Sunil Gupta
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View article: A Phase Ib Study of Indirect Immunization with Oregovomab and Toll-like-Receptor-3 Stimulation with Hiltonol® in Patients with Recurrent Platinum-Resistant Ovarian Cancer
A Phase Ib Study of Indirect Immunization with Oregovomab and Toll-like-Receptor-3 Stimulation with Hiltonol® in Patients with Recurrent Platinum-Resistant Ovarian Cancer Open
Objectives: This phase Ib study assessed the safety and compatibility of indirect oregovomab immunization and Toll-like-receptor-3 (TLR3) stimulation with immune adjuvant Hiltonol® (poly-ICLC) and induced clinically relevant CA125-specific…
View article: Gene-targeted and pathway-directed therapy in vitiligo: A scoping review of recent advances
Gene-targeted and pathway-directed therapy in vitiligo: A scoping review of recent advances Open
Vitiligo is a chronic autoimmune depigmenting disorder with limited efficacy of conventional therapies. Recent advances in immunology and genetics have delineated specific pathogenic pathways amenable to targeted intervention. To systemati…
View article: A case series of vildagliptin-associated bullous pemphigoid - Rare side effect
A case series of vildagliptin-associated bullous pemphigoid - Rare side effect Open
Vildagliptin, among the most commonly used, OHA, belongs to group dipeptidyl peptidase-4 inhibitors for managing type 2 diabetes mellitus, has recently been associated with bullous pemphigoid, characterized by fluid-filled blisters and ero…
View article: Enhancing the capability through Recycling: Doubling the World's Largest Muon Telescope with almost-buried Iron tubes
Enhancing the capability through Recycling: Doubling the World's Largest Muon Telescope with almost-buried Iron tubes Open
The GRAPES-3 experiment, housing the world's largest muon telescope at 2200 m above sea level in Ooty, is designed to study cosmic-ray effects on Earth. To double the telescope's capability, we have refurbished nearly the same number of pr…
View article: Silencing the Stray Strands: Electrolysis to Tame Latrogenic Oral Hair Growth
Silencing the Stray Strands: Electrolysis to Tame Latrogenic Oral Hair Growth Open
Intraoral hair growth following flap reconstruction for oral cancer surgery is a common but often overlooked complication. This case series presents two patients who developed iatrogenic intraoral hair after nasolabial flap reconstructions…
View article: Interconnection between pre-presbyopia, asthenopia and refractive errors among handcrafting workers
Interconnection between pre-presbyopia, asthenopia and refractive errors among handcrafting workers Open
Background: The aim and objectives of the study were to determine the effect of hand-crafting on different types of refractive errors and to verify whether there is an interconnection between asthenopia and pre presbyopia with such kind of…
View article: Keratometric changes in a population-based study: a comparative analysis of pre- and post-cataract surgery outcomes
Keratometric changes in a population-based study: a comparative analysis of pre- and post-cataract surgery outcomes Open
Background: This study aims to evaluate the distribution of keratometry in cataract patients to know the variation in pre and post of small incision cataract surgery (SICS). To determine the variation in pre and post of small incision cata…
View article: An automated algorithmic method to mitigate long-term variations in the efficiency of the GRAPES-3 muon telescope
An automated algorithmic method to mitigate long-term variations in the efficiency of the GRAPES-3 muon telescope Open
The GRAPES-3 large area muon telescope with its sixteen independent modules records the high energy (>1 GeV) muons continuously over 2.3 sr of the sky. However, the recorded muon rates are contaminated by instrumental effects and instabili…
View article: A Comparative Review on Lung Detox from Smoking-Induced Lung damage
A Comparative Review on Lung Detox from Smoking-Induced Lung damage Open
Smoking induced Lung damage is the multifaceted pathological development, which is compelled by Oxidative stress, Chronic inflammation, epithelial dysfunction and structural remodelling. Although the lungs possess intrinsic self-repair mec…
View article: Predicting Future Rainfall with Various Machine Learning Models
Predicting Future Rainfall with Various Machine Learning Models Open
This research presents a machine learning technique that improves the prediction of the annual rainfall total. Predicting the amount and timing of precipitation in a given region is known as rainfall prediction. The global community is qui…
View article: Comparative Evaluation of 4% Articaine and 2% Lignocaine Anesthetic Agents in Children: A Split-mouth Randomized Control Trial
