K. Matthew Lattal
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View article: Sex and estrous cycle effects on stress-enhanced fear learning in Long-Evans rats
Sex and estrous cycle effects on stress-enhanced fear learning in Long-Evans rats Open
Individuals diagnosed with post-traumatic stress disorder (PTSD) are hyperresponsive to otherwise ordinary stimuli (e.g., loud noises or certain smells) long after a traumatic experience. At a preclinical level, this persistent effect of t…
View article: Beyond reconsolidation: The need for a broad theoretical approach in clinical translations of research on retrieval-induced plasticity.
Beyond reconsolidation: The need for a broad theoretical approach in clinical translations of research on retrieval-induced plasticity. Open
Experimental findings showing that retrieved memories are labile and vulnerable to disruption have led to important theoretical ideas at a basic science level that have been applied to the clinic at a translational level. At a theoretical …
View article: Sex-dependent effects of acute stress in adolescence or adulthood on appetitive motivation
Sex-dependent effects of acute stress in adolescence or adulthood on appetitive motivation Open
View article: Stress, associative learning, and decision-making
Stress, associative learning, and decision-making Open
Exposure to acute and chronic stress has significant effects on the basic mechanisms of associative learning and memory. Stress can both impair and enhance associative learning depending on type, intensity, and persistence of the stressor,…
View article: Acute stress persistently alters instrumental motivation without affecting appetitive Pavlovian conditioning, extinction, or contextual renewal
Acute stress persistently alters instrumental motivation without affecting appetitive Pavlovian conditioning, extinction, or contextual renewal Open
View article: Persistent effects of acute trauma on Pavlovian-to-instrumental transfer
Persistent effects of acute trauma on Pavlovian-to-instrumental transfer Open
In humans, an acutely traumatic experience can lead to post-traumatic stress disorder (PTSD), which is often characterized by changes in anxiety and motivation months after trauma. There are few demonstrations of the persistent motivationa…
View article: Developments in associative theory: A tribute to the contributions of Robert A. Rescorla.
Developments in associative theory: A tribute to the contributions of Robert A. Rescorla. Open
The field of associative learning theory was forever changed by the contributions of Robert A. Rescorla. He created an organizational structure that gave us a framework for thinking about the key questions surrounding learning theory: what…
View article: Persistent effects of acute trauma on Pavlovian-to-instrumental transfer
Persistent effects of acute trauma on Pavlovian-to-instrumental transfer Open
In humans, an acutely traumatic experience can lead to post-traumatic stress disorder (PTSD), which is often characterized by changes in anxiety and motivation months after trauma. There are few demonstrations of the persistent motivationa…
View article: Effects of a cue associated with cocaine or food reinforcers on extinction and postextinction return of behavior.
Effects of a cue associated with cocaine or food reinforcers on extinction and postextinction return of behavior. Open
Studies of instrumental responding often include the delivery of a cue that is coincident with the delivery of the reinforcer. One purpose of this is for the cue to be removed during extinction and then presented later to assess whether re…
View article: Partial MHC/neuroantigen peptide constructs attenuate methamphetamine-seeking and brain chemokine (C–C motif) ligand 2 levels in rats
Partial MHC/neuroantigen peptide constructs attenuate methamphetamine-seeking and brain chemokine (C–C motif) ligand 2 levels in rats Open
View article: Involvement of the bed nucleus of the stria terminalis in initial conditioning and rapid reconditioning following extinction of contextual fear.
Involvement of the bed nucleus of the stria terminalis in initial conditioning and rapid reconditioning following extinction of contextual fear. Open
Although a great deal is known about neurobiological mechanisms of initial conditioning and extinction, relatively little is known about mechanisms involved in the return of behavior following extinction. In this article, we examine the ef…
View article: Behavioral and immunohistochemical characterization of rapid reconditioning following extinction of contextual fear
Behavioral and immunohistochemical characterization of rapid reconditioning following extinction of contextual fear Open
A fundamental property of extinction is that the behavior that is suppressed during extinction can be unmasked through a number of postextinction procedures. Of the commonly studied unmasking procedures (spontaneous recovery, reinstatement…
View article: Context-Dependent and Context-Independent Effects of D1 Receptor Antagonism in the Basolateral and Central Amygdala during Cocaine Self-Administration
Context-Dependent and Context-Independent Effects of D1 Receptor Antagonism in the Basolateral and Central Amygdala during Cocaine Self-Administration Open
One way that drugs of abuse perturb the dopamine system is by triggering large amounts of extracellular dopamine to efflux into limbic regions. The basolateral (BLA) and central (CeA) nuclei of the amygdala have been shown to play distinct…
View article: CREST in the Nucleus Accumbens Core Regulates Cocaine Conditioned Place Preference, Cocaine-Seeking Behavior, and Synaptic Plasticity
CREST in the Nucleus Accumbens Core Regulates Cocaine Conditioned Place Preference, Cocaine-Seeking Behavior, and Synaptic Plasticity Open
Epigenetic mechanisms result in persistent changes at the cellular level that can lead to long-lasting behavioral adaptations. Nucleosome remodeling is a major epigenetic mechanism that has not been well explored with regards to drug-seeki…
View article: Involvement of the dorsal hippocampus in expression and extinction of cocaine‐induced conditioned place preference
Involvement of the dorsal hippocampus in expression and extinction of cocaine‐induced conditioned place preference Open
A key aspect of substance abuse is that drug taking often occurs in a specific context. As a consequence, exposure to drug‐associated contexts can trigger cravings and relapse, even after long periods of abstinence. Although many studies h…
View article: Persistent effects of acute stress on fear and drug-seeking in a novel model of the comorbidity between post-traumatic stress disorder and addiction
Persistent effects of acute stress on fear and drug-seeking in a novel model of the comorbidity between post-traumatic stress disorder and addiction Open
Even following long periods of abstinence, individuals with anxiety disorders have high rates of relapse to drugs of abuse. Although many current models of relapse demonstrate effects of acute stress on drug-seeking, most of these studies …
View article: Reconsolidation and extinction: Using epigenetic signatures to challenge conventional wisdom
Reconsolidation and extinction: Using epigenetic signatures to challenge conventional wisdom Open
View article: Effects of D1 receptor knockout on fear and reward learning
Effects of D1 receptor knockout on fear and reward learning Open
View article: G Protein‐Gated Inwardly Rectifying Potassium Channel Subunit 3 Knock‐Out Mice Show Enhanced Ethanol Reward
G Protein‐Gated Inwardly Rectifying Potassium Channel Subunit 3 Knock‐Out Mice Show Enhanced Ethanol Reward Open
Background G protein‐gated inwardly rectifying potassium ( GIRK ) channels contribute to the effects of a number of drugs of abuse, including ethanol. However, the roles of individual subunits in the rewarding effects of ethanol are poorly…
View article: Fear conditioning in mouse lines genetically selected for binge-like ethanol drinking
Fear conditioning in mouse lines genetically selected for binge-like ethanol drinking Open
View article: Activation of D1/5 Dopamine Receptors: A Common Mechanism for Enhancing Extinction of Fear and Reward-Seeking Behaviors
Activation of D1/5 Dopamine Receptors: A Common Mechanism for Enhancing Extinction of Fear and Reward-Seeking Behaviors Open
View article: Acute Ethanol Withdrawal Impairs Contextual Learning and Enhances Cued Learning
Acute Ethanol Withdrawal Impairs Contextual Learning and Enhances Cued Learning Open
Background Alcohol affects many of the brain regions and neural processes that support learning and memory, and these effects are thought to underlie, at least in part, the development of addiction. Although much work has been done regardi…
View article: Epigenetics and memory: causes, consequences and treatments for post‐traumatic stress disorder and addiction
Epigenetics and memory: causes, consequences and treatments for post‐traumatic stress disorder and addiction Open
Understanding the interaction between fear and reward at the circuit and molecular levels has implications for basic scientific approaches to memory and for understanding the etiology of psychiatric disorders. Both stress and exposure to d…