Robert K. Shepherd
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View article: #2961 DMX-200 does not induce a haemodynamic effect or an acute change in GFR and has a strong cardiovascular safety profile
#2961 DMX-200 does not induce a haemodynamic effect or an acute change in GFR and has a strong cardiovascular safety profile Open
Background and Aims Focal segmental glomerulosclerosis (FSGS) is a major cause of glomerular disease that affects both adults and children and can rapidly progress to end-stage kidney disease. Lack of safe and effective treatment represent…
View article: #296 A mid-study update on the ACTION3 pivotal Phase 3 trial assessing DMX-200 in patients with focal segmental glomerulosclerosis (FSGS)
#296 A mid-study update on the ACTION3 pivotal Phase 3 trial assessing DMX-200 in patients with focal segmental glomerulosclerosis (FSGS) Open
Background and Aims Focal segmental glomerulosclerosis (FSGS) is a major cause of glomerular disease that can rapidly progress to end-stage kidney disease. Lack of safe and effective treatment represents a significant unmet need for patien…
View article: #2953 DMX-200 is effective in reducing urine monocyte chemoattractant protein 1 (MCP-1) levels in patients with FSGS without affecting plasma MCP-1 concentration
#2953 DMX-200 is effective in reducing urine monocyte chemoattractant protein 1 (MCP-1) levels in patients with FSGS without affecting plasma MCP-1 concentration Open
Background and Aims Focal segmental glomerulosclerosis (FSGS) is a major cause of glomerular disease that affects both adults and children and can rapidly progress to end-stage kidney disease. Lack of safe and effective treatment represent…
View article: Biopsychology Lab: COMT Genotype Associations with Vagal Tone and Frontal Alpha Asymmetry
Biopsychology Lab: COMT Genotype Associations with Vagal Tone and Frontal Alpha Asymmetry Open
Course-based undergraduate research experiences (CUREs) engage students in the research process to promote active learning of complex material. We created a 5-week Biopsychology Laboratory (Biopsych) CURE that integrates concepts in geneti…
View article: Gene Electrotransfer via Conductivity‐Clamped Electric Field Focusing Pivots Sensori‐Motor DNA Therapeutics: “A Spoonful of Sugar Helps the Medicine Go Down” (Adv. Sci. 30/2024)
Gene Electrotransfer via Conductivity‐Clamped Electric Field Focusing Pivots Sensori‐Motor DNA Therapeutics: “A Spoonful of Sugar Helps the Medicine Go Down” (Adv. Sci. 30/2024) Open
Vector‐Free Gene Augmentation Therapy In article number 2401392, Jeremy L. Pinyon, Gary D. Housley, and coworkers describe ‘conductivityclamped’ gene electrotransfer (CC‐GET) which broadly enables vector‐free nucleic acid therapeutics. In …
View article: Gene Electrotransfer via Conductivity‐Clamped Electric Field Focusing Pivots Sensori‐Motor DNA Therapeutics: “A Spoonful of Sugar Helps the Medicine Go Down”
Gene Electrotransfer via Conductivity‐Clamped Electric Field Focusing Pivots Sensori‐Motor DNA Therapeutics: “A Spoonful of Sugar Helps the Medicine Go Down” Open
Viral vectors and lipofection‐based gene therapies have dispersion‐dependent transduction/transfection profiles that thwart precise targeting. The study describes the development of focused close‐field gene electrotransfer (GET) technology…
View article: A Second-Generation (44-Channel) Suprachoroidal Retinal Prosthesis: A Single-Arm Clinical Trial of Feasibility
A Second-Generation (44-Channel) Suprachoroidal Retinal Prosthesis: A Single-Arm Clinical Trial of Feasibility Open
Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.
View article: #1166 ACTION3 pivotal Phase 3 & open-label extension study assessing DMX-200 in adult & paediatric patients with focal segmental glomerulosclerosis (FSGS)
#1166 ACTION3 pivotal Phase 3 & open-label extension study assessing DMX-200 in adult & paediatric patients with focal segmental glomerulosclerosis (FSGS) Open
Background and Aims Focal segmental glomerulosclerosis (FSGS) is a major cause of glomerular disease that affects both adults and children. FSGS can rapidly progress to end-stage kidney disease. Lack of safe and effective treatment represe…
View article: WCN24-1132 ACTION3 – Phase 3 study of DMX-200 for the treatment of focal segmental glomerulosclerosis (FSGS)
WCN24-1132 ACTION3 – Phase 3 study of DMX-200 for the treatment of focal segmental glomerulosclerosis (FSGS) Open
Focal segmental glomerulosclerosis (FSGS) is a cause of glomerular disease that affects both adults and children. FSGS can rapidly progress to end-stage kidney disease. With no approved treatments there is high unmet need for safe and effe…
View article: Toward smart composites: small-scale, untethered prediction and control for soft sensor/actuator systems
Toward smart composites: small-scale, untethered prediction and control for soft sensor/actuator systems Open
We present formulation and open-source tools to achieve in-material model predictive control of sensor/actuator systems using learned forward kinematics and on-device computation. Microcontroller units (MCUs) that compute the prediction an…
View article: Platinum dissolution and tissue response following long-term electrical stimulation at high charge densities
Platinum dissolution and tissue response following long-term electrical stimulation at high charge densities Open
Objective . Established guidelines for safe levels of electrical stimulation for neural prostheses are based on a limited range of the stimulus parameters used clinically. Recent studies have reported particulate platinum (Pt) associated w…
View article: A Tissue Engineering Chamber for Continuous Pulsatile Electrical Stimulation of Vascularized Cardiac Tissues <i>In Vivo</i>
