Upendra Sharma
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View article: Uncovering the Mechanisms of <i>Angelica glauca</i> Edgew. In Breast Cancer: A Combined In Vitro and In Silico Approach
Uncovering the Mechanisms of <i>Angelica glauca</i> Edgew. In Breast Cancer: A Combined In Vitro and In Silico Approach Open
Angelica glauca Edgew. is a medicinal herb native to the Himalayan region, renowned for its significant therapeutic potential and traditional use in treating various ailments. However, it has not been extensively investigated with pertinen…
View article: Role of ultrasound in management of postburn contracture of the extremities
Role of ultrasound in management of postburn contracture of the extremities Open
Aims and Objectives: This study aimed at assessing the role of ultrasound in postburn contracture evaluation of extremities. It correlated preoperative ultrasound with intraoperative findings to determine its usefulness in treatment planni…
View article: Ru(II)-Catalyzed Late-Stage C-H Amidation of Medicinally Rele-vant Benzodiazepine Scaffold
Ru(II)-Catalyzed Late-Stage C-H Amidation of Medicinally Rele-vant Benzodiazepine Scaffold Open
A late-stage C-H functionalization of 1,4-benzodiazepines for direct C-H amidation has been developed via Ru-catalyzed C-H activation. This method efficiently generates medicinally relevant functionalized products using Ru-metal. Tosyl azi…
View article: Direct site-selective C(sp<sup>3</sup>)–H functionalization of unprotected non-activated alcohols
Direct site-selective C(sp<sup>3</sup>)–H functionalization of unprotected non-activated alcohols Open
Free alcohols are ubiquitous in nature, drugs, bulk chemicals, and various complex molecules. The abundantly available free aliphatic alcohols, being inexpensive, are sustainable starting materials in organic synthesis to construct value-a…
View article: Photocatalytic Synthesis of unsymmetrical Bis-N-Heterocycles
Photocatalytic Synthesis of unsymmetrical Bis-N-Heterocycles Open
In this study, a sustainable approach has been revealed for the synthesis of bis-N-heteroaryl motifs comprising an indole and an isoquinoline/quinoline moieties. A novel photolabile phthalimide reagent based on indole was specifically desi…
View article: Two new alkaloids from the roots of <i>Cocculus hirsutus</i> (L.) W. Theob
Two new alkaloids from the roots of <i>Cocculus hirsutus</i> (L.) W. Theob Open
Two undescribed alkaloids, 15-carboxydihydroerysotrine (1) and (14 R)-4-methoxy-13,14-dihydrooxypalmatine (2), along with six known compounds, 1,6-didehydro-3,15,16-trimethoxy-9-methylerythrinanium (3), 8-oxytetrahydropalmatine (4), 20-hyd…
View article: Rh(III)-Catalyzed Regioselective C8-alkenylation of isoquinolones with methoxyallene: A Facile Access to aldehyde bearing isoquin-olones
Rh(III)-Catalyzed Regioselective C8-alkenylation of isoquinolones with methoxyallene: A Facile Access to aldehyde bearing isoquin-olones Open
A simple and facile access to isoquinolone aldehyde scaffolds has been achieved through a rhodium-catalyzed reaction between isoquinolone and methoxyallene. Herein, methoxyallene serves as an acrolein equivalent, resulting in this unique f…
View article: Ru(II)-catalyzed C7 trifluoromethylthiolation and thioaryla-tion of indolines using bench-stable reagents
Ru(II)-catalyzed C7 trifluoromethylthiolation and thioaryla-tion of indolines using bench-stable reagents Open
A Ru(II)-catalyzed C(sp2)-H trifluoromethylthiolation and thioarylation of indolines using bench-stable reagents have been explored. Diversely substituted indolines were successfully functionalized at C7 position in good to excellent yield…
View article: Examining medical urgent and patient precedence within the telemedicine landscape with its infrastructure and policies: A comprehensive review
Examining medical urgent and patient precedence within the telemedicine landscape with its infrastructure and policies: A comprehensive review Open
Medical facilities are confronted with grave issues, including a population that is aging and a physician shortage. In an effort to address these issues, telehealth and remote health monitoring systems (RHMS) aim to reduce hospital visits …
View article: Inherent directing group enabled, Co(III)-catalyzed C-H allylation/ vi-nylation of isoquinolones
Inherent directing group enabled, Co(III)-catalyzed C-H allylation/ vi-nylation of isoquinolones Open
The site-selective C8-allylation and vinylation of isoquinolones have been accomplished using allyl acetate and vinyl acetate and oxo group of isoquinolone as an inherent directing group in the presence of Co(III) catalysis. A plausible me…
View article: Chemo selective C-H alkylation of isoquinolones with maleimides: A combined experimental and computational case study
Chemo selective C-H alkylation of isoquinolones with maleimides: A combined experimental and computational case study Open
A comparative study of C8-alkylation of isoquinolone with maleimides is reported under different catalytical systems. Among different catalytical systems, Ru and Rh catalysts were found to be excellent in providing C8-alkylated products in…
View article: Laboratory-scale extraction of <i>Hildegardia barteri</i> (Mast.) Kosterm. seed oil with different solvents, purified with membrane filtration
Laboratory-scale extraction of <i>Hildegardia barteri</i> (Mast.) Kosterm. seed oil with different solvents, purified with membrane filtration Open
The shortcomings encountered from the use of conventional methods of refining draw considerable attention when it comes to the processing of edible oils. The present invention to this effect is the usage of membrane technology, which stand…
