Thallapuranam Krishnaswamy Suresh Kumar
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View article: One-step purification of a bioactive PAK1-derived peptide
One-step purification of a bioactive PAK1-derived peptide Open
The serine/threonine kinase PAK1 serves as a mediator of cytoskeletal reorganization and cancer-related signaling downstream of the small GTPases. Due to the challenges in purifying PAK1 complexes, a 46-residue peptide from PAK1, is widely…
View article: Unveiling roles of beneficial gut bacteria and optimal diets for health
Unveiling roles of beneficial gut bacteria and optimal diets for health Open
The gut microbiome plays a pivotal role in human health, influencing digestion, immunity, and disease prevention. Beneficial gut bacteria such as Akkermansia muciniphila , Adlercreutzia equolifaciens , and Christensenella minuta contribute…
View article: Pathology and Therapeutic Significance of Fibroblast Growth Factors
Pathology and Therapeutic Significance of Fibroblast Growth Factors Open
The fibroblast growth factor (FGF) family includes 22 proteins in humans. Based on their mode of action, there are three families of FGFs: paracrine FGFs (FGF 1–10, 16, 17, 18, 20, and 22), intracrine FGFs (FGF 11–14), and endocrine FGFs (…
View article: Decoding FGF/FGFR Signaling: Insights into Biological Functions and Disease Relevance
Decoding FGF/FGFR Signaling: Insights into Biological Functions and Disease Relevance Open
Fibroblast Growth Factors (FGFs) and their cognate receptors, FGFRs, play pivotal roles in a plethora of biological processes, including cell proliferation, differentiation, tissue repair, and metabolic homeostasis. This review provides a …
View article: Structural Stability Comparisons Between Natural and Engineered Group II Chaperonins: Are Crenarchaeal “Heat Shock” Proteins Also “pH Shock” Resistant?
Structural Stability Comparisons Between Natural and Engineered Group II Chaperonins: Are Crenarchaeal “Heat Shock” Proteins Also “pH Shock” Resistant? Open
Archaeal group II chaperonins, also known as heat shock proteins (HSPs), are abundantly expressed in Sulfolobales. HSPα and HSPβ gene expression is upregulated during thermal shock. HSPs form large 18-mer complexes that assist in folding n…
View article: Volunteer-Led, Short-Term, Geophysical Field Experiment: Lessons for Inviting Broader Participation, Building Public Trust, and Communicating Science
Volunteer-Led, Short-Term, Geophysical Field Experiment: Lessons for Inviting Broader Participation, Building Public Trust, and Communicating Science Open
View article: Microenvironment shapes small-cell lung cancer neuroendocrine states and presents therapeutic opportunities
Microenvironment shapes small-cell lung cancer neuroendocrine states and presents therapeutic opportunities Open
View article: A prospective, multicenter study to evaluate the effectiveness and safety of prochlorperazine in patients suffering from vestibular migraine
A prospective, multicenter study to evaluate the effectiveness and safety of prochlorperazine in patients suffering from vestibular migraine Open
Background: Prochlorperazine is commonly used for managing vertigo and dizziness-associated vestibular disorders. This study was designed to evaluate the effectiveness and safety of prochlorperazine in Indian patients with vestibular migra…
View article: Microenvironment Shapes Small Cell Lung Cancer Neuroendocrine States and Presents Therapeutic Opportunities
Microenvironment Shapes Small Cell Lung Cancer Neuroendocrine States and Presents Therapeutic Opportunities Open
Summary Small-cell lung cancer (SCLC) is the most fatal form of lung cancer. Intra-tumoral heterogeneity, marked by neuroendocrine (NE) and non-neuroendocrine (non-NE) cell states, defines SCLC, but the drivers of SCLC plasticity are poorl…
View article: Exploring the Metabolic and Mitogenic Potential of a Hyper-Stable Variant of FGF1
Exploring the Metabolic and Mitogenic Potential of a Hyper-Stable Variant of FGF1 Open