Comparative Evaluation of 4% Articaine and 2% Lignocaine Anesthetic Agents in Children: A Split-mouth Randomized Control Trial Open
In pediatric dentistry, articaine and lignocaine play a very important roles as local anesthetic agents, offering clinicians effective tools to manage pain and discomfort during dental procedures for children. How to cite this article: Gro…
View article: Patient-centered Assessment of the Efficacy and Safety of Vildagliptin Sustained-release Tablet (100 mg) Relative to Sitagliptin (100 mg) in Patients with Type 2 Diabetes Mellitus Inadequately Controlled on MEtformin (PRIME-Vilda Trial)
Patient-centered Assessment of the Efficacy and Safety of Vildagliptin Sustained-release Tablet (100 mg) Relative to Sitagliptin (100 mg) in Patients with Type 2 Diabetes Mellitus Inadequately Controlled on MEtformin (PRIME-Vilda Trial) Open
Dipeptidyl peptidase-4 inhibitors (DPP4Is) were introduced for the management of type 2 diabetes mellitus (T2DM) due to their insulinotropic effects, lack of inherent hypoglycemia risk, and neutral impact on body weight. Vildagliptin is a …
View article: Efficacy of rituximab in treating systemic sclerosis in HIV-positive patients: A novel case report
Efficacy of rituximab in treating systemic sclerosis in HIV-positive patients: A novel case report Open
HIV infection presents a variety of symptoms, including connective tissue disorders. Systemic sclerosis (SSc) with HIV is rarely reported, with limited literature. We present a 45-year-old female with HIV on HAART who developed diffuse cut…
View article: Superficial temporal artery-middle cerebral artery bypass signal intensity in time of flight magnetic resonance angiography as a marker of cerebral perfusion after revascularization procedure in moyamoya disease patients
Superficial temporal artery-middle cerebral artery bypass signal intensity in time of flight magnetic resonance angiography as a marker of cerebral perfusion after revascularization procedure in moyamoya disease patients Open
The study was conducted to evaluate whether superficial temporal artery-middle cerebral artery (STA-MCA) bypass signal intensity has any correlation with cerebral perfusion on arterial spin labeling (ASL) perfusion in patients with Moyamoy…
View article: Iron Deficiency Anemia among Sanitation Workers in a Tertiary Care Hospital: A Cross-sectional Study
Iron Deficiency Anemia among Sanitation Workers in a Tertiary Care Hospital: A Cross-sectional Study Open
A BSTRACT Background: Iron deficiency anemia (IDA) has been the main cause of the health burden in India over the past decade. The aim of the present study was to examine the iron status and prevalence of iron deficiency anemia using bioch…
View article: A CROSS-SECTIONAL STUDY ON VISUAL OUTCOME AFTER CATARACT SURGERY IN NORTHERN INDIA: AN INDIAN PERSPECTIVE
A CROSS-SECTIONAL STUDY ON VISUAL OUTCOME AFTER CATARACT SURGERY IN NORTHERN INDIA: AN INDIAN PERSPECTIVE Open
Purpose: The main purpose of this study is to determine the visual outcomes and satisfaction among the old age patients after cataract surgery in Northern India. Methodology: It was a cross sectional study conducted to estimate the visual …
View article: Frequency and pattern of Skin Disorders in Adolescents in a School of Kathmandu
Frequency and pattern of Skin Disorders in Adolescents in a School of Kathmandu Open
Introduction: Skin disorders are one of the major causes of morbidity in Nepal. The objectives of this study are to determine the relative frequency and pattern of skin disorders in a cohort of adolescents 9-18 years of age. Methods: The s…
View article: Regret Bounds for Expected Improvement Algorithms in Gaussian Process Bandit Optimization
Regret Bounds for Expected Improvement Algorithms in Gaussian Process Bandit Optimization Open
Regret Bounds for Expected Improvement Algorithms in Gaussian Process Bandit Optimization
View article: Chronic recurrent erythema nodosum due to lepromatous lymphadenitis
Chronic recurrent erythema nodosum due to lepromatous lymphadenitis Open
Leprosy is mostly confined to the skin and peripheral nervous system, although other organs including lymph nodes may sometimes be involved. A 30-year-old male presented to the OPD with fever and reddish raised lesions over the leg for 3–4…
View article: Subcutaneous cysticercosis of the scalp mimicking trichilemmal cyst: a rare case
Subcutaneous cysticercosis of the scalp mimicking trichilemmal cyst: a rare case Open
International Journal of DermatologyEarly View Clinical Correspondence Subcutaneous cysticercosis of the scalp mimicking trichilemmal cyst: a rare case Shiwangi Rana, Corresponding Author Shiwangi Rana [email protected] orcid.org/0000-0002…