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View article: Regional brain morphology and current antidepressant use: findings from 32 international cohorts from the ENIGMA major depressive disorder working group
Regional brain morphology and current antidepressant use: findings from 32 international cohorts from the ENIGMA major depressive disorder working group Open
The understanding of how antidepressant (AD) use is associated with brain structure in individuals with major depressive disorder (MDD) remains incomplete. We aimed to examine the association between AD medication use and brain morphology …
View article: Classification of major depressive disorder using vertex-wise brain sulcal depth, curvature, and thickness with a deep and a shallow learning model
Classification of major depressive disorder using vertex-wise brain sulcal depth, curvature, and thickness with a deep and a shallow learning model Open
Major depressive disorder (MDD) is a complex psychiatric disorder that affects the lives of hundreds of millions of individuals around the globe. Even today, researchers debate if morphological alterations in the brain are linked to MDD, l…
View article: Association between polygenic risk for Major Depression and brain structure in a mega-analysis of 50,975 participants across 11 studies
Association between polygenic risk for Major Depression and brain structure in a mega-analysis of 50,975 participants across 11 studies Open
Major Depression (MD) is a prevalent, disabling and life-limiting condition. The neurobiological associations of genetic risk for MD remain under-explored in large samples, with no comprehensive mega-analysis conducted to date. Our study a…
View article: Disentangling shared and unique brain functional changes associated with clinical severity and cognitive phenotypes in schizophrenia via deep learning
Disentangling shared and unique brain functional changes associated with clinical severity and cognitive phenotypes in schizophrenia via deep learning Open
Individuals with schizophrenia experience significant cognitive impairments and alterations in brain function. However, the shared and unique brain functional patterns underlying cognition deficits and symptom severity in schizophrenia rem…
View article: Genomic characterisation of nasal isolates of coagulase-negative Staphylococci from healthy medical students reveals novel Staphylococcal cassette chromosome mec elements
Genomic characterisation of nasal isolates of coagulase-negative Staphylococci from healthy medical students reveals novel Staphylococcal cassette chromosome mec elements Open
View article: Impostor syndrome, associated factors and impact on well-being across medical undergraduates and postgraduate medical professionals: a scoping review
Impostor syndrome, associated factors and impact on well-being across medical undergraduates and postgraduate medical professionals: a scoping review Open
Objectives Impostor syndrome (IS) is a psychological state whereby individuals doubt their abilities despite evidence of competence. Though IS has been studied in specific medical groups, no review to date compares findings across groups. …
View article: Global psychiatrists' opinions about <i>hikikomori</i> from biopsychosocial perspectives: International case vignette survey
Global psychiatrists' opinions about <i>hikikomori</i> from biopsychosocial perspectives: International case vignette survey Open
Aim The aim of this study was to investigate whether psychiatrists around the world believe they might encounter cases of hikikomori (prolonged social isolation), and how they formulate and treat such cases. Methods A hikikomori case vigne…
View article: Network Structure of Depression and Anxiety Symptoms in Older Asian Patients With Depressive Disorders: Findings From REAP-AD3
Network Structure of Depression and Anxiety Symptoms in Older Asian Patients With Depressive Disorders: Findings From REAP-AD3 Open
Objective The clinical presentation of depressive disorders might be influenced by age, and its diagnosis and treatment can be affected by ageism-related bias. A network analysis can reveal symptom patterns unrecognized by the reductionist…
View article: Multi-task deep learning model to disentangle shared and unique brain functional changes associated with illness severity and cognitive functioning in schizophrenia
Multi-task deep learning model to disentangle shared and unique brain functional changes associated with illness severity and cognitive functioning in schizophrenia Open
Individuals with schizophrenia experience significant cognitive impairments and alterations in brain function. However, the shared and unique functional regions underlying cognition deficits and symptom severity in schizophrenia remain poo…
