A. Stephen K. Hashmi
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View article: Synthesis and Characterization of <i>π</i> ‐Extended Azulenes via Nucleophilic Substitution and Intramolecular Cyclization of 5‐Alkynyl‐6‐Fluoroazulenes
Synthesis and Characterization of <i>π</i> ‐Extended Azulenes via Nucleophilic Substitution and Intramolecular Cyclization of 5‐Alkynyl‐6‐Fluoroazulenes Open
Herein, a methodology that allows a nucleophilic aromatic substitution followed by an intramolecular cyclization to furnish annulated heterocycles at the seven‐membered ring of alkynyl fluoroazulenes is introduced. This synthetic protocol …
View article: Facile Access to Chelating CAArC‐Phosphine (CAArCPhos) Palladium Complexes
Facile Access to Chelating CAArC‐Phosphine (CAArCPhos) Palladium Complexes Open
In this article, we present a synthetic route to 4‐(diphenyl‐phosphino) isoindolium salts based on a new protecting group strategy. Key to success is the use of hemi‐aminal methyl ether precursors, which serve as base‐stable iminium salt e…
View article: Enabling a Diversity‐Oriented Catalytic Atom Looping of a Biobased Polycarbonate
Enabling a Diversity‐Oriented Catalytic Atom Looping of a Biobased Polycarbonate Open
Herein, it is demonstrated that biobased poly(menthene carbonate) ( PMC ) can be conveniently used to enable catalysis‐promoted atom looping thereby creating functionalized synthons and new types of repolymerizable monomers. The biobased p…
View article: Domination in Rough \(m\)-Polar Fuzzy Digraphs Based on Trade Networking
Domination in Rough \(m\)-Polar Fuzzy Digraphs Based on Trade Networking Open
In graph theory, dominance has been a key idea for examining influence, control, and optimization in various systems. By examining domination in rough m-polar fuzzy digraphs—a hybrid model that combines directed graphs, m-polar fuzzy logic…
View article: Triangular Intuitionistic Fuzzy Frank Aggregation for Efficient Renewable Energy Project Selection
Triangular Intuitionistic Fuzzy Frank Aggregation for Efficient Renewable Energy Project Selection Open
Optimizing renewable energy project selection presents a complex challenge that demands intelligent decision-making under conditions of uncertainty. In multi-criteria decision-making (MCDM), the need to balance numerous conflicting factors…
View article: Late-Stage Modification of NHC Gold(I) Complexes: Fast Track to Ligand Design as a Key for New Reactivities in Gold-Catalysis
Late-Stage Modification of NHC Gold(I) Complexes: Fast Track to Ligand Design as a Key for New Reactivities in Gold-Catalysis Open
Herein we report the synthesis of bulky N-heterocyclic carbene gold(I) complexes via an “on-metal” eightfold Suzuki coupling of a suitable precursor complex. An initial screening revealed the optimal reaction conditions furnishing a series…
View article: Photochemical Preparation of (Aza−)Indolines: Diastereoselective Synthesis and Polarity Reversal Strategy
Photochemical Preparation of (Aza−)Indolines: Diastereoselective Synthesis and Polarity Reversal Strategy Open
Herein, we present the first light‐mediated, diastereoselective de novo synthesis for 2,3‐substituted indolines, a privileged scaffold in pharmaceuticals. The protocol was tested with various aryl and alkyl groups, maintaining high yields …
View article: Insights for the Hydrogen‐Mediated Deoxydehydration (DODH) with Cp*ReO <sub>3</sub> and Alkene Extrusion of Related Re(V)‐Diolates
Insights for the Hydrogen‐Mediated Deoxydehydration (DODH) with Cp*ReO <sub>3</sub> and Alkene Extrusion of Related Re(V)‐Diolates Open
To transform highly oxygenated molecules such as polyols from biomass into value‐added chemicals, the deoxygenation via the deoxydehydration (DODH) is a promising approach. We report the catalytic DODH of substrates from renewable resource…
View article: EVs@Scale FUSE Fall '24 Deep Dive
EVs@Scale FUSE Fall '24 Deep Dive Open
Electric vehicle (EV) adoption will expand beyond light-duty vehicles charging at lower-power public locations and family residences to include medium- and heavy-duty applications with more powerful charging at public stations and private …
View article: One Step Synthesis of 4,6,8‐Trimethoxyazulenes ‐ as Building Block for 2‐Functionalized Azulenes
One Step Synthesis of 4,6,8‐Trimethoxyazulenes ‐ as Building Block for 2‐Functionalized Azulenes Open
Here we present a simple gold‐catalyzed one‐pot reaction of easily available diarylbutadiynes, with trimethoxybenzene as solvent and reactant to synthesize 4,6,8‐trimethoxyazulenes. The methoxy substituents, which render the azulene very e…
View article: Influence of the charge of 1,3,5-triaza-7-phosphaadamantane-based ligands on the anticancer activity of organopalladium complexes
Influence of the charge of 1,3,5-triaza-7-phosphaadamantane-based ligands on the anticancer activity of organopalladium complexes Open
Novel organopalladium complexes bearing PTA-based ligands were synthesized in this article, showing excellent and, in some cases, selective antitumor activity.
View article: Synthesis of azulenyl-substituted gold( <scp>i</scp> )-carbene complexes and investigation of their anticancer activity
Synthesis of azulenyl-substituted gold( <span>i</span> )-carbene complexes and investigation of their anticancer activity Open
The direct and atom economic synthesis of azulenyl-substituted gold( i ) carbene complexes, based on the modular template synthesis using gold( i ) isonitrile complexes and amine nucleophiles, is presented.
View article: Exploring the catalytic and anticancer activity of gold(<scp>i</scp>) complexes bearing 1,3,5-triaza-7-phosphaadamantane (PTA) and related ligands
Exploring the catalytic and anticancer activity of gold(<span>i</span>) complexes bearing 1,3,5-triaza-7-phosphaadamantane (PTA) and related ligands Open
Novel gold( i )–PTA complexes were synthesized and tested for cyclohexane oxidation and anticancer activity. Carbon support improved catalysis, and some complexes showed selective cytotoxicity against cancer cells.
View article: Scope and mechanistic insight into the chemistry of cyanocarbenes derived from alkynyl triazenes by UV irradiation
Scope and mechanistic insight into the chemistry of cyanocarbenes derived from alkynyl triazenes by UV irradiation Open
Cyanocarbenes derived from alkynyl triazenes are investigated with respect to their reactivity with olefins and alkynes to produce cyclopropanes and cyclopropenes with high selectivity, offering eco-friendly, cost-effective synthetic advan…
View article: Gold‐Catalyzed Access to Pyrrolo‐ and (Aryl)Indolo‐Fused Phenazines
Gold‐Catalyzed Access to Pyrrolo‐ and (Aryl)Indolo‐Fused Phenazines Open
Novel fused phenazines were synthesized through a combination of gold‐catalyzed hydroamination and cascade cyclization reactions towards azaacenes. In total, 30 new compounds were synthesized and investigated with respect to their structur…
View article: Benzobischalcogeno[3,2-<i>c</i>]quinolines: tuning electronic and structural properties with group 16 elements
Benzobischalcogeno[3,2-<i>c</i>]quinolines: tuning electronic and structural properties with group 16 elements Open
Chalcogen-annulated heptacyclic N-heteropolycycles were synthesized. By photophysical and structural analysis, significant properties were observed depending on the annulated chalcogen.
View article: Oxidation State and Halogen Influence on the NHC‐Gold‐Halide‐Catalyzed Cyclization of Propargylic Amides
Oxidation State and Halogen Influence on the NHC‐Gold‐Halide‐Catalyzed Cyclization of Propargylic Amides Open
The homogeneously catalyzed cycloisomerization reaction of propargylic amides was tested as benchmark reaction for two homologous series of Au(I) and Au(III) complexes with NHC ligands. This reaction is known to afford either aromatic oxaz…
View article: Dynamic Coordination Behavior of a Structurally Constrained, Nucleophilic Sn(II) Towards Gold(I)
Dynamic Coordination Behavior of a Structurally Constrained, Nucleophilic Sn(II) Towards Gold(I) Open
Tetradentate meso ‐octaalkylcalix[4]pyrroles are well‐established ligands in d ‐ and f ‐block chemistry. In contrast to the related porphyrins, the sp 3 ‐hybridized meso ‐carbon atoms linking the four pyrrole units result in highly divers …
View article: Electrochemical meta-C−H Sulfonylation of Pyridines with Nucleophilic Sulfinates
Electrochemical meta-C−H Sulfonylation of Pyridines with Nucleophilic Sulfinates Open
Considering the indispensable significance and utilities of meta-substituted pyridines in medicinal, chemical as well as materials science, a direct meta-selective C − H functionalization of pyridines is of paramount importance, but such r…
View article: Gold(I)‐Catalyzed Intramolecular 7‐<i>endo</i>‐<i>dig</i> Cyclization of Triene‐Yne Systems: New Access towards Azulenothiophenes
Gold(I)‐Catalyzed Intramolecular 7‐<i>endo</i>‐<i>dig</i> Cyclization of Triene‐Yne Systems: New Access towards Azulenothiophenes Open
We report the direct synthesis of new azulene derivatives through gold‐catalyzed cyclization reactions. A five‐membered ring as backbone in the applied triene‐yne substrates turned out to be crucial to induce the 7‐ endo ‐ dig cyclization …
View article: Front Cover Picture: Accessing Indenoazulenes <i>via</i> a Gold‐Catalysed Cyclisation of Cycloheptatrienyl‐Substituted 1,5‐Diynes (Adv. Synth. Catal. 6/2024)
Front Cover Picture: Accessing Indenoazulenes <i>via</i> a Gold‐Catalysed Cyclisation of Cycloheptatrienyl‐Substituted 1,5‐Diynes (Adv. Synth. Catal. 6/2024) Open
The front cover picture visualises the colourful beauty of the synthesised compound class of 11H-indeno-[2,1-a]azulenes. In contrast to their colourless structural isomer naphthalene, azulenes are known for exhibiting vibrant colours, resu…
View article: CCDC 2181497: Experimental Crystal Structure Determination
CCDC 2181497: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2181496: Experimental Crystal Structure Determination
CCDC 2181496: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Comparative study of the antiproliferative activity of heterometallic carbene gold(<scp>i</scp>)–platinum(<scp>ii</scp>) and gold(<scp>i</scp>)–palladium(<scp>ii</scp>) complexes in cancer cell lines
Comparative study of the antiproliferative activity of heterometallic carbene gold(<span>i</span>)–platinum(<span>ii</span>) and gold(<span>i</span>)–palladium(<span>ii</span>) complexes in cancer cell lines Open
The stepwise, one-pot synthesis of heterobimetallic carbene gold( i ) platinum( ii ) complexes from readily available starting materials is presented and their cytotoxic properties are evaluated.
View article: CCC-NHC Au(<scp>iii</scp>) pincer complexes as a reliable platform for isolating elusive species
CCC-NHC Au(<span>iii</span>) pincer complexes as a reliable platform for isolating elusive species Open
The reactivity of unprecedented CCC-NHC Au( iii ) pincer complexes has been investigated, employing a novel methodology for their preparation.
View article: CCDC 2289805: Experimental Crystal Structure Determination
CCDC 2289805: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …