Yasodha Krishnasamy
YOU?
Author Swipe
View article: LP342, a novel histone deacetylase inhibitor, decreases nitro-oxidative stress, mitochondrial dysfunction and hepatic ischaemia/reperfusion injury in mice
LP342, a novel histone deacetylase inhibitor, decreases nitro-oxidative stress, mitochondrial dysfunction and hepatic ischaemia/reperfusion injury in mice Open
Objectives Some histone deacetylase (HDAC) isoforms contribute to ischaemia/reperfusion (IR) injury (IRI). Here, we examined whether LP342, the lead candidate of a new generation of hydrazide-based HDAC inhibitors (HDACi), decreases hepati…
View article: Mitochondrial depolarization after acute ethanol treatment drives mitophagy in living mice
Mitochondrial depolarization after acute ethanol treatment drives mitophagy in living mice Open
Ethanol increases hepatic mitophagy driven by unknown mechanisms. Type 1 mitophagy sequesters polarized mitochondria for nutrient recovery and cytoplasmic remodeling. In Type 2, mitochondrial depolarization (mtDepo) initiates mitophagy to …
View article: Green Tea Polyphenols Stimulate Mitochondrial Biogenesis and Improve Renal Function after Chronic Cyclosporin A Treatment in Rats
Green Tea Polyphenols Stimulate Mitochondrial Biogenesis and Improve Renal Function after Chronic Cyclosporin A Treatment in Rats Open
Our previous studies showed that an extract from Camellia sinenesis (green tea), which contains several polyphenols, attenuates nephrotoxicity caused by cyclosporine A (CsA). Since polyphenols are stimulators of mitochondrial biogenesis (M…
View article: Role of mitochondrial depolarization and disrupted mitochondrial homeostasis in non-alcoholic steatohepatitis and fibrosis in mice.
Role of mitochondrial depolarization and disrupted mitochondrial homeostasis in non-alcoholic steatohepatitis and fibrosis in mice. Open
The pathogenesis of non-alcoholic steatohepatitis (NASH) is poorly understood. Here, relationships between mitochondrial depolarization (mtDepo) and mitochondrial homeostasis were studied in a mouse model of NASH. C57BL/6 mice were fed a W…
View article: Ischemic preconditioning attenuates acute lung injury after partial liver transplantation.
Ischemic preconditioning attenuates acute lung injury after partial liver transplantation. Open
Pulmonary complications frequently occur after liver transplantation and are often life-threatening. Thus, we investigated whether hepatic ischemic preconditioning (IP) attenuates acute lung injury (ALI) after small-for-size liver transpla…
View article: 8-pCPT-cGMP prevents mitochondrial depolarization and improves the outcome of steatotic partial liver transplantation.
8-pCPT-cGMP prevents mitochondrial depolarization and improves the outcome of steatotic partial liver transplantation. Open
Permeant cGMP analogs prevent the mitochondria permeability transition (MPT) in vitro. In this study, we explored whether 8-pCPT-cGMP prevents the MPT and decreases post-transplant damage to fatty partial liver grafts (FPG) in vi…
View article: Ethanol and High Cholesterol Diet Causes Severe Steatohepatitis and Early Liver Fibrosis in Mice
Ethanol and High Cholesterol Diet Causes Severe Steatohepatitis and Early Liver Fibrosis in Mice Open
High dietary cholesterol and chronic ethanol consumption synergistically increase liver injury, inflammation, and profibrotic responses and suppress antifibrotic responses, leading to severe steatohepatitis and early fibrosis in mice.
View article: The mitochondria-targeted antioxidant MitoQ attenuates liver fibrosis in mice.
The mitochondria-targeted antioxidant MitoQ attenuates liver fibrosis in mice. Open
Oxidative stress plays an essential role in liver fibrosis. This study investigated whether MitoQ, an orally active mitochondrial antioxidant, decreases liver fibrosis. Mice were injected with corn oil or carbon tetrachloride (CCl4, 1:3 di…
View article: Alda-1 decreases whereas disulfiram increases malondialdehyde-acetaldehyde adducts after ethanol treatment.
Alda-1 decreases whereas disulfiram increases malondialdehyde-acetaldehyde adducts after ethanol treatment. Open
Mice were injected with vehicle, Alda-1 (50 mg/kg, i.p.) or DSF (200 mg/kg, i.p.) 30 min before gavage of saline or ethanol (6 g/kg). MAA adducts were detected in liver tissue at 6 h after ethanol treatment (A) or at 1…
View article: Disrupted Renal Mitochondrial Homeostasis after Liver Transplantation in Rats
Disrupted Renal Mitochondrial Homeostasis after Liver Transplantation in Rats Open
Suppression of MB, inhibition of mitochondrial fission/fusion and enhancement of mitophagy occur in the kidneys of recipients of liver grafts after long cold storage, which may contribute to the occurrence of AKI and increased mortality af…
View article: Improvement of liver injury and survival by JNK2 and iNOS deficiency in liver transplants from cardiac death mice
Improvement of liver injury and survival by JNK2 and iNOS deficiency in liver transplants from cardiac death mice Open