Wayne K. Goodman
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View article: A Multi-Symptom Circuit Architecture of Obsessive–Compulsive Disorder
A Multi-Symptom Circuit Architecture of Obsessive–Compulsive Disorder Open
Obsessive–compulsive disorder (OCD) manifests with diverse symptom constellations that likely arise from dysfunction in partially distinct neural circuits. Deep brain stimulation (DBS), paired with high-resolution connectomics, offers a un…
View article: Disinhibited behavior associated with rapid clinical response to deep brain stimulation for obsessive-compulsive disorder: illustrative cases.
Disinhibited behavior associated with rapid clinical response to deep brain stimulation for obsessive-compulsive disorder: illustrative cases. Open
The unusually rapid improvement (weeks vs months) in OCD symptoms coincided with clinically significant disinhibited behavior. These findings support the role of VC/VS DBS in promoting goal-oriented activation and underscore the importance…
View article: Characterizing Deep Brain Stimulation Dual Device Beat Frequency Artifacts
Characterizing Deep Brain Stimulation Dual Device Beat Frequency Artifacts Open
Introduction Recording-enabled deep brain stimulation devices are used to treat individuals with a variety of neurological disorders, but current systems are only able to connect to a maximum of two brain leads. Off-label implantation of a…
View article: Digital Biomarkers for Passive Remote Monitoring of Bipolar Disorder: Systematic Review
Digital Biomarkers for Passive Remote Monitoring of Bipolar Disorder: Systematic Review Open
Background Bipolar disorder (BD) features episodic shifts among (hypo)mania, depression, mixed states, and euthymia. Timely detection of mood transitions is difficult due to infrequent clinical touchpoints. Digital health technologies, inc…
View article: Digital Biomarkers for Passive Remote Monitoring of Bipolar Disorder: Systematic Review (Preprint)
Digital Biomarkers for Passive Remote Monitoring of Bipolar Disorder: Systematic Review (Preprint) Open
BACKGROUND Bipolar disorder (BD) features episodic shifts among (hypo)mania, depression, mixed states, and euthymia. Timely detection of mood transitions is difficult due to infrequent clinical touchpoints. Digital health technologies, inc…
View article: Translating the Transcriptome: A Connectomics Approach for Gene-Network Mapping and Clinical Application
Translating the Transcriptome: A Connectomics Approach for Gene-Network Mapping and Clinical Application Open
Gene expression shapes the brain's functional connectome, yet it is unclear whether genes linked to the same disorder converge on shared networks. We introduce gene network mapping-a framework combining spatial transcriptomics with normati…
View article: ADHD in Youth With Major Depressive Disorder in the Texas Youth Depression and Suicide Research Network (TX-YDSRN): Clinical Correlates and Moderators
ADHD in Youth With Major Depressive Disorder in the Texas Youth Depression and Suicide Research Network (TX-YDSRN): Clinical Correlates and Moderators Open
Objective: Depression is a major public health concern with a 19% lifetime prevalence in youth, often precipitating other concerns, including suicidal behavior, poor school performance, and worsened peer relationships. ADHD is also common …
View article: Transdiagnostic correlates of family accommodation in anxious youth.
