Kenichi Nishiyama
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View article: A Case of Laparoscopically Assisted Resection of a Large Mesenteric Lymphangioma with Acute Generalized Peritonitis
A Case of Laparoscopically Assisted Resection of a Large Mesenteric Lymphangioma with Acute Generalized Peritonitis Open
View article: Comprehensive Analysis of Stability and Variability of DNA Minimal I-Motif Structures
Comprehensive Analysis of Stability and Variability of DNA Minimal I-Motif Structures Open
Cytosine-rich DNA sequences form i-motif structures associated with various cellular functions including gene regulation. DNA sequences containing consecutive C residues are widely deemed essential for i-motif formation; however, some sequ…
View article: Subsurface Pleistocene chronostratigraphy in the coastal area of the southeastern Tokushima Plain, southwestern Japan
Subsurface Pleistocene chronostratigraphy in the coastal area of the southeastern Tokushima Plain, southwestern Japan Open
View article: Membrane tubulation induced by a bacterial glycolipid
Membrane tubulation induced by a bacterial glycolipid Open
Membrane protein integrase (MPIase) is a glycolipid found in Escherichia coli cell membranes. It consists of diacylglycerol and a sugar chain comprising approximately 10 repeating trisaccharide units, made up of three types of N-acetylated…
View article: YibN, a bona fide interactor of the bacterial YidC insertase with effects on membrane protein insertion and membrane lipid production
YibN, a bona fide interactor of the bacterial YidC insertase with effects on membrane protein insertion and membrane lipid production Open
YidC, a prominent member of the Oxa1 superfamily, is essential for the biogenesis of the bacterial inner membrane, significantly influencing its protein composition and lipid organization. It interacts with the Sec translocon, aiding the p…
View article: Intraventricular Pilocytic Astrocytoma in a 75-Year-Old Adult Patient: A Case Report
Intraventricular Pilocytic Astrocytoma in a 75-Year-Old Adult Patient: A Case Report Open
View article: Tectonic Control on Incised-Valley Geometry: Late Pleistocene Examples Along the Longest Active Fault in Japan
Tectonic Control on Incised-Valley Geometry: Late Pleistocene Examples Along the Longest Active Fault in Japan Open
View article: YibN, a bona fide interactor of YidC with implications in membrane protein insertion and membrane lipid production
YibN, a bona fide interactor of YidC with implications in membrane protein insertion and membrane lipid production Open
YidC, a prominent member of the Oxa1 superfamily, is essential for the biogenesis of the bacterial inner membrane, significantly influencing its protein composition and lipid organization. It interacts with the Sec translocon, aiding the p…
View article: Genetic profiles and clinical features in subcutaneous panniculitis‐like T‐cell lymphomas
Genetic profiles and clinical features in subcutaneous panniculitis‐like T‐cell lymphomas Open
Subcutaneous panniculitis‐like T‐cell lymphoma (SPTCL) is a rare peripheral T‐cell lymphoma characterized by cutaneous lesions and immunologic manifestations. The five‐year survival rate of SPTCL has been reported to be over 80%, indicatin…
View article: MucA is a small peptide encoded by an overlapping sequence with cdsA that upregulates the biosynthesis of glycolipid MPIase in the cold
MucA is a small peptide encoded by an overlapping sequence with cdsA that upregulates the biosynthesis of glycolipid MPIase in the cold Open
MPIase is a glycolipid involved in protein insertion into and preprotein translocation across the cytoplasmic membranes of E. coli. MPIase is upregulated in the cold conditions to overcome the cold-sensitive protein export. CdsA, a CDP-dia…
