K. Schellander
YOU?
Author Swipe
View article: Comparative transcriptome analysis of bovine blastocysts reveals specific effects of the oocyte source and the environments during maturation and early embryo development
Comparative transcriptome analysis of bovine blastocysts reveals specific effects of the oocyte source and the environments during maturation and early embryo development Open
Background Although differences between in vivo and in vitro derived bovine blastocysts in terms of global gene expression profiles have been reported, comparative transcriptome analyses specifically addressing the sustained impact of the …
View article: Functional COPA is indispensable for early embryo development beyond major genome activation in bovines
Functional COPA is indispensable for early embryo development beyond major genome activation in bovines Open
Embryonic genome activation is divided into a minor and a major wave of transition to endogenous transcription. In bovines, minor genome activation begins early in the 2-cell stage and is completed by the 8-cell stage when major genome act…
View article: Mitochondrial bioenergetic profiles of warmed bovine blastocysts are typically altered after cryopreservation by slow freezing and vitrification
Mitochondrial bioenergetic profiles of warmed bovine blastocysts are typically altered after cryopreservation by slow freezing and vitrification Open
The widespread use of cryopreserved in vitro produced (IVP) bovine embryos is limited due to their low post-warming viability compared to their ex vivo derived counterparts. Therefore, the present study aimed to analyse in detail the conse…
View article: Genetic parameters of immune traits for Landrace and Large White pig breeds
Genetic parameters of immune traits for Landrace and Large White pig breeds Open
Improving the immunocompetence towards pathogens represents a desirable objective of breeding strategies to increase resilience. However, the immune system is complex and the genetic foundation of the underlying components is not yet clari…
View article: The cell cycle stage of bovine zygotes electroporated with CRISPR/Cas9-RNP affects frequency of Loss-of-heterozygosity editing events
The cell cycle stage of bovine zygotes electroporated with CRISPR/Cas9-RNP affects frequency of Loss-of-heterozygosity editing events Open
At the embryonic level, CRISPR technologies have been used to edit genomes reliably and efficiently in various mammalian models, with Ribonucleoprotein (RNP) electroporation potentially representing a superior delivery method into mammalia…
View article: Sulforaphane Enhanced Proliferation of Porcine Satellite Cells via Epigenetic Augmentation of SMAD7
Sulforaphane Enhanced Proliferation of Porcine Satellite Cells via Epigenetic Augmentation of SMAD7 Open
Satellite cells take an indispensable place in skeletal muscle regeneration, maintenance, and growth. However, only limited works have investigated effects of dietary compounds on the proliferation of porcine satellite cells (PSCs) and rel…
View article: Oregano essential oil showed limited effects on pigs' carcass quality and haematology whereas a transcriptome analysis revealed significant modulations in the jejunum and the ileum
Oregano essential oil showed limited effects on pigs' carcass quality and haematology whereas a transcriptome analysis revealed significant modulations in the jejunum and the ileum Open
Pig production depends on a health and performance balance. An approach to improve intestinal health is the oregano essential oil (OEO) supplementation within a conventional diet. Intestinal integrity regulating effects, for example gene e…
View article: Genome-wide associations for immune traits in two maternal pig lines
Genome-wide associations for immune traits in two maternal pig lines Open
Background In recent years, animal welfare and health has become more and more important in pig breeding. So far, numerous parameters have been considered as important biomarkers, especially in the immune reaction and inflammation. Previou…
View article: Epigenetic Modulation of TLR4 Expression by Sulforaphane Increases Anti-Inflammatory Capacity in Porcine Monocyte-Derived Dendritic Cells
Epigenetic Modulation of TLR4 Expression by Sulforaphane Increases Anti-Inflammatory Capacity in Porcine Monocyte-Derived Dendritic Cells Open
Inflammation is regulated by epigenetic modifications, including DNA methylation and histone acetylation. Sulforaphane (SFN), a histone deacetylase (HDAC) inhibitor, is also a potent immunomodulatory agent, but its anti-inflammatory functi…
View article: NRF2-mediated signaling is a master regulator of transcription factors in bovine granulosa cells under oxidative stress condition
NRF2-mediated signaling is a master regulator of transcription factors in bovine granulosa cells under oxidative stress condition Open
Transcription factors (TFs) are known to be involved in regulating the expression of several classes of genes during folliculogenesis. However, the regulatory role of TFs during oxidative stress (OS) is not fully understood. The current st…
View article: Endocrine Fertility Parameters—Genomic Background and Their Genetic Relationship to Boar Taint in German Landrace and Large White
Endocrine Fertility Parameters—Genomic Background and Their Genetic Relationship to Boar Taint in German Landrace and Large White Open
The surgical castration of young male piglets without anesthesia is no longer allowed in Germany from 2021. One alternative is breeding against boar taint, but shared synthesis pathways of androstenone (AND) and several endocrine fertility…