Fibroblast growth factors (FGFs) are a family of 22 human cytokines involved in critical cellular processes, such as proliferation, differentiation, metabolism, angiogenesis, tumor metastasis, and wound healing. Among these, fibroblast gro…
View article: Exploring endocrine FGFs - structures, functions and biomedical applications
Exploring endocrine FGFs - structures, functions and biomedical applications Open
The family of fibroblast growth factors (FGFs) consists of 22 members with diverse biological functions in cells, from cellular development to metabolism. The family can be further categorized into three subgroups based on their three mode…
View article: Valorization and Characterization of Red Banana ( Musa Acuminata ) Peel Powder for the Development of Functional Cookies
Valorization and Characterization of Red Banana ( Musa Acuminata ) Peel Powder for the Development of Functional Cookies Open
View article: Response of Graded Fertility Levels and Zinc Application Method with and without Farm Yard Manure on Physicochemical and Biological Properties of Soil under Rice Crop
Response of Graded Fertility Levels and Zinc Application Method with and without Farm Yard Manure on Physicochemical and Biological Properties of Soil under Rice Crop Open
The field experiment was conducted during Kharif season 2022 at Student’s Instructional farm of Acharya Narendra Deva University of Agriculture and Technology Kumarganj, Ayodhya Uttar Pradesh, India. The experiment was laid out in Randomiz…
View article: Assessment of Physico-chemical Properties of Soil as Influenced by Different Moisture Regimes and Nitrogen Sources in Wheat Crop
Assessment of Physico-chemical Properties of Soil as Influenced by Different Moisture Regimes and Nitrogen Sources in Wheat Crop Open
An experiment was conducted at Student’s “Instructional farm of Acharya Narendra Deva University of Agriculture and Technology Kumarganj, Ayodhya (U.P.) during rabi season 2019-2020. The experiment was laid out in split plot design (SPD) w…
View article: cpSRP43 Is Both Highly Flexible and Stable: Structural Insights Using a Combined Experimental and Computational Approach
cpSRP43 Is Both Highly Flexible and Stable: Structural Insights Using a Combined Experimental and Computational Approach Open
The novel multidomain protein, cpSRP43, is a unique subunit of the post-translational chloroplast signal recognition particle (cpSRP) targeting pathway in higher plants. The cpSRP pathway is responsible for targeting and insertion of light…
View article: Latent Pronucleophiles in Lewis Base Catalysis: Enantioselective Allylation of Silyl Enol Ethers with Allylic Fluorides
Latent Pronucleophiles in Lewis Base Catalysis: Enantioselective Allylation of Silyl Enol Ethers with Allylic Fluorides Open
Lewis base catalyzed allylations of C‐centered nucleophiles have been largely limited to the niche substrates with acidic C−H substituted for C−F bonds at the stabilized carbanionic carbon. Herein we report that the concept of latent pronu…
View article: Supplementary information from A Combinatorial Strategy for Targeting <i>BRAF</i><sup>V600E</sup>-Mutant Cancers with BRAF<sup>V600E</sup> Inhibitor (PLX4720) and Tyrosine Kinase Inhibitor (Ponatinib)
Supplementary information from A Combinatorial Strategy for Targeting <i>BRAF</i><sup>V600E</sup>-Mutant Cancers with BRAF<sup>V600E</sup> Inhibitor (PLX4720) and Tyrosine Kinase Inhibitor (Ponatinib) Open
Supplementary method and data
View article: Supplementary Table 1 from USP7 Cooperates with NOTCH1 to Drive the Oncogenic Transcriptional Program in T-Cell Leukemia
Supplementary Table 1 from USP7 Cooperates with NOTCH1 to Drive the Oncogenic Transcriptional Program in T-Cell Leukemia Open
Supplementary Table 1
View article: Latent Pronucleophiles in Lewis Base Catalysis: Enantioselective Allylation of Silylated Stabilized Carbon Nucleophiles with Allylic Fluorides
Latent Pronucleophiles in Lewis Base Catalysis: Enantioselective Allylation of Silylated Stabilized Carbon Nucleophiles with Allylic Fluorides Open
Lewis base catalyzed allylations of C-centered nucleophiles have been largely limited to the niche substrates with acidic C-H substituted with C-F bonds at the stabilized carbanionic carbon. Here we report that the concept of latent pronuc…