View article: Renal Failure Without Hemodialysis Is a Risk Factor for Postoperative Complications in Colorectal Cancer Surgery
Renal Failure Without Hemodialysis Is a Risk Factor for Postoperative Complications in Colorectal Cancer Surgery Open
Background/Aim: Surgical outcomes of colorectal cancer (CRC) in patients with renal failure (RF) remain to be clarified. The objective of this research was to investigate how RF impacts the surgical outcomes in patients with CRC. Patients …
View article: <scp>CdsA</scp>, a <scp>CDP</scp>‐diacylglycerol synthase involved in phospholipid and glycolipid <scp>MPIase</scp> biosynthesis, possesses multiple initiation codons
<span>CdsA</span>, a <span>CDP</span>‐diacylglycerol synthase involved in phospholipid and glycolipid <span>MPIase</span> biosynthesis, possesses multiple initiation codons Open
CdsA is a CDP‐diacylglycerol synthase essential for phospholipid and glycolipid MPIase biosynthesis, and therefore for growth. The initiation codon of CdsA has been assigned as “TTG,” while methionine at the 37th codon was reported to be a…
View article: Key contributions of a glycolipid to membrane protein integration
Key contributions of a glycolipid to membrane protein integration Open
Regulation of membrane protein integration involves molecular devices such as Sec-translocons or the insertase YidC. We have identified an integration-promoting factor in the inner membrane of Escherichia coli called membrane protein integ…
View article: Hysterectomy through Minimally Invasive Surgery for Cervical High-grade Intraepithelial Neoplasia: Reassessment of the Specimens’ Eligibility for Histological Examination
Hysterectomy through Minimally Invasive Surgery for Cervical High-grade Intraepithelial Neoplasia: Reassessment of the Specimens’ Eligibility for Histological Examination Open
Objectives: The objective was to investigate the microscopic artifacts made in the uterus of cervical high-grade squamous intraepithelial lesion (HSIL) resected by hysterectomy through minimally invasive (H-MI) procedures and to verify whe…
View article: Supplementary Figure 1 from Prognostic Significance of AKT/mTOR and MAPK Pathways and Antitumor Effect of mTOR Inhibitor in NF1-Related and Sporadic Malignant Peripheral Nerve Sheath Tumors
Supplementary Figure 1 from Prognostic Significance of AKT/mTOR and MAPK Pathways and Antitumor Effect of mTOR Inhibitor in NF1-Related and Sporadic Malignant Peripheral Nerve Sheath Tumors Open
PDF file - 328K, A case of MPNST (left) arising from neurofibroma (right) in patients with neurofibromatosis type 1. Most MPNST cells are positive for p-AKT, p-mTOR, p-S6RP, p-p70S6K, and p-4E-BP1. Meanwhile, most tumor cells in the neurof…
View article: Supplementary Figure 3 from Prognostic Significance of AKT/mTOR and MAPK Pathways and Antitumor Effect of mTOR Inhibitor in NF1-Related and Sporadic Malignant Peripheral Nerve Sheath Tumors
Supplementary Figure 3 from Prognostic Significance of AKT/mTOR and MAPK Pathways and Antitumor Effect of mTOR Inhibitor in NF1-Related and Sporadic Malignant Peripheral Nerve Sheath Tumors Open
PDF file - 182K, The Kaplan-Meier curves for overall survival according to p-p70S6K, p-4E-BP1, p-MEK1/2, and p-ERK1/2 expressions. Immunoreactivity for p-p70S6K, p-4E-BP1, p-MEK1/2, and p-ERK1/2 fails to show a significant difference in ov…
View article: Supplementary Table 1 from Prognostic Significance of AKT/mTOR and MAPK Pathways and Antitumor Effect of mTOR Inhibitor in NF1-Related and Sporadic Malignant Peripheral Nerve Sheath Tumors
Supplementary Table 1 from Prognostic Significance of AKT/mTOR and MAPK Pathways and Antitumor Effect of mTOR Inhibitor in NF1-Related and Sporadic Malignant Peripheral Nerve Sheath Tumors Open
