Akira Suzuki
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View article: Jean-François Morot-Gaudry (1943–2024): A Life Devoted to Plant Science, Leadership, and Humanity
Jean-François Morot-Gaudry (1943–2024): A Life Devoted to Plant Science, Leadership, and Humanity Open
It is with deep sadness that we learned of the passing of Dr [...]
View article: Hierarchical Time Series Forecasting with Robust Reconciliation
Hierarchical Time Series Forecasting with Robust Reconciliation Open
This paper focuses on forecasting hierarchical time-series data, where each higher-level observation equals the sum of its corresponding lower-level time series. In such contexts, the forecast values should be coherent, meaning that the fo…
View article: Sustained YAP1 activation induces DNA demethylation that promotes the development of hepatocellular carcinomas lacking driver gene mutations
Sustained YAP1 activation induces DNA demethylation that promotes the development of hepatocellular carcinomas lacking driver gene mutations Open
Recent advances in next-generation nucleotide sequencing have led to the identification of driver gene mutations (DGMs) in human cancers. However, a significant percentage of human malignancies without DGMs has been reported, and the mecha…
View article: Niche-targeted therapy via YAP/TAZ activation enhances hematopoietic regeneration
Niche-targeted therapy via YAP/TAZ activation enhances hematopoietic regeneration Open
The distinctive milieu of the bone marrow (BM), known as the BM niche, supports hematopoietic stem cells (HSCs) and serves as a foundation for hematopoietic regeneration. Myeloablative stress disrupts not only hematopoietic stem and progen…
View article: On the complexity of list <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" altimg="si1.svg"><mml:mi mathvariant="script">H</mml:mi></mml:math>-packing for sparse graph classes
On the complexity of list -packing for sparse graph classes Open
View article: Estimating sales transitions between competing products via optimal transport
Estimating sales transitions between competing products via optimal transport Open
In mature markets, where products are widely adopted, understanding how customers switch between competing products is crucial for companies to conduct effective marketing actions. However, due to privacy regulations, it is increasingly di…
View article: MOB1 deletion in murine mature adipocytes ameliorates obesity and diabetes
MOB1 deletion in murine mature adipocytes ameliorates obesity and diabetes Open
There is currently a global epidemic of obesity and obesity-related diseases such as type 2 diabetes due to decreased physical activity, excessive food intake, and/or genetic predisposition. The Hippo-YAP1 pathway has attracted attention a…
View article: The two-sample Mood statistic for clustered data
The two-sample Mood statistic for clustered data Open
The classical Mood statistic is frequently used to test the equality of scale parameters in two-sample problems. However, its application requires the assumption of independent observations. In many practical situations, correlated observa…
View article: P221 Complete resection of post-chemotherapy residual tumor could improve the prognosis in Non-Seminomatous Germ Cell Tumors (NSGCT)
P221 Complete resection of post-chemotherapy residual tumor could improve the prognosis in Non-Seminomatous Germ Cell Tumors (NSGCT) Open
View article: Optimization of a pendant-shaped PEGylated linker for antibody-drug conjugates
Optimization of a pendant-shaped PEGylated linker for antibody-drug conjugates Open
View article: A highly sensitive reporter system to monitor endogenous <scp>YAP1</scp>/<scp>TAZ</scp> activity and its application in various human cells
A highly sensitive reporter system to monitor endogenous <span>YAP1</span>/<span>TAZ</span> activity and its application in various human cells Open
