Katie L. Stone
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View article: A data driven approach to assess relationships between sleep, cognition and dementia: Findings from the Sleep and Dementia Consortium
A data driven approach to assess relationships between sleep, cognition and dementia: Findings from the Sleep and Dementia Consortium Open
Background and Objectives Sleep has been associated with cognition and risk of dementia. However, sleep is a highly complex and multi-dimensional state, and there is uncertainty about which aspects of sleep are most relevant to cognitive p…
View article: Association of Objective Long Sleep Duration and Insomnia with Objective Short Sleep Duration Phenotypes with Mortality in Older Persons
Association of Objective Long Sleep Duration and Insomnia with Objective Short Sleep Duration Phenotypes with Mortality in Older Persons Open
Objective To investigate the association of objective long sleep duration (LS) and insomnia with objective short sleep duration (ISSD) with mortality in older persons. Methods In 3,054 men (average age 76.4±5.5; mean follow-up=12.1 years) …
Metabolomic biomarkers of rest-activity rhythms in older men: results from the Osteoporotic Fractures in Men (MrOS) study Open
Study Objectives Rest-activity rhythm characteristics have been linked to a wide range of health conditions; however, the molecular mechanisms underlying these associations are not well understood. This study is the first of two studies ai…
Metabolomic biomarkers of rest-activity rhythms in older women: results from the Women’s Health Initiative study Open
Study Objectives Prior research has suggested that disrupted and weakened rest-activity rhythms measured by accelerometry may be associated with risks of many diseases, including cardiometabolic diseases, cancer, and dementia, but the mech…
View article: Dementia Risk and Machine Learning-Derived Brain Age Index from Sleep Electroencephalography: A Pooled Cohort Analysis of Over 7,000 Individuals Across Five Community Cohorts
Dementia Risk and Machine Learning-Derived Brain Age Index from Sleep Electroencephalography: A Pooled Cohort Analysis of Over 7,000 Individuals Across Five Community Cohorts Open
Importance Sleep electroencephalographic (EEG) microstructures are closely related to cognition and undergo age-dependent changes. However, their multidimensional nature makes them challenging to interpret using conventional approaches. Ma…
View article: Acupuncture for Chronic Low Back Pain in Older Adults
Acupuncture for Chronic Low Back Pain in Older Adults Open
Importance The study was carried out to inform Medicare acupuncture coverage decisions addressing the gap in evidence on acupuncture effectiveness, specifically for older adults with chronic low back pain (CLBP). Objective To determine the…
Rest-activity rhythms are stronger in Mexican American compared to non-Hispanic White and Black participants: a cross-sectional study Open
Study Objectives This study aimed to investigate differences in rest-activity rhythms (RAR), key circadian rhythm markers, across race/ethnicity and sex in a diverse community-based cohort of older adults. Methods We examined RAR (amplitud…
Multidimensional sleep profiles via machine learning and risk of dementia and cardiovascular disease Open
Background Sleep health comprises several dimensions such as sleep duration and fragmentation, circadian activity, and daytime behavior. Yet, most research has focused on individual sleep characteristics. Studies are needed to identify sle…
View article: Sleep architecture and dementia risk in adults: an analysis of 5 cohorts from the Sleep and Dementia Consortium
Sleep architecture and dementia risk in adults: an analysis of 5 cohorts from the Sleep and Dementia Consortium Open
Study Objectives Poor sleep may play a role in the risk of dementia. However, few studies have investigated the association between polysomnography (PSG)-derived sleep architecture and dementia incidence. We examined the relationship betwe…
View article: 0540 Comparative Effectiveness of Medication, Digital CBT-I (dCBT-I), and Combined Therapy for Insomnia in Rural Adults
0540 Comparative Effectiveness of Medication, Digital CBT-I (dCBT-I), and Combined Therapy for Insomnia in Rural Adults Open
Introduction Cognitive Behavioral Therapy for Insomnia (CBT-I) is the recommended first-line treatment for insomnia, but medications remain widely used. Limited evidence suggests combination treatment may capitalize on the advantages of ea…
0947 Reciprocal Associations Between Daily Sleep and Pain Among Individuals with Rheumatoid Arthritis Open
Introduction Rheumatoid arthritis (RA) is a chronic autoimmune condition characterized by joint pain. Self-reported poor sleep is common in RA. This study examined the potential reciprocal relationship between sleep health and pain in RA. …
View article: Detecting Sleep/Wake Rhythm Disruption Related to Cognition in Older Adults With and Without Mild Cognitive Impairment Using the myRhythmWatch Platform: Feasibility and Correlation Study
Detecting Sleep/Wake Rhythm Disruption Related to Cognition in Older Adults With and Without Mild Cognitive Impairment Using the myRhythmWatch Platform: Feasibility and Correlation Study Open
Background Consumer wearable devices could, in theory, provide sufficient accelerometer data for measuring the 24-hour sleep/wake risk factors for dementia that have been identified in prior research. To our knowledge, no prior study in ol…
Objective Sleep Quality in Diverse Older Adults: the Importance of Race and Ethnicity and Sex Open
Background Research on sleep disparities across different sociodemographic groups is limited and often yields inconsistent findings. We aimed to examine differences in objective sleep measures by race and ethnicity, sex, and age within a d…
View article: Predicting future risk of developing cognitive impairment using ambulatory sleep EEG: Integrating univariate analysis and multivariate information theory approach
Predicting future risk of developing cognitive impairment using ambulatory sleep EEG: Integrating univariate analysis and multivariate information theory approach Open
Background Early identification of individuals at risk for cognitive impairment is crucial, as the preclinical phase offers an opportunity for interventions to slow disease progression and improve outcomes. Objective While sleep electroenc…
View article: Back pain precedes sleep problems in older men
Back pain precedes sleep problems in older men Open
Background and Objectives While cross-sectional associations between any pain and sleep problems have been established, longitudinal studies examining the temporal relationship between back pain and multidimensional sleep health remain lim…
Sleep Encephalography‐Based Brain Age Index as a Potential Biomarker for Incident Cognitive Impairment in Community‐Dwelling Older Men Open
Background Individuals with dementia frequently exhibit disturbed sleep electroencephalography (EEG) microstructures, including spindles and slow oscillations. We have previously developed a sleep EEG‐based brain age index (BAI), which int…
View article: Associations between imaging biomarkers and sleep quality in the U.S. POINTER study baseline cohort
Associations between imaging biomarkers and sleep quality in the U.S. POINTER study baseline cohort Open
Background Worse sleep is associated with a greater risk of Alzheimer’s disease (AD). However, few studies have linked objective sleep with neuroimaging outcomes, limiting our understanding of how poor sleep impacts the brain. The U.S. POI…
Objective sleep characteristics and cognitive performances: the role of race/ethnicity Open
Background A growing body of literature suggests that poor sleep has a negative effect on cognition. However, most prior research has predominantly used subjective sleep data and focused on non‐Hispanic White (NHW) populations. Our goal wa…
Associations between sleep apnea and tau in cognitively unimpaired older adults Open
Background Older age is associated with sleep disruptions and the aggregation of pathological tau in the medial temporal lobe (MTL). Associations between sleep disruptions and the progression of Alzheimer’s disease (AD) have been widely de…
View article: Associations between imaging biomarkers and sleep quality in the U.S. POINTER study baseline cohort
Associations between imaging biomarkers and sleep quality in the U.S. POINTER study baseline cohort Open
Background Worse sleep is associated with a greater risk of Alzheimer’s disease (AD). However, few studies have linked objective sleep with neuroimaging outcomes, limiting our understanding of how poor sleep impacts the brain. The U.S. POI…
The role of moderate‐vigorous physical activity and sedentary behavior on cognitive function: Cross‐sectional analysis in U.S. POINTER Open
Background Healthy lifestyle behaviors can help prevent or delay cognitive impairment in older adults, including increasing moderate‐vigorous physical activity (MVPA). However, across studies examining effects of MVPA on cognitive function…
Five‐year changes in 24‐hour sleep‐wake activity and risk of mild cognitive impairment and dementia among older women Open
Background Sleep and circadian disruption have been associated with cognitive impairment in older adults. However, little is known about the longitudinal change in 24‐hour sleep‐wake activity in oldest old adults and how profiles of sleep‐…
SLEEP AND ITS TREATMENT: EFFECTS ON PHYSICAL AND PSYCHOSOCIAL WELL-BEING Open
Sleep disturbances, dysregulated circadian rhythms, and related disorders can impact multiple aspects of life, including physical health, mobility, mental well-being, and other outcomes of relevance to aging populations. Treatments for spe…
Cardiopulmonary coupling measures of sleep stability and risk of cognitive impairment in community‐based older men Open
Background Poor sleep health is associated with cognitive impairment (CI) in older adults. The cardiopulmonary coupling (CPC) sleep spectrogram, which estimates the sleep state modulated synchronization between heart rate variability and r…