XLSX file - 9K, A comparison of p-Akt, p-mTOR, p-S6RP, p-p70S6K and p-4E-BP1 expression results in all specimens
View article: Supplementary Figure Legend from Prognostic Significance of AKT/mTOR and MAPK Pathways and Antitumor Effect of mTOR Inhibitor in NF1-Related and Sporadic Malignant Peripheral Nerve Sheath Tumors
Supplementary Figure Legend from Prognostic Significance of AKT/mTOR and MAPK Pathways and Antitumor Effect of mTOR Inhibitor in NF1-Related and Sporadic Malignant Peripheral Nerve Sheath Tumors Open
PDF file - 72K
View article: Supplementary Figure 1 from Prognostic Significance of AKT/mTOR and MAPK Pathways and Antitumor Effect of mTOR Inhibitor in NF1-Related and Sporadic Malignant Peripheral Nerve Sheath Tumors
Supplementary Figure 1 from Prognostic Significance of AKT/mTOR and MAPK Pathways and Antitumor Effect of mTOR Inhibitor in NF1-Related and Sporadic Malignant Peripheral Nerve Sheath Tumors Open
PDF file - 328K, A case of MPNST (left) arising from neurofibroma (right) in patients with neurofibromatosis type 1. Most MPNST cells are positive for p-AKT, p-mTOR, p-S6RP, p-p70S6K, and p-4E-BP1. Meanwhile, most tumor cells in the neurof…
View article: Supplementary Table 2 from Prognostic Significance of AKT/mTOR and MAPK Pathways and Antitumor Effect of mTOR Inhibitor in NF1-Related and Sporadic Malignant Peripheral Nerve Sheath Tumors
Supplementary Table 2 from Prognostic Significance of AKT/mTOR and MAPK Pathways and Antitumor Effect of mTOR Inhibitor in NF1-Related and Sporadic Malignant Peripheral Nerve Sheath Tumors Open
XLSX file - 9K, Multiivariate analysis for overall survival with p-AKT expression
View article: Supplementary Figure Legend from Prognostic Significance of AKT/mTOR and MAPK Pathways and Antitumor Effect of mTOR Inhibitor in NF1-Related and Sporadic Malignant Peripheral Nerve Sheath Tumors
Supplementary Figure Legend from Prognostic Significance of AKT/mTOR and MAPK Pathways and Antitumor Effect of mTOR Inhibitor in NF1-Related and Sporadic Malignant Peripheral Nerve Sheath Tumors Open
PDF file - 72K
View article: Supplementary Figure 5 from Prognostic Significance of AKT/mTOR and MAPK Pathways and Antitumor Effect of mTOR Inhibitor in NF1-Related and Sporadic Malignant Peripheral Nerve Sheath Tumors
Supplementary Figure 5 from Prognostic Significance of AKT/mTOR and MAPK Pathways and Antitumor Effect of mTOR Inhibitor in NF1-Related and Sporadic Malignant Peripheral Nerve Sheath Tumors Open
PDF file - 3331K, Representative examples of Everolimus-induced change in the activation of the AKT/mTOR and MAPK pathways assessed by immunocytochemistry. Decreased p-S6RP and p-p70S6K expressions by Everolimus (30 nM, a dose achievable i…
View article: Supplementary Figure 2 from Prognostic Significance of AKT/mTOR and MAPK Pathways and Antitumor Effect of mTOR Inhibitor in NF1-Related and Sporadic Malignant Peripheral Nerve Sheath Tumors
Supplementary Figure 2 from Prognostic Significance of AKT/mTOR and MAPK Pathways and Antitumor Effect of mTOR Inhibitor in NF1-Related and Sporadic Malignant Peripheral Nerve Sheath Tumors Open
PDF file - 268K, Western blotting (WB) for p-AKT, (total) AKT, p-mTOR, (total) mTOR, p-S6RP, p-p70S6K, p-MEK1/2, and p-ERK1/2 using frozen tumor samples and corresponding normal tissue. Positive or negative staining (P: positive; N: negati…
View article: Supplementary Figure 4 from Prognostic Significance of AKT/mTOR and MAPK Pathways and Antitumor Effect of mTOR Inhibitor in NF1-Related and Sporadic Malignant Peripheral Nerve Sheath Tumors
Supplementary Figure 4 from Prognostic Significance of AKT/mTOR and MAPK Pathways and Antitumor Effect of mTOR Inhibitor in NF1-Related and Sporadic Malignant Peripheral Nerve Sheath Tumors Open