Transdiagnostic correlates of family accommodation in anxious youth. Open
Anxiety disorders are common in children and cause significant impairment. Family accommodation (FA), which refers to behavioral changes that family members make to temporarily alleviate a child's anxiety, has been linked to child anxiety …
View article: Artifact Identification and Mitigation Strategies for Longitudinal Neural Data Collection Onboard the Medtronic Percept DBS Device <sup>*</sup>
Artifact Identification and Mitigation Strategies for Longitudinal Neural Data Collection Onboard the Medtronic Percept DBS Device <sup>*</sup> Open
Recent advances in deep brain stimulation (DBS) devices have enabled the ability to capture continuous neural recordings concurrently with stimulation therapy in the background of everyday life. These recordings provide the opportunity to …
Intracranial directed connectivity links subregions of the prefrontal cortex to major depression Open
Research on the neural basis of major depressive disorder suggests that it is fundamentally a disease of cortical disinhibition, where breakdowns of inhibitory neuronal systems lead to diminished emotion regulation and intrusive rumination…
View article: Feasibility and Acceptability of a Brief Intervention for Youth Suicidal Thoughts and Behaviors Among Pediatric Primary Care Providers
Feasibility and Acceptability of a Brief Intervention for Youth Suicidal Thoughts and Behaviors Among Pediatric Primary Care Providers Open
Findings suggest that a tiered training structure allowing for more flexibility in training commitment might be more feasible for busy PCPs seeking training in SAFETY-A. Ongoing efforts to feasibly scale-up SAFETY-A training efforts across…
View article: The structure of posttraumatic stress symptoms in youth with and without obsessive-compulsive disorder: New insights using factor and network analysis
The structure of posttraumatic stress symptoms in youth with and without obsessive-compulsive disorder: New insights using factor and network analysis Open
Posttraumatic stress disorder (PTSD) and obsessive-compulsive disorder (OCD) share ostensibly similar and sometimes overlapping symptoms that complicate diagnostic assessment and conceptualization. While varying models for the symptom stru…
View article: EMulator: Rapid Estimation of Complex-valued Electric Fields using a U-Net Architecture
EMulator: Rapid Estimation of Complex-valued Electric Fields using a U-Net Architecture Open
A common factor across electromagnetic methodologies of brain stimulation is the optimization of essential dosimetry parameters, like amplitude, phase, and location of one or more transducers, which controls the stimulation strength and ta…
View article: Provider Perceptions of In-Person Versus Telehealth Delivery of Habit Reversal Training for Tic Disorders
Provider Perceptions of In-Person Versus Telehealth Delivery of Habit Reversal Training for Tic Disorders Open
Background Habit reversal training (HRT) is an efficacious intervention for individuals with tic disorders that can be delivered both in-person and via telehealth. Despite noted effectiveness, no known studies have directly compared provid…
View article: Affective bias predicts changes in depression during deep brain stimulation therapy
Affective bias predicts changes in depression during deep brain stimulation therapy Open
Introduction Deep brain stimulation (DBS) is a promising treatment for refractory depression, utilizing surgically implanted electrodes to stimulate specific anatomical targets within the brain. However, limitations of patient-reported and…
View article: Latin American Trans‐ancestry INitiative for OCD genomics (LATINO): Study protocol
Latin American Trans‐ancestry INitiative for OCD genomics (LATINO): Study protocol Open
Obsessive-compulsive disorder (OCD) is a debilitating psychiatric disorder. Worldwide, its prevalence is ~2% and its etiology is mostly unknown. Identifying biological factors contributing to OCD will elucidate underlying mechanisms and mi…
Multimodal objective assessment of impulsivity in healthy and mood disorder participants Open
Impulsivity represents an individual’s tendency to act on urges without sufficient forethought. Heightened impulsivity is a hallmark of many mental health disorders. Objective impulsivity assessments could improve risk evaluation, diagnosi…
View article: High Beta Power in the Ventrolateral Prefrontal Cortex Indexes Human Approach Behavior: A Case Study
High Beta Power in the Ventrolateral Prefrontal Cortex Indexes Human Approach Behavior: A Case Study Open
Deep brain stimulation (DBS) of the ventral capsule and ventral striatum (VC/VS) is an effective therapy for treatment-resistant obsessive–compulsive disorder (trOCD). DBS initiation often produces acute improvements in mood and energy. Th…
Aperiodic spectral slope tracks the effects of brain state on saliency responses in the human auditory cortex Open
Alteration of responses to salient stimuli occurs in a wide range of brain disorders and may be rooted in pathophysiological brain state dynamics. Specifically, tonic and phasic modes of activity in the reticular activating system (RAS) in…
View article: Aperiodic (1/f) Neural Activity Robustly Tracks Symptom Severity Changes in Treatment-Resistant Depression
Aperiodic (1/f) Neural Activity Robustly Tracks Symptom Severity Changes in Treatment-Resistant Depression Open
This biomarker offers a new way to track patient responses to major depressive disorder treatment, thus paving the way for individualized therapies in both intracranial and noninvasive monitoring contexts.