The activation of yes‐associated protein 1 (YAP1) and transcriptional co‐activator with PDZ‐binding motif (TAZ) has been implicated in both regeneration and tumorigenesis, thus representing a double‐edged sword in tissue homeostasis. Howev…
View article: Evaluating Cellularity Estimation Methods: Comparing AI Counting with Pathologists’ Visual Estimates
Evaluating Cellularity Estimation Methods: Comparing AI Counting with Pathologists’ Visual Estimates Open
The development of next-generation sequencing (NGS) has enabled the discovery of cancer-specific driver gene alternations, making precision medicine possible. However, accurate genetic testing requires a sufficient amount of tumor cells in…
View article: Spin and charge interactions between nanographene host and ferrocene
Spin and charge interactions between nanographene host and ferrocene Open
Ferrocene (FeCp 2 ) was introduced as a non-magnetic guest molecule to activated carbon fibers (ACFs) as a nanographene-based host having localized spins originating from zigzag edges of graphene. The introduction of the guest molecule was…
View article: Individual disruption of 12 testis-enriched genes via the CRISPR/Cas9 system does not affect the fertility of male mice
Individual disruption of 12 testis-enriched genes via the CRISPR/Cas9 system does not affect the fertility of male mice Open
View article: Obituary Dr. Shun-ichi Udagawa (1931-2023)
Obituary Dr. Shun-ichi Udagawa (1931-2023) Open
became interested in the taxonomy of Penicillium and secondary metabolites from Penicillium spp.while
View article: A Review of Basic Analytics, Medical Data Sources, and Advanced Data Analytics in the Medical Sector
A Review of Basic Analytics, Medical Data Sources, and Advanced Data Analytics in the Medical Sector Open
This article provides a thorough examination of healthcare data analytics and identifies various unresolved questions that necessitate further investigation. The implementation of healthcare analytics has the potential to generate two supp…
View article: DEVELOPMENT OF A TELESCOPIC ACTIVE SCOPE CAMERA THAT THREADS PERFORATED PLATES FOR THE DECOMMISSIONING OF THE FUKUSHIMA DAIICHI NUCLEAR POWER PLANT
DEVELOPMENT OF A TELESCOPIC ACTIVE SCOPE CAMERA THAT THREADS PERFORATED PLATES FOR THE DECOMMISSIONING OF THE FUKUSHIMA DAIICHI NUCLEAR POWER PLANT Open
View article: Finding Induced Subgraphs from Graphs with Small Mim-Width
Finding Induced Subgraphs from Graphs with Small Mim-Width Open
In the last decade, algorithmic frameworks based on a structural graph parameter called mim-width have been developed to solve generally NP-hard problems. However, it is known that the frameworks cannot be applied to the Clique problem, an…
View article: On the complexity of list $\mathcal H$-packing for sparse graph classes
On the complexity of list $\mathcal H$-packing for sparse graph classes Open
The problem of packing as many subgraphs isomorphic to $H \in \mathcal H$ as possible in a graph for a class $\mathcal H$ of graphs is well studied in the literature. Both vertex-disjoint and edge-disjoint versions are known to be NP-compl…
View article: Oral Microbial Profile Analysis in Patients with Oral and Pharyngeal Cancer Reveals That Tumoral Fusobacterium nucleatum Promotes Oral Cancer Progression by Activating YAP
Oral Microbial Profile Analysis in Patients with Oral and Pharyngeal Cancer Reveals That Tumoral Fusobacterium nucleatum Promotes Oral Cancer Progression by Activating YAP Open
The incidence of oral cancer has recently been increasing worldwide, particularly among young individuals and women. The primary risk factors for head and neck cancers, including oral and pharyngeal cancers, are smoking, alcohol consumptio…
View article: Ferroptosis induced by plasma‐activated Ringer's lactate solution prevents oral cancer progression
Ferroptosis induced by plasma‐activated Ringer's lactate solution prevents oral cancer progression Open
