cardiac Orienting Responses Predict Later FASD in the Preschool Period Open
Background Prenatal alcohol exposure (PAE) has been identified as one of the leading preventable causes of developmental disabilities, but early identification of those impacted has been challenging. This study evaluated the use of infant …
View article: Cross‐Sectional Analysis of Spatial Working Memory Development in Children with Histories of Heavy Prenatal Alcohol Exposure
Cross‐Sectional Analysis of Spatial Working Memory Development in Children with Histories of Heavy Prenatal Alcohol Exposure Open
Background In children with prenatal alcohol exposure, spatial working memory is affected and brain regions important for spatial working memory performance exhibit atypical neurodevelopment. We therefore hypothesized that children with pr…