Mariano Serrao
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View article: Reliability and minimal detectable change for inertial measurement units − Derived stability, symmetry, and smoothness indexes of gait in people with multiple sclerosis
Reliability and minimal detectable change for inertial measurement units − Derived stability, symmetry, and smoothness indexes of gait in people with multiple sclerosis Open
This study showed moderate to excellent reliability for the investigated indexes when calculated based on 10MWT, with the LDLJ showing the highest reliability, thus providing a reliable smoothness metric in pwMS. Also, nRMS showed good rel…
View article: Clinical and instrumental gait phenotyping in people with GLUT-1 deficiency syndrome
Clinical and instrumental gait phenotyping in people with GLUT-1 deficiency syndrome Open
The gait pattern of GLUT1-DS patients is marked by reduced fluidity, stability, and smoothness. Inertial gait analysis could be a valuable tool for monitoring GLUT1-DS progression and tailoring rehabilitative strategies.
View article: Exploring the cortical effect of monoclonal antibodies against CGRP ligand: a pilot study of the cortical silent period in migraine
Exploring the cortical effect of monoclonal antibodies against CGRP ligand: a pilot study of the cortical silent period in migraine Open
Background: Evidence from animal studies suggests that monoclonal antibodies targeting the calcitonin gene-related peptide (anti-CGRP mAbs) may only minimally penetrate the blood-brain barrier due to their high molecular weight. However, n…
View article: Artificial neural networks applied to somatosensory evoked potentials for migraine classification
Artificial neural networks applied to somatosensory evoked potentials for migraine classification Open
Our findings suggest that ANNs trained with SSEP-derived variables hold promise as a noninvasive tool for migraine classification, offering potential for clinical application and deeper insights into migraine diagnostics.
View article: Discriminative ability, responsiveness, and interpretability of smoothness index of gait in people with multiple sclerosis
Discriminative ability, responsiveness, and interpretability of smoothness index of gait in people with multiple sclerosis Open
Introduction: Gait impairments are common in People with Multiple Sclerosis (PwMS). Several studies have examined the clinometric properties of Inertial Measurement Units (IMUs), with LDLJa identified as a robust metric for gait smoothness…
View article: Assisting Gait Stability in Walking Aid Users Exploiting Biomechanical Variables Correlation
Assisting Gait Stability in Walking Aid Users Exploiting Biomechanical Variables Correlation Open
Walking aids for individuals with musculoskeletal frailty or motor disabilities must ensure adequate physical support and assistance to their users. To this end, sensor-enabled human state monitoring and estimation are crucial. This letter…
View article: Neurophysiological Effects of Withdrawal from Acute Overused Medications in Chronic Migraine with Medication-Overuse Headache
Neurophysiological Effects of Withdrawal from Acute Overused Medications in Chronic Migraine with Medication-Overuse Headache Open
Background/Objectives: Chronic migraine with medication-overuse headache (CM-MOH) is neurophysiologically characterized by increased cortical excitability with sensitization at both the thalamocortical and the cortical levels. It is unclea…
View article: SkelMamba: A State Space Model for Efficient Skeleton Action Recognition of Neurological Disorders
SkelMamba: A State Space Model for Efficient Skeleton Action Recognition of Neurological Disorders Open
We introduce a novel state-space model (SSM)-based framework for skeleton-based human action recognition, with an anatomically-guided architecture that improves state-of-the-art performance in both clinical diagnostics and general action r…
View article: Local Dynamic Stability of Trunk During Gait Can Detect Dynamic Imbalance in Subjects with Episodic Migraine
Local Dynamic Stability of Trunk During Gait Can Detect Dynamic Imbalance in Subjects with Episodic Migraine Open
Background/Hypothesis: Motion sensitivity symptoms, such as dizziness or unsteadiness, are frequently reported as non-headache symptoms of migraine. Postural imbalance has been observed in subjects with vestibular migraine, chronic migrain…
View article: Local Dynamic Stability of Trunk During Gait Can Detect Dynamic Imbalance in Subjects with Episodic Migraine
Local Dynamic Stability of Trunk During Gait Can Detect Dynamic Imbalance in Subjects with Episodic Migraine Open
Background/Hypothesis: Motion sensitivity symptoms, like dizziness or unsteadiness, are frequently reported as non-headache symptoms of migraine. Postural imbalance has been observed in subjects with vestibular migraine, chronic migraine, …
View article: MRI-based microstructural and functional network analysis in episodic cluster headache: insights into hypothalamic-thalamo-cortical network
MRI-based microstructural and functional network analysis in episodic cluster headache: insights into hypothalamic-thalamo-cortical network Open
Background Neuroimaging studies have shown that hypothalamic/thalamic nuclei and other distant brain regions belonging to complex cerebral networks are involved in cluster headache (CH). However, the exact relationship between these areas,…
View article: Mixed Reality-Based Smart Occupational Therapy Personalized Protocol for Cerebellar Ataxic Patients
Mixed Reality-Based Smart Occupational Therapy Personalized Protocol for Cerebellar Ataxic Patients Open
Background: Occupational therapy (OT) is an essential component of patient care, and it is especially beneficial if focused on meaningful activities. For ataxic patients, traditional procedures are currently the most efficient, although wi…
View article: Decoding Visual Responses: Insights into Chronic Migraine and Medication Overuse Headache with Electrophysiological Analysis