Objective This study aimed to investigate the effect of plasma‐activated Ringer's lactate solution (PAL) on oral squamous cell carcinoma (OSCC) cells and carcinogenic processes with a particular focus on iron and collagenous matrix formati…
View article: A case of PSA-negative solitary pulmonary metastasis from prostate cancer diagnosed by immunostaining for NKX3.1 14 years after treatment initiation for prostate cancer
A case of PSA-negative solitary pulmonary metastasis from prostate cancer diagnosed by immunostaining for NKX3.1 14 years after treatment initiation for prostate cancer Open
前立腺癌の肺転移は他臓器への転移を伴うことや多発性であることが多く,孤立性転移は稀である.前立腺癌のマーカーとしてPSAが知られているが,PSA陰性での孤立性肺転移は原発性肺癌との鑑別に苦慮する.症例は72歳の男性.PET-CT健診で右肺中葉の結節に異常集積を指摘され当院呼吸器内科を紹介となった.他医で14年前に前立腺癌に対し前立腺全摘が行われ,以降はPSA値と5年間のみの画像診断で経過観察されていたが特に異常は指摘されていなかった.1年間のCT経過観察で右肺結節の増大を認…
View article: Secondary bladder cancer after radiotherapy for prostate cancer
Secondary bladder cancer after radiotherapy for prostate cancer Open
View article: P1.26-04 Increased Risk of Death from Other Causes After Lobectomy Compared with Sublober Resection in Lung Cancer Patients
P1.26-04 Increased Risk of Death from Other Causes After Lobectomy Compared with Sublober Resection in Lung Cancer Patients Open
View article: Lethal Phenotype-Based Database Screening Identifies Ceramide as a Negative Regulator of Primitive Streak Formation
Lethal Phenotype-Based Database Screening Identifies Ceramide as a Negative Regulator of Primitive Streak Formation Open
In early embryogenesis, the primitive streak (PrS) generates the mesendoderm and is essential for organogenesis. However, because the PrS is a minute and transient tissue, elucidating the mechanism of its formation has been challenging. We…
View article: Review of Articles Related to the Accident of TEPCO’s Fukushima Daiichi Nuclear Power Station Published on Japanese Journal of Health Physics: Environment Monitoring
Review of Articles Related to the Accident of TEPCO’s Fukushima Daiichi Nuclear Power Station Published on Japanese Journal of Health Physics: Environment Monitoring Open
The Japanese Journal of Health Physics has shown a large number of articles related to the accident at the TEPCO's Fukushima Daiichi NPP in March 2011. In these, 39 articles on environmental monitoring have been published up to March 2022.…
View article: A Case of Mesangial Proliferative Nephritis Caused by Slow Cryoglobulin
A Case of Mesangial Proliferative Nephritis Caused by Slow Cryoglobulin Open
The patient was a woman in her 60s. She was found to have proteinuria on a health checkup. She did not have any particular subjective symptoms, and no definitive diagnosis was made, despite serological findings indicative of immune abnorma…
View article: A case of uniportal video-assisted thoracoscopic resection for posterior mediastinal Müllerian cyst
A case of uniportal video-assisted thoracoscopic resection for posterior mediastinal Müllerian cyst Open
後縦隔に発生するミュラー管囊胞は良性の疾患で非侵襲的手術のよい適応と考えられる．我々は単孔式胸腔鏡手術で摘出した後縦隔ミュラー管囊胞を経験した．症例は36歳の女性．Body Mass Indexは39.2であった．背部痛があり近医を受診した．精査では背部痛の原因となる明らかな病変は認めなかったが，左後縦隔に囊胞性病変を認め当科紹介となった．囊胞性病変は第7胸椎と下行大動脈に接して存在した．当院での経験から神経原性腫瘍や胸腔内髄膜瘤などを疑い，単孔式胸腔鏡手術で切除を行った．…
View article: Data from INPP4B Is a PtdIns(3,4,5)P<sub>3</sub> Phosphatase That Can Act as a Tumor Suppressor
Data from INPP4B Is a PtdIns(3,4,5)P<sub>3</sub> Phosphatase That Can Act as a Tumor Suppressor Open
Inositol polyphosphate 4-phosphatase B (INPP4B) has been identified as a tumor suppressor mutated in human breast, ovary, and prostate cancers. The molecular mechanism underlying INPP4B's tumor-suppressive role is currently unknown. Here, …
View article: Supplementary Figure Legends from INPP4B Is a PtdIns(3,4,5)P<sub>3</sub> Phosphatase That Can Act as a Tumor Suppressor
Supplementary Figure Legends from INPP4B Is a PtdIns(3,4,5)P<sub>3</sub> Phosphatase That Can Act as a Tumor Suppressor Open
Supplementary Figure Legends