View article: Thalamocortical Structural Covariation Networks Are Related to Familial Risk for Schizophrenia in the Context of Lower Nuclei Volume Estimates in Patients: An ENIGMA Study
Thalamocortical Structural Covariation Networks Are Related to Familial Risk for Schizophrenia in the Context of Lower Nuclei Volume Estimates in Patients: An ENIGMA Study Open
View article: Dissecting heterogeneity in cortical thickness abnormalities in major depressive disorder: a large-scale ENIGMA MDD normative modelling study
Dissecting heterogeneity in cortical thickness abnormalities in major depressive disorder: a large-scale ENIGMA MDD normative modelling study Open
Importance Major depressive disorder (MDD) is highly heterogeneous, with marked individual differences in clinical presentation and neurobiology, which may obscure identification of structural brain abnormalities in MDD. To explore this, w…
View article: Accuracy of machine learning methods in predicting prognosis of patients with psychotic spectrum disorders: a systematic review
Accuracy of machine learning methods in predicting prognosis of patients with psychotic spectrum disorders: a systematic review Open
Objectives We aimed to examine the predictive accuracy of functioning, relapse or remission among patients with psychotic disorders, using machine learning methods. We also identified specific features that were associated with these clini…
View article: Impact of a Virtual Reality Intervention on Stigma, Empathy, and Attitudes Toward Patients With Psychotic Disorders Among Mental Health Care Professionals: Randomized Controlled Trial
Impact of a Virtual Reality Intervention on Stigma, Empathy, and Attitudes Toward Patients With Psychotic Disorders Among Mental Health Care Professionals: Randomized Controlled Trial Open
Background Previous studies have found that psychotic disorders are among the most stigmatized mental disorders. Of note, virtual reality (VR) interventions have been associated with improvements in attitudes and empathy and reduced stigma…
View article: Sex differences in the network structures of depressive symptom profiles in Asian patients with depressive disorders: findings from the Research on Asian Psychotropic Patterns for Antidepressants, Phase 3
Sex differences in the network structures of depressive symptom profiles in Asian patients with depressive disorders: findings from the Research on Asian Psychotropic Patterns for Antidepressants, Phase 3 Open
Background: Depression is a complex mental health disorder with highly heterogeneous symptoms that vary significantly across individuals, influenced by various factors, including sex and regional contexts. Network analysis is an analytical…
View article: Can we trust you? - Exploring enablers and barriers to grasping the entrustment concept during faculty development program for entrustable professional activities using the consolidated framework for implementation Research 2.0
Can we trust you? - Exploring enablers and barriers to grasping the entrustment concept during faculty development program for entrustable professional activities using the consolidated framework for implementation Research 2.0 Open
View article: Long-acting injectable antipsychotic use in patients with bipolar disorder: Findings from the REAP-BD study
Long-acting injectable antipsychotic use in patients with bipolar disorder: Findings from the REAP-BD study Open
This study is the first to examine LAIs use for BD across Asia. Cross-national differences in LAIs prescriptions and psychotropic drug load highlight variations in treatment practices and healthcare systems. These findings underscore the n…
View article: White matter microstructure in obesity and bipolar disorders: an ENIGMA bipolar disorder working group study in 2186 individuals
White matter microstructure in obesity and bipolar disorders: an ENIGMA bipolar disorder working group study in 2186 individuals Open
View article: No health without mental health: united we stand
No health without mental health: united we stand Open
View article: Suicidality is most centrally situated within network of depression symptom criteria in unipolar depression patients with mood stabilizer in Asia
Suicidality is most centrally situated within network of depression symptom criteria in unipolar depression patients with mood stabilizer in Asia Open
Lithium and mood stabilizers are considered effective augmentation agents of antidepressants for treatment-resistant depression. Thus, this study aimed to estimate the network structure of depression symptom criteria among unipolar depress…
View article: Prediction of Clinical Outcomes in Psychotic Disorders Using Artificial Intelligence Methods: A Scoping Review
Prediction of Clinical Outcomes in Psychotic Disorders Using Artificial Intelligence Methods: A Scoping Review Open
