K. Wallden
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View article: Structure of the central <i>Staphylococcus aureus</i> AAA+ protease MecA/ClpC/ClpP
Structure of the central <i>Staphylococcus aureus</i> AAA+ protease MecA/ClpC/ClpP Open
Bacterial AAA+ proteases are composed of a AAA+ partner (e.g. ClpC) and an associated peptidase (e.g. ClpP). They represent ATP-fuelled and self-compartmentalized proteolytic machines that are crucial for stress resistance and virulence. C…
View article: Design, structure and plasma binding of ancestral β-CoV scaffold antigens
Design, structure and plasma binding of ancestral β-CoV scaffold antigens Open
We report the application of ancestral sequence reconstruction on coronavirus spike protein, resulting in stable and highly soluble ancestral scaffold antigens (AnSAs). The AnSAs interact with plasma of patients recovered from COVID-19 but…
View article: Design, structure and plasma binding of ancestral β-CoV scaffold antigens
Design, structure and plasma binding of ancestral β-CoV scaffold antigens Open
The pandemic caused by Severe acute respiratory syndrome coronavirus 2 has had devastating consequences on global health and economy. Despite the success of vaccination campaigns emerging variants are of concern and novel viruses with the …
View article: Design, synthesis, and evaluation of peptide‐imidazo[1,2‐<i>a</i>]pyrazine bioconjugates as potential bivalent inhibitors of the VirB11 ATPase HP0525
Design, synthesis, and evaluation of peptide‐imidazo[1,2‐<i>a</i>]pyrazine bioconjugates as potential bivalent inhibitors of the VirB11 ATPase HP0525 Open
Helicobacter pylori ( H. pylori ) infections have been implicated in the development of gastric ulcers and various cancers: however, the success of current therapies is compromised by rising antibiotic resistance. The virulence and pathoge…