A Tissue Engineering Chamber for Continuous Pulsatile Electrical Stimulation of Vascularized Cardiac Tissues <i>In Vivo</i> Open
Background: Cardiomyocytes derived from pluripotent stem cells are immature. Maturation of cardiomyocytes is a multifactorial dynamic process that involves various factors in vivo that cannot be fully recapitulated in vitro. Here, we repor…
View article: Chronic intracochlear electrical stimulation at high charge densities: reducing platinum dissolution
Chronic intracochlear electrical stimulation at high charge densities: reducing platinum dissolution Open
Objective. Cochleae of long-term cochlear implant users have shown evidence of particulate platinum (Pt) corroded from the surface of Pt electrodes. The pathophysiological effect of Pt within the cochlea has not been extensively investigat…
View article: Guest editorial: Medical bionics: from emerging technologies to clinical practice
Guest editorial: Medical bionics: from emerging technologies to clinical practice Open
Medical Bionics or neuroprostheses are active implantable devices designed to: (i) provide therapeutic intervention, sensory feedback or motor function via electrical stimulation of nerves or muscles following trauma or disease; and/or (ii…
View article: Electrochemical and biological performance of chronically stimulated conductive hydrogel electrodes
Electrochemical and biological performance of chronically stimulated conductive hydrogel electrodes Open
CH coated electrodes demonstrated significant electrochemical advantages on the bench-top and in vivo and maintained neural function despite an increased tissue response and coating loss. While further research is required to understand th…
View article: Transmural impedance detects graded changes of inflammation in experimental colitis
Transmural impedance detects graded changes of inflammation in experimental colitis Open
Ulcerative colitis is a chronic disease in which the mucosa of the colon or rectum becomes inflamed. An objective biomarker of inflammation will provide quantitative measures to support qualitative assessment during an endoscopic examinati…
View article: Electrochemical and mechanical performance of reduced graphene oxide, conductive hydrogel, and electrodeposited Pt–Ir coated electrodes: an active<i>in vitro</i>study
Electrochemical and mechanical performance of reduced graphene oxide, conductive hydrogel, and electrodeposited Pt–Ir coated electrodes: an active<i>in vitro</i>study Open
This study rigorously tested the mechanical and electrochemical performance of electrode coatings in vitro and provided suitable candidates for future in vivo testing.
View article: Anti-inflammatory Effects of Abdominal Vagus Nerve Stimulation on Experimental Intestinal Inflammation
Anti-inflammatory Effects of Abdominal Vagus Nerve Stimulation on Experimental Intestinal Inflammation Open
Electrical stimulation of the cervical vagus nerve is an emerging treatment for inflammatory bowel disease (IBD). However, side effects from cervical vagal nerve stimulation (VNS) are often reported by patients. Here we hypothesized that s…
View article: Chronic intracochlear electrical stimulation at high charge densities results in platinum dissolution but not neural loss or functional changes <i>in vivo</i>
Chronic intracochlear electrical stimulation at high charge densities results in platinum dissolution but not neural loss or functional changes <i>in vivo</i> Open
Chronic electrical stimulation of Pt electrodes at 267 or 400 µC/cm2/phase evoked a vigorous tissue response and produced Pt corrosion products that were located close to the electrode. Despite these changes at the electrode/tissue interfa…
View article: Gel-Mediated Electrospray Assembly of Silica Supraparticles for Sustained Drug Delivery
Gel-Mediated Electrospray Assembly of Silica Supraparticles for Sustained Drug Delivery Open
Supraparticles (SPs) composed of smaller colloidal particles provide a platform for the long-term, controlled release of therapeutics in biomedical applications. However, current synthesis methods used to achieve high drug loading and thos…
View article: Focused electrical stimulation using a single current source
Focused electrical stimulation using a single current source Open
The present study demonstrates that SSMPS successfully limits the broadening of the excitatory field along the electrode array and a subsequent reduction in the spread of neural excitation.
View article: The development of neural stimulators: a review of preclinical safety and efficacy studies
The development of neural stimulators: a review of preclinical safety and efficacy studies Open
The pipeline from concept to commercialisation of these devices is long and expensive; careful attention to both device design and its preclinical evaluation will have significant impact on the duration and cost associated with taking a de…
View article: Safety Studies for a 44-Channel Suprachoroidal Retinal Prosthesis: A Chronic Passive Study
Safety Studies for a 44-Channel Suprachoroidal Retinal Prosthesis: A Chronic Passive Study Open
The 44-channel suprachoroidal electrode array has an acceptable passive safety profile to proceed to clinical trial. The safety profile is expected to improve in human studies, as the complications seen are specific to limitations (anatomi…
View article: An objective<i>in vivo</i>diagnostic method for inflammatory bowel disease
An objective<i>in vivo</i>diagnostic method for inflammatory bowel disease Open
Inflammatory damage to the bowel, as occurs in inflammatory bowel disease (IBD), is debilitating to patients. In both patients and animal experimental models, histological analyses of biopsies and endoscopic examinations are used to evalua…