Kevin N. Sheth
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View article: Portable Low‐Field Magnetic Resonance Imaging in People With Human Immunodeficiency Virus
Portable Low‐Field Magnetic Resonance Imaging in People With Human Immunodeficiency Virus Open
Objective The aging population of people with HIV (PWH) raises heightened concerns regarding accelerated aging and dementia. Portable, low‐field MRI (LF‐MRI) is an innovative technology that could enhance access and facilitate routine moni…
View article: Telestroke and Timely Treatment and Outcomes in Patients With Acute Ischemic Stroke
Telestroke and Timely Treatment and Outcomes in Patients With Acute Ischemic Stroke Open
Importance Telestroke has the potential to revolutionize acute stroke treatment by improving access to optimal stroke care, including time-sensitive care such as thrombolysis. However, it is unclear how treatment times and stroke outcomes …
View article: Time to Acute Treatment in Intracerebral Hemorrhage Lags Significantly Behind Ischemic Stroke: A Multicenter, Observational Retrospective Study
Time to Acute Treatment in Intracerebral Hemorrhage Lags Significantly Behind Ischemic Stroke: A Multicenter, Observational Retrospective Study Open
BACKGROUND: Time-to-treatment goals for acute ischemic stroke (AIS) have substantially improved outcomes, yet similar metrics have not been studied in patients with intracerebral hemorrhage (ICH), where mortality rates are much higher. MET…
View article: Characterizing Stroke Clots Using Single‐Cell Sequencing
Characterizing Stroke Clots Using Single‐Cell Sequencing Open
Background Ischemic stroke results in significant morbidity and mortality. By examining gene expression of cells comprising stroke clots, we aim to gain valuable insights into the underlying mechanisms of this disease and identify potentia…
View article: Apixaban Versus Aspirin to Reduce Cognitive Decline After Cryptogenic Stroke and Atrial Cardiopathy: ARCADIA‐Cognition Study
Apixaban Versus Aspirin to Reduce Cognitive Decline After Cryptogenic Stroke and Atrial Cardiopathy: ARCADIA‐Cognition Study Open
Background ARCADIA (Atrial Cardiopathy and Antithrombotic Drugs in Prevention After Cryptogenic Stroke), a secondary stroke prevention study comparing apixaban versus aspirin for cryptogenic stroke and biomarkers of atrial cardiopathy, end…
View article: Neuroanatomical Basis of Coma in Acute Ischemic Stroke
Neuroanatomical Basis of Coma in Acute Ischemic Stroke Open
Background Acute ischemic stroke (AIS) can lead to profound disturbances in consciousness, including coma, which is associated with poor prognosis and increased mortality. Clarifying the lesion patterns that precipitate loss of consciousne…
View article: Early CSF inflammatory markers after aneurysmal subarachnoid hemorrhage and their relationship to disease severity and shunt placement
Early CSF inflammatory markers after aneurysmal subarachnoid hemorrhage and their relationship to disease severity and shunt placement Open
Within 72 hours of aSAH, proinflammatory cytokines can be detected at higher concentrations in CSF than in plasma, and at higher concentrations in aSAH patients compared to controls. Early concentrations of certain pro-inflammatory cytokin…
View article: Impact of Social Determinants of Health on Outcomes of Nontraumatic Subarachnoid Hemorrhage
Impact of Social Determinants of Health on Outcomes of Nontraumatic Subarachnoid Hemorrhage Open
Background Nontraumatic subarachnoid hemorrhage (SAH) presents a significant health burden, yet the influence of social determinants of health on outcomes remains unclear. This study examines the impact of social determinants of health on …
View article: Oral Anticoagulation following intracranial haemorrhage in patients with atrial fibrillation
Oral Anticoagulation following intracranial haemorrhage in patients with atrial fibrillation Open
Purpose: To review the current evidence on anticoagulation for intracranial haemorrhage (ICrH) survivors with atrial fibrillation (AF). Method: Narrative review of the literature. Findings: AF and ICrH are age-related conditions whose prev…
View article: Short-Term Safety and Effectiveness for Tenecteplase and Alteplase in Acute Ischemic Stroke
Short-Term Safety and Effectiveness for Tenecteplase and Alteplase in Acute Ischemic Stroke Open