PDF file - 385K, Everolimus-induced change in the activation status of the AKT/mTOR and MAPK pathways evaluated by Western blotting. Decreased p-S6RP and p-p70S6K expressions by Everolimus (30 nM, a dose achievable in humans by oral admini…
View article: Supplementary Figure 3 from Prognostic Significance of AKT/mTOR and MAPK Pathways and Antitumor Effect of mTOR Inhibitor in NF1-Related and Sporadic Malignant Peripheral Nerve Sheath Tumors
Supplementary Figure 3 from Prognostic Significance of AKT/mTOR and MAPK Pathways and Antitumor Effect of mTOR Inhibitor in NF1-Related and Sporadic Malignant Peripheral Nerve Sheath Tumors Open
PDF file - 182K, The Kaplan-Meier curves for overall survival according to p-p70S6K, p-4E-BP1, p-MEK1/2, and p-ERK1/2 expressions. Immunoreactivity for p-p70S6K, p-4E-BP1, p-MEK1/2, and p-ERK1/2 fails to show a significant difference in ov…
View article: Supplementary Figure 2 from Prognostic Significance of AKT/mTOR and MAPK Pathways and Antitumor Effect of mTOR Inhibitor in NF1-Related and Sporadic Malignant Peripheral Nerve Sheath Tumors
Supplementary Figure 2 from Prognostic Significance of AKT/mTOR and MAPK Pathways and Antitumor Effect of mTOR Inhibitor in NF1-Related and Sporadic Malignant Peripheral Nerve Sheath Tumors Open
PDF file - 268K, Western blotting (WB) for p-AKT, (total) AKT, p-mTOR, (total) mTOR, p-S6RP, p-p70S6K, p-MEK1/2, and p-ERK1/2 using frozen tumor samples and corresponding normal tissue. Positive or negative staining (P: positive; N: negati…
View article: Data from Prognostic Significance of AKT/mTOR and MAPK Pathways and Antitumor Effect of mTOR Inhibitor in NF1-Related and Sporadic Malignant Peripheral Nerve Sheath Tumors
Data from Prognostic Significance of AKT/mTOR and MAPK Pathways and Antitumor Effect of mTOR Inhibitor in NF1-Related and Sporadic Malignant Peripheral Nerve Sheath Tumors Open
Purpose: Malignant peripheral nerve sheath tumor (MPNST) is a rare soft tissue sarcoma with poor prognosis. MPNSTs occur frequently in patients with neurofibromatosis type 1 (NF1), in which NF1 gene deficiency leads to Ras hy…
View article: Supplementary Figure 5 from Prognostic Significance of AKT/mTOR and MAPK Pathways and Antitumor Effect of mTOR Inhibitor in NF1-Related and Sporadic Malignant Peripheral Nerve Sheath Tumors
Supplementary Figure 5 from Prognostic Significance of AKT/mTOR and MAPK Pathways and Antitumor Effect of mTOR Inhibitor in NF1-Related and Sporadic Malignant Peripheral Nerve Sheath Tumors Open
PDF file - 3331K, Representative examples of Everolimus-induced change in the activation of the AKT/mTOR and MAPK pathways assessed by immunocytochemistry. Decreased p-S6RP and p-p70S6K expressions by Everolimus (30 nM, a dose achievable i…
View article: Data from Prognostic Significance of AKT/mTOR and MAPK Pathways and Antitumor Effect of mTOR Inhibitor in NF1-Related and Sporadic Malignant Peripheral Nerve Sheath Tumors
Data from Prognostic Significance of AKT/mTOR and MAPK Pathways and Antitumor Effect of mTOR Inhibitor in NF1-Related and Sporadic Malignant Peripheral Nerve Sheath Tumors Open
Purpose: Malignant peripheral nerve sheath tumor (MPNST) is a rare soft tissue sarcoma with poor prognosis. MPNSTs occur frequently in patients with neurofibromatosis type 1 (NF1), in which NF1 gene deficiency leads to Ras hy…
View article: Supplementary Table 1 from Prognostic Significance of AKT/mTOR and MAPK Pathways and Antitumor Effect of mTOR Inhibitor in NF1-Related and Sporadic Malignant Peripheral Nerve Sheath Tumors
Supplementary Table 1 from Prognostic Significance of AKT/mTOR and MAPK Pathways and Antitumor Effect of mTOR Inhibitor in NF1-Related and Sporadic Malignant Peripheral Nerve Sheath Tumors Open
XLSX file - 9K, A comparison of p-Akt, p-mTOR, p-S6RP, p-p70S6K and p-4E-BP1 expression results in all specimens