Decoding Visual Responses: Insights into Chronic Migraine and Medication Overuse Headache with Electrophysiological Analysis Open
Background/Objectives: Habituation and sensitization are opposite phenomena that play a role in the pathophysiology of episodic migraine and its progression to chronic migraine (CM). There have been just a few studies that have investigate…
View article: Differences in Trunk Acceleration-Derived Gait Indexes in Stroke Subjects with and without Stroke-Induced Immunosuppression
Differences in Trunk Acceleration-Derived Gait Indexes in Stroke Subjects with and without Stroke-Induced Immunosuppression Open
Background: Stroke-induced immunosuppression (SII) represents a negative rehabilitative prognostic factor associated with poor motor performance at discharge from a neurorehabilitation unit (NRB). This study aims to evaluate the associatio…
View article: Visual Evoked Potentials Sensitization/Habituation Mechanisms in Chronic Migraine Patients with or without Medication Overuse
Visual Evoked Potentials Sensitization/Habituation Mechanisms in Chronic Migraine Patients with or without Medication Overuse Open
Background/Objectives: Habituation and sensitization are opposite phenomena that play a role in the pathophysiology of episodic migraine and its progression to chronic migraine (CM). There have been just a few studies that have investigate…
View article: Lack of a direct link between macular cones function and photophobia in interictal migraine
Lack of a direct link between macular cones function and photophobia in interictal migraine Open
Background It is still debatable whether the mechanisms underlying photophobia are related to altered visual cortex excitability or specific abnormalities of colour-related focal macular retino-thalamic information processing. Methods This…
View article: The Effect of a Wearable Assistive Trunk Exoskeleton on the Motor Coordination of People with Cerebellar Ataxia
The Effect of a Wearable Assistive Trunk Exoskeleton on the Motor Coordination of People with Cerebellar Ataxia Open
The motor features of people with cerebellar ataxia suggest that locomotion is substantially impaired due to incoordination of the head, trunk, and limbs. The purpose of this study was to investigate how well a wearable soft passive exoske…
View article: Lifting Activities Assessment Using Lumbosacral Compression and Shear Forces
Lifting Activities Assessment Using Lumbosacral Compression and Shear Forces Open
In this study, we have analyzed the behavior of shear and compression forces at the L5-S1 joint during the execution of controlled lifting tasks designed on the basis of the revised NIOSH (National Institute for Occupational Safety and Hea…
View article: Optimizing Rare Disease Gait Classification through Data Balancing and Generative AI: Insights from Hereditary Cerebellar Ataxia
Optimizing Rare Disease Gait Classification through Data Balancing and Generative AI: Insights from Hereditary Cerebellar Ataxia Open
The interpretability of gait analysis studies in people with rare diseases, such as those with primary hereditary cerebellar ataxia (pwCA), is frequently limited by the small sample sizes and unbalanced datasets. The purpose of this study …
View article: Lower Limb Muscle Co-Activation Maps in Single and Team Lifting at Different Risk Levels
Lower Limb Muscle Co-Activation Maps in Single and Team Lifting at Different Risk Levels Open
The central nervous system uses muscle co-activation for body coordination, effector movement control, and joint stabilization. However, co-activation increases compression and shear stresses on the joints. Lifting activity is one of the l…
View article: Cortical excitability in patients with migraine with aura and depressive symptoms: a visual evoked potentials study
Cortical excitability in patients with migraine with aura and depressive symptoms: a visual evoked potentials study Open
Background: Migraine is a brain disorder characterized by recurring headache attacks, and emotional comorbidities, such as anxiety and depression, may influence the repetition of these attacks. The lack of sensory habituation is a common n…
View article: The role of stroke-induced immunosuppression as a predictor of functional outcome in the neurorehabilitation setting
The role of stroke-induced immunosuppression as a predictor of functional outcome in the neurorehabilitation setting Open
Stroke affects the interconnection between the nervous and immune systems, leading to a down-regulation of immunity called stroke-induced immunosuppression (SII). The primary aim of this study is to investigate SII role as a predictor of f…
View article: The Lower Limb Muscle Co-Activation Map during Human Locomotion: From Slow Walking to Running
The Lower Limb Muscle Co-Activation Map during Human Locomotion: From Slow Walking to Running Open
The central nervous system (CNS) controls movements and regulates joint stiffness with muscle co-activation, but until now, few studies have examined muscle pairs during running. This study aims to investigate differences in lower limb mus…
View article: Local Dynamic Stability of Trunk During Gait is Responsive to Rehabilitation in Subjects with Primary Degenerative Cerebellar Ataxia
Local Dynamic Stability of Trunk During Gait is Responsive to Rehabilitation in Subjects with Primary Degenerative Cerebellar Ataxia Open
This study aimed to assess the responsiveness to the rehabilitation of three trunk acceleration-derived gait indexes, namely the harmonic ratio (HR), the short-term longest Lyapunov’s exponent (sLLE), and the step-to-step coefficient of va…
View article: The Lower Limb Muscle Co-activation Map during Human Locomotion: From Slow Walking to Running.
The Lower Limb Muscle Co-activation Map during Human Locomotion: From Slow Walking to Running. Open
The central nervous system (CNS) controls movements and regulates joint stiffness with muscle coactivation, but until now few studies have examined muscle pairs during running. This study aims to investigate differences in lower limb muscl…