View article: Chemometric guided isolation of new triterpenoid saponins as acetylcholinesterase inhibitors from Achyranthes bidentata Blume
Chemometric guided isolation of new triterpenoid saponins as acetylcholinesterase inhibitors from Achyranthes bidentata Blume Open
Achyranthes bidentata Blume is an annual herb widely used as functional food and for ethnomedicinal purposes in Traditional Chinese medicine. Its seeds are widely used as cereal grain substitutes due to their excellent nutritional composit…
View article: Synthesis of Axially Chiral Biaryls via Pd(II)-Catalysed Direct C(sp2)-H Olefination and Arylation
Synthesis of Axially Chiral Biaryls via Pd(II)-Catalysed Direct C(sp2)-H Olefination and Arylation Open
Herein, two efficient reaction protocols for the construction of axially chiral biaryls via Pd-catalysed direct C-H functionalization of 1-arylisoquinoline N-oxides through kinetic resolution have been uncovered. The atroposelective C-H ol…
View article: Flavonoids from aerial parts of Cissampelos pareira L. as antimalarial agents: Computational validation of ethnopharmacological relevance
Flavonoids from aerial parts of Cissampelos pareira L. as antimalarial agents: Computational validation of ethnopharmacological relevance Open
The diverse chemical scaffolds of the Cissampelos pareira make it pharmacologically distinct because of its pleiotropic therapeutical applications. Phytochemically, C. pareira is primarily known for its isoquinoline alkaloids, but flavonoi…
View article: Identification of Novel, Potent, and Selective Compounds against Malaria Using Glideosomal-Associated Protein 50 as a Drug Target
Identification of Novel, Potent, and Selective Compounds against Malaria Using Glideosomal-Associated Protein 50 as a Drug Target Open
Phylum apicomplexan consists of parasites, such as Plasmodium and Toxoplasma. These obligate intracellular parasites enter host cells via an energy-dependent process using specialized machinery, called the glideosome. In the present study,…
View article: CCDC 2225850: Experimental Crystal Structure Determination
CCDC 2225850: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: NADES-based essential oil extraction and isolation of new epoxysesquiterpene from Ageratina adenophora flowers
NADES-based essential oil extraction and isolation of new epoxysesquiterpene from Ageratina adenophora flowers Open
During the past decade, natural deep eutectic solvents (NADESs) have emerged as a green alternative to conventional organic solvents due to properties like low toxicity, diverse metabolite solubility, and biodegradability. In the present s…
View article: Rhodium‐Catalyzed C8‐Alkenylation of Isoquinolones with Maleimides
Rhodium‐Catalyzed C8‐Alkenylation of Isoquinolones with Maleimides Open
An efficient Rh(III)‐catalyzed C−H alkenylation of N ‐protected isoquinolone with maleimides is reported. The carbonyl group of isoquinolone acts as an inherent directing group. Various N ‐substituents in the maleimide, including alkyl, ar…
View article: Identification of novel, potent, and selective compounds against malaria using Glideosomal Associated Protein 50 as a drug Target
Identification of novel, potent, and selective compounds against malaria using Glideosomal Associated Protein 50 as a drug Target Open
Phylum apicomplexan consists of parasites like Plasmodium and Toxoplasma . These obligate intracellular parasites enter host cells via an energy-dependent process using a specialized machinery called glideosome. In the present study, we us…
View article: CCDC 2218296: Experimental Crystal Structure Determination
CCDC 2218296: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2218294: Experimental Crystal Structure Determination
CCDC 2218294: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2210914: Experimental Crystal Structure Determination
CCDC 2210914: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Insecticidal potential of extracts, fractions, and molecules of <i>Aconitum heterophyllum</i> Wall ex. Royle against aphid <i>Aphis craccivora</i> Koch (Hemiptera: Aphididae)
Insecticidal potential of extracts, fractions, and molecules of <i>Aconitum heterophyllum</i> Wall ex. Royle against aphid <i>Aphis craccivora</i> Koch (Hemiptera: Aphididae) Open
BACKGROUND Aphis craccivora is the major sap‐sucking pest of leguminous crops and vector of plant viruses that cause damage to plants and reduce yield. Indiscriminate and nonjudicious use of synthetic insecticides led to resistance develop…
View article: Journey of plants natural products from plants to bioactive products
Journey of plants natural products from plants to bioactive products Open
Secondary metabolites present in medicinal plants having intrinsic functions in the host also possess vast and versatile pharmacological effects along with a crucial role in the herbal, food, cosmetics, and chemical industry sector. Tradit…
View article: A novel extraction method enhanced the osteogenic and anti-osteoporosis effect of tea extract without any hepatotoxicity in ovariectomized rats
A novel extraction method enhanced the osteogenic and anti-osteoporosis effect of tea extract without any hepatotoxicity in ovariectomized rats Open
Tea ( Camellia sinensis ) has several reported health benefits, including that on bone health attributed to catechins of which the most abundant is epigallocatechin-3-gallate (EGCG). However, several preclinical and clinical studies raise …
View article: CCDC 2175296: Experimental Crystal Structure Determination
CCDC 2175296: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1921733: Experimental Crystal Structure Determination
CCDC 1921733: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …