Explanipedia

Tumor Suppressor Role of INPP4B in Chemoresistant Retinoblastoma Open

Natalia Miroschnikov, Oliver Dräger, Dario Van Meenen, K. Metz, Bettina Budeus , et al. · 2023

The chemotherapy of retinoblastoma (RB), a malignant ocular childhood disease, is often limited by the development of resistance against commonly used drugs. We identified inositol polyphosphate 4-phosphatase type II (INPP4B) as a differen…

ADAM10 and ADAM17—Novel Players in Retinoblastoma Carcinogenesis Open

Dario Van Meenen, Annika Doege, Emily Alefeld, André Haase, Manfred Beier , et al. · 2022

A disintegrin and metalloproteinase (ADAM) family proteins, acting as sheddases, are important factors in a number of pathologies, including cancer, and have been suggested as promising therapeutic targets. The study presented focuses on t…

TFF1 in Aqueous Humor—A Potential New Biomarker for Retinoblastoma Open

Maike Busch, André Haase, Natalia Miroschnikov, Annika Doege, Eva Biewald , et al. · 2022

Retinoblastoma (RB) is the most common childhood eye cancer. The expression of trefoil factor family peptide 1 (TFF1), a small secreted peptide, has been correlated with more advanced RB stages and it might be a promising new candidate as …

Long-Term Results after Intraocular Surgery in Treated Retinoblastoma Eyes Open

Philipp Rating, Norbert Bornfeld, Sabrina Schlüter, Henrike Westekemper, Tobias Kiefer , et al. · 2022

Introduction: The aim of the study was to analyze the results of intraocular surgery in treated retinoblastoma eyes and to assess the long-term results with a priority on local recurrences, secondary enucleation, and metastas…

Role of L1CAM in retinoblastoma tumorigenesis: identification of novel therapeutic targets Open

Oliver Dräger, K. Metz, Maike Busch, Nicole Dünker · 2021

The study presented focuses on the role of the neuronal cell adhesion molecule L1 cell adhesion molecule (L1CAM) in retinoblastoma (RB), the most common malignant intraocular childhood tumor. L1CAM is differentially expressed in a variety …

Impact of RARα and miR-138 on retinoblastoma etoposide resistance Open

Maike Busch, Natalia Miroschnikov, Jaroslaw Thomas Dankert, Marc Wiesehöfer, K. Metz , et al. · 2021

BACKGROUND: Retinoblastoma (RB) is the most common childhood eye cancer. Chemotherapeutic drugs such as etoposide used in RB treatment often cause massive side effects and acquired drug resistances. Dysregulated genes and miRNAs have a lar…

Eye Tumors in Childhood as First Sign of Tumor Predisposition Syndromes: Insights from an Observational Study Conducted in Germany and Austria Open

Madlen Reschke, Eva Biewald, L Bronstein, Ines B. Brecht, Sabine Dittner‐Moormann , et al. · 2021

Retinoblastoma and other eye tumors in childhood are rare diseases. Many eye tumors are the first signs of a genetic tumor predisposition syndrome and the affected children carry a higher risk of developing other cancers later in life. Cli…

Feasibility of Proton Beam Therapy as a Rescue Therapy in Heavily Pre-Treated Retinoblastoma Eyes Open

Eva Biewald, Tobias Kiefer, Dirk Geismar, Sabrina Schlüter, Anke Manthey , et al. · 2021

Despite the increased risk of subsequent primary tumors (SPTs) external beam radiation (EBRT) may be the only therapeutic option to preserve a retinoblastoma eye. Due to their physical properties, proton beam therapy (PBT) offers the possi…

Differentiating Benign from Malignant Adrenocortical Tumors by a Single Morphological Parameter—a Clinicopathological Study on 837 Adrenocortical Neoplasias Open

Martin K. Walz, K. Metz, Sarah Theurer, Cathrin Myland, Pier Francesco Alesina , et al. · 2020

Long-Term Clinical Results and Management following Vitrectomy in Undetected Retinoblastoma Eyes Open

Eva Biewald, Sabrina Schlüter, Nikolaos E. Bechrakis, Tobias Kiefer, Philipp Rating , et al. · 2020

Introduction: Given the rarity of retinoblastoma and the consequences of accidental vitrectomy in the event of misdiagnosis, reporting on clinical experience in this area is important. Objective: The aim of this…

p53, miR-34a and EMP1—Newly Identified Targets of TFF3 Signaling in Y79 Retinoblastoma Cells Open

Maike Busch, Stefan Klein, Jan Große-Kreul, Oliver Scheiner, K. Metz , et al. · 2019

Trefoil factor family peptide 3 (TFF3) is supposed to have tumor suppressive functions in retinoblastoma (RB), but the functional pathway is not completely understood. In the study presented, we investigated the downstream pathway of TFF3 …

GNAQ Q209R Mutations Are Highly Specific for Circumscribed Choroidal Hemangioma Open

Claudia Helga Dorothee Le Guin, K. Metz, Stefan Kreis, Nikolaos E. Bechrakis, Norbert Bornfeld , et al. · 2019

Several tumors, including uveal melanoma, show somatic mutations of GNAQ/GNA11. Circumscribed choroidal hemangioma is a benign tumor that becomes symptomatic in adulthood. In some patients, morphologic examination of biopsies is required f…

Chromosome 3 is a valid marker for prognostic testing of biopsy material from uveal melanoma later treated by brachytherapy Open

Claudia Helga Dorothee Le Guin, K. Metz, Nils Lehmann, Stefan Kreis, Norbert Bornfeld , et al. · 2018

Purpose: Monosomy 3 (M3) in uveal melanoma (UM) obtained after enucleation is significantly associated with metastatic death. With improved biopsy techniques, samples from patients treated with eye-preserving methods have become ava…

Reduction of the tumorigenic potential of human retinoblastoma cell lines by<i>TFF1</i>overexpression involves p53/caspase signaling and miR-18a regulation Open

Maike Busch, Jan Große-Kreul, Janina Jasmin Wirtz, Manfred Beier, Harald Stephan , et al. · 2017

Trefoil factor family (TFF) peptides have been shown to play a pivotal role in oncogenic transformation, tumorigenesis and metastasis by changing cell proliferation, apoptosis, migration and invasion behavior of various cancer cell lines. …

Intravitreales Melphalan – Eine etwas andere Herausforderung Open

S. Schlüter, E. Biewald, C. Metz, K. Metz, Norbert Bornfeld · 2016

Hintergrund: Die intravitreale Medikamentengabe stellt bei Kindern mit Retinoblastom therapeutisch die einzige Möglichkeit dar, tumorbedingte Glaskörperzellaussaat lokal zu behandeln. Hierbei spielt die operative Technik eine maßgebliche R…

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