View article: Additional file 4 of The global gene expression outline of the bovine blastocyst: reflector of environmental conditions and predictor of developmental capacity
Additional file 4 of The global gene expression outline of the bovine blastocyst: reflector of environmental conditions and predictor of developmental capacity Open
Additional file 4: Table S1. The list of differentially expressed genes between CVO and NVO. Table S2. The list of differentially expressed genes between CVT and NVT. Table S3. Significant molecular functions enriched by differentially exp…
View article: Additional file 1 of Identification of expression QTL (eQTL) of genes expressed in porcine M. longissimus dorsi and associated with meat quality traits
Additional file 1 of Identification of expression QTL (eQTL) of genes expressed in porcine M. longissimus dorsi and associated with meat quality traits Open
Additional file 1: eQTL detected for probe-sets representing transcripts that are expressed in porcine M. longissimus dorsi. All 9,180 eQTL (at LOD score > 2) estimated for probe-sets of the Affymetrix Porcine Genome Array, their position …
View article: Additional file 2 of Genome-wide associations for immune traits in two maternal pig lines
Additional file 2 of Genome-wide associations for immune traits in two maternal pig lines Open
Additional file 2 Complete GWAS results in Large White. Significant SNPs in Large White associated with immune relevant traits identified by GWAS. MCHC: Mean corpuscular haemoglobin concentration, IFN: Interferon, IL: Interleukin, TNF: Tum…
View article: Additional file of Identification of expression QTL (eQTL) of genes expressed in porcine M. longissimus dorsi and associated with meat quality traits
Additional file of Identification of expression QTL (eQTL) of genes expressed in porcine M. longissimus dorsi and associated with meat quality traits Open
Additional file of Identification of expression QTL (eQTL) of genes expressed in porcine M. longissimus dorsi and associated with meat quality traits
View article: Additional file 1 of Genome-wide associations for immune traits in two maternal pig lines
Additional file 1 of Genome-wide associations for immune traits in two maternal pig lines Open
Additional file 1 Complete GWAS results in Landrace. Significant SNPs in Landrace associated with immune relevant traits identified by GWAS. MCHC: Mean corpuscular haemoglobin concentration, IL: Interleukin, SSC: Sus Scrofa Chromosome, MAF…
View article: Genomic background and genetic relationships between boar taint and fertility traits in German Landrace and Large White
Genomic background and genetic relationships between boar taint and fertility traits in German Landrace and Large White Open
Background Due to ethical reasons, surgical castration of young male piglets in their first week of life without anesthesia will be banned in Germany from 2021. Breeding against boar taint is already implemented in sire breeds of breeding …
View article: European Joint Doctorates: myth or reality?
European Joint Doctorates: myth or reality? Open
Today, there is a lack of consensus for the full implementation of common programmes recognizing the “highest” level of higher education in Europe. Even though cotuttelle agreements are widely used for international joint supervision of Ph…
View article: Quercetin supports bovine preimplantation embryo development under oxidative stress condition via activation of the Nrf2 signalling pathway
Quercetin supports bovine preimplantation embryo development under oxidative stress condition via activation of the Nrf2 signalling pathway Open
Nrf2 is a master regulator for antioxidant machinery against oxidative stress in bovine preimplantation embryos. The endogenous or exogenous modulation of Nrf2‐KEAP1 system in bovine embryos may contribute to the understanding of the mecha…
View article: Regulation of Nrf2 and NF-κB during lead toxicity in bovine granulosa cells
Regulation of Nrf2 and NF-κB during lead toxicity in bovine granulosa cells Open
Lead (Pb), one of the pervasive and protracted environmental heavy metals, is believed to affect the female reproductive system in many species. The Nrf2 and NF-κB are the two key transcriptional factors regulating cellular redox status an…
View article: Metabolism-associated genome-wide epigenetic changes in bovine oocytes during early lactation
Metabolism-associated genome-wide epigenetic changes in bovine oocytes during early lactation Open
Dietary intake in early lactating cows is outmatched by milk production. These cows experience a negative energy balance, resulting in a distinct blood metabolism and poor reproductive function due to impaired ovulation and increased embry…
View article: Additional file of Transcriptome dynamics and molecular cross-talk between bovine oocyte and its companion cumulus cells
Additional file of Transcriptome dynamics and molecular cross-talk between bovine oocyte and its companion cumulus cells Open
Additional file of Transcriptome dynamics and molecular cross-talk between bovine oocyte and its companion cumulus cells
View article: Additional file of Transcriptome dynamics and molecular cross-talk between bovine oocyte and its companion cumulus cells
Additional file of Transcriptome dynamics and molecular cross-talk between bovine oocyte and its companion cumulus cells Open
Additional file of Transcriptome dynamics and molecular cross-talk between bovine oocyte and its companion cumulus cells