Importance Tenecteplase is an alternative to alteplase for emergency treatment of acute ischemic stroke. However, limited data are available comparing their clinical effectiveness in routine clinical practice. Objective To compare short-te…
View article: Predicting White Matter Hyperintensity: Leveraging Portable MRI for Accessible Brain Health Screening
Predicting White Matter Hyperintensity: Leveraging Portable MRI for Accessible Brain Health Screening Open
The WMH risk score demonstrated accurate performance and reproducibility across cohorts, supporting its potential as a screening tool for identifying patients at risk of moderate WMH burden. Appropriately targeted pMRI screening in high-ri…
View article: Genetically-Determined Low-density Lipoprotein in Ischemic Stroke Survivors
Genetically-Determined Low-density Lipoprotein in Ischemic Stroke Survivors Open
Background and Objectives Polygenic susceptibility to hypertension and diabetes negatively impacts the clinical trajectory of ischemic stroke survivors. We hypothesize that polygenic susceptibility to hyperlipidemia (PSH) negatively impact…
View article: Genomics of diffusion-imaging integrating GWAS, exome data and single-cell sequencing unravels lifespan determinants of cerebral small vessel disease
Genomics of diffusion-imaging integrating GWAS, exome data and single-cell sequencing unravels lifespan determinants of cerebral small vessel disease Open
Peak width of skeletonized mean diffusivity (PSMD) is an emerging automated diffusion imaging marker showing clinically relevant changes in cerebral small vessel disease (cSVD), a leading cause of stroke and dementia with no mechanism-base…
View article: Spatial Correlates of Dementia and Disability After Intracerebral Hemorrhage
Spatial Correlates of Dementia and Disability After Intracerebral Hemorrhage Open
Background Dementia and disability are highly prevalent after spontaneous intracerebral hemorrhage (ICH). Previous studies categorizing ICH by large anatomic boundaries have demonstrated that lobar ICH is associated with dementia, while IC…
View article: Characterizing Stroke Clots Using Single-Cell Sequencing
Characterizing Stroke Clots Using Single-Cell Sequencing Open
Background Ischemic stroke result in significant morbidity and mortality. By examining gene expression of cells comprising stroke clots, we aim to gain valuable insights into the underlying mechanisms of this disease and identify potential…
View article: Improving the Robustness of Deep Learning Models in Predicting Hematoma Expansion from Admission Head CT
Improving the Robustness of Deep Learning Models in Predicting Hematoma Expansion from Admission Head CT Open
Adversarial training and inclusion of threshold-based segmentation as an additional input can improve deep learning model robustness in prediction of HE from admission head CTs in acute ICH.
View article: Detecting Patterns of Atrophy in Cognitively Impaired Individuals Using Portable, Low-Field MRI
Detecting Patterns of Atrophy in Cognitively Impaired Individuals Using Portable, Low-Field MRI Open
Low-field MRI (LF-MRI) is an emerging neuroimaging approach for evaluating patients with dementia, offering greater accessibility and lower cost, albeit with reduced image resolution. In this study, we deployed LF-MRI in an outpatient clin…
View article: Optimizing Automated Hematoma Expansion Classification from Baseline and Follow-Up Head Computed Tomography
Optimizing Automated Hematoma Expansion Classification from Baseline and Follow-Up Head Computed Tomography Open
Hematoma expansion (HE) is an independent predictor of poor outcomes and a modifiable treatment target in intracerebral hemorrhage (ICH). Evaluating HE in large datasets requires segmentation of hematomas on admission and follow-up CT scan…
View article: Intracerebral Hemorrhage Outcomes after Reversal of Subtherapeutic Warfarin: Analysis of Data from GWTG-Stroke
Intracerebral Hemorrhage Outcomes after Reversal of Subtherapeutic Warfarin: Analysis of Data from GWTG-Stroke Open
Background Current guidelines recommend reversal of warfarin anticoagulation with intracranial hemorrhages. The benefit of reversing subtherapeutic warfarin anticoagulation in acute spontaneous intracerebral hemorrhage (ICH) is uncertain. …