Background: Psychotic disorders are major psychiatric disorders that can impact multiple domains including physical, social, and psychological functioning within individuals with these conditions. Being able to better predict the outcomes …
View article: Neurostructural subgroup in 4291 individuals with schizophrenia identified using the subtype and stage inference algorithm
Neurostructural subgroup in 4291 individuals with schizophrenia identified using the subtype and stage inference algorithm Open
Machine learning can be used to define subtypes of psychiatric conditions based on shared biological foundations of mental disorders. Here we analyzed cross-sectional brain images from 4,222 individuals with schizophrenia and 7038 healthy …
View article: Brain‐age prediction: Systematic evaluation of site effects, and sample age range and size
Brain‐age prediction: Systematic evaluation of site effects, and sample age range and size Open
Structural neuroimaging data have been used to compute an estimate of the biological age of the brain (brain‐age) which has been associated with other biologically and behaviorally meaningful measures of brain development and aging. The on…
View article: Principal component analysis as an efficient method for capturing multivariate brain signatures of complex disorders—<scp>ENIGMA</scp> study in people with bipolar disorders and obesity
Principal component analysis as an efficient method for capturing multivariate brain signatures of complex disorders—<span>ENIGMA</span> study in people with bipolar disorders and obesity Open
Multivariate techniques better fit the anatomy of complex neuropsychiatric disorders which are characterized not by alterations in a single region, but rather by variations across distributed brain networks. Here, we used principal compone…
View article: Differences in the neural correlates of schizophrenia with positive and negative formal thought disorder in patients with schizophrenia in the ENIGMA dataset
Differences in the neural correlates of schizophrenia with positive and negative formal thought disorder in patients with schizophrenia in the ENIGMA dataset Open
View article: MIR137 polygenic risk for schizophrenia and ephrin-regulated pathway: Role in lateral ventricles and corpus callosum volume
MIR137 polygenic risk for schizophrenia and ephrin-regulated pathway: Role in lateral ventricles and corpus callosum volume Open
Background/Objective. Enlarged lateral ventricle (LV) volume and decreased volume in the corpus callosum (CC) are hallmarks of schizophrenia (SZ). We previously showed an inverse correlation between LV and CC volumes in SZ, with glo…
View article: Inter-Professional Education Interventions, and Practice Outcomes Related to Healthcare Setting and Patients Within Mental Healthcare: A Scoping Review
Inter-Professional Education Interventions, and Practice Outcomes Related to Healthcare Setting and Patients Within Mental Healthcare: A Scoping Review Open
Introduction: This scoping review aimed to examine 1) types of inter-professional (IPE) interventions using Strosahl’s typology framework, 2) practice outcomes related to healthcare setting and patients using Kirkpatrick’s model of trainin…
View article: Connectome architecture shapes large-scale cortical alterations in schizophrenia: a worldwide ENIGMA study
Connectome architecture shapes large-scale cortical alterations in schizophrenia: a worldwide ENIGMA study Open
Schizophrenia is a prototypical network disorder with widespread brain-morphological alterations, yet it remains unclear whether these distributed alterations robustly reflect the underlying network layout. We tested whether large-scale st…
View article: Structural brain abnormalities and aggressive behaviour in schizophrenia: Mega-analysis of data from 2095 patients and 2861 healthy controls via the ENIGMA consortium
Structural brain abnormalities and aggressive behaviour in schizophrenia: Mega-analysis of data from 2095 patients and 2861 healthy controls via the ENIGMA consortium Open
Background Schizophrenia is associated with an increased risk of aggressive behaviour, which may partly be explained by illness-related changes in brain structure. However, previous studies have been limited by group-level analyses, small …
View article: Asymmetry, cytoarchitectonic morphology and genetics associated with Broca’s area in schizophrenia
Asymmetry, cytoarchitectonic morphology and genetics associated with Broca’s area in schizophrenia Open
View article: International Trends in Lithium Use for Pharmacotherapy and Clinical Correlates in Bipolar Disorder: A Scoping Review
International Trends in Lithium Use for Pharmacotherapy and Clinical Correlates in Bipolar Disorder: A Scoping Review Open
Lithium remains an effective option in the treatment of bipolar disorder (BD). Thus, we aim to characterize the pharmaco-epidemiological patterns of lithium use internationally over time and elucidate clinical correlates associated with BD…