View article: Binding affinity estimation from restrained umbrella sampling simulations
Binding affinity estimation from restrained umbrella sampling simulations Open
The protein–ligand binding affinity quantifies the binding strength between a protein and its ligand. Computer modeling and simulations can be used to estimate the binding affinity or binding free energy using data- or physics-driven metho…
View article: Binding Affinity Estimation from Restrained Umbrella Sampling Simulations
Binding Affinity Estimation from Restrained Umbrella Sampling Simulations Open
The protein-ligand binding affinity quantifies the binding strength between a protein and its ligand. Computer modeling and simulations can be used to estimate the binding affinity or binding free energy using data- or physics-driven metho…
View article: cpSRP43 is both highly flexible and stable: Structural insights using a combined experimental and computational approach
cpSRP43 is both highly flexible and stable: Structural insights using a combined experimental and computational approach Open
The novel multidomain protein, cpSRP43, is a unique subunit of the post-translational chloroplast signal recognition particle (cpSRP) targeting pathway in higher plants. The cpSRP pathway is responsible for targeting and insertion of light…
View article: Mechanistic Picture for Monomeric Human Fibroblast Growth Factor 1 Stabilization by Heparin Binding
Mechanistic Picture for Monomeric Human Fibroblast Growth Factor 1 Stabilization by Heparin Binding Open
Human fibroblast growth factor (FGF) 1 or hFGF1 is a member of the FGF family that is involved in various vital processes such as cell proliferation, cell differentiation, angiogenesis, and wound healing. hFGF1, which is associated with lo…
View article: Binding Affinity Estimation From Restrained Umbrella Sampling Simulations
Binding Affinity Estimation From Restrained Umbrella Sampling Simulations Open
The protein-ligand binding affinity quantifies the binding strength between a protein and its ligand. Computer modeling and simulations can be used to estimate the binding affinity or binding free energy using data- or physics-driven metho…
View article: Transient local secondary structure in the intrinsically disordered C-term of the Albino3 insertase
Transient local secondary structure in the intrinsically disordered C-term of the Albino3 insertase Open
View article: Stability Comparisons between Natural versus Engineered Archaeal Heat-Shock Proteins
Stability Comparisons between Natural versus Engineered Archaeal Heat-Shock Proteins Open
Crenarchaeal group II chaperonins (a.k.a., “heat shock” proteins, HSPs) are abundantly expressed in species of the family Sulfolobaceae . HSPα and HSPβ expression is upregulated during thermal shock. HSPs are subunits of larger octadecamer…
View article: Characterization of the structural forces governing the reversibility of the thermal unfolding of the human acidic fibroblast growth factor
Characterization of the structural forces governing the reversibility of the thermal unfolding of the human acidic fibroblast growth factor Open
View article: Long-Term vs. Short-Term Forecasting Data Scientist's Strategies for Different Horizons
Long-Term vs. Short-Term Forecasting Data Scientist's Strategies for Different Horizons Open
View article: Simplification of the purification of heat stable recombinant low molecular weight proteins and peptides from GST-fusion products
Simplification of the purification of heat stable recombinant low molecular weight proteins and peptides from GST-fusion products Open
View article: DNA aptamer-based rolling circle amplification product as a novel immunological adjuvant
DNA aptamer-based rolling circle amplification product as a novel immunological adjuvant Open
Several agonists to CD40 have shown to induce acquired immune responses. Here, we developed and evaluated the rolling circle amplification (RCA) products that are based on anti-CD40 DNA aptamers as a novel vaccine adjuvant. First, we devel…