View article: Lipid‐Lowering Therapy Use When Indicated and Subsequent Ischemic Stroke Severity
Lipid‐Lowering Therapy Use When Indicated and Subsequent Ischemic Stroke Severity Open
Background Elevated low‐density lipoprotein cholesterol is a risk factor for atherosclerotic cardiovascular disease, including acute ischemic stroke (AIS), due to large‐ and small‐vessel disease. Cholesterol management guidelines recommend…
View article: Machine Learning Models for 3-Month Outcome Prediction Using Radiomics of Intracerebral Hemorrhage and Perihematomal Edema from Admission Head Computed Tomography (CT)
Machine Learning Models for 3-Month Outcome Prediction Using Radiomics of Intracerebral Hemorrhage and Perihematomal Edema from Admission Head Computed Tomography (CT) Open
Background: Intracerebral hemorrhages (ICH) and perihematomal edema (PHE) are respective imaging markers of primary and secondary brain injury in hemorrhagic stroke. In this study, we explored the potential added value of PHE radiomic feat…
View article: A Hybrid Transformer-Convolutional Neural Network for Segmentation of Intracerebral Hemorrhage and Perihematomal Edema on Non-Contrast Head Computed Tomography (CT) with Uncertainty Quantification to Improve Confidence
A Hybrid Transformer-Convolutional Neural Network for Segmentation of Intracerebral Hemorrhage and Perihematomal Edema on Non-Contrast Head Computed Tomography (CT) with Uncertainty Quantification to Improve Confidence Open
Intracerebral hemorrhage (ICH) and perihematomal edema (PHE) are key imaging markers of primary and secondary brain injury in hemorrhagic stroke. Accurate segmentation and quantification of ICH and PHE can help with prognostication and gui…
View article: Portable, low-field magnetic resonance imaging for evaluation of Alzheimer’s disease
Portable, low-field magnetic resonance imaging for evaluation of Alzheimer’s disease Open
Portable, low-field magnetic resonance imaging (LF-MRI) of the brain may facilitate point-of-care assessment of patients with Alzheimer's disease (AD) in settings where conventional MRI cannot. However, image quality is limited by a lower …
View article: Polygenic Risk of Epilepsy and Poststroke Epilepsy
Polygenic Risk of Epilepsy and Poststroke Epilepsy Open
BACKGROUND: Epilepsy is highly heritable, with numerous known genetic risk loci. However, the genetic predisposition’s role in poststroke epilepsy (PSE) remains understudied. This study assesses whether a higher genetic predisposition to e…
View article: Sex Modifies the Severity and Outcome of Spontaneous Intracerebral Hemorrhage
Sex Modifies the Severity and Outcome of Spontaneous Intracerebral Hemorrhage Open
Objective The limited existing evidence on sex differences in the clinical characteristics of patients with spontaneous, non‐traumatic intracerebral hemorrhage (ICH) comes from small, single‐center studies. Here, we performed an individual…
View article: Life's Essential 8 and Poor Brain Health Outcomes in Middle-Aged Adults
Life's Essential 8 and Poor Brain Health Outcomes in Middle-Aged Adults Open
Among middle-aged adults enrolled in 2 large population studies, poor cardiovascular health profiles were associated with two-fold higher risk of developing a composite outcome that captures the most important diseases related to poor brai…
View article: Twenty Years of Sustained Improvement in Quality of Care and Outcomes for Patients Hospitalized With Stroke or Transient Ischemic Attack: Data From The Get With The Guidelines-Stroke Program
Twenty Years of Sustained Improvement in Quality of Care and Outcomes for Patients Hospitalized With Stroke or Transient Ischemic Attack: Data From The Get With The Guidelines-Stroke Program Open
BACKGROUND: The Get With The Guidelines-Stroke program is a quality improvement initiative designed to enhance adherence to evidence-based stroke care. Since its inception in 2003, over 2800 hospitals in the United States have participated…
View article: The human claustrum tracks slow waves during sleep
The human claustrum tracks slow waves during sleep Open
Slow waves are a distinguishing feature of non-rapid-eye-movement (NREM) sleep, an evolutionarily conserved process critical for brain function. Non-human studies suggest that the claustrum, a small subcortical nucleus, coordinates slow wa…