Rukmini Mridula Kandadai
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View article: An international 20 country patient and physician survey of the usability and acceptability of Stepped Care pathway in Parkinson’s disease
An international 20 country patient and physician survey of the usability and acceptability of Stepped Care pathway in Parkinson’s disease Open
Parkinson's disease (PD) is not a single condition and has multiple heterogeneous presentations with several endophenotypes as well as collateral factors affecting care and health. However, clinical consultations globally often miss these …
View article: Conceptualizing a Personalized Care Pathway for Parkinson’s Disease Using Wearable Sensors in Muslim Patients: The Ramadan Regimen
Conceptualizing a Personalized Care Pathway for Parkinson’s Disease Using Wearable Sensors in Muslim Patients: The Ramadan Regimen Open
Parkinson's disease (PD) affects approximately 2% of individuals over the age of 60. With over two billion Muslims observing Ramadan, individuals with PD encounter specific challenges, such as deteriorating motor skills, sleep disturbances…
View article: Association of Bassoon (BSN) Gene Mutations with Gait and Motor Impairments in Parkinson's Disease
Association of Bassoon (BSN) Gene Mutations with Gait and Motor Impairments in Parkinson's Disease Open
Introduction Parkinson's Disease (PD) features debilitating motor symptoms, particularly gait and balance impairments inadequately managed by current therapies. Bassoon (BSN), a presynaptic active zone organizer, has been implicated in var…
View article: Demographic and Clinical Profiles of Parkinson's Disease in India: Observations from a Nation‐Wide Multicenter Study
Demographic and Clinical Profiles of Parkinson's Disease in India: Observations from a Nation‐Wide Multicenter Study Open
Background Parkinson's disease (PD) phenotype may vary with genetic, ethno‐geographic, cultural, and environmental factors. Objectives The aim was to develop a clinical database of PD in India and assess the influence of age‐at‐onset (AAO)…
View article: MRI-Guided Focused Ultrasound in Parkinson’s Disease and Essential Tremor: Incisionless but Invasive. A Narrative Review
MRI-Guided Focused Ultrasound in Parkinson’s Disease and Essential Tremor: Incisionless but Invasive. A Narrative Review Open
Magnetic resonance-guided focused ultrasound (MRgFUS) is an emerging and promising technology for treating movement disorders, such as essential tremors and tremor-dominant Parkinson’s disease. MRgFUS utilizes advanced ultrasound transduce…
View article: Clinical Profile and Risk Factors of Dilated Cardiomyopathy with 10 Years Follow- Up: A Study from South India
Clinical Profile and Risk Factors of Dilated Cardiomyopathy with 10 Years Follow- Up: A Study from South India Open
Introduction: Dilated cardiomyopathy (DCM) is a disease of the heart muscle, causing ventricular dilation and systolic dysfunction. Objective: To investigate the risk factors, clinical profile, mortality and long-term fellow up in dilated …
View article: Delayed Normal Pressure Hydrocephalus after Deep Brain Stimulation in Parkinson's Disease
Delayed Normal Pressure Hydrocephalus after Deep Brain Stimulation in Parkinson's Disease Open
Background Deep brain stimulation (DBS) of the bilateral subthalamic nuclei (STN) or globus pallidus internus (GPi) for Parkinson's disease (PD) and dystonia is known for its efficacy despite potential complications. Although acute complic…
View article: Deciphering the Genetic Architecture of Parkinson’s Disease in India
Deciphering the Genetic Architecture of Parkinson’s Disease in India Open
The genomic landscape of the Indian population, particularly for age-related disorders like Parkinson’s disease (PD) remains underrepresented in global research. Genetic variability in PD has been studied predominantly in European populati…
View article: Long-term safety of dexamethasone sodium phosphate encapsulated in autologous erythrocytes in pediatric patients with ataxia telangiectasia
Long-term safety of dexamethasone sodium phosphate encapsulated in autologous erythrocytes in pediatric patients with ataxia telangiectasia Open
Background Dexamethasone sodium phosphate (DSP) encapsulated in autologous erythrocytes (EryDex) was developed as an alternative to standard glucocorticoids in an effort to eliminate chronic steroid toxicity while preserving efficacy. The …
View article: Progressive Supranuclear Palsy in India: Past, Present, and Future
Progressive Supranuclear Palsy in India: Past, Present, and Future Open
Progressive supranuclear palsy (PSP) has emerged as a key area of interest among researchers worldwide, including those in India, who have actively studied the disorder over the past several decades. This review meticulously explores the e…
View article: The First cross-sectional comparative observational study of sexual dysfunction in Emirati and non-Emirati Parkinson’s disease Patients (EmPark-SD) in the UAE?
The First cross-sectional comparative observational study of sexual dysfunction in Emirati and non-Emirati Parkinson’s disease Patients (EmPark-SD) in the UAE? Open
Sexual dysfunction (SD) is common non-motor symptom in people with Parkinson’s disease (PD) yet underreported and undertreated specifically in many ethnic PD groups because of religious, social and personal perceptions. We conducted the fi…
View article: Impact of Duration of Parkinsonism and Antiparkinsonian Drugs on Coagulation Parameters in Patients with Parkinson’s Disease
Impact of Duration of Parkinsonism and Antiparkinsonian Drugs on Coagulation Parameters in Patients with Parkinson’s Disease Open
Background and Objectives: Parkinson’s disease (PD) is a neurodegenerative disorder involving depletion of dopaminergic neurons. Pathogenetic mechanisms leading to striatonigral degeneration are debatable. Chronic inflammation is proposed …
View article: Levodopa Equivalent Daily Dosage: Geographical Variations and Real‐Life Modules in Parkinson's Disease
Levodopa Equivalent Daily Dosage: Geographical Variations and Real‐Life Modules in Parkinson's Disease Open
Background The Levodopa Equivalent Daily Dosage (LEDD) calculation algorithms help in capturing and harmonization of Parkinson's Disease (PD) therapies. Analyzing these updates is essential for validating their effectiveness. Objective To …
View article: The impact of bilateral subthalamic nucleus deep brain stimulation on dyskinesia and levodopa equivalent daily dose in advanced Parkinson’s disease
The impact of bilateral subthalamic nucleus deep brain stimulation on dyskinesia and levodopa equivalent daily dose in advanced Parkinson’s disease Open
OBJECTIVE: To assess the effect of bilateral subthalamic nucleus deep brain stimulation (B/L STN DBS) on the progression of dyskinesia and the levodopa equivalent daily dose (LEDD) in advanced Parkinson’s disease (APD) patients 6 months po…
View article: Adult-Onset Neuronal Ceroid Lipofuscinosis: CLN5 Variant Presenting as Focal Dystonia
Adult-Onset Neuronal Ceroid Lipofuscinosis: CLN5 Variant Presenting as Focal Dystonia Open
Isolated focal dystonia has not been reported as an initial presentation in ANCL. Early genetic testing and periodic clinical assessments are advisable for better management and prognostication.
View article: CNS Histiocytosis- Rare Disease with An Unusual Manifestation
CNS Histiocytosis- Rare Disease with An Unusual Manifestation Open
CNS histiocytosis is a rare and debilitating disease with multiple presentations. We here present a rare case of histiocytosis in a 4 year old child manifesting with diplopia as the sole neurological symptom. The patient had only saccadic …
View article: Delayed Peri-Lead Intracerebral Hemorrhage Months after Deep Brain Stimulation: A Series of Two Patients
Delayed Peri-Lead Intracerebral Hemorrhage Months after Deep Brain Stimulation: A Series of Two Patients Open
Yaranagula, Sai Deepak; Kashyap, Manshi; Kola, Sruthi; Kandadai, Rukmini Mridula; Alugolu, Rajesh; Prasad, Vanakuru; Jasani, Garima Atulkumar; Borgohain, Rupam; Varma, Ravi Dandu Author Information
View article: The Genetic Drivers of Juvenile, Young, and Early‐Onset Parkinson's Disease in India
The Genetic Drivers of Juvenile, Young, and Early‐Onset Parkinson's Disease in India Open
Background Recent studies have advanced our understanding of the genetic drivers of Parkinson's disease (PD). Rare variants in more than 20 genes are considered causal for PD, and the latest PD genome‐wide association study (GWAS) identifi…
View article: Aceruloplasminemia with Novel Mutation, with IgG4 Related Pachymeningitis – Occam’s Razor or Hickam’s Dictum?
Aceruloplasminemia with Novel Mutation, with IgG4 Related Pachymeningitis – Occam’s Razor or Hickam’s Dictum? Open
To report a patient with concomitant aceruloplasminemia (with a novel mutation) and IgG4-related pachymeningitis and to hypothesize on the possible relation between the two diseases. Clinical, radiological, and laboratory features of a 56-…
View article: A 12-month prospective real-life study of opicapone efficacy and tolerability in Emirati and non-White subjects with Parkinson’s disease based in United Arab Emirates
A 12-month prospective real-life study of opicapone efficacy and tolerability in Emirati and non-White subjects with Parkinson’s disease based in United Arab Emirates Open
Parkinson’s disease (PD) is the second most common neurodegenerative disorder, and the condition is complicated by the emergence of wearing off/motor fluctuations with levodopa treatment after a variable period. COMT inhibitors when used a…